• 26 Citations
20152018
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Personal profile

Biography

Cell signalling is regulated by two families of proteins, kinases and phosphatases; kinases attach a phosphate group to a protein, and phosphatases remove phosphate groups. Together, these two families of proteins regulate the most critical signalling pathways within cells. While these two families have been studied extensively in a myriad of contexts, currently we have not characterised fully the regulation of myeloid cell function by phosphatases. My current work focuses on the role of PTP1B in the regulation of dendritic cells during autoimmunity and cancer. 

Education/Academic qualification

Life Sciences & Medicine, PhD

1 Oct 201330 Sep 2017

Life Sciences & Medicine, Bachelors Degree, University of Edinburgh

Life Sciences & Medicine, Higher National Qualification

Fingerprint Dive into the research topics where Samantha Le Sommer is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 41 Similar Profiles
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Research Output 2015 2018

  • 26 Citations
  • 5 Article
  • 1 Letter
5 Citations (Scopus)
6 Downloads (Pure)

Deficiency in Protein Tyrosine Phosphatase PTP1B Shortens Lifespan and Leads to Development of Acute Leukemia

Le Sommer, S., Morrice, N., Pesaresi, M., Thompson, D., Vickers, M. A., Murray, G. I., Mody, N., Neel, B. G., Bence, K. K., Wilson, H. M. & Delibegovic, M., Jan 2018, In : Cancer Research. 78, 1, p. 75-87 13 p.

Research output: Contribution to journalArticle

Open Access
File
Protein Tyrosine Phosphatases
Leukemia
Myeloid Cells
Acute Myeloid Leukemia
Liver
4 Downloads (Pure)

Response to comment by Moxon et al

Thompson, D., Morrice, N., Grant, L., Le Sommer, S., Lees, E. K., Mody, N., Wilson, H. M. & Delibegovic, M., 2 Jan 2018, In : Clinical Science. 132, 1, p. 39-41 3 p.

Research output: Contribution to journalLetter

Open Access
File
4 Citations (Scopus)
11 Downloads (Pure)
Open Access
File
Non-Receptor Type 1 Protein Tyrosine Phosphatase
AMP-Activated Protein Kinases
Apolipoproteins E
Atherosclerotic Plaques
Interleukin-10
7 Citations (Scopus)
11 Downloads (Pure)
Open Access
File
Non-Receptor Type 1 Protein Tyrosine Phosphatase
Atherosclerotic Plaques
Atherosclerosis
Pharmacology
Insulin Receptor
10 Citations (Scopus)
11 Downloads (Pure)

A key role for PTP1B in dendritic cell maturation, migration and T cell activation

Martin-Granados, C., Prescott, A. R., Le Sommer, S., Klaska, I., Yu, T., Muckersie, E., Giuraniuc, V. C., Grant, L., Delibegovic, M. & Forrester, J. V., Dec 2015, In : Journal of Molecular Cell Biology. 7, 6, p. 517-528 12 p.

Research output: Contribution to journalArticle

Open Access
File
Dendritic Cells
Cell Movement
Bone Marrow
T-Lymphocytes
Myeloid Cells

Activities 2013 2019

FEBS Advanced Course Europhosphatase 2019

Samantha Le Sommer (Participant)
11 Jun 201916 Jun 2019

Activity: Participating in or organising an eventConference

May Festival 2019

Samantha Le Sommer (Speaker)
23 May 2019

Activity: Talk, presentation, public lecture, public engagement, outreach and knowledge exchangeEngagement with Schools

Pint of Science Aberdeen

Samantha Le Sommer (Speaker)
11 May 201915 May 2019

Activity: Participating in or organising an eventFestival or Exhibition

Soapbox Science 2019

Samantha Le Sommer (Speaker)
25 May 2019

Activity: Talk, presentation, public lecture, public engagement, outreach and knowledge exchangePublic Engagement

Biochemical Society (External organisation)

Samantha Le Sommer (Member)
1 Feb 2019

Activity: MembershipMembership of research network

Press / Media

Revealed: adult leukaemia can be caused by gene implicated in breast cancer and obesity

Samantha Le Sommer

15/01/18

1 Media contribution

Press/Media: Articles in 'The Conversation'