• 963 Citations
20132020

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Research Output

  • 963 Citations
  • 38 Article
  • 1 Other Report
  • 1 Editorial
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Article
2020

Automatic spatial estimation of white matter hyperintensities evolution in brain MRI using disease evolution predictor deep neural networks

Rachmadi, M. F., Valdés-Hernández, M. D. C., Makin, S., Wardlaw, J. & Komura, T., Jul 2020, In : Medical image analysis. 63, p. 101712 19 p., 101712.

Research output: Contribution to journalArticle

Open Access
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Growing research in geriatric medicine: a trainee perspective

Welch, C. & Geriatric Medicine Research Collaborative, 9 Jun 2020, In : Age and Ageing. 5 p., afaa052.

Research output: Contribution to journalArticle

2019

Accuracy of the short-form Montreal Cognitive Assessment: Systematic review and validation

McDicken, J. A., Elliott, E., Blayney, G., Makin, S., Ali, M., Larner, A. J., Quinn, T. J. & Collaborators, VISTA-C., Oct 2019, In : The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. 34, 10, p. 1515-1525 11 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Association between Striatal Brain Iron Deposition, Microbleeds and Cognition 1 Year After a Minor Ischaemic Stroke

Valdes Hernandez, M. D. C. V., Case, T., Chappell, F. M., Glatz, A., Makin, S., Doubal, F. & Wardlaw, J. M., 14 Mar 2019, In : International Journal of Molecular Sciences. 20, 6, 1293.

Research output: Contribution to journalArticle

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Cerebral microbleeds and stroke risk after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies

Wilson, D., Ambler, G., Lee, K-J., Lim, J-S., Shiozawa, M., Koga, M., Li, L., Lovelock, C., Chabriat, H., Hennerici, M., Wong, Y. K., Mak, H. K. F., Prats-Sánchez, L., Martínez-Domeño, A., Inamura, S., Yoshifuji, K., Arsava, E. M., Horstmann, S., Purrucker, J., Lam, B. Y. K. & 291 others, Wong, A., Kim, Y. D., Song, T-J., Schrooten, M., Lemmens, R., Eppinger, S., Gattringer, T., Uysal, E., Tanriverdi, Z., Bornstein, N. M., Assayag, E. B., Hallevi, H., Tanaka, J., Hara, H., Coutts, S. B., Hert, L., Polymeris, A., Seiffge, D. J., Lyrer, P., Algra, A., Kappelle, J., Al-Shahi Salman, R., Jäger, H. R., Lip, G. Y. H., Mattle, H. P., Panos, L. D., Mas, J-L., Legrand, L., Karayiannis, C., Phan, T., Gunkel, S., Christ, N., Abrigo, J., Leung, T., Chu, W., Chappell, F., Makin, S., Hayden, D., Williams, D. J., Kooi, M. E., van Dam-Nolen, D. H. K., Barbato, C., Browning, S., Wiegertjes, K., Tuladhar, A. M., Maaijwee, N., Guevarra, C., Yatawara, C., Mendyk, A-M., Delmaire, C., Köhler, S., van Oostenbrugge, R., Zhou, Y., Xu, C., Hilal, S., Gyanwali, B., Chen, C., Lou, M., Staals, J., Bordet, R., Kandiah, N., de Leeuw, F-E., Simister, R., van der Lugt, A., Kelly, P. J., Wardlaw, J. M., Soo, Y., Fluri, F., Srikanth, V., Calvet, D., Jung, S., Kwa, V. I. H., Engelter, S. T., Peters, N., Smith, E. E., Yakushiji, Y., Orken, D. N., Fazekas, F., Thijs, V., Heo, J. H., Mok, V., Veltkamp, R., Ay, H., Imaizumi, T., Gomez-Anson, B., Lau, K. K., Jouvent, E., Rothwell, P. M., Toyoda, K., Bae, H-J., Marti-Fabregas, J., Werring, D. J., Harkness, K., Shaw, L., Sword, J., Mohd Nor, A., Sharma, P., Kelly, D., Harrington, F., Randall, M., Smith, M., Mahawish, K., Elmarim, A., Esisi, B., Cullen, C., Nallasivam, A., Price, C., Barry, A., Roffe, C., Coyle, J., Hassan, A., Birns, J., Cohen, D., Sekaran, L., Parry-Jones, A., Parry, A., Hargroves, D., Proschel, H., Datta, P., Darawil, K., Manoj, A., Burn, M., Patterson, C., Giallombardo, E., Smyth, N., Mansoor, S., Anwar, I., Marsh, R., Ispoglou, S., Chadha, D., Prabhakaran, M., Meenakishundaram, S., O'Connell, J., Scott, J., Krishnamurthy, V., Aghoram, P., McCormick, M., Sprigg, N., O'Mahony, P., Cooper, M., Choy, L., Wilkinson, P., Leach, S., Caine, S., Burger, I., Gunathilagan, G., Guyler, P., Emsley, H., Davis, M., Manawadu, D., Pasco, K., Mamun, M., Luder, R., Sajid, M., Okwera, J., Warburton, E., Saastamoinen, K., England, T., Putterill, J., Flossman, E., Power, M., Dani, K., Mangion, D., Suman, A., Corrigan, J., Lawrence, E., Vahidassr, D., Shakeshaft, C., Brown, M., Charidimou, A., Cohen, H., Banerjee, G., Houlden, H., White, M., Yousry, T., Flossmann, E., Muir, K., El-Koussy, M., Gratz, P., Molad, J., Korczyn, A., Kliper, E., Maeder, P., Gass, A., Pachai, C., Bracoub, L., Douste-Blazy, M-Y., Fratacci, M. D., Vicaut, E., Sato, S., Miwa, K., Fujita, K., Ide, T., Ma, H., Ly, J., Singhal, S., Chandra, R., Slater, L-A., Soufan, C., Moran, C., Traenka, C., Thilemann, S., Fladt, J., Gensicke, H., Bonati, L., Kim, B. J., Han, M-K., Kang, J., Ko, E., Yang, M. H., Jang, M. S., Murphy, S., Carty, F., Akijian, L., Thornton, J., Schembri, M., Douven, E., Delgado, M., Escudero, R., Marín, R., Camps-Renom, P., Guisado-Alonso, D., Nuñez, F., Medrano-Martorell, S., Merino, E., Iida, K., Ikeda, S., Nishihara, M., Irie, H., Demirelli, D. S., Medanta, J. M., Zerna, C., Hernández, M. V., Armitage, P., Heye, A., Muñoz-Maniega, S., Sakka, E., Thrippleton, M., Dennis, M., Beigneux, Y., Silva, M., Venketasubramanian, N., Ho, S. L., Cheung, R. T. F., Chan, K. H., Teo, K. C., Hui, E., Kwan, J. S. K., Chang, R., Tse, M. Y., Hoi, C. P., Chan, C. Y., Chan, O. L., Cheung, R. H. K., Wong, E. K. M., Leung, K. T., Tsang, S. F., Ip, H. L., Ma, S. H., Ma, K., Fong, W. C., Li, S. H., Li, R., Ng, P. W., Wong, K. K., Liu, W., Wong, L., Ramos, L., De Schryver, E., Jöbsis, J., van der Sande, J., Brouwers, P., Roos, Y., Stam, J., Bakker, S., Verbiest, H., Schoonewille, W., Linn, C., Hertzberger, L., van Gemert, M., Berntsen, P., Hendrikse, J., Nederkoorn, P., Mess, W., Koudstaal, P., Leff, A., Ward, N., Nachev, P., Perry, R., Ozkan, H. & Mitchell, J., Jul 2019, In : The Lancet neurology. 18, 7, p. 653-665 13 p.

Research output: Contribution to journalArticle

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15 Citations (Scopus)
3 Downloads (Pure)

Comprehensive Geriatric Assessment in hospital and hospital-at-home settings: a mixed-methods study

Gardner, M., Shepperd, S., Godfrey, M., Mäkelä, P., Tsiachristas, A., Singh-Mehta, A., Ellis, G., Khanna, P., Langhorne, P., Makin, S. & Stott, D. J., Mar 2019, In : Health Serv Deliv Res. 7, 236 p.

Research output: Contribution to journalArticle

Open Access
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Convolutional Neural Networks for Direct Inference of Pharmacokinetic Parameters: Application to Stroke Dynamic Contrast-Enhanced MRI

Ulas, C., Das, D., Thrippleton, M. J., Valdes Hernandez, M. D. C., Armitage, P. A., Makin, S. D., Wardlaw, J. M. & Menze, B. H., 8 Jan 2019, In : Frontiers in Neurology. 9, 1147.

Research output: Contribution to journalArticle

Open Access
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Functional, cognitive and physical outcomes 3 years after minor lacunar or cortical ischaemic stroke

McHutchison, C. A., Cvoro, V., Makin, S., Chappell, F. M., Shuler, K. & Wardlaw, J. M., 2019, In : Journal of Neurology, Neurosurgery & Psychiatry. 90, 4, p. 436-443 8 p.

Research output: Contribution to journalArticle

Open Access
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8 Citations (Scopus)
3 Downloads (Pure)

Growing research in geriatric medicine

Witham, M. D., Roberts, H. C., Gladman, J., Stott, D. J., Sayer, A. A., Aspray, T. J., Brock, P., Clegg, A., Cox, N., Ewan, V., Frith, J., Burton, J. K., Jackson, T., Lewis, E. G., Lim, S. E., Makin, S., Lochlainn, M. N., Richardson, S., Shenkin, S. D., Steves, C. J. & 5 others, Todd, O., Tullo, E., Walker, R., Yarnall, A. & Extended Working Group from the NIHR Newcastle Biomedical Research Centre Meeting, May 2019, In : Age and Ageing. 48, 3, p. 316-319 4 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Identification of the presence of ischaemic stroke lesions by means of texture analysis on brain magnetic resonance images

Ortiz-Ramon, R., Valdes Hernandez, M. D. C., Gonzalez-Castro, V., Makin, S., Armitage, P. A., Aribisala, B. S., Bastin, M. E., Deary, I. J., Wardlaw, J. M. & Moratal, D., Jun 2019, In : Comput Med Imaging Graph. 74, p. 12-24 13 p.

Research output: Contribution to journalArticle

Open Access
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6 Citations (Scopus)
3 Downloads (Pure)

Intensive Blood Pressure Lowering in Patients With Renal Impairment and Lacunar Stroke

Makin, S. & Whiteley, W. N., 20 Aug 2019, In : Journal of the American Heart Association. 8, 16, e013637.

Research output: Contribution to journalArticle

Open Access
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Stability of Estimated Premorbid Cognitive Ability over Time after Minor Stroke and Its Relationship with Post-Stroke Cognitive Ability

McHutchison, C. A., Chappell, F. M., Makin, S., Shuler, K., Wardlaw, J. M. & Cvoro, V., 22 May 2019, In : Brain Sciences. 9, 5, 117.

Research output: Contribution to journalArticle

Open Access
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The Meta VCI Map consortium for meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping: Design and multicenter pilot study

Weaver, N. A., Zhao, L., Biesbroek, J. M., Kuijf, H. J., Aben, H. P., Bae, H. J., Caballero, M. A. A., Chappell, F. M., Chen, C., Dichgans, M., Duering, M., Georgakis, M. K., van der Giessen, R. S., Gyanwali, B., Hamilton, O. K. L., Hilal, S., Vom Hofe, E. M., de Kort, P. L. M., Koudstaal, P. J., Lam, B. Y. K. & 12 others, Lim, J. S., Makin, S. D. J., Mok, V. C. T., Shi, L., Valdes Hernandez, M. C., Venketasubramanian, N., Wardlaw, J. M., Wollenweber, F. A., Wong, A., Xin, X., Meta, V. C. I. M. C. & Biessels, G. J., Dec 2019, In : Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring. 11, p. 310-326 17 p.

Research output: Contribution to journalArticle

Open Access
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4 Citations (Scopus)
3 Downloads (Pure)
2018

Long-term morphological changes of symptomatic lacunar infarcts and surrounding white matter on structural magnetic resonance imaging

Loos, C. M. J., Makin, S. D. J., Staals, J., Dennis, M. S., Van Oostenbrugge, R. J. & Wardlaw, J. M., May 2018, In : Stroke. 49, 5, p. 1183-1188 6 p.

Research output: Contribution to journalArticle

Open Access
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14 Citations (Scopus)
2 Downloads (Pure)

The brain health index: Towards a combined measure of neurovascular and neurodegenerative structural brain injury

Dickie, D. A., Valdes Hernandez, M. D. C., Makin, S. D., Staals, J., Wiseman, S. J., Bastin, M. E. & Wardlaw, J. M., 1 Oct 2018, In : International Journal of Stroke. 13, 8, p. 849-856 8 p.

Research output: Contribution to journalArticle

Open Access
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5 Citations (Scopus)
5 Downloads (Pure)
Open Access
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4 Citations (Scopus)
3 Downloads (Pure)

The impact of early-life intelligence quotient on post stroke cognitive impairment

Makin, S. D. J., Doubal, F. N., Shuler, K., Chappell, F. M., Staals, J., Dennis, M. S. & Wardlaw, J. M., 1 Jun 2018, In : European Stroke Journal . 3, 2, p. 145-156 12 p.

Research output: Contribution to journalArticle

Open Access
10 Citations (Scopus)

The relation between total cerebral small vessel disease burden and gait impairment in patients with minor stroke

Loos, C. M., McHutchison, C., Cvoro, V., Makin, S. D., Staals, J., Chappell, F., Dennis, M. S., van Oostenbrugge, R. J. & Wardlaw, J. M., 2018, In : International Journal of Stroke. 13, 5, p. 518-524 7 p.

Research output: Contribution to journalArticle

Open Access
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6 Citations (Scopus)
1 Downloads (Pure)
2017

Application of Texture Analysis to Study Small Vessel Disease and Blood-Brain Barrier Integrity

Valdes Hernandez, M. D. C., Gonzalez-Castro, V., Chappell, F. M., Sakka, E., Makin, S., Armitage, P. A., Nailon, W. H. & Wardlaw, J. M., 19 Jul 2017, In : Frontiers in Neurology. 8, 16 p., 327.

Research output: Contribution to journalArticle

Open Access
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13 Citations (Scopus)
1 Downloads (Pure)

Blood-brain barrier failure as a core mechanism in cerebral small vessel disease and dementia: evidence from a cohort study

Wardlaw, J. M., Makin, S. J., Valdés Hernández, M. C., Armitage, P. A., Heye, A. K., Chappell, F. M., Muñoz-Maniega, S., Sakka, E., Shuler, K., Dennis, M. S. & Thrippleton, M. J., Jun 2017, In : Alzheimer's and Dementia. 13, 6, p. 634-643 10 p.

Research output: Contribution to journalArticle

Open Access
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56 Citations (Scopus)
3 Downloads (Pure)

Integrity of normal-appearing white matter: Influence of age, visible lesion burden and hypertension in patients with small-vessel disease

Munoz Maniega, S., Chappell, F. M., Valdes Hernandez, M. C., Armitage, P. A., Makin, S. D., Heye, A. K., Thrippleton, M. J., Sakka, E., Shuler, K., Dennis, M. S. & Wardlaw, J. M., 1 Feb 2017, In : Journal of Cerebral Blood Flow and Metabolism. 37, 2, p. 644-656 13 p.

Research output: Contribution to journalArticle

Open Access
64 Citations (Scopus)

Reliability of an automatic classifier for brain enlarged perivascular spaces burden and comparison with human performance

Gonzalez-Castro, V., Valdes Hernandez, M. D. C., Chappell, F. M., Armitage, P. A., Makin, S. & Wardlaw, J. M., Jul 2017, In : Clinical Science. 131, 13, p. 1465-1481 17 p.

Research output: Contribution to journalArticle

Open Access
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10 Citations (Scopus)
1 Downloads (Pure)

Sample size considerations for trials using cerebral white matter hyperintensity progression as an intermediate outcome at 1 year after mild stroke: results of a prospective cohort study

Chappell, F. M., Valdes Hernandez, M. D. C., Makin, S. D., Shuler, K., Sakka, E., Dennis, M. S., Armitage, P. A., Munoz Maniega, S. & Wardlaw, J. M., 21 Feb 2017, In : Trials. 18, 10 p., 78.

Research output: Contribution to journalArticle

Open Access
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10 Citations (Scopus)
1 Downloads (Pure)

Small Vessel Disease and Dietary Salt Intake: Cross-Sectional Study and Systematic Review

Makin, S. D. J., Mubki, G. F., Doubal, F. N., Shuler, K., Staals, J., Dennis, M. S. & Wardlaw, J. M., 31 Dec 2017, In : Journal of Stroke and Cerebrovascular Diseases. 26, 12, p. 3020-3028 9 p.

Research output: Contribution to journalArticle

Open Access
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13 Citations (Scopus)
1 Downloads (Pure)

STROKOG (stroke and cognition consortium): An international consortium to examine the epidemiology, diagnosis, and treatment of neurocognitive disorders in relation to cerebrovascular disease

Sachdev, P. S., Lo, J. W., Crawford, J. D., Mellon, L., Hickey, A., Williams, D., Bordet, R., Mendyk, A-M., Gele, P., Deplanque, D., Bae, H-J., Lim, J-S., Brodtmann, A., Werden, E., Cumming, T., Kohler, S., Verhey, F. R. J., Dong, Y-H., Tan, H. H., Chen, C. & 47 others, Xin, X., Kalaria, R. N., Allan, L. M., Akinyemi, R. O., Ogunniyi, A., Klimkowicz-Mrowiec, A., Dichgans, M., Wollenweber, F. A., Zietemann, V., Hoffmann, M., Desmond, D. W., Linden, T., Blomstrand, C., Fagerberg, B., Skoog, I., Godefroy, O., Barbay, M., Roussel, M., Lee, B-C., Yu, K-H., Wardlaw, J., Makin, S. J., Doubal, F. N., Chappell, F. M., Srikanth, V. K., Thrift, A. G., Donnan, G. A., Kandiah, N., Chander, R. J., Lin, X., Cordonnier, C., Moulin, S., Rossi, C., Sabayan, B., Stott, D. J., Jukema, J. W., Melkas, S., Jokinen, H., Erkinjuntti, T., Mok, V. C. T., Wong, A., Lam, B. Y. K., Leys, D., Henon, H., Bombois, S., Lipnicki, D. M. & Kochan, N. A., 2017, In : Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring. 7, p. 11-23 13 p.

Research output: Contribution to journalArticle

Open Access
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18 Citations (Scopus)
1 Downloads (Pure)

White matter hyperintensity reduction and outcomes after minor stroke

Wardlaw, J. M., Chappell, F. M., Valdes Hernandez, M. D. C., Makin, S. D. J., Staals, J., Shuler, K., Thrippleton, M. J., Armitage, P. A., Munoz-Maniega, S., Heye, A. K., Sakka, E. & Dennis, M. S., 5 Sep 2017, In : Neurology. 89, 10, p. 1003-1010 8 p.

Research output: Contribution to journalArticle

Open Access
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26 Citations (Scopus)
1 Downloads (Pure)
2016

Blood pressure and sodium: Association with MRI markers in cerebral small vessel disease

Heye, A. K., Thrippleton, M. J., Chappell, F. M., Hernandez Mdel, C., Armitage, P. A., Makin, S. D., Maniega, S. M., Sakka, E., Flatman, P. W., Dennis, M. S. & Wardlaw, J. M., 1 Jan 2016, In : Journal of Cerebral Blood Flow and Metabolism. 36, 1, p. 264-274 11 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Cerebral blood flow in small vessel disease: A systematic review and meta-analysis

Shi, Y., Thrippleton, M. J., Makin, S. D., Marshall, I., Geerlings, M. I., de Craen, A. J., van Buchem, M. A. & Wardlaw, J. M., 1 Oct 2016, In : Journal of Cerebral Blood Flow and Metabolism. 36, 10, p. 1653-1667 15 p.

Research output: Contribution to journalArticle

88 Citations (Scopus)

Tracer kinetic modelling for DCE-MRI quantification of subtle blood-brain barrier permeability

Heye, A. K., Thrippleton, M. J., Armitage, P. A., Valdes Hernandez, M. D. C., Makin, S. D., Glatz, A., Sakka, E. & Wardlaw, J. M., 15 Jan 2016, In : Neuroimage. 125, p. 446-455 10 p.

Research output: Contribution to journalArticle

Open Access
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54 Citations (Scopus)
2 Downloads (Pure)
2015

A comparison of location of acute symptomatic vs. 'silent' small vessel lesions

Valdes Hernandez, M. D. C., Maconick, L. C., Munoz Maniega, S., Wang, X., Wiseman, S., Armitage, P. A., Doubal, F. N., Makin, S., Sudlow, C. L., Dennis, M. S., Deary, I. J., Bastin, M. & Wardlaw, J. M., Oct 2015, In : International Journal of Stroke. 10, 7, p. 1044-1050 7 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Cerebral small vessel disease and renal function: systematic review and meta-analysis

Makin, S. D. J., Cook, F. A. B., Dennis, M. S. & Wardlaw, J. M., Jan 2015, In : Cerebrovascular Diseases. 39, 1, p. 39-52 14 p.

Research output: Contribution to journalArticle

Open Access
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39 Citations (Scopus)
2 Downloads (Pure)

Clinically Confirmed Stroke With Negative Diffusion-Weighted Imaging Magnetic Resonance Imaging: Longitudinal Study of Clinical Outcomes, Stroke Recurrence, and Systematic Review

Makin, S. D., Doubal, F. N., Dennis, M. S. & Wardlaw, J. M., 29 Sep 2015, In : Stroke. 46, 11, p. 3142-3148 7 p.

Research output: Contribution to journalArticle

Open Access
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55 Citations (Scopus)
2 Downloads (Pure)
2014

Predicting delirium after a stroke

Makin, S. D. & Wardlaw, J., 2014, In : Journal of Neurology, Neurosurgery & Psychiatry. 85, 4, 1 p., 357.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

Stroke subtype, vascular risk factors, and total MRI brain small-vessel disease burden

Staals, J., Makin, S. D., Doubal, F. N., Dennis, M. S. & Wardlaw, J. M., 27 Aug 2014, In : Neurology. 83, 14, p. 1228-1234 7 p.

Research output: Contribution to journalArticle

Open Access
233 Citations (Scopus)
2013
Open Access
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106 Citations (Scopus)
2 Downloads (Pure)

Dystypia in acute stroke not attributable to aphasia or neglect

Cook, F. A. B., Makin, S. D. J., Wardlaw, J. & Dennis, M. S., 2013, In : BMJ Case Reports. 2013, bcr2013200257.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Variation in risk factors for recent small subcortical infarcts with infarct size, shape, and location

Del Bene, A., Makin, S. D. J., Doubal, F. N., Inzitari, D. & Wardlaw, J. M., Nov 2013, In : Stroke. 44, 11, p. 3000-3006 7 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)