Thomas Baddeley

2022

HMTM-Mediated Enhancement of Brain Bioenergetics in a Mouse Tauopathy Model Is Blocked by Chronic Administration of Rivastigmine

Santos, R. X., Melis, V., Goatman, E. A., Leith, M., Baddeley, T. C., Storey, J. M. D., Riedel, G., Wischik, C. M. & Harrington, C. R., 7 Apr 2022, In: Biomedicines. 10, 4, 21 p., 867.

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2020

Concentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal Dementia

Shiells, H., Schelter, B. O., Bentham, P., Baddeley, T. C., Rubino, C. M., Ganesan, H., Hammel, J., Vuksanovic, V., Staff, R. T., Murray, A. D., Bracoud, L., Wischik, D. J., Riedel, G., Gauthier, S., Jia, J., Moebius, H. J., Hardlund, J., Kipps, C. M., Kook, K., Storey, J. M. D., & 2 othersHarrington, C. R. & Wischik, C. M., 19 May 2020, In: Journal of Alzheimer's Disease. 75, 2, p. 501-519 19 p.

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16 Citations (Scopus)

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2019

Concentration-Dependent Activity of Hydromethylthionine on Cognitive Decline and Brain Atrophy in Mild to Moderate Alzheimer’s Disease

Schelter, B. O., Shiells, H., Baddeley, T. C., Rubino, C. M., Ganesan, H., Hammel, J., Vuksanovic, V., Staff, R. T., Murray, A. D., Bracoud, L., Riedel, G., Gauthier, S., Jia, J., Bentham, P., Kook, K., Storey, J. M. D., Harrington, C. R. & Wischik, C. M., 26 Nov 2019, In: Journal of Alzheimer's Disease. 72, 3, p. 931-946 16 p.

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25 Citations (Scopus)

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Crystal structures and Hirshfeld surface analyses of a des-A-B-aromatic steroidal compound, and two of its derivatives, having a trans-2,3,4,5-tetrahydro-3a-methyl-7-methoxybenz[e]indane skeleton-structural comparisons with reported tetrahydrobenz[e]indene derivatives

Gomes, L. R., Low, J. N., Turner, A. B., Nowicki, A. W., Baddeley, T. C. & Wardell, J. L., 22 Aug 2019, In: Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences. 74, 9, p. 649-663 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

N′-(1,3-Benzothiazol-2-yl) benzenesulfonohydrazide: crystal structure, Hirshfeld surface analysis and computational chemistry

Baddeley, T. C., de Souza, M. V. N., Wardell, J. L., Jotani, M. M. & Tiekink, E. R. T., 1 Apr 2019, In: Acta Crystallographica Section E: Crystallographic Communications. 75, 4, p. 516-523 8 p.

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2 Citations (Scopus)

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Synthesis, potent anti-TB activity against M. tuberculosis ATTC 27294, crystal structures and complex formation of selected 2-arylidenehydrazinylbenzothiazole derivatives

Pinheiro, A. C., de Souza, M. V. N., Lourenco, M. C. S., da Costa, C. F., Baddeley, T. C., Low, J. N., Wardell, S. M. S. V. & Wardell, J. L., 15 Feb 2019, In: Journal of Molecular Structure. 1178, p. 655-668 14 p.

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

2018

Crystal structures and Hirshfeld surface analyses of the di- and tri-hydrates of (5α,17E)-17-hydrazonoandrostan-3-ol: Significant differences in the hydrogen bonding patterns and supramolecular arrangements

Gomes, L. R., Low, J. N., Turner, A. B., Baddeley, T. C. & Wardell, J. L., 31 Dec 2018, In: Steroids. 140, p. 92-103 12 p.

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Cysteine-independent inhibition of Alzheimer's disease-like paired helical filament assembly by leuco-methylthioninium (LMT)

Al-Hilaly, Y. K., Pollack, S. J., Rickard, J. E., Simpson, M., Raulin, A-C., Baddeley, T., Schellenberger, P., Storey, J. M. D., Harrington, C. R., Wischik, C. M. & Serpell, L. C., 19 Oct 2018, In: Journal of Molecular Biology. 430, 21, p. 4119-4131 13 p.

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23 Citations (Scopus)

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A Protein Aggregation Inhibitor, Leuco-Methylthioninium Bis(Hydromethanesulfonate), Decreases α-Synuclein Inclusions in a Transgenic Mouse Model of Synucleinopathy

Schwab, K., Frahm, S., Horsley, D., Rickard, J. E., Melis, V., Goatman, E. A., Magbagbeolu, M., Douglas, M., Leith, M. G., Baddeley, T. C., Storey, J. M. D., Riedel, G., Wischik, C. M., Harrington, C. R. & Theuring, F., 10 Jan 2018, In: Frontiers in Molecular Neuroscience. 10, 15 p., 447.

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24 Citations (Scopus)

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2017

Structural studies of (E)-2-(benzylidene)-1- tetralone derivatives: Crystal structures and Hirshfeld surface analysis

Baddeley, T. C., Gomes, L. R., Low, J. N., Turner, A. B., Wardell, J. L. & Watson, G. J. R., 26 Oct 2017, In: Zeitschrift fur Kristallographie - Crystalline Materials. 232, 10, p. 697-718 22 p.

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

In Vitro Maturation of a Humanized Shark VNAR Domain to Improve Its Biophysical Properties to Facilitate Clinical Development

Steven, J., Müller, M. R., Carvalho, M. F., Ubah, O. C., Kovaleva, M., Donohoe, G., Baddeley, T., Cornock, D., Saunders, K., Porter, A. J. & Barelle, C. J., 23 Oct 2017, In: Frontiers in Immunology. 8, 1361.

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33 Citations (Scopus)

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Crystal structures of four 1-(aryl)-[1,2,4]triazolo[4,3-a]quinoxaline derivatives

Nogueira, T. C. M., Pinheiro, A. C., de Souza, M. V. N., Baddeley, T. C., Wardell, J. L. & Wardell, S. M. S. V., 15 Jan 2017, In: Journal of Molecular Structure. 1128, p. 579-589 11 p.

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

2015

Complex Disposition of Methylthioninium Redox Forms Determines Efficacy in Tau Aggregation Inhibitor Therapy for Alzheimer's Disease

Baddeley, T. C., McCaffrey, J., Storey, J. M. D., Cheung, J. K. S., Melis, V., Horsley, D., Harrington, C. R. & Wischik, C. M., Jan 2015, In: Journal of Pharmacology and Experimental Therapeutics. 352, 1, p. 110-118 9 p.

Research output: Contribution to journal › Article › peer-review

92 Citations (Scopus)

2013

Tautomers and polymorphs of pyrazolinone derivatives, generated from reactions of arylhydrazines, ArNHNH₂, with 1,3-dicarbonyl compounds

Baddeley, T. C., Howie, R. A., De Lima, G. M., Wardell, J. L. & Wardell, S. M. S. V., Feb 2013, In: Zeitschrift fur Kristallographie. 228, 2, p. 77-91 15 p.

Research output: Contribution to journal › Article › peer-review

2012

New phenothiazine diaminium compounds are tau protein aggregation inhibitors, useful to treat e.g. Alzheimer's disease, Pick's disease, progressive supranuclear palsy, frontotemporal dementia and frontotemporal lobar degeneration syndromes

Baddeley, T., Clunas, S., Harrington, C. R., Horsley, D., Ishaq, A., Khan, K., Loh, Y. S., Marshall, C., Rickard, J. E., Simpson, M., Sinclair, J. P., Storey, J. M. D., Williamson, C., Wischik, C. M. & Wood, B. A., 16 Aug 2012, Patent No. WO2012107706-A1, Priority date 11 Feb 2011

Research output: Patent

Variation in supramolecular arrangements of hydrazones, o-H2NC6H4CMe=NNHC6H4X (X = H, o-, m- and p-NO2), derived from o-aminoacetophenone and phenylhydrazines

Howie, R. A., Baddeley, T. C., Wardell, J. L. & Wardell, S. M. S. V., 8 Aug 2012, In: Journal of Molecular Structure. 1020, p. 16-22 7 p.

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

1,3-Diphenyl-4,5-dihydro-1H-pyrazol-5-one

Baddeley, T., Wardell, S. M. S., Tiekink, E. & Wardell, J., Apr 2012, In: Acta Crystallographica Section E: Structure Reports Online. E68, p. o1016-o1017 2 p.

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

2011

3,7-diamino-10H-phenothiazine salts and their use: WO2007110627

Wischik, C. M., Rickard, J. E., Harrington, C. R., Horsley, D., Storey, J. M. D., Marshall, C., Sinclair, J. P. & Baddeley, T., 15 Feb 2011, Patent No. US7,888,350

Research output: Patent

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2009

(Pyrazinecarbonyl)hydrazone halobenzaldehydes: Supramolecular arrays generated by face to face stacking of ribbons, formed from C-H-O interactions

Baddeley, T. C., Alan Howie, R., Da Silva Lima, C. H., Kaiser, C. R., De Souza, M. V. N., Wardell, J. L. & Wardell, S. M. S. V., 12 Oct 2009, In: Zeitschrift fur Kristallographie. 224, 10, p. 506-514 9 p.

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Open Access

21 Citations (Scopus)

2-Hydroxyacetophenone arylhydrazones. Supramolecular arrangements based on C–H · · · O(H), CH · · · O(NO), N–H · · · O(H), N–H · · · O(NO), C–H · · · π or π · · · π interactions

Baddeley, T. C., Franca, L. D. S., Howie, R. A., de Lima, G. M., Skakle, J., de Souza, J. D., Wardell, J. L. & Wardell, S. M. S. V., Sept 2009, In: Zeitschrift für Kristallographie. 224, 4, p. 213-224 12 p.

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Synthesis of Per- and Poly Substituted Trehalose Derivatives: Studies of Properties Relevant to Their Use as Excipients for Controlled Drug Release

Baddeley, T. C. & Wardell, J. L., May 2009, In: Journal of Carbohydrate Chemistry. 28, 4, p. 198-221 24 p.

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Methods of synthesis and/or purification of diaminophenothiazinium compounds

Wischik, C. M., Storey, J. M. D., Marshall, C., Sinclair, J. P. & Baddeley, T., 2009, Patent No. EP2057136

Research output: Patent

2007

Studies of distannylated-1,2-dithiolato compounds: Synthesis of 4,5-bis[(triorganostannylmethyl)thiolato]-1,3-dithiole-2-thiones, (R3SnCH2)(2)(dmit), and 4,5-bis[(triorganostannylmethyl)thiolato]-1,3-dithiole-2-ones, (R3SnCH2)(2)(dmio) - Crystal structures of (Ph3SnCH2)(2)(dmit) and (Ph3SnCH2)(2)(dmio)

Baddeley, T. C., Bordinhão, J., Comerlato, N. M., Cortás, L. D. C., Ferreira, G. B., Howie, R. A. & Wardell, J. L., 1 Dec 2007, In: Journal of Organometallic Chemistry. 692, 25, p. 5583-5588 6 p.

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Co-crystallised alpha- and beta-Anomers of 2,3,4,6-Tetra-acetyl-D-glucopyranose, in which the alpha- and beta-Anomers are Randomly Distributed in the Hydrogen-bonded Chains of Molecules

Baddeley, T. C., Harrison, W. T. A., Howie, R. A., Skakle, J. M. S. & Wardell, J. L., Dec 2007, In: Journal of Chemical Crystallography. 37, 12, p. 853-858 6 p.

Research output: Contribution to journal › Article

1 Citation (Scopus)

2006

A homologous series of eunicellin-based diterpenes from Acalycigorgia sp. characterised by tandem mass spectrometry

Kyeremeh, K., Baddeley, T., Stein, B. K. & Jaspars, M., 2006, In: Tetrahedron. 62, p. 8770-8778 9 p.

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

2005

1,2,3,4-Tetra-O-acetyl-beta-D-glucopyranuronic acid monohydrate at 120 K and anhydrous 1,2,3,4-tetra-O-acetyl-beta-D-glucopyranose at 292 K

Baddeley, T. C., Howie, R. A., Skakle, J. M. S. & Wardell, J. L., Oct 2005, In: Acta Crystallographica Section C, Crystal Structure Communications. 61, 12, p. o711-o714 4 p.

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

2004

Supramolecular structures of substituted a,a'-trehalose derivatives

Baddeley, T., Wardell, J. L., Skakle, J., Low, J., Glidewell, C. & Davidson, I., 2004, In: Acta Crystallographica Section B, Structural Science. B60, 4, p. 461-471 10 p.

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

2003

Disordered 2,2 ',3,3 ',4,6,6 '-hepta-O-pivaloyl-alpha,alpha '-trehalose

Baddeley, T. C., Clow, S. M., Cox, P. J., Davidson, I. G., Murdoch, A. M. & Wardell, J. L., 2003, In: Acta Crystallographica Section E: Structure Reports Online. 59, p. 753-755 3 p.

Research output: Contribution to journal › Article

3 Citations (Scopus)

Disordered 4,4 '-di-O-isobutyroyl-2,2 ',-3,3 ',6,6 '-hex-O-acetyl-alpha,alpha '-trehalose

Baddeley, T. C., Clow, S. M., Cox, P. J., Davidson, I. G., Ryder, C. & Wardell, J. L., 2003, In: Acta Crystallographica Section E: Structure Reports Online. 59, p. o848-o850 3 p.

Research output: Contribution to journal › Article

Ethyl 1,2,3,4-tetra-O-acetyl-beta-D-glucopyranuronate

Baddeley, T. C., Davidson, I. G., Skakle, J. M. S. & Wardell, J. L., 2003, In: Journal of Chemical Crystallography. 33, p. 33-38 6 p.

Research output: Contribution to journal › Article

2002

Ditrityl alpha,alpha-trehalose hexaacetate

Baddeley, T. C., Clow, S. M., Cox, P. J., Davidson, I. G., Howie, R. A. & Wardell, J. L., May 2002, In: Acta Crystallographica Section E: Structure Reports Online. 58, 5, p. o476-o477 2 p.

Research output: Contribution to journal › Article › peer-review

1,2,3,4-Tetra-O-acetyl-alpha-D-glucopyranuronamide

Baddeley, T. C., Davidson, I. G., Skakle, J. M. S. & Wardell, J. L., Apr 2002, In: Acta Crystallographica Section E: Structure Reports Online. 58, 4, p. o447-o449 3 p.

Research output: Contribution to journal › Article › peer-review

2001

alpha,alpha-trehalose octaacetate ethyl acetate solvate

Baddeley, T. C., Clow, S. M., Cox, P. J., McLaughlin, A. M. & Wardell, J. L., 2001, In: Acta Crystallographica Section E: Structure Reports Online. 57, 2 p.

Research output: Contribution to journal › Article

Thomas Baddeley

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