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Author

  • Harry Flint
2011

Dominant and diet-responsive groups of bacteria within the human colonic microbiota

Walker, A. W., Ince, J., Duncan, S. H., Webster, L., Holtrop, G., Ze, X., Brown, D., Stares, M. D., Scott, P., Bergerat, A., Louis, P., McIntosh, F., Johnstone, A. M., Lobley, G. E., Parkhill, J. & Flint, H. J., Feb 2011, In : The ISME Journal. 5, 2, p. 220-230 11 p.

Research output: Contribution to journalArticle

756 Citations (Scopus)
2014

Mucosa-associated Faecalibacterium prausnitzii and Escherichia coli co-abundance can distinguish Irritable Bowel Syndrome and Inflammatory Bowel Disease phenotypes

Lopez-Siles, M., Martinez-Medina, M., Busquets, D., Sabat-Mir, M., Duncan, S. H., Flint, H. J., Aldeguer, X. & Garcia-Gil, L. J., May 2014, In : International Journal of Medical Microbiology: IJMM. 304, 3-4, p. 464-475 12 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)

Faecal microbiota profiling in human volunteers on low and high fruit and vegetable intakes

Farquharson, F. M., Ze, X., Scobbie, L., Milne, L., Duncan, S. H., Holtrop, G., Flint, H. J., Rungapamestry, V., Duthie, G. G., Bestwick, C. S., Duthie, S. J. & Louis, P. G., 2014, ROWETT-INRA 2014 Gut Microbiology: From Sequence to Function. Rowett Institute of Nutrition and Health, p. 116 1 p. P131

Research output: Chapter in Book/Report/Conference proceedingOther contribution

2019

Impact of carbohydrate substrate complexity on the diversity of the human colonic microbiota

Chung, W. S. F., Walker, A. W., Vermeiren, J., Sheridan, P. O., Bosscher, D., Garcia-Campayo, V., Parkhill, J., Flint, H. J. & Duncan, S. H., 1 Jan 2019, In : FEMS Microbiology Ecology. 95, 1, fiy201.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
2015

Mucosa-associated Faecalibacterium prausnitzii phylotype richness is reduced in inflammatory bowel disease patients

Lopez-Siles, M., Martinez-Medina, M., Abellà, C., Busquets, D., Sabat-Mir, M., Duncan, S. H., Aldeguer, X., Flint, H. J. & Garcia-Gil, L. J., Nov 2015, In : Applied and Environmental Microbiology. 81, 21, p. 7582-7592 11 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)
2011

Recommendations for probiotic use: 2011 update

Floch, M. H., Walker, W. A., Madsen, K., Sanders, M. E., Macfarlane, G. T., Flint, H. J., Dieleman, L. A., Ringel, Y., Guandalini, S., Kelly, C. P. & Brandt, L. J., Nov 2011, In : Journal of Clinical Gastroenterology. 45, p. S168-S171 4 p.

Research output: Contribution to journalArticle

151 Citations (Scopus)
2015

Role of microbes in carbohydrate digestion

Flint, H. J. & Juge, N., 1 Mar 2015, In : Food Science & Technology. 29, 1, p. 24-26 3 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2017

Complexity of the Ruminococcus flavefaciens FD-1 cellulosome reflects an expansion of family-related protein-protein interactions

Israeli-Ruimy, V., Bule, P., Jindou, S., Dassa, B., Moraïs, S., Borovok, I., Barak, Y., Slutzki, M., Hamberg, Y., Cardoso, V., Alves, V. D., Najmudin, S., White, B. A., Flint, H. J., Gilbert, H. J., Lamed, R., Fontes, C. M. G. A. & Bayer, E. A., 10 Feb 2017, In : Scientific Reports. 7, 42355.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
9 Downloads (Pure)

Discovery of a novel lantibiotic nisin O from Blautia obeum A2-162, isolated from the human 2 gastrointestinal tract

Hatziioanou, D., Gherghisan-Filip, C., Saalbach, G., Horn, N., Wegmann, U., Duncan, S. H., Flint, H. J., Mayer, M. J. & Narbad, A., 1 Sep 2017, In : Microbiology . 163, 9, p. 1292-1305 14 p.

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
3 Downloads (Pure)
2012

Cultured representatives of two major phylogroups of human colonic Faecalibacterium prausnitzii can utilize pectin, uronic acids, and host-derived substrates for growth

Lopez-Siles, M., Khan, T. M., Duncan, S. H., Harmsen, H. J. M., Garcia-Gil, L. J. & Flint, H. J., Jan 2012, In : Applied and Environmental Microbiology. 78, 2, p. 420-428 9 p.

Research output: Contribution to journalArticle

165 Citations (Scopus)
2015

Functional phylotyping approach for assessing intraspecific diversity of Ruminococcus albus within the rumen microbiome

Grinberg, I. R., Yin, G., Borovok, I., Miller, M. E. B., Yeoman, C. J., Dassa, B., Yu, Z., Mizrahi, I., Flint, H. J., Bayer, E. A., White, B. A. & Lamed, R., Feb 2015, In : FEMS Microbiology Letters. 362, 3, p. 1-10 10 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2012

Targeted restoration of the intestinal microbiota with a simple, defined bacteriotherapy resolves relapsing Clostridium difficile disease in mice

Lawley, T. D., Clare, S., Walker, A. W., Stares, M. D., Connor, T. R., Raisen, C., Goulding, D., Rad, R., Schreiber, F., Brandt, C., Deakin, L. J., Pickard, D. J., Duncan, S. H., Flint, H. J., Clark, T. G., Parkhill, J. & Dougan, G., 25 Oct 2012, In : PLoS Pathogens. 8, 10, 14 p., e1002995.

Research output: Contribution to journalArticle

Open Access
File
335 Citations (Scopus)
4 Downloads (Pure)
2015

Modelling the emergent dynamics and major metabolites of the human colonic microbiota

Kettle, H., Louis, P. G. H., Holtrop, G., Duncan, S. H. & Flint, H. J., May 2015, In : Environmental Microbiology. 17, 5, p. 1615-1630 16 p.

Research output: Contribution to journalArticle

Open Access
File
47 Citations (Scopus)
3 Downloads (Pure)
2018

Specific substrate-driven changes in human faecal microbiota composition contrast with functional redundancy in short-chain fatty acid production

Reichardt, N., Vollmer, M., Holtrop, G., Farquharson, F. M., Wefers, D., Bunzel, M., Duncan, S. H., Drew, J. E., Williams, L. M., Milligan, G., Preston, T., Morrison, D., Flint, H. J. & Louis, P., 2018, In : The ISME Journal. 12, p. 610-622 13 p.

Research output: Contribution to journalArticle

Open Access
File
29 Citations (Scopus)
10 Downloads (Pure)
2013

Colonic bacterial metabolites and human health

Russell, W. R., Hoyles, L., Flint, H. J. & Dumas, M. E., Jun 2013, In : Current Opinion in Microbiology. 16, 3, p. 246-254 9 p.

Research output: Contribution to journalReview article

162 Citations (Scopus)
2011

Micro-organisms in the human gut: diversity and function

Scott, K. P., Duncan, S. H., Louis, P. & Flint, H. J., Aug 2011, In : The Biochemist. 33, 4, p. 4-9 5 p.

Research output: Contribution to journalLiterature review

1 Citation (Scopus)

Nutritional influences on the gut microbiota and the consequences for gastrointestinal health

Scott, K. P., Duncan, S. H., Louis, P. & Flint, H. J., 1 Aug 2011, In : Biochemical Society Transactions. 39, 4, p. 1073-1078 6 p.

Research output: Contribution to journalLiterature review

21 Citations (Scopus)
2014
24 Citations (Scopus)
2019

Heterologous gene expression in the human gut bacteria Eubacterium rectale and Roseburia inulinivorans by means of conjugative plasmids

Sheridan, P. O., Martin, J. C., Minton, N. P., Flint, H. J., O'Toole, P. W. & Scott, K. P., 1 Oct 2019, In : Anaerobe. 59, p. 131-140 10 p.

Research output: Contribution to journalArticle

2013

Pro-inflammatory flagellin proteins of prevalent motile commensal bacteria are variably abundant in the intestinal microbiome of elderly humans

Neville, B. A., Sheridan, P. O., Harris, H. M. B., Coughlan, S., Flint, H. J., Duncan, S. H., Jeffery, I. B., Claesson, M. J., Ross, R. P., Scott, K. P. & O'Toole, P. W., 23 Jul 2013, In : PloS ONE. 8, 7, 15 p., e68919.

Research output: Contribution to journalArticle

Open Access
File
18 Citations (Scopus)
4 Downloads (Pure)
2014

Impact of diet and individual variation on intestinal microbiota composition and fermentation products in obese men

Salonen, A., Lahti, L., Salojärvi, J., Holtrop, G., Korpela, K., Duncan, S. H., Date, P., Farquharson, F., Johnstone, A. M., Lobley, G. E., Louis, P., Flint, H. J. & de Vos, W. M., Nov 2014, In : The ISME Journal. 8, 11, p. 2218-2230 13 p.

Research output: Contribution to journalArticle

199 Citations (Scopus)
2018

Cultivation and sequencing of rumen microbiome members from the Hungate1000 Collection

Seshadri, R., Leahy, S. C., Attwood, G. T., Teh, K. H., Lambie, S. C., Cookson, A. L., Eloe-Fadrosh, E. A., Pavlopoulos, G. A., Hadjithomas, M., Varghese, N. J., Paez-Espino, D., Perry, R., Henderson, G., Creevey, C. J., Terrapon, N., Lapebie, P., Drula, E., Lombard, V., Rubin, E., Kyrpides, N. C. & 31 others, Henrissat, B., Woyke, T., Ivanova, N. N., Kelly, W. J., Palevic, N., Janssen, P. H., Ronimus, R. S., Noel, S., Soni, P., Reilly, K., Atherly, T., Ziemer, C., Wright, A. D., Ishaq, S., Cotta, M., Thompson, S., Crosley, K., McKain, N., Wallace, R. J., Flint, H. J., Martin, J. C., Forster, R. J., Gruninger, R. J., McAllister, T., Gilbert, R., Ouwerkerk, D. J., Gilbert, R., Ouwerkerk, D. J., Klieve, A. J., Jassim, R. A. & Hungate1000 project collaborators, 19 Mar 2018, In : Nature Biotechnology. 36, 4, p. 359-367 9 p.

Research output: Contribution to journalReview article

Open Access
File
66 Citations (Scopus)
6 Downloads (Pure)
2020

β-glucan is a major growth substrate for human gut bacteria related to Coprococcus eutactus

Alessi, A. M., Gray, V., Farquharson, F. M., Louis, P., Flores-López, A., Shaw, S., Stead, D., Wegmann, U., Shearman, C., Gasson, M., Collie-Duguid, E. SR., Flint, H. J. & Louis, P., 20 Mar 2020, In : Environmental Microbiology.

Research output: Contribution to journalArticle

Open Access
2015

Contribution of diet to the composition of the human gut microbiota

Graf, D., Di Cagno, R., Fåk, F., Flint, H. J., Nyman, M., Saarela, M. & Watzl, B., 2015, In : Microbial Ecology in Health and Disease. 26, 11 p., 26164.

Research output: Contribution to journalArticle

Open Access
File
4 Downloads (Pure)
2013

How our gut microbes influence our behaviour

Louis, P. & Flint, HJ., May 2013, In : Journal of Neuroendocrinology. 25, 5, p. 517-518 2 p.

Research output: Contribution to journalLetter

2 Citations (Scopus)
2016

How to Manipulate the Microbiota: Prebiotics

Louis, P., Flint, H. J. & Michel, C., 2016, Microbiota of the Human Body: Implications in Health and Disease. Schwiertz, A. (ed.). Switzerland: Springer , p. 119-142 24 p. ( Advances in Experimental Medicine and Biology; vol. 902).

Research output: Chapter in Book/Report/Conference proceedingChapter

25 Citations (Scopus)
2018

Mechanistic insights into the cross-feeding of Ruminococcus gnavus and Ruminococcus bromii on host and dietary carbohydrates

Crost, E. H., Le Gall, G., Laverde-Gomez, J. A., Mukhopadhya, I., Flint, H. J. & Juge, N., 5 Nov 2018, In : Frontiers in Microbiology. 9, 2558.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
4 Downloads (Pure)
2013

Intestinal microbiota in functional bowel disorders: a Rome foundation report

Simren, M., Barbara, G., Flint, H. J., Spiegel, B. M. R., Spiller, R. C., Vanner, S., Verdu, E. F., Whorwell, P. J. & Zoetendal, E. G., Jan 2013, In : Gut. 62, 1, p. 159-176 18 p.

Research output: Contribution to journalArticle

Open Access
File
475 Citations (Scopus)
5 Downloads (Pure)
2017

Formation of propionate and butyrate by the human colonic microbiota

Louis, P. & Flint, H. J., Jan 2017, In : Environmental Microbiology. 19, 1, p. 29-41 13 p.

Research output: Contribution to journalLiterature review

Open Access
File
228 Citations (Scopus)
7 Downloads (Pure)
2012

Microbiota of De-Novo Pediatric IBD: Increased Faecalibacterium Prausnitzii and Reduced Bacterial Diversity in Crohn's But Not in Ulcerative Colitis

Hansen, R., Russell, R. K., Reiff, C., Louis, P., McIntosh, F., Berry, S. H., Mukhopadhya, I., Bisset, W. M., Barclay, A. R., Bishop, J., Flynn, D. M., McGrogan, P., Loganathan, S., Mahdi, G., Flint, H. J., El-Omar, E. M. & Hold, G. L., 5 Dec 2012, In : American journal of gastroenterology. 107, 12, p. 1913-1922 10 p.

Research output: Contribution to journalArticle

Open Access
File
161 Citations (Scopus)
4 Downloads (Pure)

The gut anaerobe Faecalibacterium prausnitzii uses an extracellular electron shuttle to grow at oxic-anoxic interphases

Khan, M. T., Duncan, S. H., Stams, A. J. M., van Dijl, J. M., Flint, H. J. & Harmsen, H. J. M., Aug 2012, In : The ISME Journal. 6, 8, p. 1578-1585 8 p.

Research output: Contribution to journalArticle

118 Citations (Scopus)
2011

Gut environmental factors may shape the persistence of Faecalibacterium prausnitzii in the healthy and diseased large intestine

Lopez-Siles, M., Khan, T. M., Duncan, S. H., Mante, X. A., Harmsen, H. J. M., Garcia-Gil, L. J. & Flint, H. J., May 2011, In : Gastroenterology. 140, 5, p. S665 1 p., Mo1856.

Research output: Contribution to journalAbstract

2016

Lysozyme activity of the Ruminococcus champanellensis cellulosome

Moraïs, S., Cockburn, D. W., Ben-David, Y., Koropatkin, N. M., Martens, E. C., Duncan, S. H., Flint, H. J., Mizrahi, I. & Bayer, E. A., Dec 2016, In : Environmental Microbiology. 18, 12, p. 5112–5122 11 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2013

A representative of the dominant human colonic Firmicutes, Roseburia faecis M72/1, forms a novel bacteriocin-like substance

Hatziioanou, D., Mayer, M. J., Duncan, S. H., Flint, H. J. & Narbad, A., Oct 2013, In : Anaerobe. 23, p. 5-8 4 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
2014

The impact of different DNA extraction kits and laboratories upon the assessment of human gut microbiota composition by 16S rRNA gene sequencing

Kennedy, N. A., Walker, A. W., Berry, S. H., Duncan, S. H., Farquarson, F. M., Louis, P., Thomson, J. M., Satsangi, J., Flint, H. J., Parkhill, J., Lees, C. W., Hold, G. L. & UK IBD Genetics Consortium, 24 Feb 2014, In : PloS ONE. 9, 2, e88982.

Research output: Contribution to journalArticle

Open Access
File
127 Citations (Scopus)
3 Downloads (Pure)

Phylogenetic distribution of three pathways for propionate production within the human gut microbiota

Reichardt, N., Duncan, S. H., Young, P., Belenguer, A., McWilliam Leitch, C., Scott, K. P., Flint, H. J. & Louis, P., Jun 2014, In : The ISME Journal. 8, 6, p. 1323-1335 13 p.

Research output: Contribution to journalArticle

276 Citations (Scopus)
2017

The impact of nutrition on intestinal bacterial communities

Flint, H. J., Duncan, S. H. & Louis, P., Aug 2017, In : Current Opinion in Microbiology. 38, p. 59-65 7 p.

Research output: Contribution to journalLiterature review

41 Citations (Scopus)
2016

Gut microbial metabolites in health and disease

Flint, H. J., 2016, In : Gut Microbes. 7, 3, p. 187-188 2 p.

Research output: Contribution to journalEditorial

4 Citations (Scopus)
2012

The impact of nutrition on the human microbiome

Flint, H. J., Aug 2012, In : Nutrition Research Reviews. 70, Suppl. 1, p. S10-S13 4 p.

Research output: Contribution to journalLiterature review

125 Citations (Scopus)
2016
1 Citation (Scopus)

Comparative metabolomics in vegans and omnivores reveal constraints on diet-dependent gut microbiota metabolite production

Wu, G. D., Compher, C., Chen, E. Z., Smith, S. A., Shah, R. D., Bittinger, K., Chehoud, C., Albenberg, L. G., Nessel, L., Gilroy, E., Star, J., Weljie, A. M., Flint, H. J., Metz, D. C., Bennett, M. J., Li, H., Bushman, F. D. & Lewis, J. D., Jan 2016, In : Gut. 65, 1, p. 63-72 10 p.

Research output: Contribution to journalArticle

Open Access
174 Citations (Scopus)
2012

Microbiology: antibiotics and adiposity

Flint, H. J., 30 Aug 2012, In : Nature. 488, 7413, p. 601-602 2 p.

Research output: Contribution to journalEditorial

6 Citations (Scopus)
2011

Obesity and the gut microbiota

Flint, H. J., Nov 2011, In : Journal of Clinical Gastroenterology. 45, p. S128-S132 5 p.

Research output: Contribution to journalArticle

89 Citations (Scopus)

Impact of Intestinal Microbial Communities upon Health

Flint, H. J., Duncan, S. H. & Louis, P., 2011, Beneficial microorganisms in multicellular life forms. Rosenberg, E. & Gophna, U. (eds.). Springer-Verlag, p. 243-252 252 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2014

Gut microbiota signatures predict host and microbiota responses to dietary interventions in obese individuals

Korpela, K., Flint, H. J., Johnstone, A. M., Lappi, J., Poutanen, K., Dewulf, E., Delzenne, N., de Vos, W. M. & Salonen, A., 6 Mar 2014, In : PloS ONE. 9, 3, 10 p., e90702.

Research output: Contribution to journalArticle

Open Access
File
88 Citations (Scopus)
4 Downloads (Pure)

Prebiotic stimulation of human colonic butyrate-producing bacteria and bifidobacteria, in vitro

Scott, K. P., Martin, J. C., Duncan, S. H. & Flint, H. J., Jan 2014, In : FEMS Microbiology Ecology. 87, 1, p. 30-40 11 p.

Research output: Contribution to journalArticle

146 Citations (Scopus)

SATIN (Satiety Innovation) Project: Impact of type 3 resistant starch on gut microbiota and metabolites in overweight human volunteers

McKinnon, H., Romero Gonzalez, R. P. D. C., Fyfe, C. L., Whelan, A., Ze, X., Pesci, I., Farquharson, F. M., Louis, P. G. H., Bosscher, D., Bonnema, A., Ryan, S., Shirazi-Beechey, S. P., Harold, J., Halford, J. C. G., Duncan, S. H., Johnstone, A., Flint, H. J. & Gratz, S., 2014, ROWETT-INRA 2014 Gut Microbiology: From Sequence to Function. Rowett Institute of Nutrition and Health, p. 122-122 1 p. P143. (ROWETT-INRA Gut Microbiology).

Research output: Chapter in Book/Report/Conference proceedingOther contribution

2020

Evaluation of bacterial biomarkers to aid in challenging inflammatory bowel diseases diagnostics and subtype classification

Lopez-Siles, M., Aldeguer, X., Sabat-Mir, M., Serra-Pagès, M., Duncan, S. H., Flint, H. J., Garcia-Gil, L. J. & Martinez-Medina, M., 30 Mar 2020, (Accepted/In press) In : World Journal of Gastrointestinal Pathophysiology.

Research output: Contribution to journalArticle

Open Access
File
2011

Substrate-driven gene expression in Roseburia inulinivorans: Importance of inducible enzymes in the utilization of inulin and starch

Scott, K. P., Martin, J. C., Chassard, C., Clerget, M., Potrykus, J., Campbell, G. P., Mayer, C-D., Young, P., Rucklidge, G., Ramsay, A. G. & Flint, H. J., 15 Mar 2011, In : PNAS. 108, Supplement 1, p. 4672-4679 8 p.

Research output: Contribution to journalArticle

65 Citations (Scopus)

Kinetic modelling of lactate utilization and butyrate production by key human colonic bacterial species

Munoz-Tamayo, R., Laroche, B., Walter, E., Dore, J., Duncan, S. H., Flint, H. J. & Leclerc, M., Jun 2011, In : FEMS Microbiology Letters. 76, 3, p. 615-624 10 p.

Research output: Contribution to journalArticle

57 Citations (Scopus)