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  • Hai Deng
2019

α-D-glucopyranosyl-(1→2)-[6-O-(L-tryptophanyl)-β-D-fructofuranoside]

Kyeremeh, K., Kwain, S., Tetevi, G. M., Camas, A. S., Camas, M., Dofuor, A. K., Deng, H. & Jaspars, M., 16 Jun 2019, In : MolBank. 2019, 2, 11 p., M1066.

Research output: Contribution to journalArticle

Open Access
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2 Downloads (Pure)
2015

Discovery of a single monooxygenase catalyzing the carbamate formation and ring contraction in the biosynthesis of legonmycins

Huang, S., Tabudravu, J., Elsayed, S. S., Travert, J., Peace, D., Tong, M. H., Kyeremeh, K., Kelly, S., Trembleau, L. A. C., Ebel, R. P., Jaspars, M., Yu, Y. & Deng, H., 19 Oct 2015, In : Angewandte Chemie International Edition. 54, 43, p. 12697-12701 4 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
6 Downloads (Pure)
2017

Pseudochelin A, a siderophore of Pseudoalteromonas piscicida S2040

Sonnenschein, E. C., Stierhof, M., Goralczyk, S., Vabre, F. M., Pellissier, L., Hanssen, K. Ø., de la Cruz, M., Díaz, C., de Witte, P., Copmans, D., Andersen, J. H., Hansen, E., Kristoffersen, V., Tormo, J. R., Ebel, R., Milne, B. F., Deng, H., Gram, L., Jaspars, M. & Tabudravu, J. N., 4 May 2017, In : Tetrahedron. 73, 18, p. 2633-2637 5 p.

Research output: Contribution to journalArticle

Open Access
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7 Citations (Scopus)
8 Downloads (Pure)
2019

In vitro reconstitution of the biosynthetic pathway of 3-hydroxypicolinic acid

Yun, X., Zhang, Q., Lv, M., Deng, H., Deng, Z. & Yu, Y., 21 Jan 2019, In : Organic & Biomolecular Chemistry. 17, 3, p. 454-460 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2017

Targeted Dereplication of Microbial Natural Products by High-Resolution MS and Predicted LC Retention Time

Chervin, J., Stierhof, M., Tong, M. H., Peace, D., Hansen, K. Ø., Urgast, D. S., Andersen, J. H., Yu, Y., Ebel, R., Kyeremeh, K., Paget, V., Cimpan, G., Wyk, A. V., Deng, H., Jaspars, M. & Tabudravu, J. N., 26 May 2017, In : Journal of Natural Products. 80, 5, p. 1370-1377 8 p.

Research output: Contribution to journalArticle

Open Access
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16 Citations (Scopus)
5 Downloads (Pure)

Dissection of the neocarazostatin: a C4 alkyl side chain biosynthesis by in vitro reconstitution

Su, L., Zhang, R., Kyeremeh, K., Deng, Z., Deng, H. & Yu, Y., 14 May 2017, In : Organic & Biomolecular Chemistry. 15, 18, p. 3843-3848 6 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

(±)-Hippolide J – A Pair of Unusual Antifungal Enantiomeric Sesterterpenoids from the Marine Sponge Hippospongia lachne

Jiao, W. H., Hong, L. L., Sun, J. B., Piao, S. J., Chen, G. D., Deng, H., Wang, S. P., Yang, F. & Lin, H. W., 30 Jun 2017, In : European Journal of Organic Chemistry. 2017, 24, p. 3421-3426 6 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2018

Profiling of secondary metabolite gene clusters regulated by LaeA in Aspergillus niger FGSC A1279 based on genome sequencing and transcriptome analysis

Wang, B., Lv, Y., Li, X., Lin, Y., Deng, H. & Pan, L., 28 Feb 2018, In : Research in Microbiology. 169, 2, p. 67-77 11 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2020
Open Access
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1 Downloads (Pure)
2019

Novel electrochemical nanoswitch biosensor based on self-assembled pH-sensitive continuous circular DNA

Chen, X., Yao, L., Wang, Y. C., Chen, Q., Deng, H., Lin, Z. Y. & Yang, H. H., 15 Apr 2019, In : Biosensors and Bioelectronics. 131, p. 274-279 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2020

Novel NIR-II organic fluorophores for bioimaging beyond 1550 nm

Li, Y., Liu, Y., Li, Q., Tian, T., Zhou, W., Cui, Y., Wang, X., cheng, X., Ding, Q., Wang, X., Wu, J., Deng, H., Li, Y., Meng, X., Deng, Z., Hong, X. & Xiao, Y., 14 Mar 2020, In : Chemical Science. 11, 10, p. 2621-2626 6 p.

Research output: Contribution to journalArticle

Open Access
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2 Citations (Scopus)
2 Downloads (Pure)
2014

Butremycin, the 3-Hydroxyl Derivative of Ikarugamycin and a Protonated Aromatic Tautomer of 5′-Methylthioinosine from a Ghanaian Micromonospora sp. K310

Kyeremeh, K., Acquah, K., Sazak, A., Houssen, W. E., Tabudravu, J., Deng, H. & Jaspars, M., 14 Feb 2014, In : Marine Drugs. 12, 2, p. 999-1012 13 p., 12.

Research output: Contribution to journalArticle

Open Access
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30 Citations (Scopus)
5 Downloads (Pure)
2015

Biosynthesis of neocarazostatin A reveals the sequential carbazole prenylation and hydroxylation in the tailoring steps

Huang, S., Elsayed, S. S., Lv, M., Tabudravu, J., Rateb, M. E., Gyampoh, R., Kyeremeh, K., Ebel, R., Jaspars, M., Deng, Z., Yu, Y. & Deng, H., 17 Dec 2015, In : Chemistry & Biology. 22, 12, p. 1633-1642 10 p.

Research output: Contribution to journalArticle

Open Access
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17 Citations (Scopus)
10 Downloads (Pure)
2016

A ThDP-dependent enzymatic carboligation reaction involved in Neocarazostatin A tricyclic carbazole formation

Su, L., Lv, M., Kyeremeh, K., Deng, Z., Deng, H. & Yu, Y., 2016, In : Organic & Biomolecular Chemistry. 14, 37, p. 8679-8684 6 p.

Research output: Contribution to journalArticle

Open Access
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10 Citations (Scopus)
10 Downloads (Pure)
2013

The fish pathogen Yersinia ruckeri produces holomycin and uses an RNA methyltransferase for self-resistance

Qin, Z., Baker, A. T., Raab, A., Huang, S., Wang, T., Yu, Y., Jaspars, M., Secombes, C. J. & Deng, H., 24 May 2013, In : The Journal of Biological Chemistry. 288, 21, p. 14688-14697 10 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)
2 Downloads (Pure)
2014

Identification of Fluorinases from Streptomyces sp MA37, Norcardia brasiliensis, and Actinoplanes sp N902-109 by Genome Mining

Deng, H., Ma, L., Bandaranayaka, N., Qin, Z., Mann, G., Kyeremeh, K., Yu, Y., Shepherd, T., Naismith, J. & O'Hagan, D., 10 Feb 2014, In : ChemBioChem. 15, 3, p. 364-368 5 p.

Research output: Contribution to journalArticle

66 Citations (Scopus)

Fluoroacetate biosynthesis from the marine-derived bacterium Streptomyces xinghaiensis NRRL B-24674

Huang, S., Ma, L., Tong, M. H., Yu, Y., O'Hagan, D. & Deng, H., 21 Jul 2014, In : Organic & Biomolecular Chemistry. 27, 12, p. 4828-4831 4 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)
2019

Mn-Loaded apolactoferrin dots for in vivo MRI and NIR-II cancer imaging

Zhou, H., Yang, H., Tang, L., Wang, Y., Li, Y., Liu, N., Zeng, X., Yan, Y., Wu, J., Chen, S., Xiao, L., Yu, Y., Deng, Z., Deng, H., Hong, X. & Xiao, Y., 21 Aug 2019, In : Journal of Materials Chemistry A. 7, 31, p. 9448-9454 7 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Legonoxamines A-B, two new hydroxamate siderophores from the soil bacterium, Streptomyces sp. MA37

Maglangit, F., Tong, M. H., Jaspars, M., Kyeremeh, K. & Deng, H., 3 Jan 2019, In : Tetrahedron Letters. 60, 1, p. 75-79 5 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Enzymatic Reconstitution and Biosynthetic Investigation of the Bacterial Carbazole Neocarazostatin A

Liu, Y., Su, L., Fang, Q., Tabudravu, J., Yang, X., Rickaby, K., Trembleau, L., Kyeremeh, K., Deng, Z., Deng, H. & Yu, Y., 20 Dec 2019, In : Journal of Organic Chemistry. 84, 24, p. 16323-16328 6 p.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
2020

A Co-Culturing Approach Enables Discovery and Biosynthesis of a Bioactive Indole Alkaloid Metabolite

Maglangit, F., Fang, Q., Kyeremeh, K., Sternberg, J. M., Ebel, R. & Deng, H., 2020, In : Molecules. 25, 2, 256.

Research output: Contribution to journalArticle

Open Access
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2 Citations (Scopus)
2 Downloads (Pure)
2015

Legonaridin, a new member of linaridin RiPP from a Ghanaian Streptomyces Isolate

Rateb, M. E., Zhai, Y., Ehrner, E., Rath, C., Wang, X., Tabudravu, J., Ebel, R. P., Bibb, M., Kyeremeh, K., Dorrestein, P., Hong, K., Jaspars, M. & Deng, H., 2015, In : Organic & Biomolecular Chemistry. 13, 37, p. 9585-9592 8 p.

Research output: Contribution to journalArticle

Open Access
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16 Citations (Scopus)
16 Downloads (Pure)

Chaxapeptin, a Lasso Peptide from Extremotolerant Streptomyces leeuwenhoekii Strain C58 from the Hyperarid Atacama Desert

Elsayed, S. S., Trusch, F., Deng, H., Raab, A., Prokes, I., Busarakam, K., Asenjo, J. A., Andrews, B. A., van West, P., Bull, A. T., Goodfellow, M., Yi, Y., Ebel, R., Jaspars, M. & Rateb, M. E., 2015, In : Journal of Organic Chemistry. 80, 20, p. 10252-10260 9 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)
2020

Characterization of the promiscuous N-acyl CoA transferase, LgoC, in legonoxamine biosynthesis

Maglangit, F., Alrashdi, S., Renault, J., Trembleau, L., Victoria, C., Tong, M. H., Wang, S., Kyeremeh, K. & Deng, H., 28 Mar 2020, In : Organic & Biomolecular Chemistry. 18, 12, p. 2219-2222 4 p.

Research output: Contribution to journalArticle

2018

Paenidigyamycin A, Potent Antiparasitic Imidazole Alkaloid from the Ghanaian Paenibacillus sp. DE2SH

Osei, E., Kwain, S., Mawuli, G. T., Anang, A. K., Owusu, K. B-A., Camas, M., Camas, A. S., Ohashi, M., Alexandru-Crivac, C-N., Deng, H., Jaspars, M. & Kyeremeh, K., 24 Dec 2018, In : Marine Drugs. 17, 1, 9.

Research output: Contribution to journalArticle

Open Access
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2 Citations (Scopus)
6 Downloads (Pure)
2019

LC-HRMS-Database Screening Metrics for Rapid Prioritization of Samples to Accelerate the Discovery of Structurally New Natural Products

Tabudravu, J. N., Pellissier, L., Smith, A. J., Subko, K., Autréau, C., Feussner, K., Hardy, D., Butler, D., Kidd, R., Milton, E. J., Deng, H., Ebel, R., Salonna, M., Gissi, C., Montesanto, F., Kelly, S. M., Milne, B. F., Cimpan, G. & Jaspars, M., 2019, In : Journal of Natural Products. 82, 2, p. 211-220 10 p.

Research output: Contribution to journalArticle

Open Access
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3 Citations (Scopus)
2 Downloads (Pure)
2016

Biological fluorination from the sea: discovery of a SAM-dependent nucleophilic fluorinating enzyme from the marine-derived bacterium Streptomyces xinghaiensis NRRL B24674

Ma, L., Li, Y., Meng, L., Deng, H., Li, Y., Zhang, Q. & Diao, A., 2016, In : RSC Advances. 32, 6, p. 27047-27051 5 p.

Research output: Contribution to journalArticle

Open Access
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19 Citations (Scopus)
5 Downloads (Pure)
2014

Action in pairs: Two tandem genes in the fish pathogen Yersinia ruckeri are virulence factors

Deng, H. & Secombes, C. J., 2014, In : Virulence. 5, 5, p. 585-586 1 p.

Research output: Contribution to journalEditorial

2013

Identification and characterization of the actinomycin G gene cluster in Streptomyces iakyrus

Wang, X., Tabudravu, J., Rateb, M., Annand, K. J., Qin, Z., Jaspars, M., Deng, Z., Yu, Y. & Deng, H., Jun 2013, In : Molecular BioSystems. 9, 6, p. 1286-1289 4 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2015

Enzymatic fluorination and biotechnological development of the fluorinase

O'Hagan, D. & Deng, H., 28 Jan 2015, In : Chemical Reviews. 115, 2, p. 634-649 16 p.

Research output: Contribution to journalArticle

129 Citations (Scopus)
2013
7 Citations (Scopus)
2018

Deletion of the epigenetic regulator GcnE in Aspergillus niger FGSC A1279 activates the production of multiple polyketide metabolites

Wang, B., Li, X., Yu, D., Chen, X., Tabudravu, J., Deng, H. & Pan, L., 31 Dec 2018, In : Microbiological Research. 217, p. 101-107 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2013

Tianchimycins A-B, 16-membered macrolides from the rare actinomycete Saccharothrix xinjiangensis

Wang, X., Tabudravu, J., Jaspars, M. & Deng, H., 29 Jul 2013, In : Tetrahedron. 69, 30, p. 6060-6064 5 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2015

Draft Genome Sequence of Streptomyces sp. Strain CT34, Isolated from a Ghanaian Soil Sample

Zhai, Y., Cheng, B., Hu, J., Kyeremeh, K., Wang, X., Jaspars, M., Deng, H., Deng, Z-X. & Hong, K., 2015, In : Genome Announcements. 3, 1, 01508-14.

Research output: Contribution to journalArticle

Open Access
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4 Citations (Scopus)
7 Downloads (Pure)
2013

Dithiolopyrrolone Natural Products: Isolation, Synthesis and Biosynthesis

Qin, Z., Huang, S., Yu, Y. & Deng, H., 17 Oct 2013, In : Marine Drugs. 11, 10, p. 3970-3997 28 p.

Research output: Contribution to journalArticle

Open Access
File
26 Citations (Scopus)
5 Downloads (Pure)
2014

Butrepyrazinone, a New Pyrazinone with an Unusual Methylation Pattern from a Ghanaian Verrucosispora sp. K51G

Kyeremeh, K., Acquah, K., Camas, M., Tabudravu, J., Houssen, W. E., Deng, H. & Jaspars, M., 16 Oct 2014, In : Marine Drugs. 12, 10, p. 5197-5208 12 p.

Research output: Contribution to journalArticle

Open Access
File
19 Citations (Scopus)
5 Downloads (Pure)
2015

Identification and characterization of the biosynthetic gene cluster of thiolutin, a tumor angiogenesis inhibitor, in Saccharothrix algeriensis NRRL B-24137

Huang, S., Tong, M. H., Qin, Z., Deng, Z., Deng, H. & Yu, Y., 1 Mar 2015, In : Anti-Cancer Agents in Medicinal Chemistry. 15, 3, p. 277-284 8 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2020

Signalling and Bioactive Metabolites from Streptomyces sp. RK44

Fang, Q., Maglangit, F., Wu, L., Ebel, R., Kyeremeh, K., Andersen, J. H., Annang, F., Perez de Nanclares, G., Reyes, F. & Deng, H., 22 Jan 2020, In : Molecules. 25, 3, 460.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
6 Downloads (Pure)

Targeted isolation of indole alkaloids from Streptomyces sp. CT37

Fang, Q., Maglangit, F., Mugat, M., Urwald, C., Kyeremeh, K. & Deng, H., Mar 2020, In : Molecules. 25, 5, 10 p., 1108.

Research output: Contribution to journalArticle

Open Access
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2 Downloads (Pure)

Fluorine biocatalysis

Wu, L., Maglangit, F. & Deng, H., Apr 2020, In : Current Opinion in Chemical Biology. 55, p. 119-126 6 p.

Research output: Contribution to journalArticle

An unusual metal-bound 4-fluorothreonine transaldolase from Streptomyces sp. MA37 catalyses promiscuous transaldol reactions

Wu, L., Tong, M. H., Raab, A., Fang, Q., Wang, S., Kyeremeh, K., Yu, Y. & Deng, H., May 2020, In : Applied Microbiology and Biotechnology. 104, p. 3885-3896 12 p.

Research output: Contribution to journalArticle

Open Access
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1 Downloads (Pure)
2019

Paenidigyamycin g: 1-acetyl-2,4-dimethyl-3-phenethyl-1H-imidazol-3-ium

Tetevi, G. M., Kwain, S., Mensah, T., Camas, A. S., Camas, M., Dofuor, A. K., Azerigyik, F. A., Oluwabusola, E., Deng, H., Jaspars, M. & Kyeremeh, K., 21 Nov 2019, In : MolBank. 2019, 4, 9 p., M1094.

Research output: Contribution to journalComment/debate

Open Access
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3 Downloads (Pure)
2020

Identification Of 5-Fluoro-5-deoxy-ribulose As A Shut Metabolite In Streptomyces sp. MA37

Wu, L., Tong, M. H., Kyeremeh, K. & Deng, H., 7 Jul 2020, (Accepted/In press) In : Biomolecules.

Research output: Contribution to journalArticle

2018

Directed Accumulation of Anticancer Depsipeptides by Characterization of Neoantimycins Biosynthetic Pathway and an NADPH-Dependent Reductase

Zhou, Y., Lin, X., Williams, S. R., Liu, L., Shen, Y., Wang, S-P., Sun, F., Xu, S., Deng, H., Leadlay, P. F. & Lin, H-W., 17 Aug 2018, In : ACS Chemical Biology. 13, 8, p. 2153-2160 8 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2015

Identification of a fluorometabolite from Streptomyces sp. MA37: (2R,3S,4S)-5-Fluoro-2,3,4-trihydroxypentanoic acid

Ma, L., Bartholome, A., Tong, M. H., Qin, Z., Yu, Y., Shepherd, T., Kyeremeh, K., Deng, H. & O’Hagan, D., 2015, In : Chemical Science. 6, 2, p. 1414-1419 6 p.

Research output: Contribution to journalArticle

Open Access
File
23 Citations (Scopus)
7 Downloads (Pure)
2019

Investigation of Penicillin Binding Protein (PBP)-like Peptide Cyclase and Hydrolase in Surugamide Non-ribosomal Peptide Biosynthesis

Zhou, Y., Lin, X., Xu, C., Shen, Y., Wang, S-P., Liao, H., Li, L., Deng, H. & Lin, H-W., 16 May 2019, In : Cell chemical biology. 26, 5, p. 737-744 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2014

Disruption of a methyltransferase gene in actinomycin G gene cluster in Streptomyces iakyrus increases the production of phenazinomycin

Qin, Z., Wang, X., Rateb, M., Ass'ad, L. A., Jaspars, M., Deng, Z., Yu, Y. & Deng, H., Mar 2014, In : FEMS Microbiology Letters. 352, 1, p. 62-68 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2015

Diversity of organic structures of marine microbial origin with drug potential

Jaspars, M., Ebel, R. P. & Deng, H., 2015, Phycotoxins: Chemistry and Biochemistry. Botana, LM. & Alfonso, A. (eds.). 2 ed. Blackwell Science, p. 361-380 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)