Roger Pertwee

Professor

    • 26771 Citations
    1970 …2020

    Research output per year

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    WIN55,212-2 induced deficits in spatial learning are mediated by cholinergic hypofunction

    Robinson, L., Goonawardena, A. V., Pertwee, R. G., Hampson, R., Platt, B. & Riedel, G., 2 Apr 2010, In : Behavioural Brain Research. 208, 2, p. 584-592 9 p.

    Research output: Contribution to journalArticle

    34 Citations (Scopus)

    Tricyclic fused pyrazoles with a 'Click' 1,2,3-triazole substituent in position 3 are nanomolar CB1 receptor ligands

    Zanato, C., Cascio, M. G., Lazzari, P., Pertwee, R., Testa, A. & Zanda, M., Mar 2015, In : Synthesis. 47, 6, p. 817-826 10 p.

    Research output: Contribution to journalArticle

    Open Access
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    6 Citations (Scopus)
    16 Downloads (Pure)

    The synthetic cannabinoid HU210 induces spatial memory deficits and suppresses hippocampal firing rate in rats

    Robinson, L., Goonawardena, A. V., Pertwee, R. G., Hampson, R. E. & Riedel, G., Jul 2007, In : British Journal of Pharmacology. 151, 5, p. 688-700 13 p.

    Research output: Contribution to journalArticle

    39 Citations (Scopus)

    Thermoregulatory effects of N6-2'-0-dibutyryl adenosine-3',5'-monophosphate in the restrained mouse

    Dascombe, M. J., Milton, AS., Nyemiteiaddo, I. & Pertwee, R. G., 1980, In : British Journal of Pharmacology. 70, 3, p. 453-459 7 p.

    Research output: Contribution to journalArticle

    4 Citations (Scopus)
    171 Citations (Scopus)

    The psychoactive plant cannabinoid, Δ9-tetrahydrocannabinol, is antagonized by Δ8- and Δ9-tetrahydrocannabivarin in mice in vivo

    Pertwee, R. G., Thomas, A., Stevenson, L. A., Ross, R. A., Varvel, S. A., Lichtman, A. H., Martin, B. R. & Razdan, R. K., Mar 2007, In : British Journal of Pharmacology. 150, 5, p. 586-594 9 p.

    Research output: Contribution to journalArticle

    60 Citations (Scopus)

    The plant cannabinoid Δ9-tetrahydrocannabivarin can decrease signs of inflammation and inflammatory pain in mice

    Bolognini, D., Costa, B., Maione, S., Comelli, F., Marini, P., Di Marzo, V., Parolaro, D., Ross, R. A., Gauson, L. A., Cascio, M. G. & Pertwee, R. G., Jun 2010, In : British Journal of Pharmacology. 160, 3, p. 677-687 11 p.

    Research output: Contribution to journalArticle

    63 Citations (Scopus)

    The phytocannabinoid, Δ(9) -tetrahydrocannabivarin, can act through 5-HT1 A receptors to produce antipsychotic effects

    Cascio, M. G., Zamberletti, E., Marini, P., Parolaro, D. & Pertwee, R. G., Mar 2015, In : British Journal of Pharmacology. 172, 5, p. 1305-1318 14 p.

    Research output: Contribution to journalArticle

    Open Access
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    13 Citations (Scopus)
    5 Downloads (Pure)

    The pharmacology of cannabinoid receptors and their ligands: an overview

    Pertwee, R. G., 2006, In : International Journal of Obesity. 30, Supplement 1, p. S13–S18 6 p.

    Research output: Contribution to journalArticle

    321 Citations (Scopus)

    The perceived effects of smoked cannabis on patients with multiple sclerosis

    Consroe, P., Musty, R., Rein, J., Tillery, W. & Pertwee, R. G., 1997, In : European Journal of Neurology. 38, 1, p. 44-48 5 p.

    Research output: Contribution to journalArticle

    251 Citations (Scopus)
    6 Citations (Scopus)

    The endogenous cannabinoid anandamide activates vanilloid receptors in the rat hippocampal slice

    Al-Hayani, A., Wease, K., Ross, R. A., Pertwee, R. G. & Davies, S. N., Dec 2001, In : Neuropharmacology. 41, 8, p. 1000-1005 5 p.

    Research output: Contribution to journalArticle

    109 Citations (Scopus)

    The effects of ¿9-tetrahydrocannabinol and cannabidiol alone and in combination on damage, inflammation and in vitro motility disturbances in rat colitis

    Jamontt, J. M., Molleman, A., Pertwee, R. G. & Parsons, M. E., Jun 2010, In : British Journal of Pharmacology. 160, 3, p. 712-723 12 p.

    Research output: Contribution to journalArticle

    68 Citations (Scopus)

    The design, synthesis and testing of deoxy-CBD : further evidence for a region of steric interference at the cannabinoid receptor

    Reggio, P. H., Bramblett, R. D., Yuknavich, H., Seltzman, H. H., Fleming, D. N., Fernando, S. R., Stevenson, L. A. & Pertwee, R. G., 5 May 1995, In : Life Sciences. 56, 23-24, p. 2025-2032 8 p.

    Research output: Contribution to journalArticle

    13 Citations (Scopus)

    The cannabinoid TRPA1 agonist cannabichromene inhibits nitric oxide production in macrophages and ameliorates murine colitis

    Romano, B., Borrelli, F., Fasolino, I., Capasso, R., Piscitelli, F., Cascio, M. G., Pertwee, R. G., Coppola, D., Vassallo, L., Orlando, P., Di Marzo, V. & Izzo, A. A., May 2013, In : British Journal of Pharmacology. 169, 1, p. 213-229 16 p.

    Research output: Contribution to journalArticle

    73 Citations (Scopus)

    The bioactive conformation of aminoalkylindoles at the cannabinoid CB1 and CB2 receptors: Insights gained from (E)- and (Z)-naphthylidene indenes

    Reggio, P. H., Basu-Dutt, S., Barnett-Norris, J., Castro, M. T., Hurst, D. P., Seltzman, H. H., Roche, M. J., Gilliam, A. F., Thomas, B. F., Stevenson, L. A., Pertwee, R. G. & Abood, M. E., 1998, In : Journal of Medicinal Chemistry. 41, p. 5177-5187 11 p.

    Research output: Contribution to journalArticle

    60 Citations (Scopus)

    Synthetic and plant-derived cannabinoid receptor antagonists show hypophagic properties in fasted and non-fasted mice

    Riedel, G., Fadda, P., McKillop-Smith, S., Pertwee, R. G., Platt, B. & Robinson, L., Apr 2009, In : British Journal of Pharmacology. 156, 7, p. 1154-1166 13 p.

    Research output: Contribution to journalArticle

    72 Citations (Scopus)

    Synthesis of long-chain amide analogs of the cannabinoid CB1 receptor antagonist N-(piperidinyl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716) with unique binding selectivities and pharmacological activities

    Thomas, B. F., Francisco, M. E. Y., Seltzman, H. H., Thomas, J. B., Fix, S. E., Schulz, A. K., Gilliam, A. F., Pertwee, R. G. & Stevenson, L. A., 2005, In : Bioorganic & Medicinal Chemistry. 13, p. 5463-5474 12 p.

    Research output: Contribution to journalArticle

    26 Citations (Scopus)

    Synthesis and structure-activity relationships of amide and hydrazide analogues of the cannabinoid CB1 receptor antagonist N-(piperidinyl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716)

    Francisco, M. E. Y., Seltzman, H. H., Gilliam, A. F., Mitchell, R. A., Rider, S. L., Pertwee, R. G., Stevenson, L. A. & Thomas, B. F., 2002, In : Journal of Medicinal Chemistry. 45, p. 2708-2719 12 p.

    Research output: Contribution to journalArticle

    93 Citations (Scopus)

    Synthesis and pharmacological comparison of dimethylheptyl and pentyl analogs of anandamide

    Seltzman, H. H., Fleming, D. N., Thomas, B. F., Gilliam, A. F., McCallion, D. S., Pertwee, R. G., Compton, D. R. & Martin, B. R., 24 Oct 1997, In : Journal of Medicinal Chemistry. 40, 22, p. 3626-3634 9 p.

    Research output: Contribution to journalArticle

    58 Citations (Scopus)

    Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1)

    Hillard, C. J., Manna, S., Greenberg, M. J., Dicamelli, R., Ross, R. A., Stevenson, L. A., Murphy, V., Pertwee, R. G. & Campbell, W. B., 1 Jun 1999, In : Journal of Pharmacology and Experimental Therapeutics. 289, 3, p. 1427-1433 7 p.

    Research output: Contribution to journalArticle

    281 Citations (Scopus)

    Synthesis, radio-synthesis and in vitro evaluation of terminally fluorinated derivatives of HU-210 and HU-211 as novel candidate PET tracers

    Zanato, C., Pelagalli, A., Marwick, K. F. M., Piras, M., Dall'Angelo, S., Spinaci, A., Pertwee, R. G., Wyllie, D. J. A., Hardingham, G. E. & Zanda, M., 2017, In : Organic & Biomolecular Chemistry. 15, 9, p. 2086-2096 11 p.

    Research output: Contribution to journalArticle

    Open Access
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    3 Citations (Scopus)
    8 Downloads (Pure)

    Structure-affinity relationships and pharmacological characterization of new alkyl-resorcinol cannabinoid receptor ligands: Identification of a dual cannabinoid receptor/TRPA1 channel agonist

    Brizzi, A., Aiello, F., Marini, P., Cascio, M. G., Corelli, F., Brizzi, V., De Petrocellis, L., Ligresti, A., Luongo, L., Lamponi, S., Maione, S., Pertwee, R. G. & Di Marzo, V., 1 Sep 2014, In : Behavioral and Brain Sciences. 22, 17, p. 4770-4783 14 p.

    Research output: Contribution to journalArticle

    6 Citations (Scopus)
    1 Downloads (Pure)

    Structure-activity relationships of pyrazole derivatives as cannabinoid receptor antagonists

    Lan, R. X., Liu, Q., Fan, P. S., Lin, S. Y., Fernando, S. R., McCallion, D., Pertwee, R. & Makriyannis, A., 1999, In : Journal of Medicinal Chemistry. 42, p. 769-776 8 p.

    Research output: Contribution to journalArticle

    391 Citations (Scopus)

    Structure-activity relationship for the endogenous cannabinoid, anandamide, and certain of its analogues at vanilloid receptors in transfected cells and vas deferens

    Ross, R. A., Gibson, T. M., Brockie, H. C., Leslie, M., Pashmi, G., Craib, S., Di Marzo, V. & Pertwee, R. G., Feb 2001, In : British Journal of Pharmacology. 132, 3, p. 631-640 9 p.

    Research output: Contribution to journalArticle

    205 Citations (Scopus)

    Structural determinants of the partial agonist-inverse agonist properties of 6'-azidohex-2'-yne-¿8-tetrahydrocannabinol at cannabinoid receptors

    Ross, R. A., Gibson, T. M., Stevenson, L. A., Saha, B., Crocker, P., Razdan, R. K. & Pertwee, R. G., Oct 1999, In : British Journal of Pharmacology. 128, 3, p. 735-743 9 p.

    Research output: Contribution to journalArticle

    47 Citations (Scopus)

    Structural and pharmacological analysis of O-2050, a putative neutral cannabinoid CB(1) receptor antagonist

    Wiley, J. L., Breivogel, C. S., Mahadevan, A., Pertwee, R. G., Cascio, M. G., Bolognini, D., Huffman, J. W., Walentiny, D. M., Vann, R. E., Razdan, R. K. & Martin, B. R., 25 Jan 2011, In : European Journal of Pharmacology. 651, 1-3, p. 96-105 10 p.

    Research output: Contribution to journalArticle

    27 Citations (Scopus)

    Significance of cardiac cannabinoid receptors in regulation of cardiac rhythm, myocardial contractility, and electrophysiologic processes in heart

    Krylatov, A. V., Maslov, L. N., Ermakov, S. Y., Lasukova, O. V., Barzakh, E. I., Crawford, D. & Pertwee, R. G., Jan 2007, In : Bulletin of Experimental Biology and Medicine. 34, 1, p. 28-35 8 p.

    Research output: Contribution to journalArticle

    4 Citations (Scopus)

    Selective cannabinoiod receptor agonist HU-210 decreases pump function of isolated perfused heart: Role of cAMP and cGMP

    Maslov, L. N., Lasukova, O. V., Krylatov, A. V., Uzhachenko, R. V. & Pertwee, R., 2004, In : Bulletin of Experimental Biology and Medicine. 138, p. 550-553 4 p.

    Research output: Contribution to journalArticle

    Scopolamine and MK801-induced working memory deficits in rats are not reversed by CBD-rich cannabis extracts

    Fadda, P., Robinson, L., Fratta, W., Pertwee, R. G. & Riedel, G., 2006, In : Behavioural Brain Research. 168, p. 307-311 5 p.

    Research output: Contribution to journalArticle

    25 Citations (Scopus)

    Sativex-like Combination of Phytocannabinoids is Neuroprotective in Malonate-Lesioned Rats, an Inflammatory Model of Huntington's Disease: Role of CB1 and CB2 Receptors

    Valdeolivas, S., Satta, V., Pertwee, R. G., Fernandez-Ruiz, J. & Sagredo, O., 9 Feb 2012, In : ACS Chemical Neuroscience. 3, 5, p. 400-406 7 p.

    Research output: Contribution to journalArticle

    63 Citations (Scopus)

    Role of cannabinoid receptors in the regulation of cardiac contractility during ischemia/reperfusion

    Maslov, L. N., Lasukova, O. V., Krylatov, A. V., Hanus, L. O., Pertwee, R. G., Ivanchuk, I. I. & Crowford, D., 2006, In : Bulletin of Experimental Biology and Medicine. 142, 5, p. 557-561 5 p.

    Research output: Contribution to journalArticle

    4 Citations (Scopus)

    Relative pharmacological potency in mice of optical isomers of delta1-tetrahydrocannabinol

    Jones, G., Pertwee, R. G., Gill, E. W., Paton, W. D. M., Nilsson, I. M., Widman, M. & Agurell, S., 15 Jan 1974, In : Biochemical Pharmacology. 23, 2, p. 439-446 8 p.

    Research output: Contribution to journalArticle

    27 Citations (Scopus)

    Pyrazoles with a "click" 4-[N-(4-fluorobutyl)-1,2,3-triazole] substituent in position 3 are nanomolar CB1 receptor ligands

    Distinto, R., Zanato, C., Montanari, S., Cascio, M. G., Lazzari, P., Pertwee, R. & Zanda, M., Nov 2014, In : Journal of Fluorine Chemistry. 167, p. 184-191 8 p.

    Research output: Contribution to journalArticle

    4 Citations (Scopus)

    Prescribing cannabinoids for multiple sclerosis - Current issues

    Pertwee, R. G., 1999, In : CNS Drugs. 11, p. 327-334 8 p.

    Research output: Contribution to journalArticle

    8 Citations (Scopus)

    Preliminary experiments on chemistry and pharmacology of cannabis

    Gill, E. W., Paton, W. D. M. & Pertwee, R. G., 1970, In : Nature. 228, 5267, p. 134

    Research output: Contribution to journalArticle

    150 Citations (Scopus)

    Positive Allosteric Modulation of Cannabinoid Receptor Type 1 Suppresses Pathological Pain Without Producing Tolerance or Dependence

    Slivicki, R. A., Xu, Z., Kulkarni, P. M., Pertwee, R. G., Mackie, K., Thakur, G. A. & Hohmann, A. G., 15 Nov 2018, In : Biological Psychiatry. 84, 10, p. 722-733 12 p.

    Research output: Contribution to journalArticle

    26 Citations (Scopus)

    Phytocannabinoids beyond the Cannabis plant - do they exist?

    Gertsch, J., Pertwee, R. G. & Di Marzo, V., Jun 2010, In : British Journal of Pharmacology. 160, 3, p. 523-529 7 p.

    Research output: Contribution to journalArticle

    85 Citations (Scopus)

    Pharmacophoric requirements for the cannabinoid side chain. Probing the cannabinoid receptor subsite at C1'

    Papahatjis, D. P., Nikas, S. P., Kourouli, T., Chari, R., Xu, W., Pertwee, R. G. & Makriyannis, A., 2003, In : Journal of Medicinal Chemistry. 46, p. 3221-3229 9 p.

    Research output: Contribution to journalArticle

    42 Citations (Scopus)

    Pharmacological characterization of three novel cannabinoid receptor agonists in the mouse isolated vas deferens

    Pertwee, R. G., GRIFFIN, G., LAINTON, J. A. H. & HUFFMAN, J. W., 25 Sep 1995, In : European Journal of Pharmacology. 284, 3, p. 241-247 7 p.

    Research output: Contribution to journalArticle

    59 Citations (Scopus)

    Pharmacological characterization of the anandamide cyclooxygenase metabolite

    Ross, R. A., Craib, S., Stevenson, L. A., Pertwee, R. G., Henderson, A., Toole, J. & Ellington, H. C., 1 Jun 2002, In : Journal of Pharmacology and Experimental Therapeutics. 301, 3, p. 900-907 7 p.

    Research output: Contribution to journalArticle

    93 Citations (Scopus)

    Pharmacological and therapeutic targets for Delta(9)-tetrahydrocannabinol and cannabidiol

    Pertwee, R. G., 2004, In : Euphytica. 140, p. 73-82 10 p.

    Research output: Contribution to journalArticle

    Overlap between the ligand recognition properties of the anandamide transporter and the VR1 vanilloid receptor: inhibitors of anandamide uptake with negligible capsaicin-like activity

    De Petrocellis, L., Bisogno, T., Davis, J. B., Pertwee, R. G. & Di Marzo, V., 2000, In : FEBS Letters. 483, p. 52-56 5 p.

    Research output: Contribution to journalArticle

    312 Citations (Scopus)

    Omega-3 N-acylethanolamines are endogenously synthesised from omega-3 fatty acids in different human prostate and breast cancer cell lines

    Brown, I., Wahle, K. W., Cascio, M. G., Smoum, R., Mechoulam, R., Pertwee, R. G. & Heys, S. D., Dec 2011, In : Prostaglandins, Leukotrienes and Essential Fatty Acids. 85, 6, p. 305-310 6 p.

    Research output: Contribution to journalArticle

    28 Citations (Scopus)

    O-1057, a potent water-soluble cannabinoid receptor agonist with antinociceptive properties

    Pertwee, R. G., Gibson, T. M., Stevenson, L. A., Ross, R. A., Banner, W. K., Saha, B., Razdan, R. K. & Martin, B. R., Apr 2000, In : British Journal of Pharmacology. 129, 8, p. 1577-1584 8 p.

    Research output: Contribution to journalArticle

    44 Citations (Scopus)

    Novel Electrophilic and Photoaffinity Covalent Probes for Mapping the Cannabinoid 1 Receptor Allosteric Site(s)

    Kulkarni, P. M., Kulkarni, A. R., Korde, A., Tichkule, R. B., Laprairie, R. B., Denovan-Wright, E. M., Zhou, H., Janero, D. R., Zvonok, N., Makriyannis, A., Cascio, M. G., Pertwee, R. G. & Thakur, G. A., 14 Jan 2016, In : Journal of Medicinal Chemistry. 59, 1, p. 44-60 17 p.

    Research output: Contribution to journalArticle

    Open Access
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    33 Citations (Scopus)
    6 Downloads (Pure)

    Novel compounds that interact with both leukotriene B-4 receptors and vanilloid TRPV1 receptors

    McHugh, D., McMaster, R. S., Pertwee, R. G., Roy, S., Mahadevan, A., Razdan, R. K. & Ross, R. A., 2006, In : Journal of Pharmacology and Experimental Therapeutics. 316, p. 955-965 11 p.

    Research output: Contribution to journalArticle

    18 Citations (Scopus)

    Neuroprotective Effects of the Nonpsychoactive Cannabinoid Cannabidiol in Hypoxic-Ischemic Newborn Piglets

    Alvarez, F. J., Lafuente, H., Rey-Santano, M. C., Mielgo, V. E., Gastiasoro, E., Rueda, M., Pertwee, R. G., Castillo, A. I., Romero, J. & Martinez-Orgado, J., Dec 2008, In : Pediatric Research. 64, 6, p. 653-658 6 p.

    Research output: Contribution to journalArticle

    91 Citations (Scopus)