• 1330 Citations
20002019
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Research Output 2000 2019

  • 1330 Citations
  • 31 Article
  • 2 Chapter
  • 2 Literature review
  • 1 Editorial
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Article
2019
1 Citation (Scopus)

Interaction of the Mechanosensitive Channel, MscS, with the Membrane Bilayer through Lipid Intercalation into Grooves and Pockets

Rasmussen, T., Rasmussen, A., Yang, L., Kaul, C., Black, S., Galbiati, H., Conway, S. J., Miller, S., Blount, P. & Booth, I. R., 9 Aug 2019, In : Journal of Molecular Biology. 431, 17, p. 3339-3352 14 p.

Research output: Contribution to journalArticle

Open Access
File
Lipid Bilayers
Lipids
Membranes
Cardiolipins
Membrane Lipids
2017
1 Citation (Scopus)
4 Downloads (Pure)

Adenosine Monophosphate Binding Stabilizes the KTN Domain of the Shewanella denitrificans Kef Potassium Efflux System

Pliotas, C., Grayer, S. C., Ekkerman, S., Chan, A. K. N., Healy, J., Marius, P., Bartlett, W., Khan, A., Cortopassi, W. A., Chandler, S. A., Rasmussen, T., Benesch, J. L. P., Paton, R. S., Claridge, T. D. W., Miller, S., Booth, I. R., Naismith, J. H. & Conway, S. J., Aug 2017, In : Biochemistry. 56, 32, p. 4219-4234 16 p.

Research output: Contribution to journalArticle

Open Access
File
Shewanella
Adenosine Monophosphate
Potassium
Ligands
Dimers
2016
7 Citations (Scopus)
4 Downloads (Pure)

On the mobility, membrane location and functionality of mechanosensitive channels in Escherichia coli

van den Berg, J., Galbiati, H., Rasmussen, A., Miller, S. & Poolman, B., 6 Sep 2016, In : Scientific Reports. 6, 32709.

Research output: Contribution to journalArticle

Open Access
File
Escherichia coli
Membranes
Proteins
Microscopy
Shock
4 Citations (Scopus)
5 Downloads (Pure)
Open Access
File
Sulfhydryl Compounds
Glutathione
Potassium
Carrier Proteins
Pathogens
2015
7 Citations (Scopus)
4 Downloads (Pure)

Properties of the mechanosensitive channel MscS pore revealed by tryptophan scanning mutagenesis

Rasmussen, T., Rasmussen, A., Singh, S., Galbiati, H., Edwards, M. D., Miller, S. & Booth, I. R., Jul 2015, In : Biochemistry. 54, 29, p. 4519-4530 12 p.

Research output: Contribution to journalArticle

Open Access
File
rifaximin
Mutagenesis
Tryptophan
Crystal structure
Fluorescence
57 Citations (Scopus)
17 Downloads (Pure)

The role of lipids in mechanosensation

Pilotas, C., Dahl, A. C. E., Rasmussen, T., Mahendran, K. R., Smith, T. K., Marius, P., Gault, J., Banda, T., Rasmussen, A., Miller, S., Robinson, C. V., Bayley, H., Sansom, M. S. P., Booth, I. R. & Naismith, J. H., Dec 2015, In : Nature Structural & Molecular Biology. 22, 12, p. 991-998 8 p.

Research output: Contribution to journalArticle

Open Access
File
Phospholipids
Lipids
Escherichia coli
Membranes
Molecular Dynamics Simulation
2014
24 Citations (Scopus)
4 Downloads (Pure)

Mechanosensitive channels and bacterial cell wall integrity: does life end with a bang or a whimper?

Reuter, M., Hayward, N. J., Black, S. S., Miller, S., Dryden, D. T. F. & Booth, I. R., Feb 2014, In : Journal of the Royal Society Interface. 11, 91, 9 p., 20130850.

Research output: Contribution to journalArticle

Open Access
File
Cell Wall
Cells
Proteins
Optical tweezers
Green Fluorescent Proteins
27 Citations (Scopus)
4 Downloads (Pure)

Probing the structure of the mechanosensitive channel of small conductance in lipid bilayers with pulsed electron-electron double resonance

Ward, R., Pliotas, C., Branigan, E., Hacker, C., Rasmussen, A., Hagelueken, G., Booth, I. R., Miller, S., Lucocq, J., Naismith, J. H. & Schiemann, O., 18 Feb 2014, In : Biophysical Journal. 106, 4, p. 834-842 9 p.

Research output: Contribution to journalArticle

Open Access
File
Lipid Bilayers
Detergents
Electrons
Proteins
Osmotic Pressure
15 Citations (Scopus)
5 Downloads (Pure)

Understanding the structural requirements for activators of the Kef bacterial potassium efflux system

Healy, J., Ekkerman, S., Pliotas, C., Richard, M., Bartlett, W., Grayer, S. C., Morris, G. M., Miller, S., Booth, I. R., Conway, S. J. & Rasmussen, T., 1 Apr 2014, In : Biochemistry. 53, 12, p. 1982-1992 11 p.

Research output: Contribution to journalArticle

Open Access
File
Potassium
Ligands
Rigid structures
Glutathione
Assays
2013
18 Citations (Scopus)
4 Downloads (Pure)
Open Access
File
Lactoylglutathione Lyase
Pyruvaldehyde
Operon
Escherichia coli
DNA Repair
2012
53 Citations (Scopus)

Characterization of three novel mechanosensitive channel activities in Escherichia coli

Edwards, M. D., Black, S., Rasmussen, T., Rasmussen, A., Stokes, N. R., Stephen, T-L., Miller, S. & Booth, I. R., Jul 2012, In : Channels. 6, 4, p. 272-281 10 p.

Research output: Contribution to journalArticle

Escherichia coli
Shock
Genes
Membranes
Induced currents
2 Citations (Scopus)
3 Downloads (Pure)

Optimality in DNA repair

Richard, M. C., Fryett, M., Miller, S., Booth, I., Grebogi, C. & Moura, A., 7 Jan 2012, In : Journal of Theoretical Biology. 292, p. 39-43 5 p.

Research output: Contribution to journalArticle

Open Access
File
DNA repair
DNA Repair
Repair
Optimality
DNA
2011
11 Citations (Scopus)

A matter of life or death: modeling DNA damage and repair in bacteria

Karschau, J., de Almeida, C., Richard, M. C., Miller, S., Booth, I. R., Grebogi, C. & de Moura, A. P. S., 16 Feb 2011, In : Biophysical Journal. 100, 4, p. 814-821 8 p.

Research output: Contribution to journalArticle

DNA Repair
DNA Damage
Bacteria
Enzymes
Double-Stranded DNA Breaks
5 Citations (Scopus)
6 Downloads (Pure)
Open Access
File
Clustering
Cooperative Behavior
Ion Channels
Physical process
Interaction
8 Citations (Scopus)

KefF, the regulatory subunit of the potassium efflux system KefC, shows quinone oxidoreductase activity

Lyngberg, L. K., Healy, J., Bartlett, W., Miller, S., Conway, S. J., Booth, I. R. & Rasmussen, T., Sep 2011, In : Journal of Bacteriology. 193, 18, p. 4925-4932 8 p.

Research output: Contribution to journalArticle

Quinones
Potassium
Oxidoreductases
Glutathione
Poisons
19 Citations (Scopus)

Sensing bilayer tension: bacterial mechanosensitive channels and their gating mechanisms

Booth, I. R., Rasmussen, T., Edwards, M. D., Black, S., Rasmussen, A., Bartlett, W. & Miller, S., 1 Jun 2011, In : Biochemical Society Transactions. 39, 3, p. 733-740 8 p.

Research output: Contribution to journalArticle

Electrophysiology
Membranes
Depolarization
Molecular Biology
Homeostasis
2010
40 Citations (Scopus)

Mechanism of ligand-gated potassium efflux in bacterial pathogens

Roosild, T. P., Castronovo, S., Healy, J., Miller, S., Pliotas, C., Rasmussen, T., Bartlett, W., Conway, S. J. & Booth, I. R., 16 Nov 2010, In : PNAS. 107, 46, p. 19784-19789 6 p.

Research output: Contribution to journalArticle

Glutathione
Potassium
Ligands
Poisons
Potassium Channels
26 Citations (Scopus)

The critical role of S-lactoylglutathione formation during methylglyoxal detoxification in Escherichia coli

Ozyamak, E., Black, S. S., Walker, C. A., Maclean, M. J., Bartlett, W., Miller, S. & Booth, I. R., Dec 2010, In : Molecular Microbiology. 78, 6, p. 1577-1590 14 p.

Research output: Contribution to journalArticle

Pyruvaldehyde
Escherichia coli
Glutathione
Enzymes
Potassium
15 Citations (Scopus)

Tryptophan in the pore of the mechanosensitive channel MscS: assessment of pore conformations by fluorescence spectroscopy

Rasmussen, T., Edwards, M. D., Black, S. S., Rasmussen, A., Miller, S. & Booth, I. R., 19 Feb 2010, In : The Journal of Biological Chemistry. 285, 8, p. 5377-5384 8 p.

Research output: Contribution to journalArticle

2009
35 Citations (Scopus)

KTN (RCK) Domains Regulate K+ Channels and Transporters by Controlling the Dimer-Hinge Conformation

Roosild, T. P., Castronovo, S., Miller, S., Li, C., Rasmussen, T., Bartlett, W., Gunasekera, B., Choe, S. & Booth, I. R., 10 Jun 2009, In : Structure. 17, 6, p. 893-903 11 p.

Research output: Contribution to journalArticle

2008
124 Citations (Scopus)

The structure of an open form of an E. coli mechanosensitive channel at 3.45 Å resolution

Wang, W., Black, S. S., Edwards, M. D., Miller, S., Morrison, E. L., Bartlett, W., Dong, C., Naismith, J. H. & Booth, I. R., 29 Aug 2008, In : Science. 321, 5893, p. 1179-1183 5 p.

Research output: Contribution to journalArticle

2007
9 Citations (Scopus)

The C-terminus of α2-antiplasmin interacts with endothelial cells

Thomas, L., Moore, N. R., Miller, S. & Booth, N. A., Feb 2007, In : British Journal of Haematology. 136, 3, p. 472-479 8 p.

Research output: Contribution to journalArticle

Antifibrinolytic Agents
Endothelial Cells
Integrins
Peptides
Immobilized Cells
24 Citations (Scopus)

The role of tryptophan residues in the function and stability of the mechanosensitive channel MscS from Escherichia coli

Rasmussen, A., Rasmussen, T., Edwards, M. D., Schauer, D. S., Schumann, U., Miller, S. & Booth, I. R., 25 Sep 2007, In : Biochemistry. 46, 38, p. 10899-10908 10 p.

Research output: Contribution to journalArticle

Tryptophan
Escherichia coli
Membrane Proteins
Proteins
Periplasm
2005
97 Citations (Scopus)

Pivotal role of the glycine-rich TM3 helix in gating the MscS mechanosensitive channel

Edwards, M. D., Li, Y., Kim, S., Miller, S., Bartlett, W., Black, S., Dennison, S., Iscla, I., Blount, P., Bowie, J. U. & Booth, I. R., Jan 2005, In : Nature Structural & Molecular Biology. 12, 2, p. 113-119 6 p.

Research output: Contribution to journalArticle

2004
41 Citations (Scopus)

Gating the bacterial mechanosensitive channels: MscS a new paradigm?

Edwards, M. D., Booth, I. R. & Miller, S., Apr 2004, In : Current Opinion in Microbiology. 7, 2, p. 163-167 4 p.

Research output: Contribution to journalArticle

2003
75 Citations (Scopus)

A role for mechanosensitive channels in survival of stationary phase: regulation of channel expression by RpoS

Stokes, N. R., Murray, H. D., Subramaniam, C., Gourse, R. L., Louis, P., Bartlett, W., Miller, S. & Booth, I. R., 23 Dec 2003, In : PNAS. 100, 26, p. 15959-15964 6 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Bacterial ion channels

Booth, I. R., Edwards, M. D. & Miller, S., 2003, In : Biochemistry. 42, 34, p. 10045-10053 8 p.

Research output: Contribution to journalArticle

90 Citations (Scopus)

Domain organization of the MscS mechanosensitive channel of Escherichia coli

Miller, S., Bartlett, W., Chandrasekaran, S., Simpson, S. A., Edwards, M. D. & Booth, I. R., Jan 2003, In : EMBO Journal. 22, 1, p. 36-46 10 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)

The closed structure of the MscS mechanosensitive channel. Cross-linking of single cysteine mutants

Miller, S., Edwards, M. D., Ozdemir, C. & Booth, I. R., Aug 2003, In : The Journal of Biological Chemistry. 278, 34, p. 32246-32250 4 p.

Research output: Contribution to journalArticle

2002
90 Citations (Scopus)

A mechanism of regulating transmembrane potassium flux through a ligand-mediated conformational switch

Roosild, T. P., Miller, S., Booth, I. R. & Choe, S., Jun 2002, In : Cell. 109, 6, p. 781-791 10 p.

Research output: Contribution to journalArticle

2000
26 Citations (Scopus)

Identification of an ancillary protein, YabF, required for activity of the KefC glutathione-gated potassium efflux system in Escherichia coli

Miller, S., Ness, L. S., Wood, C. M., Fox, B. C. & Booth, I. R., 2000, In : Journal of Bacteriology. 182, p. 6536-6540 5 p.

Research output: Contribution to journalArticle