3-D Tissue Modelling and Virtual Pathology as New Approaches to Study Ductal Carcinoma In Situ

Mary E. Booth, Claire E. Nash, Nicholas P. Roberts, Derek R. Magee, Darren Treanor, Andrew M. Hanby, Valerie Speirs*

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Widespread screening mammography programmes mean that ductal carcinoma in situ (DCIS), a pre-invasive breast lesion, is now more frequently diagnosed. However, not all diagnosed DCIS lesions progress to invasive breast cancer, which presents a dilemma for clinicians. As such, there is much interest in studying DCIS in the laboratory, in order to help understand more about its biology and determine the characteristics of those that progress to invasion. Greater knowledge would lead to targeted and better DCIS treatment. Here, we outline some of the models available to study DCIS, with a particular focus on animal-free systems.

Original languageEnglish
Pages (from-to)377-383
Number of pages7
JournalATLA Alternatives to Laboratory Animals
Volume43
Issue number6
Publication statusPublished - 1 Dec 2015

Keywords

  • 3-D
  • Cell culture
  • DCIS
  • Virtual pathology

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Toxicology
  • Medical Laboratory Technology

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