• 34 Citations
20152018

Research output per year

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Personal profile

Biography

Cell signalling is regulated by two families of proteins, kinases and phosphatases; kinases attach a phosphate group to a protein, and phosphatases remove phosphate groups. Together, these two families of proteins regulate the most critical signalling pathways within cells. While these two families have been studied extensively in a myriad of contexts, currently we have not characterised fully the regulation of myeloid cell function by phosphatases. My current work focuses on the role of PTP1B in the regulation of dendritic cells during autoimmunity and cancer. 

Education/Academic qualification

Life Sciences & Medicine, PhD

1 Oct 201330 Sep 2017

Award Date: 30 Mar 2018

Life Sciences & Medicine, Bachelors Degree, University of Edinburgh

Award Date: 22 Jun 2012

Life Sciences & Medicine, Higher National Qualification

Award Date: 5 Aug 2008

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Research Output

  • 34 Citations
  • 5 Article
  • 1 Letter

Deficiency in Protein Tyrosine Phosphatase PTP1B Shortens Lifespan and Leads to Development of Acute Leukemia

Le Sommer, S., Morrice, N., Pesaresi, M., Thompson, D., Vickers, M. A., Murray, G. I., Mody, N., Neel, B. G., Bence, K. K., Wilson, H. M. & Delibegovic, M., Jan 2018, In : Cancer Research. 78, 1, p. 75-87 13 p.

Research output: Contribution to journalArticle

Open Access
File
  • 6 Citations (Scopus)
    9 Downloads (Pure)

    Response to comment by Moxon et al

    Thompson, D., Morrice, N., Grant, L., Le Sommer, S., Lees, E. K., Mody, N., Wilson, H. M. & Delibegovic, M., 2 Jan 2018, In : Clinical Science. 132, 1, p. 39-41 3 p.

    Research output: Contribution to journalLetter

    Open Access
    File
    9 Downloads (Pure)
    Open Access
    File
  • 8 Citations (Scopus)
    15 Downloads (Pure)
    Open Access
    File
  • 9 Citations (Scopus)
    18 Downloads (Pure)

    A key role for PTP1B in dendritic cell maturation, migration and T cell activation

    Martin-Granados, C., Prescott, A. R., Le Sommer, S., Klaska, I., Yu, T., Muckersie, E., Giuraniuc, V. C., Grant, L., Delibegovic, M. & Forrester, J. V., Dec 2015, In : Journal of Molecular Cell Biology. 7, 6, p. 517-528 12 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 11 Citations (Scopus)
    13 Downloads (Pure)

    Activities

    Biochemical Society (External organisation)

    Samantha Le Sommer (Member)

    1 Feb 2019

    Activity: Membership (e.g. panels, networks, committees, etc.)Membership of research network

    FEBS Advanced Course Europhosphatase 2019

    Samantha Le Sommer (Participant)

    11 Jun 201916 Jun 2019

    Activity: Attending or organising an eventAttending/organising a Conference

    Soapbox Science 2019

    Samantha Le Sommer (Speaker)

    25 May 2019

    Activity: Talk, presentation, public lecture, public engagement, outreach and knowledge exchangePublic Engagement

    May Festival 2019

    Samantha Le Sommer (Speaker)

    23 May 2019

    Activity: Talk, presentation, public lecture, public engagement, outreach and knowledge exchangeEngagement with Schools

    Pint of Science Aberdeen

    Samantha Le Sommer (Speaker)

    11 May 201915 May 2019

    Activity: Attending or organising an eventAttending/organising Festival or Exhibition

    Press / Media

    Revealed: adult leukaemia can be caused by gene implicated in breast cancer and obesity

    Samantha Le Sommer

    15/01/18

    1 Media contribution

    Press/Media: Articles in 'The Conversation'