4-Hydroxybenzoyl derivative from the aqueous extract of the hydroid Campanularia sp

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A new compound, N-(4-guanidinobutyl)-2-(4-hydroxyphenyl)-2-oxo-acetamide (1) was isolated from the aqueous extract of the hydroid Campanularia sp. Its structure was elucidated using NMR spectroscopic techniques and mass spectrometric analysis. The most stable conformation was determined using molecular modeling and the results of a NOESY experiment. Although compound 1 shows structural similarities to some highly potent histone deacetylase inhibitors (HDACi), e.g., suberoylanilide hydroxamic acid (SAHA) (2) and trichostatin A (TSA) (3), it does not inhibit the growth of ARP-1 cells at 100 microM concentration, a significant indication that it has no inhibitory activity to HDACs.
Original languageEnglish
Pages (from-to)453-455
Number of pages3
JournalJournal of Natural Products
Volume68
Issue number3
DOIs
Publication statusPublished - 2005

Keywords

  • histone deacetylase
  • inhibitor
  • cancer
  • expression
  • P21(WAF1)
  • peptide
  • growth
  • cells

Cite this

4-Hydroxybenzoyl derivative from the aqueous extract of the hydroid Campanularia sp. / Houssen, Wael E; Jaspars, Marcel.

In: Journal of Natural Products, Vol. 68, No. 3, 2005, p. 453-455.

Research output: Contribution to journalArticle

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abstract = "A new compound, N-(4-guanidinobutyl)-2-(4-hydroxyphenyl)-2-oxo-acetamide (1) was isolated from the aqueous extract of the hydroid Campanularia sp. Its structure was elucidated using NMR spectroscopic techniques and mass spectrometric analysis. The most stable conformation was determined using molecular modeling and the results of a NOESY experiment. Although compound 1 shows structural similarities to some highly potent histone deacetylase inhibitors (HDACi), e.g., suberoylanilide hydroxamic acid (SAHA) (2) and trichostatin A (TSA) (3), it does not inhibit the growth of ARP-1 cells at 100 microM concentration, a significant indication that it has no inhibitory activity to HDACs.",
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AU - Jaspars, Marcel

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AB - A new compound, N-(4-guanidinobutyl)-2-(4-hydroxyphenyl)-2-oxo-acetamide (1) was isolated from the aqueous extract of the hydroid Campanularia sp. Its structure was elucidated using NMR spectroscopic techniques and mass spectrometric analysis. The most stable conformation was determined using molecular modeling and the results of a NOESY experiment. Although compound 1 shows structural similarities to some highly potent histone deacetylase inhibitors (HDACi), e.g., suberoylanilide hydroxamic acid (SAHA) (2) and trichostatin A (TSA) (3), it does not inhibit the growth of ARP-1 cells at 100 microM concentration, a significant indication that it has no inhibitory activity to HDACs.

KW - histone deacetylase

KW - inhibitor

KW - cancer

KW - expression

KW - P21(WAF1)

KW - peptide

KW - growth

KW - cells

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