Roger Pertwee

Professor

    • 26754 Citations
    1970 …2020

    Research output per year

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    Delta(8)-Tetrahydrocannabivarin prevents hepatic ischaemia/reperfusion injury by decreasing oxidative stress and inflammatory responses through cannabinoid CB2 receptors

    Batkai, S., Mukhopadhyay, P., Horvath, B., Rajesh, M., Gao, R. Y., Mahadevan, A., Amere, M., Battista, N., Lichtman, A. H., Gauson, L. A., Maccarrone, M., Pertwee, R. G. & Pacher, P., Apr 2012, In : British Journal of Pharmacology. 165, 8, p. 2450-2461 12 p.

    Research output: Contribution to journalArticle

    27 Citations (Scopus)

    Delta-9-tetrahydrocannabinol-induced catalepsy in mice is enhanced by pretreatment with flurazepam or chlorodiazepoxide

    Pertwee, R. G. & Greentree, S. G., May 1988, In : Neuropharmacology. 27, 5, p. 485-491 7 p.

    Research output: Contribution to journalArticle

    33 Citations (Scopus)

    Design and synthesis of the CB1 selective cannabinoid antagonist AM281

    Lan, R. X., Lu, Q., Fan, P. S., Gatley, J., Volkow, N. D., Fernando, S. R., Pertwee, R. G. & Makriyannis, A., Jun 1999, In : AAPS PharmSci. 1, 2, p. 39-45 7 p.

    Research output: Contribution to journalArticle

    Development of agonists, partial agonists and antagonists in the Delta(8)-tetrahydrocannabinol series

    Crocker, P. J., Saha, B., Ryan, W. J., Wiley, J. L., Martin, B. R., Ross, R. A., Pertwee, R. G. & Razdan, R. K., 3 Dec 1999, In : Tetrahedron. 55, 49, p. 13907-13926 20 p.

    Research output: Contribution to journalArticle

    18 Citations (Scopus)

    Differential effects of cannabis extracts and pure plant cannabinoids on hippocampal neurones and glia

    Ryan, D., Drysdale, A. J., Pertwee, R. G. & Platt, B., 20 Nov 2006, In : Neuroscience Letters. 408, 3, p. 236-241 6 p.

    Research output: Contribution to journalArticle

    22 Citations (Scopus)

    Differential effects of THC or CBD-rich cannabis extracts on working memory in rats

    Fadda, P., Robinson, L., Fratta, W., Pertwee, R. G. & Riedel, G., 2004, In : Neuropharmacology. 47, p. 1170-1179 10 p.

    Research output: Contribution to journalArticle

    78 Citations (Scopus)
    Open Access
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    4 Citations (Scopus)
    4 Downloads (Pure)
    58 Citations (Scopus)

    Early phytocannabinoid chemistry to endocannabinoids and beyond

    Mechoulam, R., Hanus, L. O., Pertwee, R. & Howlett, A. C., Nov 2014, In : Nature reviews neuroscience. 15, 11, p. 757-764 8 p.

    Research output: Contribution to journalArticle

    122 Citations (Scopus)
    104 Citations (Scopus)

    Effect of phenylmethylsulfonyl fluoride on the potency of anandamide as an inhibitor of electrically-evoked contractions in 2 isolated tissue preparations

    Pertwee, R. G., Fernando, S. R., Griffin, G., Abadji, V. & Makriyannis, A., 5 Jan 1995, In : European Journal of Pharmacology. 272, 1, p. 73-78 6 p.

    Research output: Contribution to journalArticle

    78 Citations (Scopus)

    Effect of sublingual application of cannabinoids on intraocular pressure: A pilot study

    Tomida, I., Azuara-Blanco, A., House, H., Flint, M., Pertwee, R. G. & Robson, P. J., Oct 2006, In : Journal of Glaucoma. 15, 5, p. 349-353 5 p.

    Research output: Contribution to journalArticle

    60 Citations (Scopus)

    Effects of cannabinoid receptor ligands on electrophysiological properties of myenteric neurones of the guinea-pig ileum

    LopezRedondo, F., Lees, G. M. & Pertwee, R. G., Sep 1997, In : British Journal of Pharmacology. 122, 2, p. 330-334 5 p.

    Research output: Contribution to journalArticle

    47 Citations (Scopus)
    6 Citations (Scopus)

    Effects of delta-9-tetrahydrocannabinol and cannabidiol on a MG2+-atpase of synaptic vesicles prepared from rat cerebral-cortex

    Gilbert, J., Pertwee, R. G. & Wyllie, M. G., 1977, In : British Journal of Pharmacology. 59, 4, p. 599-601 3 p.

    Research output: Contribution to journalArticle

    8 Citations (Scopus)

    Effects of delta-9-tetrahydrocannabinol on rates of oxygen-consumption of mice

    Pertwee, R. G. & Tavendale, R., 1977, In : British Journal of Pharmacology. 60, 4, p. 559-568 10 p.

    Research output: Contribution to journalArticle

    21 Citations (Scopus)

    Effects of delta-9-THC and WIN-55,212-2 on place preference in the water maze in rats

    Robinson, L., Hinder, L., Pertwee, R. G. & Riedel, G., Feb 2003, In : Psychopharmacology. 166, 1, p. 40-50 10 p.

    Research output: Contribution to journalArticle

    25 Citations (Scopus)

    Effects of subanesthetic doses of inert-gases on behavioral thermoregulation in mice

    Pertwee, R. G., MacDonald, A. G. & Marshall, N. R., Nov 1986, In : Journal of Applied Physiology. 61, 5, p. 1623-1633 11 p.

    Research output: Contribution to journalArticle

    5 Citations (Scopus)

    Effects of two endogenous fatty acid ethanolamides on mouse vasa deferentia

    Pertwee, R. G., Griffin, G., Hanus, L. & Mechoulam, R., 1 Jul 1994, In : European Journal of Pharmacology. 259, 2, p. 115-120 6 p.

    Research output: Contribution to journalArticle

    49 Citations (Scopus)
    46 Citations (Scopus)

    Endocannabinoids control spasticity in a multiple sclerosis model.

    Baker, D., Pryce, G., Croxford, J. L., Brown, P., Pertwee, R. G., Makriyannis, A., Khanolkar, A., Fezza, F., Bisogno, T. & Di Marzo, V., Feb 2001, In : The FASEB Journal. 15, 2, p. 300-302 2 p.

    Research output: Contribution to journalArticle

    342 Citations (Scopus)

    Endogenous cannabinoids improve myocardial resistance to arrhythmogenic effects of coronary occlusion and reperfusion: a possible mechanism

    Krylatov, A. V., Uzhachenko, R. V., Maslov, L. N., Bernatskaya, N. A., Makriyannis, A., Mechoulam, R., Pertwee, R. G., Sal'nikova, O. M., Stefano, J. B. & Lishmanov, Y. B., 2002, In : Bulletin of Experimental Biology and Medicine. 133, p. 122-124 3 p.

    Research output: Contribution to journalArticle

    22 Citations (Scopus)
    65 Citations (Scopus)

    Enhancement of the hypothermic response of mice to delta-9-tetrahydrocannabinol by subhypothermic doses of chloropromazine and phentolamine

    Gray, G. A., Hedley, D. & Pertwee, R. G., Feb 1987, In : Neuropharmacology. 26, 2-3, p. 229-235 7 p.

    Research output: Contribution to journalArticle

    4 Citations (Scopus)

    Evidence for the presence of cannabinoid CB1 receptors in mouse urinary bladder

    Pertwee, R. G. & Fernando, S. R., Aug 1996, In : British Journal of Pharmacology. 118, 8, p. 2053-2058 6 p.

    Research output: Contribution to journalArticle

    117 Citations (Scopus)

    Evidence for the presence of CB2-like cannabinoid receptors on peripheral nerve terminals

    Griffin, G., Fernando, S. R., Ross, R. A., McKay, G., Ashford, M. L. J., Shire, D., Huffman, J. W., Yu, S., Lainton, J. A. H. & Pertwee, R. G., 19 Nov 1997, In : European Journal of Pharmacology. 339, 1, p. 53-61 9 p.

    Research output: Contribution to journalArticle

    152 Citations (Scopus)

    Evidence that (-)-7-hydroxy-4 '-dimethylheptyl-cannabidiol activates a non-CB1, non-CB2, non-TRPV1 target in the mouse vas deferens

    Pertwee, R. G., Thomas, A., Stevenson, L. A., Maor, Y. & Mechoulam, R., 2005, In : Neuropharmacology. 48, p. 1139-1146 8 p.

    Research output: Contribution to journalArticle

    26 Citations (Scopus)

    Evidence that methyl arachidonyl fluorophosphonate is an irreversible cannabinoid receptor antagonist

    Fernando, S. R. & Pertwee, R. G., Aug 1997, In : British Journal of Pharmacology. 121, 8, p. 1716-1720 5 p.

    Research output: Contribution to journalArticle

    47 Citations (Scopus)

    Evidence that the plant cannabinoid ¿9-tetrahydrocannabivarin is a cannabinoid CB1 and CB2 receptor antagonist

    Thomas, A., Stevenson, L. A., Wease, K., Price, M., Baillie, G., Ross, R. A. & Pertwee, R. G., Dec 2005, In : British Journal of Pharmacology. 146, 7, p. 917-926 9 p.

    Research output: Contribution to journalArticle

    110 Citations (Scopus)

    Evidence that the plant cannabinoid cannabigerol is a highly potent α2-adrenoceptor agonist and moderately potent 5HT1A receptor antagonist

    Cascio, M. G., Gauson, L. A., Stevenson, L. A., Ross, R. A. & Pertwee, R. G., Jan 2010, In : British Journal of Pharmacology. 159, 1, p. 129-141 13 p.

    Research output: Contribution to journalArticle

    77 Citations (Scopus)

    Fatty acid suppression of glial activation prevents central neuropathic pain after spinal cord injury

    Georgieva, M., Wei, Y., Dumitrascuta, M., Pertwee, R., Finnerup, N. B. & Huang, W., Dec 2019, In : Pain. 160, 12, p. 2724-2742 19 p.

    Research output: Contribution to journalArticle

    1 Citation (Scopus)

    First "hybrid" ligands of vanilloid TRPV1 and cannabinoid CB2 receptors and non-polyunsaturated fatty acid-derived CB2-selective ligands

    Appendino, G., Cascio, M. G., Bacchiega, S., Moriello, A. S., Minassi, A., Thomas, A., Ross, R., Pertwee, R., De Petrocellis, L. & Di Marzo, V., 2006, In : FEBS Letters. 580, p. 568-574 7 p.

    Research output: Contribution to journalArticle

    23 Citations (Scopus)

    Functional expression of cell surface cannabinoid CB(1) receptors on presynaptic inhibitory terminals in cultured rat hippocampal neurons

    Irving, A. J., Coutts, A. A., Harvey, J., Rae, M. G., Mackie, K., Bewick, G. S. & Pertwee, R. G., Jun 2000, In : Neuroscience. 98, 2, p. 253-262 10 p.

    Research output: Contribution to journalArticle

    75 Citations (Scopus)

    Functional expression of cell surface cannabinoid CB1 receptors on presynaptic inhibitory terminals in cultured rat hippocampal neurons

    Irving, A. J., Coutts, A. A., Harvey, J., Rae, M. G., Mackie, K., Bewick, G. S. & Pertwee, R. G., 2000, In : Neuroscience. 98, p. 253-262 10 p.

    Research output: Contribution to journalArticle

    75 Citations (Scopus)

    Functions of cannabinoid receptors in the hippocampus

    Davies, S. N., Pertwee, R. G. & Riedel, G., Jun 2002, In : Neuropharmacology. 42, 8, p. 993-1007 14 p.

    Research output: Contribution to journalArticle

    145 Citations (Scopus)

    Further evidence for the presence of cannabinoid CB1, receptors in mouse vas deferens

    Pertwee, R. G., JoeAdigwe, G. & Hawksworth, G. M., 25 Jan 1996, In : European Journal of Pharmacology. 296, 2, p. 169-172 4 p.

    Research output: Contribution to journalArticle

    32 Citations (Scopus)

    Further evidence for the presence of cannabinoid CB1 receptors in guinea-pig small intestine

    Pertwee, R. G., Fernando, S. R., Nash, J. E. & Coutts, A. A., Aug 1996, In : British Journal of Pharmacology. 118, 8, p. 2199-2205 7 p.

    Research output: Contribution to journalArticle

    156 Citations (Scopus)

    Hippocampal endocannabinoids inhibit spatial learning and limit spatial memory in rats

    Robinson, L., McKillop-Smith, S., Ross, N. L., Pertwee, R. G., Hampson, R. E., Platt, B. & Riedel, G., Jul 2008, In : Psychopharmacology. 198, 4, p. 551-563 13 p.

    Research output: Contribution to journalArticle

    44 Citations (Scopus)

    HU-308: A specific agonist for CB2, a peripheral cannabinoid receptor

    Hanus, L., Breuer, A., Tchilibon, S., Shiloah, S., Goldenberg, D., Horowitz, M., Pertwee, R. G., Ross, R. A., Mechoulam, R. & Fride, E., 7 Dec 1999, In : PNAS. 96, 25, p. 14228-14233 6 p.

    Research output: Contribution to journalArticle

    437 Citations (Scopus)

    IDENTIFICATION OF AN ENDOGENOUS 2-MONOGLYCERIDE, PRESENT IN CANINE GUT, THAT BINDS TO CANNABINOID RECEPTORS

    MECHOULAM, R., BENSHABAT, S., HANUS, L., LIGUMSKY, M., KAMINSKI, N. E., SCHATZ, A. R., GOPHER, A., ALMOG, S., COMPTON, D. R., Pertwee, R. G., GRIFFIN, G., BAYEWITCH, M., BARG, J., VOGEL, Z. & Martin, B. R., 29 Jun 1995, In : Biochemical Pharmacology. 50, 1, p. 83-90 8 p.

    Research output: Contribution to journalArticle

    2071 Citations (Scopus)

    Identification of the First Synthetic Allosteric Modulator of the CB2 Receptors and Evidence of Its Efficacy for Neuropathic Pain Relief

    Gado, F., Di Cesare Mannelli, L., Lucarini, E., Bertini, S., Cappelli, E., Digiacomo, M., Stevenson, L. A., Macchia, M., Tuccinardi, T., Ghelardini, C., Pertwee, R. G. & Manera, C., 10 Jan 2019, In : Journal of Medicinal Chemistry. 62, 1, p. 276-287 12 p.

    Research output: Contribution to journalArticle

    8 Citations (Scopus)

    Importance of the C-1 substituent in classical cannabinoids to CB2 receptor selectivity: Synthesis and characterization of a series of O,2-propano-Delta(8)-tetrahydrocannabinol analogs

    Reggio, P. H., Wang, T., Brown, A. E., Fleming, D. N., Seltzman, H. H., Griffin, G., Pertwee, R. G., Compton, D. R., Abood, M. E. & Martin, R., 26 Sep 1997, In : Journal of Medicinal Chemistry. 40, 20, p. 3312-3318 7 p.

    Research output: Contribution to journalArticle

    20 Citations (Scopus)

    Increasing levels of the endocannabinoid 2-AG is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

    Mounsey, R. B., Mustafa, S., Robinson, L., Ross, R. A., Riedel, G., Pertwee, R. G. & Teismann, P., Nov 2015, In : Experimental Neurology. 273, p. 36-44 9 p.

    Research output: Contribution to journalArticle

    Open Access
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    28 Citations (Scopus)
    5 Downloads (Pure)

    Influence of the degree of unsaturation of the acyl side chain upon the interaction of analogues of 1-arachidonoylglycerol with monoacylglycerol lipase and fatty acid amide hydrolase

    Vandevoorde, S., Saha, B., Mahadevan, A., Razdan, R. K., Pertwee, R. G., Martin, B. R. & Fowler, C. J., 2005, In : Biochemical and Biophysical Research Communications. 337, p. 104-109 6 p.

    Research output: Contribution to journalArticle

    40 Citations (Scopus)

    Inhibition by cannabinoid receptor agonists of acetylcholine release from the guinea-pig myenteric plexus

    Coutts, A. A. & Pertwee, R. G., Aug 1997, In : British Journal of Pharmacology. 121, 8, p. 1557-1566 10 p.

    Research output: Contribution to journalArticle

    132 Citations (Scopus)