Research output per year
Research output per year
Research output
- 17 Article
- 17 results
Search results
-
2023
BACE cleavage of APP does not drive the diabetic phenotype of PLB4 mice
Franklin, Z. J., Croce, L., Dekeryte, R., Delibegovic, M. & Platt, B., 15 Jun 2023, In: Neurobiology of Disease. 182, 14 p., 106142.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Downloads (Pure) -
2022
Sustained glucagon receptor antagonism in insulin deficient high fat fed mice
Lafferty, R., University, U., Franklin, Z., Flatt, P., University, U. & Irwin, N., 14 Sept 2022, In: The Journal of endocrinology. 255, p. 91-101 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Metabolic effects of combined glucagon receptor antagonism and glucagon-like peptide-1 receptor agonism in high fat fed mice
Franklin, Z., Lafferty, R., Flatt, P., O'Harte, F. & Irwin, N., 1 Aug 2022, In: Biochimie. 199, p. 60-67 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)3 Downloads (Pure) -
2021
The BACE1 inhibitor LY2886721 improves diabetic phenotypes of BACE1 knock-in mice
Dekeryte, R., Franklin, Z., Hull, C., Croce, L., Kamli-Salino, S., Helk, O. W., Hoffmann, P., Yang, Z., Riedel, G., Delibegovic, M. & Platt, B., 1 Jul 2021, In: Biochimica et Biophysica Acta. Molecular Basis of Disease : BBA . 1867, 7, 9 p., 166149.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)4 Downloads (Pure) -
2019
Modelling pancreatic β-cell inflammation in zebrafish identifies the natural product wedelolactone for human islet protection
Delgadillo-Silva, L. F., Tsakmaki, A., Akhtar, N., Franklin, Z. J., Konantz, J., Bewick, G. A. & Ninov, N., 23 Jan 2019, In: Disease Models & Mechanisms. 12, 1Research output: Contribution to journal › Article › peer-review
Open Access25 Citations (Scopus) -
2018
Islet neuropeptide Y receptors are functionally conserved and novel targets for the preservation of beta-cell mass.
Franklin, ZJ., Tsakmaki, A., Pedro, P. F., King, AJ., Huang, GC., Amjad, S., Persaud, S. J. & Bewick, G. A., Mar 2018, In: Diabetes, Obesity & Metabolism. 20, 3, p. 599-609 11 p.Research output: Contribution to journal › Article › peer-review
18 Citations (Scopus) -
2016
Glucagon receptor antagonist and GIP agonist combination for diet-induced obese mice.
McShane, L. M., Irwin, N., O'Flynn, D., Franklin, Z. J., Hewage, C. M. & O'Harte, F. P. M., Jun 2016, In: The Journal of endocrinology. 229, 3, p. 319-330Research output: Contribution to journal › Article › peer-review
Open Access10 Citations (Scopus) -
Prolonged activation of human islet cannabinoid receptors in vitro induces adaptation but not dysfunction.
Vilches-Flores, A., Franklin, Z., Hauge-Evans, AC., Liu, B., Huang, GC., Choudhary, P., Jones, PM. & Persaud, SJ., Jun 2016, In: BBA clinical. 5, p. 143-150Research output: Contribution to journal › Article › peer-review
9 Citations (Scopus) -
2015
Inhibitory effect of somatostatin on insulin secretion is not mediated via the CNS.
Hauge-Evans, AC., Bowe, J., Franklin, ZJ., Hassan, Z. & Jones, PM., Apr 2015, In: The Journal of endocrinology. 225, 1, p. 19-26Research output: Contribution to journal › Article › peer-review
Open Access11 Citations (Scopus) -
2014
Two novel glucagon receptor antagonists prove effective therapeutic agents in high-fat-fed and obese diabetic mice.
O'Harte, FP., Franklin, ZJ. & Irwin, N., Dec 2014, In: Diabetes, Obesity & Metabolism. 16, 12, p. 1214-1222 8 p., 12360.Research output: Contribution to journal › Article › peer-review
23 Citations (Scopus) -
Ablation of glucagon receptor signaling by peptide-based glucagon antagonists improves glucose tolerance in high fat fed mice.
McShane, LM., Franklin, ZJ., O'Harte, FP. & Irwin, N., Oct 2014, In: Peptides. 60, p. 95-101Research output: Contribution to journal › Article › peer-review
18 Citations (Scopus) -
Effect of hyperglycaemia on muscarinic M3 receptor expression and secretory sensitivity to cholinergic receptor activation in islets.
Hauge-Evans, AC., Reers, C., Kerby, A., Franklin, Z., Amisten, S., King, AJ., Hassan, Z., Vilches-Flores, A., Tippu, Z., Persaud, SJ. & Jones, PM., Oct 2014, In: Diabetes, Obesity & Metabolism. 16, 10, p. 947-956Research output: Contribution to journal › Article › peer-review
11 Citations (Scopus) -
Metabolic phenotyping guidelines: assessing glucose homeostasis in rodent models.
Bowe, JE., Franklin, ZJ., Hauge-Evans, AC., King, AJ., Persaud, SJ. & Jones, PM., Sept 2014, In: The Journal of endocrinology. 222, 3, p. G13-G25Research output: Contribution to journal › Article › peer-review
187 Citations (Scopus) -
Effects of short-term chemical ablation of glucagon signalling by peptide-based glucagon receptor antagonists on insulin secretion and glucose homeostasis in mice.
Franklin, ZJ., O'Harte, FP. & Irwin, N., Apr 2014, In: Biological chemistry. 395, 4Research output: Contribution to journal › Article › peer-review
14 Citations (Scopus) -
2013
Characterisation of structurally modified analogues of glucagon as potential glucagon receptor antagonists.
O'Harte, FP., Franklin, ZJ., Rafferty, EP. & Irwin, N., Dec 2013, In: Molecular and Cellular Endocrinology.Research output: Contribution to journal › Article › peer-review
25 Citations (Scopus) -
desHis¹Glu⁹-glucagon-[mPEG] and desHis¹Glu⁹(Lys³⁰PAL)-glucagon: long-acting peptide-based PEGylated and acylated glucagon receptor antagonists with potential antidiabetic activity.
Irwin, N., Franklin, ZJ. & O'Harte, FP., Jun 2013, In: European Journal of Pharmacology.Research output: Contribution to journal › Article › peer-review
17 Citations (Scopus) -
2011
Dual modulation of GIP and glucagon action by the low molecular weight compound 4-hydroxybenzoic acid 2-bromobenzylidene hydrazide.
Franklin, ZJ., McDonnell, B., Montgomery, IA., Flatt, PR. & Irwin, N., Aug 2011, In: Diabetes, Obesity & Metabolism.Research output: Contribution to journal › Article › peer-review
5 Citations (Scopus)