Roger Pertwee

Professor

    • 26766 Citations
    1970 …2020

    Research output per year

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    Research Output

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    2008

    Hippocampal endocannabinoids inhibit spatial learning and limit spatial memory in rats

    Robinson, L., McKillop-Smith, S., Ross, N. L., Pertwee, R. G., Hampson, R. E., Platt, B. & Riedel, G., Jul 2008, In : Psychopharmacology. 198, 4, p. 551-563 13 p.

    Research output: Contribution to journalArticle

    44 Citations (Scopus)

    Inhibition of human neutrophil chemotaxis by endogenous cannabinoids and phytocannabinoids: Evidence for a site distinct from CB1 and CB2

    McHugh, D., Tanner, C., Mechoulam, R., Pertwee, R. G. & Ross, R. A., Feb 2008, In : Molecular Pharmacology. 73, 2, p. 441-450 10 p.

    Research output: Contribution to journalArticle

    87 Citations (Scopus)

    Neuroprotective Effects of the Nonpsychoactive Cannabinoid Cannabidiol in Hypoxic-Ischemic Newborn Piglets

    Alvarez, F. J., Lafuente, H., Rey-Santano, M. C., Mielgo, V. E., Gastiasoro, E., Rueda, M., Pertwee, R. G., Castillo, A. I., Romero, J. & Martinez-Orgado, J., Dec 2008, In : Pediatric Research. 64, 6, p. 653-658 6 p.

    Research output: Contribution to journalArticle

    91 Citations (Scopus)
    2007

    Anti-inflammatory property of the cannaboinid receptor-2-selective agonist JWH-133 in a rodent model of autoimmune uveoretinitis

    Xu, H., Cheng, C. L., Chen, M., Manivannan, A., Cabay, L., Pertwee, R. G., Coutts, A. A. & Forrester, J. V., 1 Sep 2007, In : Journal of Leukocyte Biology. 82, 3, p. 532-541 10 p.

    Research output: Contribution to journalArticle

    79 Citations (Scopus)

    Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro

    Thomas, A., Baillie, G., Phillips, A. M., Razdan, R. K., Ross, R. A. & Pertwee, R. G., Mar 2007, In : British Journal of Pharmacology. 150, 5, p. 613-623 11 p.

    Research output: Contribution to journalArticle

    336 Citations (Scopus)

    Cannabinoids and multiple sclerosis

    Pertwee, R. G., Aug 2007, In : Molecular Neurobiology. 36, 1, p. 45-59 15 p.

    Research output: Contribution to journalArticle

    66 Citations (Scopus)

    Significance of cardiac cannabinoid receptors in regulation of cardiac rhythm, myocardial contractility, and electrophysiologic processes in heart

    Krylatov, A. V., Maslov, L. N., Ermakov, S. Y., Lasukova, O. V., Barzakh, E. I., Crawford, D. & Pertwee, R. G., Jan 2007, In : Bulletin of Experimental Biology and Medicine. 34, 1, p. 28-35 8 p.

    Research output: Contribution to journalArticle

    4 Citations (Scopus)

    The psychoactive plant cannabinoid, Δ9-tetrahydrocannabinol, is antagonized by Δ8- and Δ9-tetrahydrocannabivarin in mice in vivo

    Pertwee, R. G., Thomas, A., Stevenson, L. A., Ross, R. A., Varvel, S. A., Lichtman, A. H., Martin, B. R. & Razdan, R. K., Mar 2007, In : British Journal of Pharmacology. 150, 5, p. 586-594 9 p.

    Research output: Contribution to journalArticle

    60 Citations (Scopus)

    The synthetic cannabinoid HU210 induces spatial memory deficits and suppresses hippocampal firing rate in rats

    Robinson, L., Goonawardena, A. V., Pertwee, R. G., Hampson, R. E. & Riedel, G., Jul 2007, In : British Journal of Pharmacology. 151, 5, p. 688-700 13 p.

    Research output: Contribution to journalArticle

    39 Citations (Scopus)
    2006

    Cannabidiol-induced intracellular Ca2+ elevations in hippocampal cells

    Drysdale, A. J., Ryan, D., Pertwee, R. G. & Platt, B., Apr 2006, In : Neuropharmacology. 50, 5, p. 621-631 11 p.

    Research output: Contribution to journalArticle

    60 Citations (Scopus)

    Cannabinoid-mediated immunosuppression in experimental allergic encephalomyelitis

    Baker, D., Croxford, J. L., Pryce, G., Jackson, S. M., Ledent, C., Marsicano, G., Lutz, B., Giovannoni, G., Pertwee, R. G. & Yamamura, T., Sep 2006, In : Journal of Neuroimmunology. 178, Suppl. 1, p. 90-91 2 p.

    Research output: Contribution to journalArticle

    Cannabinoid pharmacology

    Pertwee, R. G., Jan 2006, In : British Journal of Pharmacology. 147, S1, p. S163-S171 9 p.

    Research output: Contribution to journalArticle

    335 Citations (Scopus)

    Differential effects of cannabis extracts and pure plant cannabinoids on hippocampal neurones and glia

    Ryan, D., Drysdale, A. J., Pertwee, R. G. & Platt, B., 20 Nov 2006, In : Neuroscience Letters. 408, 3, p. 236-241 6 p.

    Research output: Contribution to journalArticle

    22 Citations (Scopus)

    Effect of sublingual application of cannabinoids on intraocular pressure: A pilot study

    Tomida, I., Azuara-Blanco, A., House, H., Flint, M., Pertwee, R. G. & Robson, P. J., Oct 2006, In : Journal of Glaucoma. 15, 5, p. 349-353 5 p.

    Research output: Contribution to journalArticle

    60 Citations (Scopus)

    First "hybrid" ligands of vanilloid TRPV1 and cannabinoid CB2 receptors and non-polyunsaturated fatty acid-derived CB2-selective ligands

    Appendino, G., Cascio, M. G., Bacchiega, S., Moriello, A. S., Minassi, A., Thomas, A., Ross, R., Pertwee, R., De Petrocellis, L. & Di Marzo, V., 2006, In : FEBS Letters. 580, p. 568-574 7 p.

    Research output: Contribution to journalArticle

    23 Citations (Scopus)

    In vitro and in vivo pharmacology of synthetic olivetol- or resorcinol-derived cannabinoid receptor ligands

    Cascio, M. G., Bisogno, T., Palazzo, E., Thomas, A. D., van der Stelt, M., Brizzi, A., De Novellis, V., Marabese, I., Ross, R. A., van de Doelen, T., Brizzi, V., Pertwee, R. G., Maione, S. & Di Marzo, V., Oct 2006, In : British Journal of Pharmacology. 149, 4, p. 431-440 10 p.

    Research output: Contribution to journalArticle

    12 Citations (Scopus)

    Novel compounds that interact with both leukotriene B-4 receptors and vanilloid TRPV1 receptors

    McHugh, D., McMaster, R. S., Pertwee, R. G., Roy, S., Mahadevan, A., Razdan, R. K. & Ross, R. A., 2006, In : Journal of Pharmacology and Experimental Therapeutics. 316, p. 955-965 11 p.

    Research output: Contribution to journalArticle

    18 Citations (Scopus)

    Role of cannabinoid receptors in the regulation of cardiac contractility during ischemia/reperfusion

    Maslov, L. N., Lasukova, O. V., Krylatov, A. V., Hanus, L. O., Pertwee, R. G., Ivanchuk, I. I. & Crowford, D., 2006, In : Bulletin of Experimental Biology and Medicine. 142, 5, p. 557-561 5 p.

    Research output: Contribution to journalArticle

    4 Citations (Scopus)

    Scopolamine and MK801-induced working memory deficits in rats are not reversed by CBD-rich cannabis extracts

    Fadda, P., Robinson, L., Fratta, W., Pertwee, R. G. & Riedel, G., 2006, In : Behavioural Brain Research. 168, p. 307-311 5 p.

    Research output: Contribution to journalArticle

    25 Citations (Scopus)

    The pharmacology of cannabinoid receptors and their ligands: an overview

    Pertwee, R. G., 2006, In : International Journal of Obesity. 30, Supplement 1, p. S13–S18 6 p.

    Research output: Contribution to journalArticle

    321 Citations (Scopus)
    2005

    Allosteric modulation of the cannabinoid CB1 receptor

    Price, M. R., Baillie, G. L., Thomas, A., Stevenson, L. A., Easson, M., Goodwin, R., McLean, A., McIntosh, L., Goodwin, G., Walker, G., Westwood, P., Marrs, J., Thomson, F., Cowley, P., Christopoulos, A., Pertwee, R. G. & Ross, R. A., Nov 2005, In : Molecular Pharmacology. 68, 5, p. 1484-1495 12 p.

    Research output: Contribution to journalArticle

    313 Citations (Scopus)

    Cannabinoid receptor antagonists SR141716 and SR144528 exhibit properties of partial agonists in experiments on isolated perfused rat heart

    Krylatov, A. V., Maslov, L. N., Lasukova, O. V. & Pertwee, R. G., 2005, In : Bulletin of Experimental Biology and Medicine. 139, p. 558-561 4 p.

    Research output: Contribution to journalArticle

    17 Citations (Scopus)

    Evidence that (-)-7-hydroxy-4 '-dimethylheptyl-cannabidiol activates a non-CB1, non-CB2, non-TRPV1 target in the mouse vas deferens

    Pertwee, R. G., Thomas, A., Stevenson, L. A., Maor, Y. & Mechoulam, R., 2005, In : Neuropharmacology. 48, p. 1139-1146 8 p.

    Research output: Contribution to journalArticle

    26 Citations (Scopus)

    Evidence that the plant cannabinoid ¿9-tetrahydrocannabivarin is a cannabinoid CB1 and CB2 receptor antagonist

    Thomas, A., Stevenson, L. A., Wease, K., Price, M., Baillie, G., Ross, R. A. & Pertwee, R. G., Dec 2005, In : British Journal of Pharmacology. 146, 7, p. 917-926 9 p.

    Research output: Contribution to journalArticle

    110 Citations (Scopus)

    Influence of the degree of unsaturation of the acyl side chain upon the interaction of analogues of 1-arachidonoylglycerol with monoacylglycerol lipase and fatty acid amide hydrolase

    Vandevoorde, S., Saha, B., Mahadevan, A., Razdan, R. K., Pertwee, R. G., Martin, B. R. & Fowler, C. J., 2005, In : Biochemical and Biophysical Research Communications. 337, p. 104-109 6 p.

    Research output: Contribution to journalArticle

    40 Citations (Scopus)

    Synthesis of long-chain amide analogs of the cannabinoid CB1 receptor antagonist N-(piperidinyl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716) with unique binding selectivities and pharmacological activities

    Thomas, B. F., Francisco, M. E. Y., Seltzman, H. H., Thomas, J. B., Fix, S. E., Schulz, A. K., Gilliam, A. F., Pertwee, R. G. & Stevenson, L. A., 2005, In : Bioorganic & Medicinal Chemistry. 13, p. 5463-5474 12 p.

    Research output: Contribution to journalArticle

    26 Citations (Scopus)
    2004

    Cannabinoids and glaucoma

    Tomida, I., Pertwee, R. G. & Azuara-Blanco, A., May 2004, In : British Journal of Ophthalmology. 88, 5, p. 708-713 5 p.

    Research output: Contribution to journalArticle

    87 Citations (Scopus)

    Differential effects of THC or CBD-rich cannabis extracts on working memory in rats

    Fadda, P., Robinson, L., Fratta, W., Pertwee, R. G. & Riedel, G., 2004, In : Neuropharmacology. 47, p. 1170-1179 10 p.

    Research output: Contribution to journalArticle

    78 Citations (Scopus)

    Inhibition of monoacylglycerol lipase and fatty acid amide hydrolase by analogues of 2-arachidonoylglycerol

    Ghafouri, N., Tiger, G., Razdan, R. K., Mahadevan, A., Pertwee, R. G., Martin, B. R. & Fowler, C. J., 2004, In : British Journal of Pharmacology. 143, p. 774-784 11 p.

    Research output: Contribution to journalArticle

    73 Citations (Scopus)

    Pharmacological and therapeutic targets for Delta(9)-tetrahydrocannabinol and cannabidiol

    Pertwee, R. G., 2004, In : Euphytica. 140, p. 73-82 10 p.

    Research output: Contribution to journalArticle

    Selective cannabinoiod receptor agonist HU-210 decreases pump function of isolated perfused heart: Role of cAMP and cGMP

    Maslov, L. N., Lasukova, O. V., Krylatov, A. V., Uzhachenko, R. V. & Pertwee, R., 2004, In : Bulletin of Experimental Biology and Medicine. 138, p. 550-553 4 p.

    Research output: Contribution to journalArticle

    2003

    Effects of delta-9-THC and WIN-55,212-2 on place preference in the water maze in rats

    Robinson, L., Hinder, L., Pertwee, R. G. & Riedel, G., Feb 2003, In : Psychopharmacology. 166, 1, p. 40-50 10 p.

    Research output: Contribution to journalArticle

    25 Citations (Scopus)

    Pharmacophoric requirements for the cannabinoid side chain. Probing the cannabinoid receptor subsite at C1'

    Papahatjis, D. P., Nikas, S. P., Kourouli, T., Chari, R., Xu, W., Pertwee, R. G. & Makriyannis, A., 2003, In : Journal of Medicinal Chemistry. 46, p. 3221-3229 9 p.

    Research output: Contribution to journalArticle

    42 Citations (Scopus)
    2002

    Activation of cannabinoid receptors decreases the area of ischemic myocardial necrosis

    Ugdyzhekova, D. S., Krylatov, A. V., Bernatskaya, N. A., Maslov, L. N., Mechoulam, R. & Pertwee, R. G., 2002, In : Bulletin of Experimental Biology and Medicine. 133, p. 125-126 2 p.

    Research output: Contribution to journalArticle

    16 Citations (Scopus)

    Cannabinoid receptors and their ligands

    Pertwee, R. G. & Ross, R., Feb 2002, In : Prostaglandins, Leukotrienes and Essential Fatty Acids. 66, 2-3, p. 101-121 20 p.

    Research output: Contribution to journalArticle

    396 Citations (Scopus)

    Cannabinoids and multiple sclerosis

    Pertwee, R. G., Aug 2002, In : Pharmacology & Therapeutics. 95, 2, p. 165-174 10 p.

    Research output: Contribution to journalArticle

    152 Citations (Scopus)

    Endogenous cannabinoids improve myocardial resistance to arrhythmogenic effects of coronary occlusion and reperfusion: a possible mechanism

    Krylatov, A. V., Uzhachenko, R. V., Maslov, L. N., Bernatskaya, N. A., Makriyannis, A., Mechoulam, R., Pertwee, R. G., Sal'nikova, O. M., Stefano, J. B. & Lishmanov, Y. B., 2002, In : Bulletin of Experimental Biology and Medicine. 133, p. 122-124 3 p.

    Research output: Contribution to journalArticle

    22 Citations (Scopus)

    Functions of cannabinoid receptors in the hippocampus

    Davies, S. N., Pertwee, R. G. & Riedel, G., Jun 2002, In : Neuropharmacology. 42, 8, p. 993-1007 14 p.

    Research output: Contribution to journalArticle

    145 Citations (Scopus)

    Localisation of cannabinoid CB1 receptor-immunoreactivity in the guinea-pig and rat myenteric plexus

    Coutts, A. A., Irving, A. J., Mackie, K., Pertwee, R. G. & Anavi-Goffer, S., Jul 2002, In : Journal of Comparative Neurology. 448, 4, p. 410-422 12 p.

    Research output: Contribution to journalArticle

    123 Citations (Scopus)

    Pharmacological characterization of the anandamide cyclooxygenase metabolite

    Ross, R. A., Craib, S., Stevenson, L. A., Pertwee, R. G., Henderson, A., Toole, J. & Ellington, H. C., 1 Jun 2002, In : Journal of Pharmacology and Experimental Therapeutics. 301, 3, p. 900-907 7 p.

    Research output: Contribution to journalArticle

    93 Citations (Scopus)

    Synthesis and structure-activity relationships of amide and hydrazide analogues of the cannabinoid CB1 receptor antagonist N-(piperidinyl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716)

    Francisco, M. E. Y., Seltzman, H. H., Gilliam, A. F., Mitchell, R. A., Rider, S. L., Pertwee, R. G., Stevenson, L. A. & Thomas, B. F., 2002, In : Journal of Medicinal Chemistry. 45, p. 2708-2719 12 p.

    Research output: Contribution to journalArticle

    93 Citations (Scopus)
    2001

    Actions of cannabinoid receptor ligands on rat cultured sensory neurones: implications for antinociception

    Ross, R. A., Coutts, A. A., McFarlane, S. M., Anavi-Goffer, S., Irving, A. J., Pertwee, R. G., MacEwan, D. J. & Scott, R. H., Jan 2001, In : Neuropharmacology. 40, 2, p. 221-232 11 p.

    Research output: Contribution to journalArticle

    148 Citations (Scopus)

    Activation of type II cannabinoid receptors improves myocardial tolerance to arrhythmogenic effects of coronary occlusion and reperfusion

    Krylatov, A. V., Ugdyshekova, D. S., Bernatskaya, N. A., Maslov, L. N., Mekhoulam, R., Pertwee, R. G. & Stephano, G. B., 2001, In : Bulletin of Experimental Biology and Medicine. 131, p. 523-525 3 p.

    Research output: Contribution to journalArticle

    41 Citations (Scopus)

    Agonist-induced internalization and trafficking of cannabinoid CB1 receptors in hippocampal neurons

    Coutts, A. A., Anavi-Goffer, S., Ross, R. A., MacEwan, D. J., Mackie, K., Pertwee, R. G. & Irving, A. J., Apr 2001, In : Journal of Neuroscience. 21, 7, p. 2425-2433 9 p.

    Research output: Contribution to journalArticle

    130 Citations (Scopus)

    Anandamide activates peripheral nociceptors in normal and arthritic rat knee joints

    Gauldie, S. D., McQueen, D. S., Pertwee, R. & Chessell, I. P., 2001, In : British Journal of Pharmacology. 132, p. 617-621 5 p.

    Research output: Contribution to journalArticle

    64 Citations (Scopus)

    A possible role of lipoxygenase in the activation of vanilloid receptors by anandamide in the guinea-pig bronchus

    Craib, S., Ellington, H. C., Pertwee, R. G. & Ross, R. A., Sep 2001, In : British Journal of Pharmacology. 134, 1, p. 30-37 7 p.

    Research output: Contribution to journalArticle

    89 Citations (Scopus)

    Cannabinoid receptors and pain

    Pertwee, R. G., Apr 2001, In : Progress in Neurobiology. 63, 5, p. 569-611 42 p.

    Research output: Contribution to journalArticle

    580 Citations (Scopus)

    Cannabinoids and the gastrointestinal tract

    Pertwee, R. G., Jun 2001, In : Gut. 48, 6, p. 859-867 8 p.

    Research output: Contribution to journalArticle

    238 Citations (Scopus)

    Endocannabinoids control spasticity in a multiple sclerosis model.

    Baker, D., Pryce, G., Croxford, J. L., Brown, P., Pertwee, R. G., Makriyannis, A., Khanolkar, A., Fezza, F., Bisogno, T. & Di Marzo, V., Feb 2001, In : The FASEB Journal. 15, 2, p. 300-302 2 p.

    Research output: Contribution to journalArticle

    342 Citations (Scopus)

    Structure-activity relationship for the endogenous cannabinoid, anandamide, and certain of its analogues at vanilloid receptors in transfected cells and vas deferens

    Ross, R. A., Gibson, T. M., Brockie, H. C., Leslie, M., Pashmi, G., Craib, S., Di Marzo, V. & Pertwee, R. G., Feb 2001, In : British Journal of Pharmacology. 132, 3, p. 631-640 9 p.

    Research output: Contribution to journalArticle

    205 Citations (Scopus)