Abstract
Doses of 3 or 30 mug of DELTA9-tetrahydrocannabinol markedly increased the ability of 25 ng of muscimol to delay the descent of rats from a horizontal bar (descent latency) when these drugs were coadministered bilaterally into the globus pallidus. Intrapallidal injections of 30 mug of the putative endogenous cannabinoid, anandamide, also increased the effect of muscimol on descent latency. These data indicate that the production of catalepsy by cannabinoids may depend at toast in part on an ability to enhance GABAergic transmission in the globus pallidus and support the hypothesis that anandamide is indeed an endogenous ligand for the cannabinoid receptor.
Original language | English |
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Pages (from-to) | 205-208 |
Number of pages | 4 |
Journal | European Journal of Pharmacology |
Volume | 250 |
Issue number | 1 |
DOIs |
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Publication status | Published - 30 Nov 1993 |
Keywords
- DELTA-9-TETRAHYDROCANNABINOL
- ANANDAMIDE
- MUSCIMOL
- GLOBUS PALLIDUS
- CATALEPSY
- DRUG INTERACTION
- ENANTIOMERIC CANNABINOIDS
- RECEPTOR
- CHLORDIAZEPOXIDE
- BRAIN
- MICE
- ¿9-Tetrahydrocannabinol
- Anandamide
- Muscimol
- Globus pallidus
- Catalepsy
- Drug interaction