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2019

Interaction of the Mechanosensitive Channel, MscS, with the Membrane Bilayer through Lipid Intercalation into Grooves and Pockets

Rasmussen, T., Rasmussen, A., Yang, L., Kaul, C., Black, S., Galbiati, H., Conway, S. J., Miller, S., Blount, P. & Booth, I. R., 9 Aug 2019, In : Journal of Molecular Biology. 431, 17, p. 3339-3352 14 p.

Research output: Contribution to journalArticle

Open Access
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3 Citations (Scopus)
2 Downloads (Pure)
2017

Adenosine Monophosphate Binding Stabilizes the KTN Domain of the Shewanella denitrificans Kef Potassium Efflux System

Pliotas, C., Grayer, S. C., Ekkerman, S., Chan, A. K. N., Healy, J., Marius, P., Bartlett, W., Khan, A., Cortopassi, W. A., Chandler, S. A., Rasmussen, T., Benesch, J. L. P., Paton, R. S., Claridge, T. D. W., Miller, S., Booth, I. R., Naismith, J. H. & Conway, S. J., Aug 2017, In : Biochemistry. 56, 32, p. 4219-4234 16 p.

Research output: Contribution to journalArticle

Open Access
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3 Citations (Scopus)
6 Downloads (Pure)
2016

On the mobility, membrane location and functionality of mechanosensitive channels in Escherichia coli

van den Berg, J., Galbiati, H., Rasmussen, A., Miller, S. & Poolman, B., 6 Sep 2016, In : Scientific Reports. 6, 32709.

Research output: Contribution to journalArticle

Open Access
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8 Citations (Scopus)
6 Downloads (Pure)
Open Access
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6 Citations (Scopus)
7 Downloads (Pure)
2015

Properties of the mechanosensitive channel MscS pore revealed by tryptophan scanning mutagenesis

Rasmussen, T., Rasmussen, A., Singh, S., Galbiati, H., Edwards, M. D., Miller, S. & Booth, I. R., Jul 2015, In : Biochemistry. 54, 29, p. 4519-4530 12 p.

Research output: Contribution to journalArticle

Open Access
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8 Citations (Scopus)
6 Downloads (Pure)

The role of lipids in mechanosensation

Pilotas, C., Dahl, A. C. E., Rasmussen, T., Mahendran, K. R., Smith, T. K., Marius, P., Gault, J., Banda, T., Rasmussen, A., Miller, S., Robinson, C. V., Bayley, H., Sansom, M. S. P., Booth, I. R. & Naismith, J. H., Dec 2015, In : Nature Structural & Molecular Biology. 22, 12, p. 991-998 8 p.

Research output: Contribution to journalArticle

Open Access
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75 Citations (Scopus)
60 Downloads (Pure)
2014

Mechanosensitive channels and bacterial cell wall integrity: does life end with a bang or a whimper?

Reuter, M., Hayward, N. J., Black, S. S., Miller, S., Dryden, D. T. F. & Booth, I. R., Feb 2014, In : Journal of the Royal Society Interface. 11, 91, 9 p., 20130850.

Research output: Contribution to journalArticle

Open Access
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25 Citations (Scopus)
6 Downloads (Pure)

Probing the structure of the mechanosensitive channel of small conductance in lipid bilayers with pulsed electron-electron double resonance

Ward, R., Pliotas, C., Branigan, E., Hacker, C., Rasmussen, A., Hagelueken, G., Booth, I. R., Miller, S., Lucocq, J., Naismith, J. H. & Schiemann, O., 18 Feb 2014, In : Biophysical Journal. 106, 4, p. 834-842 9 p.

Research output: Contribution to journalArticle

Open Access
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30 Citations (Scopus)
6 Downloads (Pure)

Understanding the structural requirements for activators of the Kef bacterial potassium efflux system

Healy, J., Ekkerman, S., Pliotas, C., Richard, M., Bartlett, W., Grayer, S. C., Morris, G. M., Miller, S., Booth, I. R., Conway, S. J. & Rasmussen, T., 1 Apr 2014, In : Biochemistry. 53, 12, p. 1982-1992 11 p.

Research output: Contribution to journalArticle

Open Access
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16 Citations (Scopus)
7 Downloads (Pure)
2013
Open Access
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20 Citations (Scopus)
6 Downloads (Pure)
2012

Characterization of three novel mechanosensitive channel activities in Escherichia coli

Edwards, M. D., Black, S., Rasmussen, T., Rasmussen, A., Stokes, N. R., Stephen, T-L., Miller, S. & Booth, I. R., Jul 2012, In : Channels. 6, 4, p. 272-281 10 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)

Optimality in DNA repair

Richard, M. C., Fryett, M., Miller, S., Booth, I., Grebogi, C. & Moura, A., 7 Jan 2012, In : Journal of Theoretical Biology. 292, p. 39-43 5 p.

Research output: Contribution to journalArticle

Open Access
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2 Citations (Scopus)
5 Downloads (Pure)
2011

A matter of life or death: modeling DNA damage and repair in bacteria

Karschau, J., de Almeida, C., Richard, M. C., Miller, S., Booth, I. R., Grebogi, C. & de Moura, A. P. S., 16 Feb 2011, In : Biophysical Journal. 100, 4, p. 814-821 8 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
Open Access
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5 Citations (Scopus)
8 Downloads (Pure)

KefF, the regulatory subunit of the potassium efflux system KefC, shows quinone oxidoreductase activity

Lyngberg, L. K., Healy, J., Bartlett, W., Miller, S., Conway, S. J., Booth, I. R. & Rasmussen, T., Sep 2011, In : Journal of Bacteriology. 193, 18, p. 4925-4932 8 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Sensing bilayer tension: bacterial mechanosensitive channels and their gating mechanisms

Booth, I. R., Rasmussen, T., Edwards, M. D., Black, S., Rasmussen, A., Bartlett, W. & Miller, S., 1 Jun 2011, In : Biochemical Society Transactions. 39, 3, p. 733-740 8 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
2010

Mechanism of ligand-gated potassium efflux in bacterial pathogens

Roosild, T. P., Castronovo, S., Healy, J., Miller, S., Pliotas, C., Rasmussen, T., Bartlett, W., Conway, S. J. & Booth, I. R., 16 Nov 2010, In : PNAS. 107, 46, p. 19784-19789 6 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)

The critical role of S-lactoylglutathione formation during methylglyoxal detoxification in Escherichia coli

Ozyamak, E., Black, S. S., Walker, C. A., Maclean, M. J., Bartlett, W., Miller, S. & Booth, I. R., Dec 2010, In : Molecular Microbiology. 78, 6, p. 1577-1590 14 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Tryptophan in the pore of the mechanosensitive channel MscS: assessment of pore conformations by fluorescence spectroscopy

Rasmussen, T., Edwards, M. D., Black, S. S., Rasmussen, A., Miller, S. & Booth, I. R., 19 Feb 2010, In : The Journal of Biological Chemistry. 285, 8, p. 5377-5384 8 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
2009

KTN (RCK) Domains Regulate K+ Channels and Transporters by Controlling the Dimer-Hinge Conformation

Roosild, T. P., Castronovo, S., Miller, S., Li, C., Rasmussen, T., Bartlett, W., Gunasekera, B., Choe, S. & Booth, I. R., 10 Jun 2009, In : Structure. 17, 6, p. 893-903 11 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)
2008

The structure of an open form of an E. coli mechanosensitive channel at 3.45 Å resolution

Wang, W., Black, S. S., Edwards, M. D., Miller, S., Morrison, E. L., Bartlett, W., Dong, C., Naismith, J. H. & Booth, I. R., 29 Aug 2008, In : Science. 321, 5893, p. 1179-1183 5 p.

Research output: Contribution to journalArticle

135 Citations (Scopus)
2007

The C-terminus of α2-antiplasmin interacts with endothelial cells

Thomas, L., Moore, N. R., Miller, S. & Booth, N. A., Feb 2007, In : British Journal of Haematology. 136, 3, p. 472-479 8 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

The role of tryptophan residues in the function and stability of the mechanosensitive channel MscS from Escherichia coli

Rasmussen, A., Rasmussen, T., Edwards, M. D., Schauer, D. S., Schumann, U., Miller, S. & Booth, I. R., 25 Sep 2007, In : Biochemistry. 46, 38, p. 10899-10908 10 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)
2005

Pivotal role of the glycine-rich TM3 helix in gating the MscS mechanosensitive channel

Edwards, M. D., Li, Y., Kim, S., Miller, S., Bartlett, W., Black, S., Dennison, S., Iscla, I., Blount, P., Bowie, J. U. & Booth, I. R., Jan 2005, In : Nature Structural & Molecular Biology. 12, 2, p. 113-119 6 p.

Research output: Contribution to journalArticle

101 Citations (Scopus)
2004

Gating the bacterial mechanosensitive channels: MscS a new paradigm?

Edwards, M. D., Booth, I. R. & Miller, S., Apr 2004, In : Current Opinion in Microbiology. 7, 2, p. 163-167 4 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)
2003

A role for mechanosensitive channels in survival of stationary phase: regulation of channel expression by RpoS

Stokes, N. R., Murray, H. D., Subramaniam, C., Gourse, R. L., Louis, P., Bartlett, W., Miller, S. & Booth, I. R., 23 Dec 2003, In : PNAS. 100, 26, p. 15959-15964 6 p.

Research output: Contribution to journalArticle

81 Citations (Scopus)

Bacterial ion channels

Booth, I. R., Edwards, M. D. & Miller, S., 2003, In : Biochemistry. 42, 34, p. 10045-10053 8 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Domain organization of the MscS mechanosensitive channel of Escherichia coli

Miller, S., Bartlett, W., Chandrasekaran, S., Simpson, S. A., Edwards, M. D. & Booth, I. R., Jan 2003, In : EMBO Journal. 22, 1, p. 36-46 10 p.

Research output: Contribution to journalArticle

92 Citations (Scopus)

The closed structure of the MscS mechanosensitive channel. Cross-linking of single cysteine mutants

Miller, S., Edwards, M. D., Ozdemir, C. & Booth, I. R., Aug 2003, In : The Journal of Biological Chemistry. 278, 34, p. 32246-32250 4 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)
2002

A mechanism of regulating transmembrane potassium flux through a ligand-mediated conformational switch

Roosild, T. P., Miller, S., Booth, I. R. & Choe, S., Jun 2002, In : Cell. 109, 6, p. 781-791 10 p.

Research output: Contribution to journalArticle

94 Citations (Scopus)
2000

Identification of an ancillary protein, YabF, required for activity of the KefC glutathione-gated potassium efflux system in Escherichia coli

Miller, S., Ness, L. S., Wood, C. M., Fox, B. C. & Booth, I. R., 2000, In : Journal of Bacteriology. 182, p. 6536-6540 5 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)