3-D Tissue Modelling and Virtual Pathology as New Approaches to Study Ductal Carcinoma In Situ

Mary E. Booth; Claire E. Nash; Nicholas P. Roberts; Derek R. Magee; Darren Treanor; Andrew M. Hanby; Valerie Speirs

3-D Tissue Modelling and Virtual Pathology as New Approaches to Study Ductal Carcinoma In Situ

Mary E. Booth, Claire E. Nash, Nicholas P. Roberts, Derek R. Magee, Darren Treanor, Andrew M. Hanby, Valerie Speirs^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Widespread screening mammography programmes mean that ductal carcinoma in situ (DCIS), a pre-invasive breast lesion, is now more frequently diagnosed. However, not all diagnosed DCIS lesions progress to invasive breast cancer, which presents a dilemma for clinicians. As such, there is much interest in studying DCIS in the laboratory, in order to help understand more about its biology and determine the characteristics of those that progress to invasion. Greater knowledge would lead to targeted and better DCIS treatment. Here, we outline some of the models available to study DCIS, with a particular focus on animal-free systems.

Original language	English
Pages (from-to)	377-383
Number of pages	7
Journal	ATLA Alternatives to Laboratory Animals
Volume	43
Issue number	6
Publication status	Published - 1 Dec 2015

Keywords

3-D
Cell culture
DCIS
Virtual pathology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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http://www.atla.org.uk/booth43-6/Licence: Unspecified

Cite this

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title = "3-D Tissue Modelling and Virtual Pathology as New Approaches to Study Ductal Carcinoma In Situ",

abstract = "Widespread screening mammography programmes mean that ductal carcinoma in situ (DCIS), a pre-invasive breast lesion, is now more frequently diagnosed. However, not all diagnosed DCIS lesions progress to invasive breast cancer, which presents a dilemma for clinicians. As such, there is much interest in studying DCIS in the laboratory, in order to help understand more about its biology and determine the characteristics of those that progress to invasion. Greater knowledge would lead to targeted and better DCIS treatment. Here, we outline some of the models available to study DCIS, with a particular focus on animal-free systems.",

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AU - Booth, Mary E.

AU - Nash, Claire E.

AU - Roberts, Nicholas P.

AU - Magee, Derek R.

AU - Treanor, Darren

AU - Hanby, Andrew M.

AU - Speirs, Valerie

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Widespread screening mammography programmes mean that ductal carcinoma in situ (DCIS), a pre-invasive breast lesion, is now more frequently diagnosed. However, not all diagnosed DCIS lesions progress to invasive breast cancer, which presents a dilemma for clinicians. As such, there is much interest in studying DCIS in the laboratory, in order to help understand more about its biology and determine the characteristics of those that progress to invasion. Greater knowledge would lead to targeted and better DCIS treatment. Here, we outline some of the models available to study DCIS, with a particular focus on animal-free systems.

AB - Widespread screening mammography programmes mean that ductal carcinoma in situ (DCIS), a pre-invasive breast lesion, is now more frequently diagnosed. However, not all diagnosed DCIS lesions progress to invasive breast cancer, which presents a dilemma for clinicians. As such, there is much interest in studying DCIS in the laboratory, in order to help understand more about its biology and determine the characteristics of those that progress to invasion. Greater knowledge would lead to targeted and better DCIS treatment. Here, we outline some of the models available to study DCIS, with a particular focus on animal-free systems.

KW - 3-D

KW - Cell culture

KW - DCIS

KW - Virtual pathology

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M3 - Article

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AN - SCOPUS:84956891387

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JO - ATLA-Alternatives to Laboratory Animals

JF - ATLA-Alternatives to Laboratory Animals

SN - 0261-1929

IS - 6

ER -

3-D Tissue Modelling and Virtual Pathology as New Approaches to Study Ductal Carcinoma In Situ

Abstract

Keywords

UN SDGs

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