Ryohei Sekido

Dr

    • AB25 2ZD

    • 3235 Citations
    19932018
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    Research Output 1993 2018

    • 3235 Citations
    • 20 Article
    • 3 Literature review
    • 2 Chapter
    • 1 Abstract
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    Article
    2018
    33 Citations (Scopus)

    Sex reversal following deletion of a single distal enhancer of Sox9

    Gonen, N., Futtner, C. R., Wood, S., Alexandra Garcia-Moreno, S., Salamone, I. M., Samson, S. C., Sekido, R., Poulat, F., Maatouk, D. M. & Lovell-Badge, R., 29 Jun 2018, In : Science. 360, 6396, p. 1469-1471 3 p.

    Research output: Contribution to journalArticle

    Gonads
    Genes
    Chromatin
    Testis
    XY female 46
    2017
    19 Citations (Scopus)

    Identical NR5A1 Missense Mutations in Two Unrelated 46,XX Individuals with Testicular Tissues

    Igarashi, M., Takasawa, K., Hakoda, A., Kanno, J., Takada, S., Miyado, M., Baba, T., Morohashi, K-I., Tajima, T., Hata, K., Nakabayashi, K., Matsubara, Y., Sekido, R., Ogata, T., Kashimada, K. & Fukami, M., 1 Jan 2017, In : Human Mutation. 38, 1, p. 39-42 4 p.

    Research output: Contribution to journalArticle

    Missense Mutation
    Mutation
    46, XX Testicular Disorders of Sex Development
    46,XY Gonadal Dysgenesis
    Ovotesticular Disorders of Sex Development
    2013
    28 Citations (Scopus)

    A microRNA (mmu-miR-124) prevents Sox9 expression in developing mouse ovarian cells

    Real, F. M., Sekido, R., Lupiáñez, D. G., Lovell-Badge, R., Jiménez, R. & Burgos, M., Oct 2013, In : Biology of Reproduction. 89, 4, p. 78

    Research output: Contribution to journalArticle

    MicroRNAs
    Gonads
    Testis
    Genes
    Sex Differentiation
    2012
    44 Citations (Scopus)

    Excess DAX1 leads to XY ovotesticular disorder of sex development (DSD) in mice by inhibiting steroidogenic factor-1 (SF1) activation of the testis enhancer of SRY-box-9 (Sox9)

    Ludbrook, L. M., Bernard, P., Bagheri-Fam, S., Ryan, J., Sekido, R., Wilhelm, D., Lovell-Badge, R. & Harley, V. R., 1 Apr 2012, In : Endocrinology. 153, 4, p. 1948-1958 11 p.

    Research output: Contribution to journalArticle

    21 Citations (Scopus)

    Sox9 gene regulation and the loss of the XY/XX sex-determining mechanism in the mole vole Ellobius lutescens

    Bagheri-Fam, S., Sreenivasan, R., Bernard, P., Knower, K. C., Sekido, R., Lovell-Badge, R., Just, W. & Harley, V. R., Jan 2012, In : Chromosome Research. 20, 1, p. 191-199 9 p.

    Research output: Contribution to journalArticle

    Arvicolinae
    Genes
    Gonads
    Up-Regulation
    sry Genes
    2011
    44 Citations (Scopus)
    5 Downloads (Pure)

    Failure of SOX9 regulation in 46XY disorders of sex development with SRY, SOX9 and SF1 mutations

    Knower, K. C., Kelly, S., Ludbrook, L. M., Bagheri-Fam, S., Sim, H., Bernard, P., Sekido, R., Lovell-Badge, R. & Harley, V. R., 11 Mar 2011, In : PloS ONE. 6, 3, 9 p., e17751.

    Research output: Contribution to journalArticle

    Open Access
    File
    Steroidogenic Factor 1
    Disorders of Sex Development
    mutation
    Mutation
    gender
    143 Citations (Scopus)

    Identification of SOX3 as an XX male sex reversal gene in mice and humans

    Sutton, E., Hughes, J., White, S., Sekido, R., Tan, J., Arboleda, V., Rogers, N., Knower, K., Rowley, L., Eyre, H., Rizzoti, K., McAninch, D., Goncalves, J., Slee, J., Turbitt, E., Bruno, D., Bengtsson, H., Harley, V., Vilain, E., Sinclair, A. & 2 others, Lovell-Badge, R. & Thomas, P., 4 Jan 2011, In : The Journal of Clinical Investigation. 121, 1, p. 328-341 14 p.

    Research output: Contribution to journalArticle

    2009
    494 Citations (Scopus)

    Somatic sex reprogramming of adult ovaries to testes by FOXL2 ablation

    Uhlenhaut, N. H., Jakob, S., Anlag, K., Eisenberger, T., Sekido, R., Kress, J., Treier, A-C., Klugmann, C., Klasen, C., Holter, N. I., Riethmacher, D., Schutz, G., Cooney, A. J., Lovell-Badge, R. & Treier, M., 11 Dec 2009, In : Cell. 139, 6, p. 1130-1142 13 p.

    Research output: Contribution to journalArticle

    2008
    554 Citations (Scopus)

    Sex determination involves synergistic action of SRY and SF1 on a specific Sox9 enhancer

    Sekido, R. & Lovell-Badge, R., 12 Jun 2008, In : Nature. 453, 7197, p. 930-934 5 p.

    Research output: Contribution to journalArticle

    2007
    116 Citations (Scopus)

    Fibroblast growth factor receptor 2 regulates proliferation and Sertoli differentiation during male sex determination

    Kim, Y., Bingham, N., Sekido, R., Parker, K. L., Lovell-Badge, R. & Capel, B., 16 Oct 2007, In : PNAS. 104, 42, p. 16558-16563 6 p.

    Research output: Contribution to journalArticle

    Receptor, Fibroblast Growth Factor, Type 2
    Sertoli Cells
    Gonads
    Testis
    Fibroblast Growth Factor Receptors
    27 Citations (Scopus)

    Mechanisms of gonadal morphogenesis are not conserved between chick and mouse

    Sekido, R. & Lovell-Badge, R., 1 Feb 2007, In : Developmental Biology. 302, 1, p. 132-142 11 p.

    Research output: Contribution to journalArticle

    Morphogenesis
    Sertoli Cells
    Gonads
    Mesoderm
    Epithelium
    58 Citations (Scopus)

    The origin of the Mullerian duct in chick and mouse

    Guioli, S., Sekido, R. & Lovell-Badge, R., 15 Feb 2007, In : Developmental Biology. 302, 2, p. 389-398 10 p.

    Research output: Contribution to journalArticle

    Mullerian Ducts
    Epithelium
    Mesonephros
    Wolffian Ducts
    Vertebrates
    2006
    238 Citations (Scopus)
    4 Downloads (Pure)

    Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination

    Kim, Y., Kobayashi, A., Sekido, R., DiNapoli, L., Brennan, J., Chaboissier, M-C., Poulat, F., Behringer, R. R., Lovell-Badge, R. & Capel, B., Jun 2006, In : PLoS Biology. 4, 6, 10 p., e187.

    Research output: Contribution to journalArticle

    Open Access
    File
    Gonads
    gonads
    gender
    Fibroblast Growth Factor 9
    fibroblast growth factors
    2004
    228 Citations (Scopus)

    SOX9 is up-regulated by the transient expression of SRY specifically in Sertoli cell precursors

    Sekido, R., Bar, I., Narváez, V., Penny, G. & Lovell-Badge, R., 15 Oct 2004, In : Developmental Biology. 274, 2, p. 271-9 9 p.

    Research output: Contribution to journalArticle

    Sertoli Cells
    Gonads
    Epithelium
    Y-Linked Genes
    Transgenes
    2001
    270 Citations (Scopus)

    Pax6 and SOX2 form a co-DNA-binding partner complex that regulates initiation of lens development

    Kamachi, Y., Uchikawa, M., Tanouchi, A., Sekido, R. & Kondoh, H., 15 May 2001, In : Genes & Development. 15, 10, p. 1272-86 15 p.

    Research output: Contribution to journalArticle

    Lenses
    delta-Crystallins
    DNA
    Binding Sites
    Ectoderm
    1997
    98 Citations (Scopus)

    Impairment of T cell development in deltaEF1 mutant mice

    Higashi, Y., Moribe, H., Takagi, T., Sekido, R., Kawakami, K., Kikutani, H. & Kondoh, H., 21 Apr 1997, In : Journal of Experimental Medicine. 185, 8, p. 1467-79 13 p.

    Research output: Contribution to journalArticle

    Thymocytes
    T-Lymphocytes
    Zinc Fingers
    Integrin alpha4
    T-Lymphoid Precursor Cells
    52 Citations (Scopus)

    Two mechanisms in the action of repressor deltaEF1: binding site competition with an activator and active repression

    Sekido, R., Murai, K., Kamachi, Y. & Kondoh, H., Dec 1997, In : Genes to Cells. 2, 12, p. 771-83 13 p.

    Research output: Contribution to journalArticle

    Zinc Fingers
    Binding Sites
    DNA
    Crystallins
    Repressor Proteins
    1996
    46 Citations (Scopus)

    Organization of the gene encoding transcriptional repressor deltaEF1 and cross-species conservation of its domains

    Sekido, R., Takagi, T., Okanami, M., Moribe, H., Yamamura, M., Higashi, Y. & Kondoh, H., 16 Sep 1996, In : Gene. 173, 2, p. 227-32 6 p.

    Research output: Contribution to journalArticle

    Exons
    Zinc Fingers
    Genes
    Chickens
    delta-Crystallins
    1994
    176 Citations (Scopus)

    The delta-crystallin enhancer-binding protein delta EF1 is a repressor of E2-box-mediated gene activation

    Sekido, R., Murai, K., Funahashi, J., Kamachi, Y., Fujisawa-Sehara, A., Nabeshima, Y. & Kondoh, H., Sep 1994, In : Molecular and Cellular Biology. 14, 9, p. 5692-700 9 p.

    Research output: Contribution to journalArticle

    delta-Crystallins
    Muscle Development
    Transcriptional Activation
    Carrier Proteins
    MyoD Protein
    1993
    163 Citations (Scopus)

    Delta-crystallin enhancer binding protein delta EF1 is a zinc finger-homeodomain protein implicated in postgastrulation embryogenesis

    Funahashi, J., Sekido, R., Murai, K., Kamachi, Y. & Kondoh, H., Oct 1993, In : Development. 119, 2, p. 433-46 14 p.

    Research output: Contribution to journalArticle

    delta-Crystallins
    Homeodomain Proteins
    Zinc Fingers
    Embryonic Development
    Carrier Proteins