Roger Pertwee

Professor

    • 26449 Citations
    1970 …2020

    Research output per year

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    Research Output

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    Actions of cannabinoid receptor ligands on rat cultured sensory neurones: implications for antinociception

    Ross, R. A., Coutts, A. A., McFarlane, S. M., Anavi-Goffer, S., Irving, A. J., Pertwee, R. G., MacEwan, D. J. & Scott, R. H., Jan 2001, In : Neuropharmacology. 40, 2, p. 221-232 11 p.

    Research output: Contribution to journalArticle

    148 Citations (Scopus)

    Activation of cannabinoid receptors decreases the area of ischemic myocardial necrosis

    Ugdyzhekova, D. S., Krylatov, A. V., Bernatskaya, N. A., Maslov, L. N., Mechoulam, R. & Pertwee, R. G., 2002, In : Bulletin of Experimental Biology and Medicine. 133, p. 125-126 2 p.

    Research output: Contribution to journalArticle

    16 Citations (Scopus)

    Activation of type II cannabinoid receptors improves myocardial tolerance to arrhythmogenic effects of coronary occlusion and reperfusion

    Krylatov, A. V., Ugdyshekova, D. S., Bernatskaya, N. A., Maslov, L. N., Mekhoulam, R., Pertwee, R. G. & Stephano, G. B., 2001, In : Bulletin of Experimental Biology and Medicine. 131, p. 523-525 3 p.

    Research output: Contribution to journalArticle

    40 Citations (Scopus)

    Agonist-antagonist characterization of 6'-cyanohex-2'-yne-Delta(8)-tetrahydrocannabinol in two isolated tissue preparations

    Pertwee, R. G., Fernando, S. R., Griffin, G., Ryan, W., Razdan, R. K., Compton, D. R. & Billy R., M., 14 Nov 1996, In : European Journal of Pharmacology. 315, 2, p. 195-201 7 p.

    Research output: Contribution to journalArticle

    40 Citations (Scopus)

    Agonist-induced internalization and trafficking of cannabinoid CB1 receptors in hippocampal neurons

    Coutts, A. A., Anavi-Goffer, S., Ross, R. A., MacEwan, D. J., Mackie, K., Pertwee, R. G. & Irving, A. J., Apr 2001, In : Journal of Neuroscience. 21, 7, p. 2425-2433 9 p.

    Research output: Contribution to journalArticle

    130 Citations (Scopus)

    Agonist inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656 and AM630

    Ross, R. A., Brockie, H. C., Stevenson, L. A., Murphy, V. L., Templeton, F., Makriyannis, A. & Pertwee, R. G., Feb 1999, In : British Journal of Pharmacology. 126, 3, p. 665-672 8 p.

    Research output: Contribution to journalArticle

    320 Citations (Scopus)

    Allosteric modulation of the cannabinoid CB1 receptor

    Price, M. R., Baillie, G. L., Thomas, A., Stevenson, L. A., Easson, M., Goodwin, R., McLean, A., McIntosh, L., Goodwin, G., Walker, G., Westwood, P., Marrs, J., Thomson, F., Cowley, P., Christopoulos, A., Pertwee, R. G. & Ross, R. A., Nov 2005, In : Molecular Pharmacology. 68, 5, p. 1484-1495 12 p.

    Research output: Contribution to journalArticle

    307 Citations (Scopus)

    AM630, a competitive cannabinoid receptor antagonist

    Pertwee, R. G., Griffin, G., Fernando, S., Li, X., Hill, A. & Makriyannis, A., 5 May 1995, In : Life Sciences. 56, 23-24, p. 1949-1955 7 p.

    Research output: Contribution to journalArticle

    117 Citations (Scopus)

    AM630 behaves as a protean ligand at the human cannabinoid CB2 receptor

    Bolognini, D., Cascio, M. G., Parolaro, D. & Pertwee, R. G., Apr 2012, In : British Journal of Pharmacology. 165, 8, p. 2561-2574 14 p.

    Research output: Contribution to journalArticle

    33 Citations (Scopus)

    Anandamide activates peripheral nociceptors in normal and arthritic rat knee joints

    Gauldie, S. D., McQueen, D. S., Pertwee, R. & Chessell, I. P., 2001, In : British Journal of Pharmacology. 132, p. 617-621 5 p.

    Research output: Contribution to journalArticle

    64 Citations (Scopus)

    An investigation of the involvement of GABA in certain pharmacological effects of delta-9-tetrahydrocannabinol

    Pertwee, R. G., Browne, S. E., Stretton, C. D. & Ross, T. M., Nov 1991, In : Pharmacology, Biochemistry & Behavior. 40, 3, p. 581-585 5 p.

    Research output: Contribution to journalArticle

    19 Citations (Scopus)

    Anticancer effects of n-3 EPA and DHA and their endocannabinoid derivatives on breast cancer cell growth and invasion

    Brown, I., Lee, J., Sneddon, A. A., Cascio, M. G., Pertwee, R. G., Wahle, K. W. J., Rotondo, D. & Heys, S. D., 16 Oct 2019, In : Prostaglandins, Leukotrienes and Essential Fatty Acids. 102024.

    Research output: Contribution to journalArticle

    Anti-inflammatory property of the cannaboinid receptor-2-selective agonist JWH-133 in a rodent model of autoimmune uveoretinitis

    Xu, H., Cheng, C. L., Chen, M., Manivannan, A., Cabay, L., Pertwee, R. G., Coutts, A. A. & Forrester, J. V., 1 Sep 2007, In : Journal of Leukocyte Biology. 82, 3, p. 532-541 10 p.

    Research output: Contribution to journalArticle

    79 Citations (Scopus)

    A possible role of lipoxygenase in the activation of vanilloid receptors by anandamide in the guinea-pig bronchus

    Craib, S., Ellington, H. C., Pertwee, R. G. & Ross, R. A., Sep 2001, In : British Journal of Pharmacology. 134, 1, p. 30-37 7 p.

    Research output: Contribution to journalArticle

    89 Citations (Scopus)

    A preliminary investigation of the mechanisms underlying cannabinoid tolerance in the mouse vas deferens

    Pertwee, R. G. & Griffin, G., 5 Jan 1995, In : European Journal of Pharmacology. 272, 1, p. 67-72 6 p.

    Research output: Contribution to journalArticle

    19 Citations (Scopus)

    Behavioral thermoregulation in mice subjected to high-pressure

    MacDonald, A. G., Pertwee, R. G. & Marshall, N. R., Jan 1989, In : Journal of Applied Physiology. 66, 1, p. 238-244 7 p.

    Research output: Contribution to journalArticle

    2 Citations (Scopus)

    Behavioural thermoregulation in mice: effects of low-doses of general-anesthetics of different potency

    Pertwee, R. G., Marshall, N. R. & MacDonald, A. G., Sep 1990, In : Experimental Physiology. 75, 5, p. 629-637 9 p.

    Research output: Contribution to journalArticle

    9 Citations (Scopus)

    Biochanin A, a naturally occurring inhibitor of fatty acid amide hydrolase

    Thors, L., Burston, J. J., Alter, B. J., McKinney, M. K., Cravatt, B. F., Ross, R. A., Pertwee, R. G., Gereau, R. W., Wiley, J. L. & Fowler, C. J., Jun 2010, In : British Journal of Pharmacology. 160, 3, p. 549-560 12 p.

    Research output: Contribution to journalArticle

    25 Citations (Scopus)

    Brain levels and relative potency of 1,2-dimethylheptyl analog of delta1-tetrahydrocannabinol in mice

    Lawrence, D. K., Pertwee, R. G., Gill, E. W. & Piper, J. M., 1974, In : Biochemical Pharmacology. 23, 21, p. 3017-3027 11 p.

    Research output: Contribution to journalArticle

    2 Citations (Scopus)

    Cannabidiol, a non-psychotropic component of cannabis, attenuates vomiting and nausea-like behaviour via indirect agonism of 5-HT1A somatodendritic autoreceptors in the dorsal raphe nucleus

    Rock, E. M., Bolognini, D., Limebeer, C. L., Cascio, M. G., Anavi-Goffer, S., Fletcher, P. J., Mechoulam, R., Pertwee, R. G. & Parker, L. A., Apr 2012, In : British Journal of Pharmacology. 165, 8, p. 2620-2634 15 p.

    Research output: Contribution to journalArticle

    98 Citations (Scopus)

    Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro

    Thomas, A., Baillie, G., Phillips, A. M., Razdan, R. K., Ross, R. A. & Pertwee, R. G., Mar 2007, In : British Journal of Pharmacology. 150, 5, p. 613-623 11 p.

    Research output: Contribution to journalArticle

    323 Citations (Scopus)

    Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid?

    Fernandez-Ruiz, J., Sagredo, O., Ruth Pazos, M., Garcia, C., Pertwee, R., Mechoulam, R. & Martinez-Orgado, J., Feb 2013, In : British Journal of Clinical Pharmacology. 75, 2, p. 323-333 11 p.

    Research output: Contribution to journalArticle

    133 Citations (Scopus)

    Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behaviour in rats by enhancing 5-HT(1A) receptor activation

    Bolognini, D., Rock, EM., Cluny, NL., Cascio, MG., Limebeer, CL., Duncan, M., Stott, CG., Javid, FA., Parker, LA. & Pertwee, RG., Mar 2013, In : British Journal of Pharmacology. 168, 6, p. 1456-1470 15 p.

    Research output: Contribution to journalArticle

    65 Citations (Scopus)

    Cannabidiol-induced intracellular Ca2+ elevations in hippocampal cells

    Drysdale, A. J., Ryan, D., Pertwee, R. G. & Platt, B., Apr 2006, In : Neuropharmacology. 50, 5, p. 621-631 11 p.

    Research output: Contribution to journalArticle

    59 Citations (Scopus)

    Cannabidiol targets mitochondria to regulate intracellular Ca2+ levels

    Ryan, D., Drysdale, A. J., Lafourcade, C., Pertwee, R. G. & Platt, B., 18 Feb 2009, In : Journal of Neuroscience. 29, 7, p. 2053-2063 11 p.

    Research output: Contribution to journalArticle

    122 Citations (Scopus)

    Cannabidivarin-rich cannabis extracts are anticonvulsant in mouse and rat via a CB1 receptor-independent mechanism

    Hill, T. D. M., Cascio, M-G., Romano, B., Duncan, M., Pertwee, R. G., Williams, C. M., Whalley, B. J. & Hill, A. J., Oct 2013, In : British Journal of Pharmacology. 170, 3, p. 679-692 14 p.

    Research output: Contribution to journalArticle

    88 Citations (Scopus)

    Cannabinoid-mediated immunosuppression in experimental allergic encephalomyelitis

    Baker, D., Croxford, J. L., Pryce, G., Jackson, S. M., Ledent, C., Marsicano, G., Lutz, B., Giovannoni, G., Pertwee, R. G. & Yamamura, T., Sep 2006, In : Journal of Neuroimmunology. 178, Suppl. 1, p. 90-91 2 p.

    Research output: Contribution to journalArticle

    Cannabinoid-mediated neuroprotection, not immunosuppression, may be more relevant to multiple sclerosis

    Croxford, J. L., Pryce, G., Jackson, S. J., Ledent, C., Giovannoni, G., Pertwee, R. G., Yamamura, T. & Baker, D., Jan 2008, In : Journal of Neuroimmunology. 193, 1-2, p. 120-129 10 p.

    Research output: Contribution to journalArticle

    74 Citations (Scopus)

    Cannabinoid pharmacology

    Pertwee, R. G., Jan 2006, In : British Journal of Pharmacology. 147, S1, p. S163-S171 9 p.

    Research output: Contribution to journalArticle

    329 Citations (Scopus)

    Cannabinoid receptor antagonists SR141716 and SR144528 exhibit properties of partial agonists in experiments on isolated perfused rat heart

    Krylatov, A. V., Maslov, L. N., Lasukova, O. V. & Pertwee, R. G., 2005, In : Bulletin of Experimental Biology and Medicine. 139, p. 558-561 4 p.

    Research output: Contribution to journalArticle

    17 Citations (Scopus)

    Cannabinoid receptor-dependent and -independent anti-proliferative effects of omega-3 ethanolamides in androgen receptor-positive and -negative prostate cancer cell lines

    Brown, I., Cascio, M. G., Wahle, K. W. J., Smoum, R., Mechoulam, R., Ross, R. A., Pertwee, R. G. & Heys, S. D., Sep 2010, In : Carcinogenesis. 31, 9, p. 1584-1591 8 p.

    Research output: Contribution to journalArticle

    95 Citations (Scopus)

    Cannabinoid receptors and pain

    Pertwee, R. G., Apr 2001, In : Progress in Neurobiology. 63, 5, p. 569-611 42 p.

    Research output: Contribution to journalArticle

    576 Citations (Scopus)

    Cannabinoid receptors and their ligands

    Pertwee, R. G. & Ross, R., Feb 2002, In : Prostaglandins, Leukotrienes and Essential Fatty Acids. 66, 2-3, p. 101-121 20 p.

    Research output: Contribution to journalArticle

    388 Citations (Scopus)

    Cannabinoids and glaucoma

    Tomida, I., Pertwee, R. G. & Azuara-Blanco, A., May 2004, In : British Journal of Ophthalmology. 88, 5, p. 708-713 5 p.

    Research output: Contribution to journalArticle

    87 Citations (Scopus)

    Cannabinoids and multiple sclerosis

    Pertwee, R. G., Aug 2002, In : Pharmacology & Therapeutics. 95, 2, p. 165-174 10 p.

    Research output: Contribution to journalArticle

    151 Citations (Scopus)

    Cannabinoids and multiple sclerosis

    Pertwee, R. G., Aug 2007, In : Molecular Neurobiology. 36, 1, p. 45-59 15 p.

    Research output: Contribution to journalArticle

    65 Citations (Scopus)

    Cannabinoids and omega-3/6 endocannabinoids as cell death and anticancer modulators

    Brown, I., Cascio, M. G., Rotondo, D., Pertwee, R. G., Heys, S. D. & Wahle, K. W. J., Jan 2013, In : Progress in Lipid Research. 52, 1, p. 80-109 30 p.

    Research output: Contribution to journalArticle

    60 Citations (Scopus)

    Cannabinoids and the gastrointestinal tract

    Pertwee, R. G., Jun 2001, In : Gut. 48, 6, p. 859-867 8 p.

    Research output: Contribution to journalArticle

    236 Citations (Scopus)

    Cannabinoids control spasticity and tremor in a multiple sclerosis model

    Baker, D., Pryce, G., Croxford, J. L., Brown, P., Pertwee, R. G., Huffman, J. W. & Layward, L., 2000, In : Nature. 404, p. 84-87 4 p.

    Research output: Contribution to journalArticle

    449 Citations (Scopus)

    Cannabis and cannabinoids: Pharmacology and rationale for clinical use

    Pertwee, R. G., 1999, In : Forschende Komplementärmedizin. 6, p. 12-15 4 p.

    Research output: Contribution to journalArticle

    60 Citations (Scopus)

    CB1 Receptor Allosteric Modulators Display Both Agonist and Signaling Pathway Specificity

    Baillie, G. L., Horswill, J. G., Anavi-Goffer, S., Reggio, P. H., Bolognini, D., Abood, M. E., McAllister, S., Strange, P. G., Stephens, G. J., Pertwee, R. G. & Ross, R. A., Feb 2013, In : Molecular Pharmacology. 83, 2, p. 322-338 17 p.

    Research output: Contribution to journalArticle

    75 Citations (Scopus)

    CB2 cannabinoid receptor agonist enantiomers HU-433 and HU-308: An inverse relationship between binding affinity and biological potency

    Smoum, R., Baraghithy, S., Chourasia, M., Breuer, A., Mussai, N., Attar-Namdar, M., Kogan, N. M., Raphael, B., Bolognini, D., Cascio, M. G., Marini, P., Pertwee, R. G., Shurki, A., Mechoulam, R. & Bab, I., 14 Jul 2015, In : PNAS. 112, 28, p. 8774-8779 6 p.

    Research output: Contribution to journalArticle

    25 Citations (Scopus)

    Characterization of cannabinoid receptor ligands in tissues natively expressing cannabinoid CB2 receptors

    Marini, P., Cascio, M. G., King, A., Pertwee, R. G. & Ross, R. A., Jun 2013, In : British Journal of Pharmacology. 169, 4, p. 887-899 13 p.

    Research output: Contribution to journalArticle

    13 Citations (Scopus)

    Comparison of cannabinoid binding sites in guinea-pig forebrain and small intestine

    Ross, R. A., Brockie, H. C., Fernando, S. R., Saha, B., Razdan, R. K. & Pertwee, R. G., Nov 1998, In : British Journal of Pharmacology. 125, 6, p. 1345-1351 7 p.

    Research output: Contribution to journalArticle

    41 Citations (Scopus)

    Comparison of novel cannabinoid partial agonists and SR141716A in the guinea-pig small intestine

    Coutts, A. A., Brewster, N., Ingram, T., Razdan, R. K. & Pertwee, R. G., 2000, In : British Journal of Pharmacology. 129, p. 645-652 8 p.

    Research output: Contribution to journalArticle

    39 Citations (Scopus)

    Conformationally Constrained Fatty Acid Ethanolamides as Cannabinoid and Vanilloid Receptor Probes

    Appendino, G., Ligresti, A., Minassi, A., Cascio, M. G., Allara, M., Taglialatela-Scafati, O., Pertwee, R. G., De Petrocellis, L. & Di Marzo, V., 14 May 2009, In : Journal of Medicinal Chemistry. 52, 9, p. 3001-3009 9 p.

    Research output: Contribution to journalArticle

    16 Citations (Scopus)
    50 Citations (Scopus)