31P magnetic resonance spectroscopy to measure in vivo cardiac energetics in normal myocardium and hypertrophic cardiomyopathy

Experiences at 3 T

Ganesh Nallur Shivu, Khalid Abozguia, Thanh Trung Phan, Ibrar Ahmed, Anke Henning, Michael Frenneaux

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Background: P-31 magnetic resonance spectroscopy (MRS) allows measurement of in vivo high-energy phosphate kinetics in the myocardium. While traditionally P-31 cardiac spectroscopy is performed at 1.5T, cardiac MRS at higher field strength can theoretically increase signal to noise ratio (SNR) and spectral resolution therefore improving sensitivity and specificity of the cardiac spectra. The reproducibility and feasibility of performing cardiac spectroscopy at 3T is presented here in this study in healthy volunteers and patients with hypertrophic cardiomyopathy.

Methods: Cardiac spectroscopy was performed using a Phillips 3T Achieva scanner in 37 healthy volunteers and 26 patients with hypertrophic cardiomyopathy (HCM) to test the feasibility of the protocol. To test the reproducibility a single volunteer was scanned eight times on separate occasions. A single voxel P-31 MRS was performed using Image Selected In vivo Spectroscopy (ISIS) volume localization.

Results: The mean phosphocreatine/adenosine triphosphate (PCr/ATP) ratio of the eight measurements performed on one individual was 2.11 +/- 0.25. Bland Altman plots showed a variance of 12% in the measurement of PCr/ATP ratios. The PCr/ATP ratio was significantly reduced in HCM patients compared to controls, 1.42 +/- 0.51 and 2.11 +/- 0.57, respectively, P < 0.0001. (All results are expressed as mean standard deviation).

Conclusions: Here we demonstrate that cardiac P-31 MRS at 3T is a reliable method of measuring in vivo high-energy phosphate kinetics in the myocardium for clinical studies and diagnostics. Based on our data an impairment of cardiac energetic state in patients with hypertrophic cardiomyopathy is indisputable.

Original languageEnglish
Pages (from-to)255-259
Number of pages5
JournalEuropean Journal of Radiology
Volume73
Issue number2
Early online date3 Dec 2008
DOIs
Publication statusPublished - Feb 2010

Keywords

  • cardiac magnetic resonance spectroscopy
  • 3T
  • hypertrophic cardiomyopathy
  • reproducibility
  • P-31 spectroscopy
  • energy phosphate-metabolism
  • creatine-kinase
  • heart-failure
  • MR spectroscopy
  • NMR-spectroscopy
  • volume tracking
  • ATP ratio
  • tesla
  • phosphocreatine
  • quantitation

Cite this

31P magnetic resonance spectroscopy to measure in vivo cardiac energetics in normal myocardium and hypertrophic cardiomyopathy : Experiences at 3 T. / Shivu, Ganesh Nallur; Abozguia, Khalid; Phan, Thanh Trung; Ahmed, Ibrar; Henning, Anke; Frenneaux, Michael.

In: European Journal of Radiology, Vol. 73, No. 2, 02.2010, p. 255-259.

Research output: Contribution to journalArticle

Shivu, Ganesh Nallur ; Abozguia, Khalid ; Phan, Thanh Trung ; Ahmed, Ibrar ; Henning, Anke ; Frenneaux, Michael. / 31P magnetic resonance spectroscopy to measure in vivo cardiac energetics in normal myocardium and hypertrophic cardiomyopathy : Experiences at 3 T. In: European Journal of Radiology. 2010 ; Vol. 73, No. 2. pp. 255-259.
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abstract = "Background: P-31 magnetic resonance spectroscopy (MRS) allows measurement of in vivo high-energy phosphate kinetics in the myocardium. While traditionally P-31 cardiac spectroscopy is performed at 1.5T, cardiac MRS at higher field strength can theoretically increase signal to noise ratio (SNR) and spectral resolution therefore improving sensitivity and specificity of the cardiac spectra. The reproducibility and feasibility of performing cardiac spectroscopy at 3T is presented here in this study in healthy volunteers and patients with hypertrophic cardiomyopathy.Methods: Cardiac spectroscopy was performed using a Phillips 3T Achieva scanner in 37 healthy volunteers and 26 patients with hypertrophic cardiomyopathy (HCM) to test the feasibility of the protocol. To test the reproducibility a single volunteer was scanned eight times on separate occasions. A single voxel P-31 MRS was performed using Image Selected In vivo Spectroscopy (ISIS) volume localization.Results: The mean phosphocreatine/adenosine triphosphate (PCr/ATP) ratio of the eight measurements performed on one individual was 2.11 +/- 0.25. Bland Altman plots showed a variance of 12{\%} in the measurement of PCr/ATP ratios. The PCr/ATP ratio was significantly reduced in HCM patients compared to controls, 1.42 +/- 0.51 and 2.11 +/- 0.57, respectively, P < 0.0001. (All results are expressed as mean standard deviation).Conclusions: Here we demonstrate that cardiac P-31 MRS at 3T is a reliable method of measuring in vivo high-energy phosphate kinetics in the myocardium for clinical studies and diagnostics. Based on our data an impairment of cardiac energetic state in patients with hypertrophic cardiomyopathy is indisputable.",
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T1 - 31P magnetic resonance spectroscopy to measure in vivo cardiac energetics in normal myocardium and hypertrophic cardiomyopathy

T2 - Experiences at 3 T

AU - Shivu, Ganesh Nallur

AU - Abozguia, Khalid

AU - Phan, Thanh Trung

AU - Ahmed, Ibrar

AU - Henning, Anke

AU - Frenneaux, Michael

PY - 2010/2

Y1 - 2010/2

N2 - Background: P-31 magnetic resonance spectroscopy (MRS) allows measurement of in vivo high-energy phosphate kinetics in the myocardium. While traditionally P-31 cardiac spectroscopy is performed at 1.5T, cardiac MRS at higher field strength can theoretically increase signal to noise ratio (SNR) and spectral resolution therefore improving sensitivity and specificity of the cardiac spectra. The reproducibility and feasibility of performing cardiac spectroscopy at 3T is presented here in this study in healthy volunteers and patients with hypertrophic cardiomyopathy.Methods: Cardiac spectroscopy was performed using a Phillips 3T Achieva scanner in 37 healthy volunteers and 26 patients with hypertrophic cardiomyopathy (HCM) to test the feasibility of the protocol. To test the reproducibility a single volunteer was scanned eight times on separate occasions. A single voxel P-31 MRS was performed using Image Selected In vivo Spectroscopy (ISIS) volume localization.Results: The mean phosphocreatine/adenosine triphosphate (PCr/ATP) ratio of the eight measurements performed on one individual was 2.11 +/- 0.25. Bland Altman plots showed a variance of 12% in the measurement of PCr/ATP ratios. The PCr/ATP ratio was significantly reduced in HCM patients compared to controls, 1.42 +/- 0.51 and 2.11 +/- 0.57, respectively, P < 0.0001. (All results are expressed as mean standard deviation).Conclusions: Here we demonstrate that cardiac P-31 MRS at 3T is a reliable method of measuring in vivo high-energy phosphate kinetics in the myocardium for clinical studies and diagnostics. Based on our data an impairment of cardiac energetic state in patients with hypertrophic cardiomyopathy is indisputable.

AB - Background: P-31 magnetic resonance spectroscopy (MRS) allows measurement of in vivo high-energy phosphate kinetics in the myocardium. While traditionally P-31 cardiac spectroscopy is performed at 1.5T, cardiac MRS at higher field strength can theoretically increase signal to noise ratio (SNR) and spectral resolution therefore improving sensitivity and specificity of the cardiac spectra. The reproducibility and feasibility of performing cardiac spectroscopy at 3T is presented here in this study in healthy volunteers and patients with hypertrophic cardiomyopathy.Methods: Cardiac spectroscopy was performed using a Phillips 3T Achieva scanner in 37 healthy volunteers and 26 patients with hypertrophic cardiomyopathy (HCM) to test the feasibility of the protocol. To test the reproducibility a single volunteer was scanned eight times on separate occasions. A single voxel P-31 MRS was performed using Image Selected In vivo Spectroscopy (ISIS) volume localization.Results: The mean phosphocreatine/adenosine triphosphate (PCr/ATP) ratio of the eight measurements performed on one individual was 2.11 +/- 0.25. Bland Altman plots showed a variance of 12% in the measurement of PCr/ATP ratios. The PCr/ATP ratio was significantly reduced in HCM patients compared to controls, 1.42 +/- 0.51 and 2.11 +/- 0.57, respectively, P < 0.0001. (All results are expressed as mean standard deviation).Conclusions: Here we demonstrate that cardiac P-31 MRS at 3T is a reliable method of measuring in vivo high-energy phosphate kinetics in the myocardium for clinical studies and diagnostics. Based on our data an impairment of cardiac energetic state in patients with hypertrophic cardiomyopathy is indisputable.

KW - cardiac magnetic resonance spectroscopy

KW - 3T

KW - hypertrophic cardiomyopathy

KW - reproducibility

KW - P-31 spectroscopy

KW - energy phosphate-metabolism

KW - creatine-kinase

KW - heart-failure

KW - MR spectroscopy

KW - NMR-spectroscopy

KW - volume tracking

KW - ATP ratio

KW - tesla

KW - phosphocreatine

KW - quantitation

U2 - 10.1016/j.ejrad.2008.10.018

DO - 10.1016/j.ejrad.2008.10.018

M3 - Article

VL - 73

SP - 255

EP - 259

JO - European Journal of Radiology

JF - European Journal of Radiology

SN - 0720-048X

IS - 2

ER -