102T/C polymorphism of serotonin receptor type 2A gene is not associated with schizophrenia in either Chinese or British populations

L He, T Li, C Melville, S Liu, G Y Feng, N F Gu, H Fox, D Shaw, G Breen, X H Liu, P Sham, J Brown, D Collier, D St Clair

Research output: Contribution to journalArticle

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Abstract

Several pieces of evidence implicate serotonin receptors in the aetiology of schizophrenia, and recently a number of studies have reported a genetic association between the 102T/C polymorphism of serotonin receptor type 2A gene and schizophrenia. Unfortunately a number of failures to replicate these positive associations in both Caucasian and Chinese populations have also been reported, We have examined the 102T/C polymorphism by PCR amplification and restriction analysis of DNA from: 202 schizophrenics and 202 controls from Shanghai; 112 schizophrenics and 224 parents from Chengdu, Cina; and 253 schizophrenics and 244 controls from the the UK, We find no evidence of association or transmission disequilibrium between the 102T/C polymorphism and schizophrenia in any of the groups we have examined. We conclude that either the original positive reports occurred by chance or any effect must be minimal, and urge caution in interpreting small positive results derived using data from different centres. Am. J. Med. Genet. (Neuropsychiatr. Genet,) 88:95-98, 1999. (C) 1999 Wiley-Liss, Inc.

Original languageEnglish
Pages (from-to)95-98
Number of pages4
JournalAmerican Journal of Medical Genetics
Volume88
Publication statusPublished - 1999

Keywords

  • serotonin
  • 5-HT-2a
  • schizophrenia
  • association
  • meta-analysis
  • genetic

Cite this

102T/C polymorphism of serotonin receptor type 2A gene is not associated with schizophrenia in either Chinese or British populations. / He, L ; Li, T ; Melville, C ; Liu, S ; Feng, G Y ; Gu, N F ; Fox, H ; Shaw, D ; Breen, G ; Liu, X H ; Sham, P ; Brown, J ; Collier, D ; St Clair, D .

In: American Journal of Medical Genetics, Vol. 88, 1999, p. 95-98.

Research output: Contribution to journalArticle

He, L, Li, T, Melville, C, Liu, S, Feng, GY, Gu, NF, Fox, H, Shaw, D, Breen, G, Liu, XH, Sham, P, Brown, J, Collier, D & St Clair, D 1999, '102T/C polymorphism of serotonin receptor type 2A gene is not associated with schizophrenia in either Chinese or British populations', American Journal of Medical Genetics, vol. 88, pp. 95-98.
He, L ; Li, T ; Melville, C ; Liu, S ; Feng, G Y ; Gu, N F ; Fox, H ; Shaw, D ; Breen, G ; Liu, X H ; Sham, P ; Brown, J ; Collier, D ; St Clair, D . / 102T/C polymorphism of serotonin receptor type 2A gene is not associated with schizophrenia in either Chinese or British populations. In: American Journal of Medical Genetics. 1999 ; Vol. 88. pp. 95-98.
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T1 - 102T/C polymorphism of serotonin receptor type 2A gene is not associated with schizophrenia in either Chinese or British populations

AU - He, L

AU - Li, T

AU - Melville, C

AU - Liu, S

AU - Feng, G Y

AU - Gu, N F

AU - Fox, H

AU - Shaw, D

AU - Breen, G

AU - Liu, X H

AU - Sham, P

AU - Brown, J

AU - Collier, D

AU - St Clair, D

PY - 1999

Y1 - 1999

N2 - Several pieces of evidence implicate serotonin receptors in the aetiology of schizophrenia, and recently a number of studies have reported a genetic association between the 102T/C polymorphism of serotonin receptor type 2A gene and schizophrenia. Unfortunately a number of failures to replicate these positive associations in both Caucasian and Chinese populations have also been reported, We have examined the 102T/C polymorphism by PCR amplification and restriction analysis of DNA from: 202 schizophrenics and 202 controls from Shanghai; 112 schizophrenics and 224 parents from Chengdu, Cina; and 253 schizophrenics and 244 controls from the the UK, We find no evidence of association or transmission disequilibrium between the 102T/C polymorphism and schizophrenia in any of the groups we have examined. We conclude that either the original positive reports occurred by chance or any effect must be minimal, and urge caution in interpreting small positive results derived using data from different centres. Am. J. Med. Genet. (Neuropsychiatr. Genet,) 88:95-98, 1999. (C) 1999 Wiley-Liss, Inc.

AB - Several pieces of evidence implicate serotonin receptors in the aetiology of schizophrenia, and recently a number of studies have reported a genetic association between the 102T/C polymorphism of serotonin receptor type 2A gene and schizophrenia. Unfortunately a number of failures to replicate these positive associations in both Caucasian and Chinese populations have also been reported, We have examined the 102T/C polymorphism by PCR amplification and restriction analysis of DNA from: 202 schizophrenics and 202 controls from Shanghai; 112 schizophrenics and 224 parents from Chengdu, Cina; and 253 schizophrenics and 244 controls from the the UK, We find no evidence of association or transmission disequilibrium between the 102T/C polymorphism and schizophrenia in any of the groups we have examined. We conclude that either the original positive reports occurred by chance or any effect must be minimal, and urge caution in interpreting small positive results derived using data from different centres. Am. J. Med. Genet. (Neuropsychiatr. Genet,) 88:95-98, 1999. (C) 1999 Wiley-Liss, Inc.

KW - serotonin

KW - 5-HT-2a

KW - schizophrenia

KW - association

KW - meta-analysis

KW - genetic

M3 - Article

VL - 88

SP - 95

EP - 98

JO - American Journal of Medical Genetics

JF - American Journal of Medical Genetics

SN - 0148-7299

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