Roger Pertwee

Professor

    • 26771 Citations
    1970 …2020

    Research output per year

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    Research Output

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    2014

    Inhibition of colon carcinogenesis by a standardized Cannabis sativa extract with high content of cannabidiol

    Romano, B., Borrelli, F., Pagano, E., Cascio, M. G., Pertwee, R. G. & Izzo, A. A., 15 Apr 2014, In : Phytomedicine. 21, 5, p. 631-639 9 p.

    Research output: Contribution to journalArticle

    45 Citations (Scopus)

    In-vivo pharmacological evaluation of the CB1-receptor allosteric modulator Org-27569

    Gamage, T. F., Ignatowska-Jankowska, B. M., Wiley, J. L., Abdelrahman, M., Trembleau, L., Greig, I. R., Thakur, G. A., Tichkule, R., Poklis, J., Ross, R. A., Pertwee, R. G. & Lichtman, A. H., Apr 2014, In : Behavioural Pharmacology. 25, 2, p. 182-185 4 p.

    Research output: Contribution to journalArticle

    40 Citations (Scopus)

    Pyrazoles with a "click" 4-[N-(4-fluorobutyl)-1,2,3-triazole] substituent in position 3 are nanomolar CB1 receptor ligands

    Distinto, R., Zanato, C., Montanari, S., Cascio, M. G., Lazzari, P., Pertwee, R. & Zanda, M., Nov 2014, In : Journal of Fluorine Chemistry. 167, p. 184-191 8 p.

    Research output: Contribution to journalArticle

    4 Citations (Scopus)

    Structure-affinity relationships and pharmacological characterization of new alkyl-resorcinol cannabinoid receptor ligands: Identification of a dual cannabinoid receptor/TRPA1 channel agonist

    Brizzi, A., Aiello, F., Marini, P., Cascio, M. G., Corelli, F., Brizzi, V., De Petrocellis, L., Ligresti, A., Luongo, L., Lamponi, S., Maione, S., Pertwee, R. G. & Di Marzo, V., 1 Sep 2014, In : Behavioral and Brain Sciences. 22, 17, p. 4770-4783 14 p.

    Research output: Contribution to journalArticle

    6 Citations (Scopus)
    1 Downloads (Pure)
    2015

    CB2 cannabinoid receptor agonist enantiomers HU-433 and HU-308: An inverse relationship between binding affinity and biological potency

    Smoum, R., Baraghithy, S., Chourasia, M., Breuer, A., Mussai, N., Attar-Namdar, M., Kogan, N. M., Raphael, B., Bolognini, D., Cascio, M. G., Marini, P., Pertwee, R. G., Shurki, A., Mechoulam, R. & Bab, I., 14 Jul 2015, In : PNAS. 112, 28, p. 8774-8779 6 p.

    Research output: Contribution to journalArticle

    27 Citations (Scopus)

    Increasing levels of the endocannabinoid 2-AG is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

    Mounsey, R. B., Mustafa, S., Robinson, L., Ross, R. A., Riedel, G., Pertwee, R. G. & Teismann, P., Nov 2015, In : Experimental Neurology. 273, p. 36-44 9 p.

    Research output: Contribution to journalArticle

    Open Access
    File
    28 Citations (Scopus)
    5 Downloads (Pure)

    Modulation of food consumption and sleep-wake cycle in mice by the neutral CB1 antagonist ABD459

    Goonawardena, A. V., Plano, A., Robinson, L., Ross, R., Greig, I., Pertwee, R. G., Hampson, R. E., Platt, B. & Riedel, G., Apr 2015, In : Behavioural Pharmacology. 26, 3, p. 289-303 15 p.

    Research output: Contribution to journalArticle

    10 Citations (Scopus)

    The phytocannabinoid, Δ(9) -tetrahydrocannabivarin, can act through 5-HT1 A receptors to produce antipsychotic effects

    Cascio, M. G., Zamberletti, E., Marini, P., Parolaro, D. & Pertwee, R. G., Mar 2015, In : British Journal of Pharmacology. 172, 5, p. 1305-1318 14 p.

    Research output: Contribution to journalArticle

    Open Access
    File
    13 Citations (Scopus)
    5 Downloads (Pure)

    Tricyclic fused pyrazoles with a 'Click' 1,2,3-triazole substituent in position 3 are nanomolar CB1 receptor ligands

    Zanato, C., Cascio, M. G., Lazzari, P., Pertwee, R., Testa, A. & Zanda, M., Mar 2015, In : Synthesis. 47, 6, p. 817-826 10 p.

    Research output: Contribution to journalArticle

    Open Access
    File
    6 Citations (Scopus)
    16 Downloads (Pure)
    2016

    Mapping Cannabinoid 1 Receptor Allosteric Site(s): Critical Molecular Determinant and Signaling Profile of GAT100, a Novel, Potent, and Irreversibly Binding Probe

    Laprairie, R. B., Kulkarni, A. R., Kulkarni, P. M., Hurst, D. P., Lynch, D., Reggio, P. H., Janero, D. R., Pertwee, R. G., Stevenson, L. A., Kelly, M. E. M., Denovan-Wright, E. M. & Thakur, G. A., 15 Jun 2016, In : ACS Chemical Neuroscience. 7, 6, p. 776-798 23 p.

    Research output: Contribution to journalArticle

    22 Citations (Scopus)

    Novel Electrophilic and Photoaffinity Covalent Probes for Mapping the Cannabinoid 1 Receptor Allosteric Site(s)

    Kulkarni, P. M., Kulkarni, A. R., Korde, A., Tichkule, R. B., Laprairie, R. B., Denovan-Wright, E. M., Zhou, H., Janero, D. R., Zvonok, N., Makriyannis, A., Cascio, M. G., Pertwee, R. G. & Thakur, G. A., 14 Jan 2016, In : Journal of Medicinal Chemistry. 59, 1, p. 44-60 17 p.

    Research output: Contribution to journalArticle

    Open Access
    File
    33 Citations (Scopus)
    6 Downloads (Pure)
    2017

    Synthesis, radio-synthesis and in vitro evaluation of terminally fluorinated derivatives of HU-210 and HU-211 as novel candidate PET tracers

    Zanato, C., Pelagalli, A., Marwick, K. F. M., Piras, M., Dall'Angelo, S., Spinaci, A., Pertwee, R. G., Wyllie, D. J. A., Hardingham, G. E. & Zanda, M., 2017, In : Organic & Biomolecular Chemistry. 15, 9, p. 2086-2096 11 p.

    Research output: Contribution to journalArticle

    Open Access
    File
    3 Citations (Scopus)
    8 Downloads (Pure)
    2018

    Positive Allosteric Modulation of Cannabinoid Receptor Type 1 Suppresses Pathological Pain Without Producing Tolerance or Dependence

    Slivicki, R. A., Xu, Z., Kulkarni, P. M., Pertwee, R. G., Mackie, K., Thakur, G. A. & Hohmann, A. G., 15 Nov 2018, In : Biological Psychiatry. 84, 10, p. 722-733 12 p.

    Research output: Contribution to journalArticle

    26 Citations (Scopus)
    2019
    Open Access
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    4 Citations (Scopus)
    4 Downloads (Pure)

    Fatty acid suppression of glial activation prevents central neuropathic pain after spinal cord injury

    Georgieva, M., Wei, Y., Dumitrascuta, M., Pertwee, R., Finnerup, N. B. & Huang, W., Dec 2019, In : Pain. 160, 12, p. 2724-2742 19 p.

    Research output: Contribution to journalArticle

    1 Citation (Scopus)

    Identification of the First Synthetic Allosteric Modulator of the CB2 Receptors and Evidence of Its Efficacy for Neuropathic Pain Relief

    Gado, F., Di Cesare Mannelli, L., Lucarini, E., Bertini, S., Cappelli, E., Digiacomo, M., Stevenson, L. A., Macchia, M., Tuccinardi, T., Ghelardini, C., Pertwee, R. G. & Manera, C., 10 Jan 2019, In : Journal of Medicinal Chemistry. 62, 1, p. 276-287 12 p.

    Research output: Contribution to journalArticle

    8 Citations (Scopus)
    2020

    Anticancer effects of n-3 EPA and DHA and their endocannabinoid derivatives on breast cancer cell growth and invasion

    Brown, I., Lee, J., Sneddon, A. A., Cascio, M. G., Pertwee, R. G., Wahle, K. W. J., Rotondo, D. & Heys, S. D., May 2020, In : Prostaglandins, Leukotrienes and Essential Fatty Acids. 156, 10 p., 102024.

    Research output: Contribution to journalArticle

    2 Citations (Scopus)
    Open Access
    File
    3 Downloads (Pure)