γ-synuclein is a novel player in the control of body lipid metabolism

Steven Millership, Natalia Ninkina, Justin J Rochford, Vladimir L Buchman

Research output: Contribution to journalArticle

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Abstract

Synucleins are a family of homologous, predominantly neuronal proteins known for their involvement in synaptic transmission and neurodegeneration. γ-synuclein is predominantly localized in axons and presynaptic terminals of selected populations of peripheral and central neurons but is also highly expressed in human white adipose tissue (WAT) and increased in obesity. We have recently shown that γ-synuclein is nutritionally regulated in murine adipocytes while its loss protects mice from high fat diet (HFD)-induced obesity and associated metabolic complications. This protection was coupled with increased adipocyte lipolysis, lipid oxidation, and energy expenditure in HFD-fed γ-synuclein-null mutant compared with wild-type mice. Cellular studies suggest that relocalization of ATGL to the lipid droplet in γ-synuclein-deficient adipocytes may contribute to increased lipolysis in these cells. Loss of γ-synuclein in adipocytes also attenuates the assembly of SNARE complexes, an important component of lipid droplet fusion machinery, possibly due to reduced chaperoning of SNAP-23 to the assembling SNARE complex by γ-synuclein. Together our data suggests that not only is γ-synuclein a novel regulator of lipid handling in adipocytes but also that the deficiency of this protein has a significant effect on whole body energy expenditure.
Original languageEnglish
Pages (from-to)276-280
Number of pages5
JournalAdipocyte
Volume2
Issue number4
Early online date28 May 2013
DOIs
Publication statusPublished - Oct 2013

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Synucleins
Lipid Metabolism
Adipocytes
SNARE Proteins
Lipolysis
Presynaptic Terminals
High Fat Diet
Energy Metabolism
Obesity
Lipids
Protein Deficiency
White Adipose Tissue
Synaptic Transmission
Neurons

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γ-synuclein is a novel player in the control of body lipid metabolism. / Millership, Steven; Ninkina, Natalia; Rochford, Justin J; Buchman, Vladimir L.

In: Adipocyte, Vol. 2, No. 4, 10.2013, p. 276-280.

Research output: Contribution to journalArticle

Millership, Steven ; Ninkina, Natalia ; Rochford, Justin J ; Buchman, Vladimir L. / γ-synuclein is a novel player in the control of body lipid metabolism. In: Adipocyte. 2013 ; Vol. 2, No. 4. pp. 276-280.
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