Roger Pertwee

Professor

    • 26727 Citations
    1970 …2020

    Research output per year

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    Inhibition of colon carcinogenesis by a standardized Cannabis sativa extract with high content of cannabidiol

    Romano, B., Borrelli, F., Pagano, E., Cascio, M. G., Pertwee, R. G. & Izzo, A. A., 15 Apr 2014, In : Phytomedicine. 21, 5, p. 631-639 9 p.

    Research output: Contribution to journalArticle

    45 Citations (Scopus)

    Inhibition of human neutrophil chemotaxis by endogenous cannabinoids and phytocannabinoids: Evidence for a site distinct from CB1 and CB2

    McHugh, D., Tanner, C., Mechoulam, R., Pertwee, R. G. & Ross, R. A., Feb 2008, In : Molecular Pharmacology. 73, 2, p. 441-450 10 p.

    Research output: Contribution to journalArticle

    87 Citations (Scopus)

    Inhibition of monoacylglycerol lipase and fatty acid amide hydrolase by analogues of 2-arachidonoylglycerol

    Ghafouri, N., Tiger, G., Razdan, R. K., Mahadevan, A., Pertwee, R. G., Martin, B. R. & Fowler, C. J., 2004, In : British Journal of Pharmacology. 143, p. 774-784 11 p.

    Research output: Contribution to journalArticle

    73 Citations (Scopus)

    Inhibition of nitric oxide production in RAW264.7 macrophages by cannabinoids and palmitoylethanolamide

    Ross, R. A., Brockie, H. C. & Pertwee, R. G., 4 Aug 2000, In : European Journal of Pharmacology. 401, 2, p. 121-130 10 p.

    Research output: Contribution to journalArticle

    92 Citations (Scopus)

    Inhibitory effects of certain enantiomeric cannabinoids in the mouse vas-deferens and the myenteric plexus preparation of guinea-pig small-intestine

    Pertwee, R. G., Stevenson, L. A., Elrick, D. B., Mechoulam, R. & Corbett, A. D., Apr 1992, In : British Journal of Pharmacology. 105, 4, p. 980-984 5 p.

    Research output: Contribution to journalArticle

    134 Citations (Scopus)

    Interactions between synthetic vanilloids and the endogenous cannabinoid system

    Di Marzo, V., Bisogno, T., Melck, D., Ross, R. A., Brockie, H., Stevenson, L. A., Pertwee, R. G. & De Petrocellis, L., 9 Oct 1998, In : FEBS Letters. 436, 3, p. 449-454 6 p.

    Research output: Contribution to journalArticle

    132 Citations (Scopus)

    Investigations on the 4-quinolone-3-carboxylic acid motif. 3. Synthesis, structure-affinity relationships, and pharmacological characterization of 6-substituted 4-quinolone-3-carboxamides as highly selective cannabinoid-2 receptor ligands.

    Pasquini, S., Ligresti, A., Mugnaini, C., Semeraro, T., Cicione, L., De Rosa, M., Guida, F., Luongo, L., De Chiaro, M., Cascio, M. G., Bolognini, D., Marini, P., Pertwee, R. G., Maione, S., Di Marzo, V. & Corelli, F., 26 Aug 2010, In : Journal of Medicinal Chemistry. 53, 16, p. 5915-5928 14 p.

    Research output: Contribution to journalArticle

    30 Citations (Scopus)

    Investigations on the 4-quinolone-3-carboxylic acid motif. 6. Synthesis and pharmacological evaluation of 7-substituted quinolone-3-carboxamide derivatives as high affinity ligands for cannabinoid receptors

    Pasquini, S., De Rosa, M., Ligresti, A., Mugnaini, C., Brizzi, A., Caradonna, N. P., Cascio, M. G., Bolognini, D., Pertwee, R. G., Di Marzo, V. & Corelli, F., Dec 2012, In : European Journal of Medicinal Chemistry. 58, p. 30-43 14 p.

    Research output: Contribution to journalArticle

    14 Citations (Scopus)

    Investigations on the 4-Quinolone-3-Carboxylic Acid Motif Part 5: Modulation of the Physicochemical Profile of a Set of Potent and Selective Cannabinoid-2 Receptor Ligands through a Bioisosteric Approach

    Mugnaini, C., Nocerino, S., Pedani, V., Pasquini, S., Tafi, A., De Chiaro, M., Bellucci, L., Valoti, M., Guida, F., Luongo, L., Dragoni, S., Ligresti, A., Rosenberg, A., Bolognini, D., Cascio, M. G., Pertwee, R. G., Moaddel, R., Maione, S., Di Marzo, V. & Corelli, F., May 2012, In : ChemMedChem. 7, 5, p. 920-934 15 p.

    Research output: Contribution to journalArticle

    23 Citations (Scopus)

    In vitro and in vivo pharmacological characterization of two novel selective cannabinoid CB2 receptor inverse agonists

    Cascio, M. G., Bolognini, D., Pertwee, R. G., Palazzo, E., Corelli, F., Pasquini, S., Di Marzo, V. & Maione, S., Apr 2010, In : Pharmacological Research. 61, 4, p. 349-354 6 p.

    Research output: Contribution to journalArticle

    20 Citations (Scopus)

    In vitro and in vivo pharmacology of synthetic olivetol- or resorcinol-derived cannabinoid receptor ligands

    Cascio, M. G., Bisogno, T., Palazzo, E., Thomas, A. D., van der Stelt, M., Brizzi, A., De Novellis, V., Marabese, I., Ross, R. A., van de Doelen, T., Brizzi, V., Pertwee, R. G., Maione, S. & Di Marzo, V., Oct 2006, In : British Journal of Pharmacology. 149, 4, p. 431-440 10 p.

    Research output: Contribution to journalArticle

    12 Citations (Scopus)

    In-vivo pharmacological evaluation of the CB1-receptor allosteric modulator Org-27569

    Gamage, T. F., Ignatowska-Jankowska, B. M., Wiley, J. L., Abdelrahman, M., Trembleau, L., Greig, I. R., Thakur, G. A., Tichkule, R., Poklis, J., Ross, R. A., Pertwee, R. G. & Lichtman, A. H., Apr 2014, In : Behavioural Pharmacology. 25, 2, p. 182-185 4 p.

    Research output: Contribution to journalArticle

    40 Citations (Scopus)

    Isolation and structure of a brain constituent that binds to the cannabinoid receptor

    Devane, W. A., Hanus, L., Breuer, A., Pertwee, R. G., Stevenson, L. A., Griffin, G., Gibson, D., Mandelbaum, A., Etinger, A. & Mechoulam, R., 18 Dec 1992, In : Science. 258, 5090, p. 1946-1949 4 p.

    Research output: Contribution to journalArticle

    4171 Citations (Scopus)

    Localisation of cannabinoid CB1 receptor-immunoreactivity in the guinea-pig and rat myenteric plexus

    Coutts, A. A., Irving, A. J., Mackie, K., Pertwee, R. G. & Anavi-Goffer, S., Jul 2002, In : Journal of Comparative Neurology. 448, 4, p. 410-422 12 p.

    Research output: Contribution to journalArticle

    123 Citations (Scopus)

    Mapping Cannabinoid 1 Receptor Allosteric Site(s): Critical Molecular Determinant and Signaling Profile of GAT100, a Novel, Potent, and Irreversibly Binding Probe

    Laprairie, R. B., Kulkarni, A. R., Kulkarni, P. M., Hurst, D. P., Lynch, D., Reggio, P. H., Janero, D. R., Pertwee, R. G., Stevenson, L. A., Kelly, M. E. M., Denovan-Wright, E. M. & Thakur, G. A., 15 Jun 2016, In : ACS Chemical Neuroscience. 7, 6, p. 776-798 23 p.

    Research output: Contribution to journalArticle

    22 Citations (Scopus)

    Modulation of food consumption and sleep-wake cycle in mice by the neutral CB1 antagonist ABD459

    Goonawardena, A. V., Plano, A., Robinson, L., Ross, R., Greig, I., Pertwee, R. G., Hampson, R. E., Platt, B. & Riedel, G., Apr 2015, In : Behavioural Pharmacology. 26, 3, p. 289-303 15 p.

    Research output: Contribution to journalArticle

    10 Citations (Scopus)

    Modulation of L-α-lysophosphatidylinositol/GPR55 mitogen-activated protein kinase (MAPK) signaling by cannabinoids

    Anavi-Goffer, S., Baillie, G., Irving, A., Gertsch, J., Greig, I. R., Pertwee, R. G. & Ross, R. A., 2 Jan 2012, In : The Journal of Biological Chemistry. 287, 1, p. 91-104 15 p.

    Research output: Contribution to journalArticle

    75 Citations (Scopus)

    Motor effects of the non-psychotropic phytocannabinoid cannabidiol that are mediated by 5-HT1A receptors

    Espejo-Porras, F., Fernandez-Ruiz, J., Pertwee, R. G., Mechoulam, R. & Garcia, C., Dec 2013, In : Neuropharmacology. 75, p. 155-163 9 p.

    Research output: Contribution to journalArticle

    24 Citations (Scopus)

    Neuroprotective Effects of the Nonpsychoactive Cannabinoid Cannabidiol in Hypoxic-Ischemic Newborn Piglets

    Alvarez, F. J., Lafuente, H., Rey-Santano, M. C., Mielgo, V. E., Gastiasoro, E., Rueda, M., Pertwee, R. G., Castillo, A. I., Romero, J. & Martinez-Orgado, J., Dec 2008, In : Pediatric Research. 64, 6, p. 653-658 6 p.

    Research output: Contribution to journalArticle

    91 Citations (Scopus)

    Novel compounds that interact with both leukotriene B-4 receptors and vanilloid TRPV1 receptors

    McHugh, D., McMaster, R. S., Pertwee, R. G., Roy, S., Mahadevan, A., Razdan, R. K. & Ross, R. A., 2006, In : Journal of Pharmacology and Experimental Therapeutics. 316, p. 955-965 11 p.

    Research output: Contribution to journalArticle

    18 Citations (Scopus)

    Novel Electrophilic and Photoaffinity Covalent Probes for Mapping the Cannabinoid 1 Receptor Allosteric Site(s)

    Kulkarni, P. M., Kulkarni, A. R., Korde, A., Tichkule, R. B., Laprairie, R. B., Denovan-Wright, E. M., Zhou, H., Janero, D. R., Zvonok, N., Makriyannis, A., Cascio, M. G., Pertwee, R. G. & Thakur, G. A., 14 Jan 2016, In : Journal of Medicinal Chemistry. 59, 1, p. 44-60 17 p.

    Research output: Contribution to journalArticle

    Open Access
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    33 Citations (Scopus)
    6 Downloads (Pure)

    O-1057, a potent water-soluble cannabinoid receptor agonist with antinociceptive properties

    Pertwee, R. G., Gibson, T. M., Stevenson, L. A., Ross, R. A., Banner, W. K., Saha, B., Razdan, R. K. & Martin, B. R., Apr 2000, In : British Journal of Pharmacology. 129, 8, p. 1577-1584 8 p.

    Research output: Contribution to journalArticle

    44 Citations (Scopus)

    Omega-3 N-acylethanolamines are endogenously synthesised from omega-3 fatty acids in different human prostate and breast cancer cell lines

    Brown, I., Wahle, K. W., Cascio, M. G., Smoum, R., Mechoulam, R., Pertwee, R. G. & Heys, S. D., Dec 2011, In : Prostaglandins, Leukotrienes and Essential Fatty Acids. 85, 6, p. 305-310 6 p.

    Research output: Contribution to journalArticle

    28 Citations (Scopus)

    Overlap between the ligand recognition properties of the anandamide transporter and the VR1 vanilloid receptor: inhibitors of anandamide uptake with negligible capsaicin-like activity

    De Petrocellis, L., Bisogno, T., Davis, J. B., Pertwee, R. G. & Di Marzo, V., 2000, In : FEBS Letters. 483, p. 52-56 5 p.

    Research output: Contribution to journalArticle

    312 Citations (Scopus)

    Pharmacological and therapeutic targets for Delta(9)-tetrahydrocannabinol and cannabidiol

    Pertwee, R. G., 2004, In : Euphytica. 140, p. 73-82 10 p.

    Research output: Contribution to journalArticle

    Pharmacological characterization of the anandamide cyclooxygenase metabolite

    Ross, R. A., Craib, S., Stevenson, L. A., Pertwee, R. G., Henderson, A., Toole, J. & Ellington, H. C., 1 Jun 2002, In : Journal of Pharmacology and Experimental Therapeutics. 301, 3, p. 900-907 7 p.

    Research output: Contribution to journalArticle

    93 Citations (Scopus)

    Pharmacological characterization of three novel cannabinoid receptor agonists in the mouse isolated vas deferens

    Pertwee, R. G., GRIFFIN, G., LAINTON, J. A. H. & HUFFMAN, J. W., 25 Sep 1995, In : European Journal of Pharmacology. 284, 3, p. 241-247 7 p.

    Research output: Contribution to journalArticle

    59 Citations (Scopus)

    Pharmacophoric requirements for the cannabinoid side chain. Probing the cannabinoid receptor subsite at C1'

    Papahatjis, D. P., Nikas, S. P., Kourouli, T., Chari, R., Xu, W., Pertwee, R. G. & Makriyannis, A., 2003, In : Journal of Medicinal Chemistry. 46, p. 3221-3229 9 p.

    Research output: Contribution to journalArticle

    42 Citations (Scopus)

    Phytocannabinoids beyond the Cannabis plant - do they exist?

    Gertsch, J., Pertwee, R. G. & Di Marzo, V., Jun 2010, In : British Journal of Pharmacology. 160, 3, p. 523-529 7 p.

    Research output: Contribution to journalArticle

    85 Citations (Scopus)

    Positive Allosteric Modulation of Cannabinoid Receptor Type 1 Suppresses Pathological Pain Without Producing Tolerance or Dependence

    Slivicki, R. A., Xu, Z., Kulkarni, P. M., Pertwee, R. G., Mackie, K., Thakur, G. A. & Hohmann, A. G., 15 Nov 2018, In : Biological Psychiatry. 84, 10, p. 722-733 12 p.

    Research output: Contribution to journalArticle

    26 Citations (Scopus)

    Preliminary experiments on chemistry and pharmacology of cannabis

    Gill, E. W., Paton, W. D. M. & Pertwee, R. G., 1970, In : Nature. 228, 5267, p. 134

    Research output: Contribution to journalArticle

    150 Citations (Scopus)

    Prescribing cannabinoids for multiple sclerosis - Current issues

    Pertwee, R. G., 1999, In : CNS Drugs. 11, p. 327-334 8 p.

    Research output: Contribution to journalArticle

    8 Citations (Scopus)

    Pyrazoles with a "click" 4-[N-(4-fluorobutyl)-1,2,3-triazole] substituent in position 3 are nanomolar CB1 receptor ligands

    Distinto, R., Zanato, C., Montanari, S., Cascio, M. G., Lazzari, P., Pertwee, R. & Zanda, M., Nov 2014, In : Journal of Fluorine Chemistry. 167, p. 184-191 8 p.

    Research output: Contribution to journalArticle

    4 Citations (Scopus)

    Relative pharmacological potency in mice of optical isomers of delta1-tetrahydrocannabinol

    Jones, G., Pertwee, R. G., Gill, E. W., Paton, W. D. M., Nilsson, I. M., Widman, M. & Agurell, S., 15 Jan 1974, In : Biochemical Pharmacology. 23, 2, p. 439-446 8 p.

    Research output: Contribution to journalArticle

    27 Citations (Scopus)

    Role of cannabinoid receptors in the regulation of cardiac contractility during ischemia/reperfusion

    Maslov, L. N., Lasukova, O. V., Krylatov, A. V., Hanus, L. O., Pertwee, R. G., Ivanchuk, I. I. & Crowford, D., 2006, In : Bulletin of Experimental Biology and Medicine. 142, 5, p. 557-561 5 p.

    Research output: Contribution to journalArticle

    4 Citations (Scopus)

    Sativex-like Combination of Phytocannabinoids is Neuroprotective in Malonate-Lesioned Rats, an Inflammatory Model of Huntington's Disease: Role of CB1 and CB2 Receptors

    Valdeolivas, S., Satta, V., Pertwee, R. G., Fernandez-Ruiz, J. & Sagredo, O., 9 Feb 2012, In : ACS Chemical Neuroscience. 3, 5, p. 400-406 7 p.

    Research output: Contribution to journalArticle

    63 Citations (Scopus)

    Scopolamine and MK801-induced working memory deficits in rats are not reversed by CBD-rich cannabis extracts

    Fadda, P., Robinson, L., Fratta, W., Pertwee, R. G. & Riedel, G., 2006, In : Behavioural Brain Research. 168, p. 307-311 5 p.

    Research output: Contribution to journalArticle

    25 Citations (Scopus)

    Selective cannabinoiod receptor agonist HU-210 decreases pump function of isolated perfused heart: Role of cAMP and cGMP

    Maslov, L. N., Lasukova, O. V., Krylatov, A. V., Uzhachenko, R. V. & Pertwee, R., 2004, In : Bulletin of Experimental Biology and Medicine. 138, p. 550-553 4 p.

    Research output: Contribution to journalArticle

    Significance of cardiac cannabinoid receptors in regulation of cardiac rhythm, myocardial contractility, and electrophysiologic processes in heart

    Krylatov, A. V., Maslov, L. N., Ermakov, S. Y., Lasukova, O. V., Barzakh, E. I., Crawford, D. & Pertwee, R. G., Jan 2007, In : Bulletin of Experimental Biology and Medicine. 34, 1, p. 28-35 8 p.

    Research output: Contribution to journalArticle

    4 Citations (Scopus)

    Structural and pharmacological analysis of O-2050, a putative neutral cannabinoid CB(1) receptor antagonist

    Wiley, J. L., Breivogel, C. S., Mahadevan, A., Pertwee, R. G., Cascio, M. G., Bolognini, D., Huffman, J. W., Walentiny, D. M., Vann, R. E., Razdan, R. K. & Martin, B. R., 25 Jan 2011, In : European Journal of Pharmacology. 651, 1-3, p. 96-105 10 p.

    Research output: Contribution to journalArticle

    27 Citations (Scopus)

    Structural determinants of the partial agonist-inverse agonist properties of 6'-azidohex-2'-yne-¿8-tetrahydrocannabinol at cannabinoid receptors

    Ross, R. A., Gibson, T. M., Stevenson, L. A., Saha, B., Crocker, P., Razdan, R. K. & Pertwee, R. G., Oct 1999, In : British Journal of Pharmacology. 128, 3, p. 735-743 9 p.

    Research output: Contribution to journalArticle

    47 Citations (Scopus)

    Structure-activity relationship for the endogenous cannabinoid, anandamide, and certain of its analogues at vanilloid receptors in transfected cells and vas deferens

    Ross, R. A., Gibson, T. M., Brockie, H. C., Leslie, M., Pashmi, G., Craib, S., Di Marzo, V. & Pertwee, R. G., Feb 2001, In : British Journal of Pharmacology. 132, 3, p. 631-640 9 p.

    Research output: Contribution to journalArticle

    205 Citations (Scopus)

    Structure-activity relationships of pyrazole derivatives as cannabinoid receptor antagonists

    Lan, R. X., Liu, Q., Fan, P. S., Lin, S. Y., Fernando, S. R., McCallion, D., Pertwee, R. & Makriyannis, A., 1999, In : Journal of Medicinal Chemistry. 42, p. 769-776 8 p.

    Research output: Contribution to journalArticle

    391 Citations (Scopus)

    Structure-affinity relationships and pharmacological characterization of new alkyl-resorcinol cannabinoid receptor ligands: Identification of a dual cannabinoid receptor/TRPA1 channel agonist

    Brizzi, A., Aiello, F., Marini, P., Cascio, M. G., Corelli, F., Brizzi, V., De Petrocellis, L., Ligresti, A., Luongo, L., Lamponi, S., Maione, S., Pertwee, R. G. & Di Marzo, V., 1 Sep 2014, In : Behavioral and Brain Sciences. 22, 17, p. 4770-4783 14 p.

    Research output: Contribution to journalArticle

    6 Citations (Scopus)
    1 Downloads (Pure)

    Synthesis, radio-synthesis and in vitro evaluation of terminally fluorinated derivatives of HU-210 and HU-211 as novel candidate PET tracers

    Zanato, C., Pelagalli, A., Marwick, K. F. M., Piras, M., Dall'Angelo, S., Spinaci, A., Pertwee, R. G., Wyllie, D. J. A., Hardingham, G. E. & Zanda, M., 2017, In : Organic & Biomolecular Chemistry. 15, 9, p. 2086-2096 11 p.

    Research output: Contribution to journalArticle

    Open Access
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    3 Citations (Scopus)
    8 Downloads (Pure)

    Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1)

    Hillard, C. J., Manna, S., Greenberg, M. J., Dicamelli, R., Ross, R. A., Stevenson, L. A., Murphy, V., Pertwee, R. G. & Campbell, W. B., 1 Jun 1999, In : Journal of Pharmacology and Experimental Therapeutics. 289, 3, p. 1427-1433 7 p.

    Research output: Contribution to journalArticle

    281 Citations (Scopus)

    Synthesis and pharmacological comparison of dimethylheptyl and pentyl analogs of anandamide

    Seltzman, H. H., Fleming, D. N., Thomas, B. F., Gilliam, A. F., McCallion, D. S., Pertwee, R. G., Compton, D. R. & Martin, B. R., 24 Oct 1997, In : Journal of Medicinal Chemistry. 40, 22, p. 3626-3634 9 p.

    Research output: Contribution to journalArticle

    58 Citations (Scopus)

    Synthesis and structure-activity relationships of amide and hydrazide analogues of the cannabinoid CB1 receptor antagonist N-(piperidinyl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716)

    Francisco, M. E. Y., Seltzman, H. H., Gilliam, A. F., Mitchell, R. A., Rider, S. L., Pertwee, R. G., Stevenson, L. A. & Thomas, B. F., 2002, In : Journal of Medicinal Chemistry. 45, p. 2708-2719 12 p.

    Research output: Contribution to journalArticle

    93 Citations (Scopus)

    Synthesis of long-chain amide analogs of the cannabinoid CB1 receptor antagonist N-(piperidinyl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716) with unique binding selectivities and pharmacological activities

    Thomas, B. F., Francisco, M. E. Y., Seltzman, H. H., Thomas, J. B., Fix, S. E., Schulz, A. K., Gilliam, A. F., Pertwee, R. G. & Stevenson, L. A., 2005, In : Bioorganic & Medicinal Chemistry. 13, p. 5463-5474 12 p.

    Research output: Contribution to journalArticle

    26 Citations (Scopus)