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2020

Concentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal Dementia

Shiells, H., Schelter, B. O., Bentham, P., Baddeley, T. C., Rubino, C. M., Ganesan, H., Hammel, J., Vuksanovic, V., Staff, R. T., Murray, A. D., Bracoud, L., Wischik, D. J., Riedel, G., Gauthier, S., Jia, J., Moebius, H. J., Hardlund, J., Kipps, C. M., Kook, K., Storey, J. M. D. & 2 others, Harrington, C. R. & Wischik, C. M., 19 May 2020, In : Journal of Alzheimer's Disease. 75, 2, p. 501-519 19 p.

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Klotho gene polymorphism, brain structure and cognition in early-life development

de Vries, C. F., Staff, R., Noble, K. G., Muetzel, R. L., Vernooij, M. W., White, T., Waiter, G. D. & Murray, A. D., 2020, In : Brain Imaging and Behavior. 14, p. 213-225 13 p.

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Motion during Acquisition is Associated with fMRI Brain Entropy

de Vries, C., Staff, R. T., Waiter, G. D., Sokunbi, M. O., Sandu, A. L. & Murray, A. D., Feb 2020, In : IEEE journal of biomedical and health informatics. 24, 2, p. 586-593 8 p.

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Open Access
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2019

Concentration-Dependent Activity of Hydromethylthionine on Cognitive Decline and Brain Atrophy in Mild to Moderate Alzheimer’s Disease

Schelter, B. O., Shiells, H. C., Baddeley, T. C., Rubino, C. M., Ganesan, H., Hammel, J., Vuksanovic, V., Staff, R. T., Murray, A. D., Bracoud, L., Riedel, G., Gauthier, S., Jia, J., Bentham, P., Kook, K., Storey, J. M. D., Harrington, C. R. & Wischik, C. M., 26 Nov 2019, In : Journal of Alzheimer's Disease. 72, 3, p. 931-946 16 p.

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Open Access
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3 Citations (Scopus)
3 Downloads (Pure)
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2 Citations (Scopus)
10 Downloads (Pure)
2018
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5 Citations (Scopus)
12 Downloads (Pure)

Intellectual engagement and cognitive ability in later life (the "use it or lose it" conjecture): Longitudinal, prospective study

Staff, R. T., Hogan, M. J., Williams, D. S. & Whalley, L. J., 10 Dec 2018, In : BMJ (Online). 363, k4925.

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7 Citations (Scopus)
8 Downloads (Pure)

Life-course determinants of cognitive reserve (CR) in cognitive aging and dementia: a systematic literature review

Chapko, D., McCormack, R., Black, C., Staff, R. & Murray, A., 2018, In : Aging & Mental Health. 22, 8, p. 915-926 12 p.

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Open Access
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20 Citations (Scopus)
7 Downloads (Pure)

The influence of childhood intelligence, social class, education and social mobility on memory and memory decline in late life

Staff, R. T., Hogan, M. J. & Whalley, L. J., Nov 2018, In : Age and Ageing. 47, 6, p. 847-852 6 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2017

A brain imaging repository of normal structural MRI across the life course: Brain Images of Normal Subjects (BRAINS)

Job, D. E., Dickie, D. A., Rodriguez, D., Robson, A., Pernet, C., Bastin, M. E., Boardman, J. P., Murray, A. D., Ahearn, T., Waiter, G. D., Staff, R. T., Deary, I. J., Shenkin, S. D. & Wardlaw, J. M., 1 Jan 2017, In : Neuroimage. 144, Part B, p. 299–304 6 p.

Research output: Contribution to journalArticle

Open Access
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21 Citations (Scopus)
14 Downloads (Pure)
Open Access
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6 Citations (Scopus)
9 Downloads (Pure)

Klotho, APOEε4, cognitive ability, brain size, atrophy and survival: A study in the Aberdeen Birth Cohort of 1936

de Vries, C. F., Staff, R. T., Harris, S. E., Chapko, D., Williams, D. S., Reichert, P., Ahearn, T., McNeil, C. J., Whalley, L. J. & Murray, A. D., Jul 2017, In : Neurobiology of Aging. 55, p. 91-98 8 p.

Research output: Contribution to journalArticle

Open Access
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6 Citations (Scopus)
12 Downloads (Pure)

Potential of Low Dose Leuco-Methylthioninium Bis(Hydromethanesulphonate) (LMTM) Monotherapy for Treatment of Mild Alzheimer’s Disease: Cohort Analysis as Modified Primary Outcome in a Phase III Clinical Trial

Wilcock, G. K., Gauthier, S., Frisoni, G. B., Jia, J., Hardlund, J. H., Moebius, H. J., Bentham, P., Kook, K. A., Schelter, B. O., Wischik, D. J., Davis, C. S., Staff, R. T., Vuksanovic, V., Ahearn, T., Bracoud, L., Shamsi, K., Marek, K., Seibyl, J., Riedel, G., Storey, J. M. D. & 2 others, Harrington, C. R. & Wischik, C. M., 28 Nov 2017, In : Journal of Alzheimer's Disease. 61, 1, p. 435-457 24 p.

Research output: Contribution to journalArticle

Open Access
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28 Citations (Scopus)
18 Downloads (Pure)
2016
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10 Citations (Scopus)
11 Downloads (Pure)

Cerebral correlates of cognitive reserve

Whalley, L. J., Staff, R. T., Fox, H. C. & Murray, A. D., 30 Jan 2016, In : Psychiatry Research. 247, p. 65-70 6 p.

Research output: Contribution to journalArticle

Open Access
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16 Citations (Scopus)
10 Downloads (Pure)

Efficacy and safety of tau-aggregation inhibitor therapy in patients with mild or moderate Alzheimer's disease: a randomised, controlled, double-blind, parallel-arm, phase 3 trial

Gauthier, S., Feldman, H. H., Schneider, L. S., Wilcock, G. K., Frisoni, G. B., Hardlund, J. H., Moebius, H. J., Bentham, P., Kook, K. A., Wischik, D. J., Schelter, B. O., Davis, C. S., Staff, R. T., Bracoud, L., Shamsi, K., Storey, J. M. D., Harrington, C. R. & Wischik, C. M., Dec 2016, In : The Lancet. 388, 10062, p. 2873-2884 12 p.

Research output: Contribution to journalArticle

Open Access
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119 Citations (Scopus)
6 Downloads (Pure)
Open Access
8 Citations (Scopus)
2015

Fuzzy approximate entropy analysis of resting state fMRI signal complexity across the adult life span

Sokunbi, M. O., Cameron, G. G., Ahearn, T. S., Murray, A. D. & Staff, R. T., Nov 2015, In : Medical Engineering & Physics. 37, 11, p. 1082-1090 9 p.

Research output: Contribution to journalArticle

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17 Citations (Scopus)
17 Downloads (Pure)

Tau Aggregation Inhibitor Therapy: An Exploratory Phase 2 Study in Mild or Moderate Alzheimer's Disease

Wischik, C. M., Staff, R. T., Wischik, D. J., Bentham, P., Murray, A. D., Storey, J. M. D., Kook, K. A. & Harrington, C. R., 22 Jan 2015, In : Journal of Alzheimer's Disease. 44, 2, p. 705-720 16 p.

Research output: Contribution to journalArticle

Open Access
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130 Citations (Scopus)
5 Downloads (Pure)
2014

Early life socioeconomic circumstances and late life brain hyperintensities: a population based cohort study

Murray, A. D., McNeil, C. J., Salarirad, S., Whalley, L. J. & Staff, R. T., 18 Feb 2014, In : PloS ONE. 9, 2, 7 p., e88969.

Research output: Contribution to journalArticle

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18 Citations (Scopus)
7 Downloads (Pure)

Homocysteine, antioxidant micronutrients and late onset dementia

Whalley, L. J., Duthie, S. J., Collins, A. R., Starr, J. M., Deary, I. J., Lemmon, H., Duthie, A. C., Murray, A. D. & Staff, R. T., Feb 2014, In : European Journal of Nutrition. 53, 1, p. 277-285 9 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Improving the cost-effectiveness of photographic screening for diabetic macular oedema: a prospective, multi-centre, UK study

Prescott, G., Sharp, P., Goatman, K., Scotland, G., Fleming, A., Philip, S., Staff, R., Santiago, C., Borooah, S., Broadbent, D., Chong, V., Dodson, P., Harding, S., Leese, G., Megaw, R., Styles, C., Swa, K., Wharton, H. & Olson, J., Aug 2014, In : British Journal of Ophthalmology. 98, 8, p. 1042-1049 8 p.

Research output: Contribution to journalArticle

Open Access
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23 Citations (Scopus)
7 Downloads (Pure)

Nonlinear complexity analysis of brain FMRI signals in schizophrenia

Sokunbi, M. O., Gradin, V. B., Waiter, G. D., Cameron, G. G., Ahearn, T. S., Murray, A. D., Steele, D. J. & Staff, R. T., 13 May 2014, In : PloS ONE. 9, 5, 10 p., e95146.

Research output: Contribution to journalArticle

Open Access
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51 Citations (Scopus)
7 Downloads (Pure)

Structural brain complexity and cognitive decline in late life: A longitudinal study in the Aberdeen 1936 Birth Cohort

Sandu-Giuraniuc, A-L., Staff, R. T., McNeil, C. J., Mustafa, N., Ahearn, T., Whalley, L. J. & Murray, A. D., 15 Oct 2014, In : Neuroimage. 100, p. 558-563 6 p.

Research output: Contribution to journalArticle

Open Access
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18 Citations (Scopus)
8 Downloads (Pure)
2013

Depressive symptoms in late life and cerebrovascular disease: the importance of intelligence and lesion location

Murray, A. D., Staff, R. T., McNeil, C. J., Salarirad, S., Phillips, L. H., Starr, J., Deary, I. J. & Whalley, L. J., Jan 2013, In : Depression and Anxiety. 30, 1, p. 77-84 8 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Genetic and environmental factors in late onset dementia: possible role for early parental death

Whalley, L. J., Staff, R. T., Murray, A. D., Deary, I. J. & Starr, J. M., Jan 2013, In : International Journal of Geriatric Psychiatry. 28, 1, p. 75-81 7 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2012

Anticholinergic drugs in late life: adverse effects on cognition but not on progress to dementia

Whalley, L. J., Sharma, S., Fox, H. C., Murray, A. D., Staff, R. T., Duthie, A. C., Deary, I. J. & Starr, J. M., May 2012, In : Journal of Alzheimer's Disease. 30, 2, p. 253-261 9 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Brain lesions, hypertension and cognitive aging in the 1921 and 1936 Aberdeen birth cohorts

Murray, A. D., Staff, R. T., McNeil, C. J., Salarirad, S., Starr, J. M., Deary, I. J. & Whalley, L. J., Apr 2012, In : Age. 34, 2, p. 451-459 9 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Brain structural complexity and life course cognitive change

Mustafa, N., Ahearn, T. S., Waiter, G. D., Murray, A. D., Whalley, L. J. & Staff, R. T., 2 Jul 2012, In : Neuroimage. 61, 3, p. 694-701 8 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)
88 Citations (Scopus)

Do brain image databanks support understanding of normal ageing brain structure? A systematic review

Dickie, D. A., Job, D. E., Poole, I., Ahearn, T. S., Staff, R. T., Murray, A. D. & Wardlaw, J. M., Jul 2012, In : European Radiology. 22, 7, p. 1385-1394 10 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2011

Cerebellar brain volume accounts for variance in cognitive performance in older adults

Hogan, M. J., Staff, R. T., Bunting, B. P., Murray, A. D., Ahearn, T. S., Deary, I. J. & Whalley, L. J., Apr 2011, In : Cortex. 47, 4, p. 441-450 10 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Childhood intelligence and brain white matter hyperintensities predict fluid intelligence age 78-81 years: a 1921 Aberdeen birth cohort study

Salarirad, S., Staff, R. T., Fox, H. C., Deary, I. J., Whalley, L. & Murray, A. D., Sep 2011, In : Age and Ageing. 40, 5, p. 562-567 6 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

How the 1932 and 1947 mental surveys of Aberdeen schoolchildren provide a framework to explore the childhood origins of late onset disease and disability

Whalley, L. J., Murray, A. D., Staff, R. T., Starr, J. M., Deary, I. J., Fox, H. C., Lemmon, H., Duthie, S. J., Collins, A. R. & Crawford, J. R., Aug 2011, In : Maturitas. 69, 4, p. 365-372 8 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Inter-individual differences in fMRI entropy measurements in old age

Sokunbi, M. O., Staff, R. T., Waiter, G. D., Ahearn, T. S., Fox, H. C., Deary, I. J., Starr, J. M., Whalley, L. J. & Murray, A. D., Nov 2011, In : IEEE Transactions on Biomedical Engineering. 58, 11, p. 3206-3214 9 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Regional cerebral blood flow and aberrant motor behaviour in Alzheimer's disease

Reilly, T. J., Staff, R. T., Ahearn, T. S., Bentham, P., Wischik, C. M. & Murray, A. D., 23 Sep 2011, In : Behavioural Brain Research. 222, 2, p. 375-379 5 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

The balance between cognitive reserve and brain imaging biomarkers of cerebrovascular and Alzheimer's diseases

Murray, A. D., Staff, R. T., McNeil, C. J., Salarirad, S., Ahearn, T. S., Mustafa, N. & Whalley, L. J., Dec 2011, In : Brain. 134, 12, p. 3687-3696 10 p.

Research output: Contribution to journalArticle

72 Citations (Scopus)
2010

Brain volume and survival from age 78 to 85: the contribution of Alzheimer-type magnetic resonance imaging findings

Staff, R. T., Murray, A. D., Ahearn, T., Salarirad, S., Mowat, D., Starr, J. M., Deary, I. J., Lemmon, H. & Whalley, L. J., Apr 2010, In : Journal of the American Geriatrics Society. 58, 4, p. 688-695 8 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
59 Citations (Scopus)
2009
14 Citations (Scopus)
2007

Monitoring primary breast cancer throughout chemotherapy using FDG-PET

McDermott, G. M., Welch, A., Staff, R. T., Gilbert, F. J., Schweiger, L. F., Semple, S. I. K., Smith, T. A. D., Hutcheon, A. W., Miller, I. D., Smith, I. C. & Heys, S. D., Mar 2007, In : Breast Cancer Research and Treatment. 102, 1, p. 75-84 10 p.

Research output: Contribution to journalArticle

88 Citations (Scopus)
2006

A55 A rCBF study of hallucinations in dementia.

Staff, R. T., Benjamin, K. D., Murray, A. D., Gemmell, H. . G. & Wischik, C. M., 2006, In : Nuclear Medicine Communications. 27, 3

Research output: Contribution to journalArticle

Baseline MRI delivery characteristics predict change in invasive ductal breast carcinoma PET metabolism as a result of primary chemotherapy administration

Semple, S. I. K., Staff, R. T., Heys, S. D., Redpath, T. W., Welch, A., Ahearn, T. S., Hutcheon, A. W. & Gilbert, F. J., Sep 2006, In : Annals of Oncology. 17, p. 1393-1398 5 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Generality and specificity in cognitive aging: a volumetric brain analysis

Staff, R. T., Murray, A. D., Deary, I. J. & Whalley, L. J., May 2006, In : Neuroimage. 30, 4, p. 1433-1440 7 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)
2005

Brain white matter hyperintensities: Relative importance of different vascular risk factors in non-demented elderly people

Murray, A. D., Staff, R. T., Shenkin, S. D., Deary, I. J., Starr, J. M. & Whalley, L. J., Aug 2005, In : Radiology. 237, p. 251-257 6 p.

Research output: Contribution to journalArticle

134 Citations (Scopus)

FPCIT.net: a web based archive for use with 123I ioflupane

Staff, R. T., Murray, A. D., Ahearn, T. S., Counsell, C. E., Taylor, K. S. M., Wilson, K. & Gemmell, H. . G., 2005, In : Nuclear Medicine Communications. 26

Research output: Contribution to journalArticle

62 Citations (Scopus)