• 3286 Citations
19932018
If you made any changes in Pure these will be visible here soon.

Research Output 1993 2018

  • 3286 Citations
  • 20 Article
  • 3 Literature review
  • 2 Chapter
  • 1 Abstract
2018
38 Citations (Scopus)

Sex reversal following deletion of a single distal enhancer of Sox9

Gonen, N., Futtner, C. R., Wood, S., Alexandra Garcia-Moreno, S., Salamone, I. M., Samson, S. C., Sekido, R., Poulat, F., Maatouk, D. M. & Lovell-Badge, R., 29 Jun 2018, In : Science. 360, 6396, p. 1469-1471 3 p.

Research output: Contribution to journalArticle

Gonads
Genes
Chromatin
Testis
XY female 46
2017
23 Citations (Scopus)

Identical NR5A1 Missense Mutations in Two Unrelated 46,XX Individuals with Testicular Tissues

Igarashi, M., Takasawa, K., Hakoda, A., Kanno, J., Takada, S., Miyado, M., Baba, T., Morohashi, K-I., Tajima, T., Hata, K., Nakabayashi, K., Matsubara, Y., Sekido, R., Ogata, T., Kashimada, K. & Fukami, M., 1 Jan 2017, In : Human Mutation. 38, 1, p. 39-42 4 p.

Research output: Contribution to journalArticle

Missense Mutation
Mutation
46, XX Testicular Disorders of Sex Development
46,XY Gonadal Dysgenesis
Ovotesticular Disorders of Sex Development
2016

Regulation of Sox9 in the gonad during sex determination

Lovell-Badge, R., Gonen, N., Samson, S., O'Neill, H., Sekido, R. & Maatouk, D., Apr 2016, In : Transgenic Research. 25, 2, p. 216 1 p.

Research output: Contribution to journalAbstract

2014
13 Citations (Scopus)

The Potential Role of SRY in Epigenetic Gene Regulation During Brain Sexual Differentiation in Mammals

Sekido, R., 2014, Epigenetic Shaping of Sociosexual Interactions: From Plants to Humans. Yamamoto, D. (ed.). Elsevier, Vol. 86. p. 135-165 31 p. (Advances in Genetics; vol. 86).

Research output: Chapter in Book/Report/Conference proceedingChapter

Sex Differentiation
Epigenomics
Mammals
Brain
Genes
2013
29 Citations (Scopus)

A microRNA (mmu-miR-124) prevents Sox9 expression in developing mouse ovarian cells

Real, F. M., Sekido, R., Lupiáñez, D. G., Lovell-Badge, R., Jiménez, R. & Burgos, M., Oct 2013, In : Biology of Reproduction. 89, 4, p. 78

Research output: Contribution to journalArticle

MicroRNAs
Gonads
Testis
Genes
Sex Differentiation
46 Citations (Scopus)
Testis
Mammals
Ovary
Sertoli Cells
Embryonic Development
2012
44 Citations (Scopus)

Excess DAX1 leads to XY ovotesticular disorder of sex development (DSD) in mice by inhibiting steroidogenic factor-1 (SF1) activation of the testis enhancer of SRY-box-9 (Sox9)

Ludbrook, L. M., Bernard, P., Bagheri-Fam, S., Ryan, J., Sekido, R., Wilhelm, D., Lovell-Badge, R. & Harley, V. R., 1 Apr 2012, In : Endocrinology. 153, 4, p. 1948-1958 11 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Sox9 gene regulation and the loss of the XY/XX sex-determining mechanism in the mole vole Ellobius lutescens

Bagheri-Fam, S., Sreenivasan, R., Bernard, P., Knower, K. C., Sekido, R., Lovell-Badge, R., Just, W. & Harley, V. R., Jan 2012, In : Chromosome Research. 20, 1, p. 191-199 9 p.

Research output: Contribution to journalArticle

Arvicolinae
Genes
Gonads
Up-Regulation
sry Genes
2011
44 Citations (Scopus)
5 Downloads (Pure)

Failure of SOX9 regulation in 46XY disorders of sex development with SRY, SOX9 and SF1 mutations

Knower, K. C., Kelly, S., Ludbrook, L. M., Bagheri-Fam, S., Sim, H., Bernard, P., Sekido, R., Lovell-Badge, R. & Harley, V. R., 11 Mar 2011, In : PloS ONE. 6, 3, 9 p., e17751.

Research output: Contribution to journalArticle

Open Access
File
Steroidogenic Factor 1
Disorders of Sex Development
mutation
Mutation
gender
148 Citations (Scopus)

Identification of SOX3 as an XX male sex reversal gene in mice and humans

Sutton, E., Hughes, J., White, S., Sekido, R., Tan, J., Arboleda, V., Rogers, N., Knower, K., Rowley, L., Eyre, H., Rizzoti, K., McAninch, D., Goncalves, J., Slee, J., Turbitt, E., Bruno, D., Bengtsson, H., Harley, V., Vilain, E., Sinclair, A. & 2 others, Lovell-Badge, R. & Thomas, P., 4 Jan 2011, In : The Journal of Clinical Investigation. 121, 1, p. 328-341 14 p.

Research output: Contribution to journalArticle

2010
45 Citations (Scopus)

SRY: a transcriptional activator of mammalian testis determination

Sekido, R., Mar 2010, In : International Journal of Biochemistry & Cell Biology. 42, 3, p. 417-420 4 p.

Research output: Contribution to journalLiterature review

Testis
Genes
HMGB Proteins
sry Genes
Mammalian Chromosomes
2009
212 Citations (Scopus)

Sex determination and SRY: down to a wink and a nudge?

Sekido, R. & Lovell-Badge, R., Jan 2009, In : Trends in Genetics. 25, 1, p. 19-29 11 p.

Research output: Contribution to journalLiterature review

Genes
Mammals
Sex Differentiation
Sertoli Cells
Gonads
505 Citations (Scopus)

Somatic sex reprogramming of adult ovaries to testes by FOXL2 ablation

Uhlenhaut, N. H., Jakob, S., Anlag, K., Eisenberger, T., Sekido, R., Kress, J., Treier, A-C., Klugmann, C., Klasen, C., Holter, N. I., Riethmacher, D., Schutz, G., Cooney, A. J., Lovell-Badge, R. & Treier, M., 11 Dec 2009, In : Cell. 139, 6, p. 1130-1142 13 p.

Research output: Contribution to journalArticle

2008
561 Citations (Scopus)

Sex determination involves synergistic action of SRY and SF1 on a specific Sox9 enhancer

Sekido, R. & Lovell-Badge, R., 12 Jun 2008, In : Nature. 453, 7197, p. 930-934 5 p.

Research output: Contribution to journalArticle

2007
117 Citations (Scopus)

Fibroblast growth factor receptor 2 regulates proliferation and Sertoli differentiation during male sex determination

Kim, Y., Bingham, N., Sekido, R., Parker, K. L., Lovell-Badge, R. & Capel, B., 16 Oct 2007, In : PNAS. 104, 42, p. 16558-16563 6 p.

Research output: Contribution to journalArticle

Receptor, Fibroblast Growth Factor, Type 2
Sertoli Cells
Gonads
Testis
Fibroblast Growth Factor Receptors
27 Citations (Scopus)

Mechanisms of gonadal morphogenesis are not conserved between chick and mouse

Sekido, R. & Lovell-Badge, R., 1 Feb 2007, In : Developmental Biology. 302, 1, p. 132-142 11 p.

Research output: Contribution to journalArticle

Morphogenesis
Sertoli Cells
Gonads
Mesoderm
Epithelium
59 Citations (Scopus)

The origin of the Mullerian duct in chick and mouse

Guioli, S., Sekido, R. & Lovell-Badge, R., 15 Feb 2007, In : Developmental Biology. 302, 2, p. 389-398 10 p.

Research output: Contribution to journalArticle

Mullerian Ducts
Epithelium
Mesonephros
Wolffian Ducts
Vertebrates
2006
241 Citations (Scopus)
4 Downloads (Pure)

Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination

Kim, Y., Kobayashi, A., Sekido, R., DiNapoli, L., Brennan, J., Chaboissier, M-C., Poulat, F., Behringer, R. R., Lovell-Badge, R. & Capel, B., Jun 2006, In : PLoS Biology. 4, 6, 10 p., e187.

Research output: Contribution to journalArticle

Open Access
File
Gonads
gonads
gender
Fibroblast Growth Factor 9
fibroblast growth factors
2004
233 Citations (Scopus)

SOX9 is up-regulated by the transient expression of SRY specifically in Sertoli cell precursors

Sekido, R., Bar, I., Narváez, V., Penny, G. & Lovell-Badge, R., 15 Oct 2004, In : Developmental Biology. 274, 2, p. 271-9 9 p.

Research output: Contribution to journalArticle

Sertoli Cells
Gonads
Epithelium
Y-Linked Genes
Transgenes
2002
72 Citations (Scopus)

Sex-determining genes in mice: building pathways

Lovell-Badge, R., Canning, C. & Sekido, R., 2002, The genetics and biology of sex determination. Novartis Foundation, p. 4-18; discussion 18-22, 35-42, 253-7 (Novartis Foundation Symposia; vol. 244).

Research output: Chapter in Book/Report/Conference proceedingChapter

Sertoli Cells
Genes
Cell Differentiation
Maintenance
Sexual Development
2001
272 Citations (Scopus)

Pax6 and SOX2 form a co-DNA-binding partner complex that regulates initiation of lens development

Kamachi, Y., Uchikawa, M., Tanouchi, A., Sekido, R. & Kondoh, H., 15 May 2001, In : Genes & Development. 15, 10, p. 1272-86 15 p.

Research output: Contribution to journalArticle

Lenses
delta-Crystallins
DNA
Binding Sites
Ectoderm
1997
99 Citations (Scopus)

Impairment of T cell development in deltaEF1 mutant mice

Higashi, Y., Moribe, H., Takagi, T., Sekido, R., Kawakami, K., Kikutani, H. & Kondoh, H., 21 Apr 1997, In : Journal of Experimental Medicine. 185, 8, p. 1467-79 13 p.

Research output: Contribution to journalArticle

Thymocytes
T-Lymphocytes
Zinc Fingers
Integrin alpha4
T-Lymphoid Precursor Cells
52 Citations (Scopus)

Two mechanisms in the action of repressor deltaEF1: binding site competition with an activator and active repression

Sekido, R., Murai, K., Kamachi, Y. & Kondoh, H., Dec 1997, In : Genes to Cells. 2, 12, p. 771-83 13 p.

Research output: Contribution to journalArticle

Zinc Fingers
Binding Sites
DNA
Crystallins
Repressor Proteins
1996
46 Citations (Scopus)

Organization of the gene encoding transcriptional repressor deltaEF1 and cross-species conservation of its domains

Sekido, R., Takagi, T., Okanami, M., Moribe, H., Yamamura, M., Higashi, Y. & Kondoh, H., 16 Sep 1996, In : Gene. 173, 2, p. 227-32 6 p.

Research output: Contribution to journalArticle

Exons
Zinc Fingers
Genes
Chickens
delta-Crystallins
1994
176 Citations (Scopus)

The delta-crystallin enhancer-binding protein delta EF1 is a repressor of E2-box-mediated gene activation

Sekido, R., Murai, K., Funahashi, J., Kamachi, Y., Fujisawa-Sehara, A., Nabeshima, Y. & Kondoh, H., Sep 1994, In : Molecular and Cellular Biology. 14, 9, p. 5692-700 9 p.

Research output: Contribution to journalArticle

delta-Crystallins
Muscle Development
Transcriptional Activation
Carrier Proteins
MyoD Protein
1993
163 Citations (Scopus)

Delta-crystallin enhancer binding protein delta EF1 is a zinc finger-homeodomain protein implicated in postgastrulation embryogenesis

Funahashi, J., Sekido, R., Murai, K., Kamachi, Y. & Kondoh, H., Oct 1993, In : Development. 119, 2, p. 433-46 14 p.

Research output: Contribution to journalArticle

delta-Crystallins
Homeodomain Proteins
Zinc Fingers
Embryonic Development
Carrier Proteins