Research Output per year
Personal profile
Biography
Cell signalling is regulated by two families of proteins, kinases and phosphatases; kinases attach a phosphate group to a protein, and phosphatases remove phosphate groups. Together, these two families of proteins regulate the most critical signalling pathways within cells. While these two families have been studied extensively in a myriad of contexts, currently we have not characterised fully the regulation of myeloid cell function by phosphatases. My current work focuses on the role of PTP1B in the regulation of dendritic cells during autoimmunity and cancer.
Education/Academic qualification
Life Sciences & Medicine, PhD
1 Oct 2013 → 30 Sep 2017
Life Sciences & Medicine, Bachelors Degree, University of Edinburgh
Life Sciences & Medicine, Higher National Qualification
Fingerprint Dive into the research topics where Samantha Le Sommer is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 41 Similar Profiles
Non-Receptor Type 1 Protein Tyrosine Phosphatase
Medicine & Life Sciences
Atherosclerotic Plaques
Medicine & Life Sciences
Atherosclerosis
Medicine & Life Sciences
AMP-Activated Protein Kinases
Medicine & Life Sciences
Interleukin-10
Medicine & Life Sciences
Insulin Receptor
Medicine & Life Sciences
Myeloid Cells
Medicine & Life Sciences
Protein Tyrosine Phosphatases
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Research Output 2015 2018
Deficiency in Protein Tyrosine Phosphatase PTP1B Shortens Lifespan and Leads to Development of Acute Leukemia
Le Sommer, S., Morrice, N., Pesaresi, M., Thompson, D., Vickers, M. A., Murray, G. I., Mody, N., Neel, B. G., Bence, K. K., Wilson, H. M. & Delibegovic, M., Jan 2018, In : Cancer Research. 78, 1, p. 75-87 13 p.Research output: Contribution to journal › Article
Open Access
File
Protein Tyrosine Phosphatases
Leukemia
Myeloid Cells
Acute Myeloid Leukemia
Liver
Response to comment by Moxon et al
Thompson, D., Morrice, N., Grant, L., Le Sommer, S., Lees, E. K., Mody, N., Wilson, H. M. & Delibegovic, M., 2 Jan 2018, In : Clinical Science. 132, 1, p. 39-41 3 p.Research output: Contribution to journal › Letter
Open Access
File
Myeloid protein tyrosine phosphatase 1B (PTP1B) deficiency protects against atherosclerotic plaque formation in the ApoE−/− mouse model of atherosclerosis with alterations in IL10/AMPKα pathway
Thompson, D., Morrice, N., Grant, L., Le Sommer, S., Ziegler, K., Whitfield, P., Mody, N., Wilson, H. M. & Delibegovic, M., 1 Aug 2017, In : Molecular Metabolism. 6, 8, p. 845-853 9 p.Research output: Contribution to journal › Article
Open Access
File
Non-Receptor Type 1 Protein Tyrosine Phosphatase
AMP-Activated Protein Kinases
Apolipoproteins E
Atherosclerotic Plaques
Interleukin-10
Pharmacological inhibition of protein tyrosine phosphatase 1B (PTP1B) protects against atherosclerotic plaque formation in the LDLR-/- mouse model of atherosclerosis
Thompson, D., Morrice, N., Grant, L., Le Sommer, S., Lees, E. K., Mody, N., Wilson, H. M. & Delibegovic, M., 29 Sep 2017, In : Clinical Science. 131, 20, p. 2489-2501 13 p.Research output: Contribution to journal › Article
Open Access
File
Non-Receptor Type 1 Protein Tyrosine Phosphatase
Atherosclerotic Plaques
Atherosclerosis
Pharmacology
Insulin Receptor
A key role for PTP1B in dendritic cell maturation, migration and T cell activation
Martin-Granados, C., Prescott, A. R., Le Sommer, S., Klaska, I., Yu, T., Muckersie, E., Giuraniuc, V. C., Grant, L., Delibegovic, M. & Forrester, J. V., Dec 2015, In : Journal of Molecular Cell Biology. 7, 6, p. 517-528 12 p.Research output: Contribution to journal › Article
Open Access
File
Dendritic Cells
Cell Movement
Bone Marrow
T-Lymphocytes
Myeloid Cells
Activities 2013 2019
FEBS Advanced Course Europhosphatase 2019
Samantha Le Sommer (Participant)11 Jun 2019 → 16 Jun 2019
Activity: Participating in or organising an event › Conference
May Festival 2019
Samantha Le Sommer (Speaker)23 May 2019
Activity: Talk, presentation, public lecture, public engagement, outreach and knowledge exchange › Engagement with Schools
Pint of Science Aberdeen
Samantha Le Sommer (Speaker)11 May 2019 → 15 May 2019
Activity: Participating in or organising an event › Festival or Exhibition
Soapbox Science 2019
Samantha Le Sommer (Speaker)25 May 2019
Activity: Talk, presentation, public lecture, public engagement, outreach and knowledge exchange › Public Engagement
Biochemical Society (External organisation)
Samantha Le Sommer (Member)1 Feb 2019
Activity: Membership › Membership of research network
Press / Media
Revealed: adult leukaemia can be caused by gene implicated in breast cancer and obesity
15/01/18
1 Media contribution
Press/Media: Articles in 'The Conversation'