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  • Paul Alfred François Fowler

Activation of the aryl hydrocarbon receptor by a component of cigarette smoke reduces germ cell proliferation in the human fetal ovary: corrigendum

Anderson, R. A., McIlwain, L., Coutts, S., Kinnell, H., Fowler, P. A. & Childs, A. J., Sep 2015, In : Molecular Human Reproduction. 21, 9, p. 753

Research output: Contribution to journalArticle

Open Access
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2 Citations (Scopus)
4 Downloads (Pure)

Activation of the aryl hydrocarbon receptor by a component of cigarette smoke reduces germ cell proliferation in the human fetal ovary

Anderson, R. A., McIlwain, L., Coutts, S., Kinnell, H. L., Fowler, P. A. & Childs, A. J., Jan 2014, In : Molecular Human Reproduction. 20, 1, p. 42-48 7 p.

Research output: Contribution to journalArticle

Open Access
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26 Citations (Scopus)
4 Downloads (Pure)

Alternative (backdoor) androgen production and masculinization in the human fetus

O'Shaughnessy, P. J., Antignac, J-P., Le Bizec, B., Morvan, M-L., Svechnikov, K., Söder, O., Savchuk, I., Monteiro, A., Soffientini, U., Johnston, Z. C., Bellingham, M., Hough, D., Walker, N., Filis, P. & Fowler, P., 14 Feb 2019, In : PLoS Biology. 17, 2, e3000002.

Research output: Contribution to journalArticle

Open Access
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22 Citations (Scopus)
14 Downloads (Pure)

Aspects of UGT2B15 in the Human

O'Shaughnessy, P. J. & Fowler, P. A. F., Feb 2015, In : Toxicological Sciences. 143, 2, p. 230 1 p.

Research output: Contribution to journalLetter

Open Access

A statement on the developmental immunotoxicity of bisphenol A (BPA): answer to the question from the Dutch Ministry of Health, Welfare and Sport

Silano, V., Bolognesi, C., Castle, L., Cravedi, J-P., Engel, K-H., Fowler, P., Franz, R., Grob, K., Gürtler, R., Kärenlampi, S., Mennes, W., Rosaria Milana, M., Penninks, A., Smith, A., de Fátima Tavares Poças, M., Tlustos, C., Wölfle, D., Zorn, H., Zugravu, C-A., Anderson, S. & 5 others, Germolec, D., Pieters, R., Castoldi, A. F., Husøy, T. & Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF), Oct 2016, EFSA Journal, 14, 10, p. 4580 22 p.

Research output: Contribution to specialist publicationArticle

Open Access
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5 Downloads (Pure)

Calretinin is a novel candidate marker for adverse ovarian effects of early life exposure to mixtures of endocrine disruptors in the rat

Johansson, H. K. L., Svingen, T., Boberg, J., Fowler, P. A., Stead, D., Vinggaard, A. M. & Filis, P., Apr 2020, In : Archives of Toxicology. 94, p. 1241-1250 10 p.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
1 Downloads (Pure)
Open Access
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1 Citation (Scopus)
125 Downloads (Pure)
Open Access
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2 Citations (Scopus)
10 Downloads (Pure)

Development of the human fetal testis

O'Shaughnessy, P. J. & Fowler, P. A., May 2014, In : Annales d'Endocrinologie. 75, 2, p. 48-53 6 p.

Research output: Contribution to journalLiterature review

10 Citations (Scopus)

Does Candida albicans play a role in the etiology of endometriosis?

Gazvani, R., Fowler, P. A., Coyne, L., Odds, F. C. & Gow, N. A. R., 14 May 2013, In : Journal of Endometriosis and Pelvic Pain Disorders. 5, 1, p. 2-9 8 p.

Research output: Contribution to journalArticle

Does grazing on biosolids treated pasture pose a pathophysiological risk associated with increased exposure to endocrine disrupting compounds?

Evans, N. P., Bellingham, M., Sharpe, R. M., Cotinot, C., Rhind, S. M., Kyle, C., Erhard, H., Hombach-Klonisch, S., Lind, P. M. & Fowler, P. A., Aug 2014, In : Journal of Animal Science. 92, 8, p. 3185-3198 14 p.

Research output: Contribution to journalLiterature review

11 Citations (Scopus)

Dynamics of the transcriptional landscape during human fetal testis and ovary development

Lecluze, E., Rolland, A. D., Filis, P., Evrard, B., Leverrier-Penna, S., Ben Maamar, M., Coiffec, I., Lavoué, V., Fowler, P. A., Mazaud Guittot, S., Jégou, B. & Chalmel, F., May 2020, In : Human Reproduction. 35, 5, p. 1099-1119 21 p.

Research output: Contribution to journalArticle

Effects of exposure to environmental chemicals during pregnancy on the development of the male and female reproductive axes

Bellingham, M., Fiandanese, N., Byers, A., Cotinot, C., Evans, N. P., Pocar, P., Amezaga, M. R., Lea, R. G., Sinclair, K. D., Rhind, S. M. & Fowler, P. A. F., Aug 2012, In : Reproduction in Domestic Animals. 47, Suppl. 4, p. 15-22 8 p.

Research output: Contribution to journalLiterature review

9 Citations (Scopus)

Effects of maternal smoking on offspring reproductive outcomes: an intergenerational study in the North East of Scotland

Tweed, S., Bhattacharya, S. & Fowler, P. A., 12 Jul 2017, In : Human Reproduction Open. 2017, 2, p. 1-7 7 p., hox006.

Research output: Contribution to journalArticle

Open Access
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7 Downloads (Pure)

Endocrine disruptors and ovine reproductive development

Lea, R. G., Byres, A. S., Bellingham, M., Cotinot, C., Evans, N., Mandon-Pepin, B., Sinclair, K. D. & Fowler, P. A., 2014, Reproduction in Domestic Ruminants VIII. Juengel, JL., Miyamoto, A., Price, C., Reynolds, LP., Smith, MF. & Webb, R. (eds.). 1 ed. Leicestershire, UK: Context Products Ltd, Vol. VIII. p. 209-228 20 p. (Reproduction in Domestic Rumminants).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Endocrinology of the mammalian fetal testis

O'Shaughnessy, P. & Fowler, P. A. F., 2011, In : Reproduction. 141, p. 37-46 10 p.

Research output: Contribution to journalLiterature review

67 Citations (Scopus)

Environmental influences on ovarian dysgenesis: developmental windows sensitive to chemical exposures

Johansson, H. K. L., Svingen, T., Fowler, P. A., Vinggaard, A. M. & Boberg, J., Jul 2017, In : Nature Reviews Endocrinology . 13, 7, p. 400-414 15 p.

Research output: Contribution to journalLiterature review

Open Access
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27 Citations (Scopus)
8 Downloads (Pure)

Estrogen-independent actions of environmentally relevant AhR-agonists in human endometrial epithelial cells

Willing, C., Peich, M., Danescu, A., Kehlen, A., Fowler, P. & Hombach-Klonisch, S., Feb 2011, In : Molecular Human Reproduction. 17, 2, p. 115-126 12 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Exposure assessment of food enzymes

Silano, V., Bolognesi, C., Castle, L., Cravedi, J-P., Fowler, P., Franz, R., Grob, K., Gürtler, R., Husøy, T., Kärenlampi, S., Mennes, W., Rosaria Milana, M., Penninks, A., Smith, A., de Fátima Tavares Poças, M., Tlustos, C., Wölfle, D., Zorn, H., Zugravu, C-A., Arcella, D. & 3 others, Liu, Y., Engel, K-H. & EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF), Nov 2016, EFSA Journal, 14, 11, p. e04581.

Research output: Contribution to specialist publicationArticle

Open Access
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5 Downloads (Pure)

Exposure to chemical cocktails before or after conception: The effect of timing on ovarian development

Bellingham, M., Amezaga, M. R., Mandon-Pepin, B., Speers, C. J. B., Kyle, C. E., Evans, N. P., Sharpe, R. M., Cotinot, C., Rhind, S. M. & Fowler, P. A., 25 Aug 2013, In : Molecular and Cellular Endocrinology. 376, 1-2, p. 156-172 17 p.

Research output: Contribution to journalArticle

Open Access
File
20 Citations (Scopus)
4 Downloads (Pure)
13 Citations (Scopus)

Expression of the Insulin-like Growth Factor system in first and second trimester human embryonic and fetal gonads

Mamsen, L. S., Zafeiri, A., Bøtkjær, J. A., Rasmussen, J. H., Ernst, E., Oxvig, C., Fowler, P. A. & Andersen, C. Y., 29 Jul 2020, In : Journal of Clinical Endocrinology and Metabolism.

Research output: Contribution to journalArticle

Female Reproductive Disorders, Diseases, and Costs of Exposure to Endocrine Disrupting Chemicals in the European Union

Hunt, P. A., Sathyanarayana, S., Fowler, P. A. & Trasande, L., 1 Apr 2016, In : Journal of Clinical Endocrinology and Metabolism. 101, 4, p. 1562–1570 9 p.

Research output: Contribution to journalArticle

Open Access
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25 Citations (Scopus)
3 Downloads (Pure)

Fetal androgen exposure is a determinant of adult male metabolic health

Siemienowicz, K., Filis, P., Shaw, S., Douglas, A., Thomas, J., Mulroy, S., Howie, F., Fowler, P. A., Duncan, W. C. & Rae, M. T., 27 Dec 2019, In : Scientific Reports. 9, 20195.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
3 Downloads (Pure)

Foetal and post-natal exposure of sheep to sewage sludge chemicals disrupts sperm production in adulthood in a subset of animals

Bellingham, M., McKinnell, C., Fowler, P. A., Amezaga, M. R., Zhang, Z., Rhind, S. M., Cotinot, C., Mandon-Pepin, B., Evans, N. P. & Sharpe, R. M., Jun 2012, In : International journal of andrology. 35, 3, p. 317-329 13 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Human anogenital distance: an update on fetal smoke-exposure and integration of the perinatal literature on sex differences

Fowler, P. A., Filis, P., Bhattacharya, S., Le Bizec, B., Antignac, J-P., Morvan, M-L., Drake, A. J., Soffientini, U. & O'Shaughnessy, P. J., Feb 2016, In : Human Reproduction. 31, 2, p. 463-472 10 p.

Research output: Contribution to journalArticle

Open Access
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12 Citations (Scopus)
9 Downloads (Pure)

Identification of Leydig cell-specific mRNA transcripts in the adult rat testis

O'Shaughnessy, P. J., Monteiro, A., Fowler, P. A. & Morris, I. D., May 2014, In : Reproduction. 147, 5, p. 671-682 12 p.

Research output: Contribution to journalArticle

Open Access
13 Citations (Scopus)

Identification of Sertoli cell-specific transcripts in the mouse testis and the role of FSH and androgen in the control of Sertoli cell activity

Soffientini, U., Rebourcet, D., Abel, M. H., Lee, S., Hamilton, G., Fowler, P. A., Smith, L. B. & O'Shaughnessy, P. J., 15 Dec 2017, In : BMC Genomics. 18, 972.

Research output: Contribution to journalArticle

Open Access
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8 Citations (Scopus)
6 Downloads (Pure)

Identification of stable endogenous reference genes for real-time PCR in the human fetal gonad using an external standard technique

O'Shaughnessy, P. J., Monteiro, A. & Fowler, P. A. F., 2011, In : Molecular Human Reproduction. 17, 10, p. 620-625 6 p.

Research output: Contribution to journalArticle

Open Access
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11 Citations (Scopus)
3 Downloads (Pure)

Impact of endocrine-disrupting compounds (EDCs) on female reproductive health

Fowler, P. AF., Bellingham, M., Sinclair, K. D., Evans, N. P., Pocar, P., Fischer, B., Schaedlich, K., Schmidt, S-J., Amezaga, M. R., Bhattacharya, S., Rhind, S. M. & O'Shaughnessy, P. J., May 2012, In : Molecular and Cellular Endocrinology. 355, 2, p. 231-239 9 p.

Research output: Contribution to journalArticle

132 Citations (Scopus)

Impact of sublethal levels of environmental pollutants found in sewage sludge on a novel Caenorhabditis elegans model biosensor

McLaggan, D., Amezaga, M. R., Petra, E., Frost, A., Duff, E. I., Rhind, S. M., Fowler, P. A., Glover, L. A. & Lagido, C., 2012, In : PloS ONE. 7, 10, 12 p., e46503.

Research output: Contribution to journalArticle

Open Access
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14 Citations (Scopus)
6 Downloads (Pure)

Interaction between hedgehog signalling and PAX6 dosage mediates maintenance and regeneration of the corneal epithelium

Kucerova, R., Dorà, N., Mort, R. L., Wallace, K., Leiper, L. J., Lowes, C., Neves, C., Walczysko, P., Bruce, F., Fowler, P. A., Rajnicek, A. M., McCaig, C. D., Zhao, M., West, J. D. & Collinson, J. M., 2012, In : Molecular vision. 18, p. 139-150 12 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

In utero exposure to cigarette chemicals induces sex-specific disruption of one-carbon metabolism and DNA methylation in the human fetal liver

Drake, A. J., O'Shaughnessy, P. J., Bhattacharya, S., Monteiro, A., Kerrigan, D., Goetz, S., Raab, A., Rhind, S. M., Sinclair, K. D., Meharg, A. A., Feldmann, J. & Fowler, P. A., 29 Jan 2015, In : BMC medicine . 13, 18.

Research output: Contribution to journalArticle

Open Access
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40 Citations (Scopus)
6 Downloads (Pure)

In utero exposure to cigarette smoke dysregulates human fetal ovarian developmental signalling

Fowler, P. A., Childs, A. J., Courant, F., MacKenzie, A., Rhind, S. M., Antignac, J-P., Le Bizec, B., Filis, P., Evans, F., Flannigan, S., Maheshwari, A., Bhattacharya, S., Monteiro, A., Anderson, R. A. & O'Shaughnessy, P. J., Jul 2014, In : Human Reproduction. 29, 7, p. 1471-1489 19 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

In utero exposure to environmental chemicals: lessons from maternal cigarette smoking and its effects on gonad development and puberty

McKinlay, R., O'Shaughnessy, P. J., Sharpe, R. M. & Fowler, P. A. F., 2012, Endocrine Disruptors and Puberty: Contemporary Endocrinology. Diamanti-Kandarakis, E. & Gore, A. (eds.). Humana Press, p. 11 48 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

1 Citation (Scopus)

In Utero Exposure to Environmentally Relevant Concentrations of PCB 153 and PCB 118 Disrupts Fetal Testis Development in Sheep

Krogenæs, A. K., Ropstad, E., Gutleb, A. C., Hårdnes, N., Berg, V., Dahl, E. & Fowler, P. A., 2014, In : Journal of Toxicology and Environmental Health. Part A. 77, 9-11, p. 628-649 22 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Long-term exposure to chemicals in sewage sludge fertilizer alters liver lipid content in females and cancer marker expression in males

Filis, P., Walker, N., Robertson, L., Eaton-Turner, E., Ramona, L., Bellingham, M., Amezaga, M. R., Zhang, Z., Mandon-Pepin, B., Evans, N. P., Sharpe, R. M., Cotinot, C., Rees, W. D., O'Shaughnessy, P. & Fowler, P. A., Mar 2019, In : Environment International. 124, p. 98-108 10 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
12 Downloads (Pure)

Maternal cigarette smoking and effects on androgen action in male offspring: unexpected effects on second-trimester anogenital distance

Fowler, P. A., Bhattacharya, S., Flannigan, S., Drake, A. J. & O'Shaughnessy, P. J., 1 Sep 2011, In : Journal of Clinical Endocrinology and Metabolism. 96, 9, p. E1502-E1506 5 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Maternal smoking and fetal sex significantly affect metabolic enzyme expression in the human fetal liver

O'Shaughnessy, P. J., Monteiro, A., Bhattacharya, S. & Fowler, P. A., 2011, In : Journal of Clinical Endocrinology and Metabolism. 96, 9, p. 2851-2860 10 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Maternal smoking and high BMI disrupt thyroid gland development

Filis, P., Hombach-Klonisch, S., Ayotte, P., Nagrath, N., Soffientini, U., Klonisch, T., O'Shaughnessy, P. J. & Fowler, P. A., 23 Oct 2018, In : BMC medicine . 16, 194.

Research output: Contribution to journalArticle

Open Access
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6 Citations (Scopus)
7 Downloads (Pure)

Maternal smoking dysregulates protein expression in second trimester human fetal livers in a sex-specific manner

Filis, P., Nagrath, N., Fraser, M., Hay, D. C., Iredale, J. P., O'Shaughnessy, P. & Fowler, P. A., 2015, In : Journal of Clinical Endocrinology and Metabolism. 100, 6, p. E861–E870 10 p.

Research output: Contribution to journalArticle

Open Access
File
18 Citations (Scopus)
6 Downloads (Pure)

Modelling foetal exposure to maternal smoking using hepatoblasts from pluripotent stem cells

Lucendo-Villarin, B., Filis, P., Swortwood, M. J., Huestis, M. A., Meseguer-Ripolles, J., Cameron, K., Iredale, J. P., O’Shaughnesy, P. J., Fowler, P. A. & Hay, D. C., Nov 2017, In : Archives of Toxicology. 91, 11, p. 3633-3643 11 p.

Research output: Contribution to journalArticle

Open Access
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10 Citations (Scopus)
10 Downloads (Pure)

Nutrient transporter expression in both the placenta and fetal liver are affected by maternal smoking

Walker, N., Filis, P., O'Shaughnessy, P. J., Bellingham, M. & Fowler, P. A., Mar 2019, In : Placenta. 78, p. 10-17 8 p.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
6 Downloads (Pure)

Ovine corpus luteum proteins, with functions including oxidative stress and lipid metabolism, show complex alterations during implantation

Arianmanesh, M., McIntosh, R. H., Lea, R. G., Fowler, P. A. & Al-Gubory, K. H., Jul 2011, In : Journal of Endocrinology. 210, p. 47-58 12 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Peri-conceptional changes in maternal exposure to sewage sludge chemicals disturbs fetal thyroid gland development in sheep

Hombach-Klonisch, S., Danescu, A., Begum, F., Amezaga, M. R., Rhind, S. M., Sharpe, R. M., Evans, N. P., Bellingham, M., Cotinot, C., Mandon-Pepin, B., Fowler, P. A. & Klonisch, T., 10 Mar 2013, In : Molecular and Cellular Endocrinology. 367, 1-2, p. 98-108 11 p.

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
4 Downloads (Pure)

Placental transporter localization and expression in the Human: the importance of species, sex, and gestational age differences

Walker, N., Filis, P., Soffientini, U., Bellingham, M., O'Shaughnessy, P. J. & Fowler, P. A., Apr 2017, In : Biology of Reproduction. 96, 4, p. 733-742 10 p.

Research output: Contribution to journalLiterature review

Open Access
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26 Citations (Scopus)
9 Downloads (Pure)

Proteomic analysis of the sheep caruncular and intercaruncular endometrium reveals changes in functional proteins crucial for the establishment of pregnancy

Al-Gubory, K. H., Arianmanesh, M., Garrel, C., Bhattacharya, S., Cash, P. & Fowler, P. A., May 2014, In : Reproduction. 147, 5, p. 599-614 16 p.

Research output: Contribution to journalArticle

Open Access
13 Citations (Scopus)

Putative adverse outcome pathways for female reproductive disorders to improve testing and regulation of chemicals

Johansson, H. K. L., Damdimopoulou, P., van Duursen, M. B. M., Boberg, J., Franssen, D., de Cock, M., Jääger, K., Wagner, M., Velthut-Meikas, A., Xie, Y., Connolly, L., Lelandais, P., Mazaud Guittot, S., Salumets, A., Draskau, M. K., Filis, P., Fowler, P. A., Christiansen, S., Parent, A-S. & Svingen, T., 7 Jul 2020, In : Archives of Toxicology. 21 p.

Research output: Contribution to journalReview article

Open Access
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1 Downloads (Pure)

Quantification of ethyl glucuronide, ethyl sulfate, nicotine, and its metabolites in human fetal liver and placenta

Swortwood, M. J., Bartock, S. H., Scheidweiler, K. B., Shaw, S., Filis, P., Douglas, A., O'Shaughnessy, P. J., Soffientini, U., Lucendo-Villarin, B., Iredale, J. P., Hay, D. C., Fowler, P. A. & Huestis, M. A., Jan 2018, In : Forensic Toxicology. 36, 1, p. 102-112 11 p.

Research output: Contribution to journalArticle

Open Access
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3 Citations (Scopus)
7 Downloads (Pure)

Response to the Letter by G. M. H. Swaen and R. Otter

Hunt, P. A., Sathyanarayana, S., Fowler, P. A. & Trasande, L., 2016, In : Journal of Clinical Endocrinology and Metabolism. 101, 11, p. 110-111 2 p.

Research output: Contribution to journalLetter

Open Access
File
1 Citation (Scopus)