Abstract
Th1/Th2 cytokines in AIDS: sorting out the confusion: D.J. Blackbourn, Page 715
The type I/type 2 cytokine balance concept may help to account, at least in part, for the immunopathogenesis of AIDS. Type 1 cytokines are suggested by Clerici and Shearer (this Forum) to prevent CD4 ÷ cell loss and dysfunction by programmed cell death (PCD) and type 2 cytokines enhance PCD. However, the type 1/type 2 cytokine profile relationship and its involvement in disease progression in HIV-
infected individuals is incompletely understood.
The type I/type 2 cytokine balance concept may help to account, at least in part, for the immunopathogenesis of AIDS. Type 1 cytokines are suggested by Clerici and Shearer (this Forum) to prevent CD4 ÷ cell loss and dysfunction by programmed cell death (PCD) and type 2 cytokines enhance PCD. However, the type 1/type 2 cytokine profile relationship and its involvement in disease progression in HIV-
infected individuals is incompletely understood.
Original language | English |
---|---|
Pages (from-to) | 714-724 (715) |
Number of pages | 1 |
Journal | Research in Immunology |
Volume | 145 |
Issue number | 8-9 |
Publication status | Published - 1994 |
Keywords
- AIDS
- Cytokine
- Forum
- HIV
- Macrophage
- Pathogenesis
- Regulation
- T lymphocyte