¿9-tetrahydrocannabinol and anandamide enhance the ability of muscimol to induce catalepsy in the globus pallidus of rats

A P Wickens, Roger Guy Pertwee

Research output: Contribution to journalComment/debate

49 Citations (Scopus)

Abstract

Doses of 3 or 30 mug of DELTA9-tetrahydrocannabinol markedly increased the ability of 25 ng of muscimol to delay the descent of rats from a horizontal bar (descent latency) when these drugs were coadministered bilaterally into the globus pallidus. Intrapallidal injections of 30 mug of the putative endogenous cannabinoid, anandamide, also increased the effect of muscimol on descent latency. These data indicate that the production of catalepsy by cannabinoids may depend at toast in part on an ability to enhance GABAergic transmission in the globus pallidus and support the hypothesis that anandamide is indeed an endogenous ligand for the cannabinoid receptor.

Original languageEnglish
Pages (from-to)205-208
Number of pages4
JournalEuropean Journal of Pharmacology
Volume250
Issue number1
DOIs
Publication statusPublished - 30 Nov 1993

Keywords

  • DELTA-9-TETRAHYDROCANNABINOL
  • ANANDAMIDE
  • MUSCIMOL
  • GLOBUS PALLIDUS
  • CATALEPSY
  • DRUG INTERACTION
  • ENANTIOMERIC CANNABINOIDS
  • RECEPTOR
  • CHLORDIAZEPOXIDE
  • BRAIN
  • MICE
  • ¿9-Tetrahydrocannabinol
  • Anandamide
  • Muscimol
  • Globus pallidus
  • Catalepsy
  • Drug interaction

Cite this

¿9-tetrahydrocannabinol and anandamide enhance the ability of muscimol to induce catalepsy in the globus pallidus of rats . / Wickens, A P ; Pertwee, Roger Guy.

In: European Journal of Pharmacology, Vol. 250, No. 1, 30.11.1993, p. 205-208.

Research output: Contribution to journalComment/debate

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title = "¿9-tetrahydrocannabinol and anandamide enhance the ability of muscimol to induce catalepsy in the globus pallidus of rats",
abstract = "Doses of 3 or 30 mug of DELTA9-tetrahydrocannabinol markedly increased the ability of 25 ng of muscimol to delay the descent of rats from a horizontal bar (descent latency) when these drugs were coadministered bilaterally into the globus pallidus. Intrapallidal injections of 30 mug of the putative endogenous cannabinoid, anandamide, also increased the effect of muscimol on descent latency. These data indicate that the production of catalepsy by cannabinoids may depend at toast in part on an ability to enhance GABAergic transmission in the globus pallidus and support the hypothesis that anandamide is indeed an endogenous ligand for the cannabinoid receptor.",
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T1 - ¿9-tetrahydrocannabinol and anandamide enhance the ability of muscimol to induce catalepsy in the globus pallidus of rats

AU - Wickens, A P

AU - Pertwee, Roger Guy

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N2 - Doses of 3 or 30 mug of DELTA9-tetrahydrocannabinol markedly increased the ability of 25 ng of muscimol to delay the descent of rats from a horizontal bar (descent latency) when these drugs were coadministered bilaterally into the globus pallidus. Intrapallidal injections of 30 mug of the putative endogenous cannabinoid, anandamide, also increased the effect of muscimol on descent latency. These data indicate that the production of catalepsy by cannabinoids may depend at toast in part on an ability to enhance GABAergic transmission in the globus pallidus and support the hypothesis that anandamide is indeed an endogenous ligand for the cannabinoid receptor.

AB - Doses of 3 or 30 mug of DELTA9-tetrahydrocannabinol markedly increased the ability of 25 ng of muscimol to delay the descent of rats from a horizontal bar (descent latency) when these drugs were coadministered bilaterally into the globus pallidus. Intrapallidal injections of 30 mug of the putative endogenous cannabinoid, anandamide, also increased the effect of muscimol on descent latency. These data indicate that the production of catalepsy by cannabinoids may depend at toast in part on an ability to enhance GABAergic transmission in the globus pallidus and support the hypothesis that anandamide is indeed an endogenous ligand for the cannabinoid receptor.

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KW - RECEPTOR

KW - CHLORDIAZEPOXIDE

KW - BRAIN

KW - MICE

KW - ¿9-Tetrahydrocannabinol

KW - Anandamide

KW - Muscimol

KW - Globus pallidus

KW - Catalepsy

KW - Drug interaction

U2 - 10.1016/0014-2999(93)90646-Y

DO - 10.1016/0014-2999(93)90646-Y

M3 - Comment/debate

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JO - European Journal of Pharmacology

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