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  • Harry Flint

16S rRNA gene-based profiling of the human infant gut microbiota is strongly influenced by sample processing and PCR primer choice

Walker, A. W., Martin, J. C., Scott, P., Parkhill, J., Flint, H. J. & Scott, K. P., 22 Jun 2015, In : Microbiome. 3, 26.

Research output: Contribution to journalArticle

Open Access
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102 Citations (Scopus)
7 Downloads (Pure)

Alterations in microbiota and fermentation products in equine large intestine in response to dietary variation and intestinal disease

Daly, K., Proudman, C. J., Duncan, S. H., Flint, H. J., Dyer, J. & Shirazi-Beechey, S. P., 14 Apr 2012, In : British Journal of Nutrition. 107, 7, p. 989-995 7 p.

Research output: Contribution to journalArticle

73 Citations (Scopus)

Anaerostipes hadrus comb. nov., a dominant species within the human colonic microbiota; reclassification of Eubacterium hadrum Moore et al. 1976

Allen-Vercoe, E., Daigneault, M., White, A., Panaccione, R., Duncan, S. H., Flint, H. J., O'Neal, L. & Lawson, P. A., Oct 2012, In : Anaerobe. 18, 5, p. 523-529 7 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

A representative of the dominant human colonic Firmicutes, Roseburia faecis M72/1, forms a novel bacteriocin-like substance

Hatziioanou, D., Mayer, M. J., Duncan, S. H., Flint, H. J. & Narbad, A., Oct 2013, In : Anaerobe. 23, p. 5-8 4 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Biomass Utilization by Gut Microbiomes

White, B. A., Lamed, R., Bayer, E. A. & Flint, H. J., 16 Jun 2014, In : Annual Review of Microbiology. 68, p. 279-296 18 p.

Research output: Contribution to journalArticle

65 Citations (Scopus)

Cellulosomics, a gene-centric approach to investigating the intraspecific diversity and adaptation of Ruminococcus flavefaciens within the rumen

Brulc, J. M., Yeoman, C. J., Wilson, M. K., Miller, M. E. B., Jeraldo, P., Jindou, S., Goldenfeld, N., Flint, H. J., Lamed, R., Borovok, I., Vodovnik, M., Nelson, K. E., Bayer, E. A. & White, B. A., 17 Oct 2011, In : PloS ONE. 6, 10, 10 p., e25329.

Research output: Contribution to journalArticle

Open Access
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25 Citations (Scopus)
4 Downloads (Pure)

Challenges in microbial ecology: building predictive understanding of community function and dynamics

Widder, S., Allen, R. J., Pfeiffer, T., Curtis, T. P., Wiuf, C., Sloan, W. T., Cordero, O. X., Brown, S. P., Momeni, B., Shou, W., Kettle, H., Flint, H. J., Haas, A. F., Laroche, B., Kreft, J-U., Rainey, P. B., Freilich, S., Schuster, S., Milferstedt, K., van der Meer, J. R. & 11 others, Groszkopf, T., Huisman, J., Free, A., Picioreanu, C., Quince, C., Klapper, I., Labarthe, S., Smets, B. F., Wang, H., Soyer, O. S. & Isaac Newton Institute Fellows, Nov 2016, In : The ISME Journal. 10, 11, p. 2557-2568 12 p.

Research output: Contribution to journalArticle

Open Access
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236 Citations (Scopus)
6 Downloads (Pure)

Changes in the Abundance of Faecalibacterium prausnitzii Phylogroups I and II in the Intestinal Mucosa of Inflammatory Bowel Disease and Patients with Colorectal Cancer

Lopez-Siles, M., Martinez-Medina, M., Surís-Valls, R., Aldeguer, X., Sabat-Mir, M., Duncan, S. H., Flint, H. J. & Garcia-Gil, L. J., Jan 2016, In : Inflammatory Bowel Diseases. 22, 1, p. 28-41 14 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Colonic bacterial metabolites and human health

Russell, W. R., Hoyles, L., Flint, H. J. & Dumas, M. E., Jun 2013, In : Current Opinion in Microbiology. 16, 3, p. 246-254 9 p.

Research output: Contribution to journalReview article

176 Citations (Scopus)

Comparative metabolomics in vegans and omnivores reveal constraints on diet-dependent gut microbiota metabolite production

Wu, G. D., Compher, C., Chen, E. Z., Smith, S. A., Shah, R. D., Bittinger, K., Chehoud, C., Albenberg, L. G., Nessel, L., Gilroy, E., Star, J., Weljie, A. M., Flint, H. J., Metz, D. C., Bennett, M. J., Li, H., Bushman, F. D. & Lewis, J. D., Jan 2016, In : Gut. 65, 1, p. 63-72 10 p.

Research output: Contribution to journalArticle

Open Access
192 Citations (Scopus)
25 Citations (Scopus)

Complete Genome Sequence of the Human Gut Symbiont Roseburia hominis

Travis, A. J., Kelly, D., Flint, H. J. & Aminov, R. I., 5 Nov 2015, In : Genome Announcements. 3, 6, 2 p., e01286-15.

Research output: Contribution to journalArticle

Open Access
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6 Citations (Scopus)
7 Downloads (Pure)

Complexity of the Ruminococcus flavefaciens FD-1 cellulosome reflects an expansion of family-related protein-protein interactions

Israeli-Ruimy, V., Bule, P., Jindou, S., Dassa, B., Moraïs, S., Borovok, I., Barak, Y., Slutzki, M., Hamberg, Y., Cardoso, V., Alves, V. D., Najmudin, S., White, B. A., Flint, H. J., Gilbert, H. J., Lamed, R., Fontes, C. M. G. A. & Bayer, E. A., 10 Feb 2017, In : Scientific Reports. 7, 42355.

Research output: Contribution to journalArticle

Open Access
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11 Citations (Scopus)
11 Downloads (Pure)

Contribution of diet to the composition of the human gut microbiota

Graf, D., Di Cagno, R., Fåk, F., Flint, H. J., Nyman, M., Saarela, M. & Watzl, B., 2015, In : Microbial Ecology in Health and Disease. 26, 11 p., 26164.

Research output: Contribution to journalArticle

Open Access
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6 Downloads (Pure)

Cultivation and sequencing of rumen microbiome members from the Hungate1000 Collection

Seshadri, R., Leahy, S. C., Attwood, G. T., Teh, K. H., Lambie, S. C., Cookson, A. L., Eloe-Fadrosh, E. A., Pavlopoulos, G. A., Hadjithomas, M., Varghese, N. J., Paez-Espino, D., Perry, R., Henderson, G., Creevey, C. J., Terrapon, N., Lapebie, P., Drula, E., Lombard, V., Rubin, E., Kyrpides, N. C. & 31 others, Henrissat, B., Woyke, T., Ivanova, N. N., Kelly, W. J., Palevic, N., Janssen, P. H., Ronimus, R. S., Noel, S., Soni, P., Reilly, K., Atherly, T., Ziemer, C., Wright, A. D., Ishaq, S., Cotta, M., Thompson, S., Crosley, K., McKain, N., Wallace, R. J., Flint, H. J., Martin, J. C., Forster, R. J., Gruninger, R. J., McAllister, T., Gilbert, R., Ouwerkerk, D. J., Gilbert, R., Ouwerkerk, D. J., Klieve, A. J., Jassim, R. A. & Hungate1000 project collaborators, 19 Mar 2018, In : Nature Biotechnology. 36, 4, p. 359-367 9 p.

Research output: Contribution to journalReview article

Open Access
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76 Citations (Scopus)
8 Downloads (Pure)

Cultured representatives of two major phylogroups of human colonic Faecalibacterium prausnitzii can utilize pectin, uronic acids, and host-derived substrates for growth

Lopez-Siles, M., Khan, T. M., Duncan, S. H., Harmsen, H. J. M., Garcia-Gil, L. J. & Flint, H. J., Jan 2012, In : Applied and Environmental Microbiology. 78, 2, p. 420-428 9 p.

Research output: Contribution to journalArticle

181 Citations (Scopus)

Dietary fibers inhibit obesity in mice, but host responses in the cecum and liver appear unrelated to fiber-specific changes in cecal bacterial taxonomic composition

Drew, J. E., Reichardt, N., Williams, L. M., Mayer, C-D., Walker, A. W., Farquharson, A. J., Kastora, S., Farquharson, F., Milligan, G., Morrison, D. J., Preston, T., Flint, H. J. & Louis, P., 22 Oct 2018, In : Scientific Reports. 8, 15566.

Research output: Contribution to journalArticle

Open Access
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7 Citations (Scopus)
5 Downloads (Pure)

Discovery of a novel lantibiotic nisin O from Blautia obeum A2-162, isolated from the human 2 gastrointestinal tract

Hatziioanou, D., Gherghisan-Filip, C., Saalbach, G., Horn, N., Wegmann, U., Duncan, S. H., Flint, H. J., Mayer, M. J. & Narbad, A., 1 Sep 2017, In : Microbiology . 163, 9, p. 1292-1305 14 p.

Research output: Contribution to journalArticle

Open Access
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14 Citations (Scopus)
5 Downloads (Pure)

Dominant and diet-responsive groups of bacteria within the human colonic microbiota

Walker, A. W., Ince, J., Duncan, S. H., Webster, L., Holtrop, G., Ze, X., Brown, D., Stares, M. D., Scott, P., Bergerat, A., Louis, P., McIntosh, F., Johnstone, A. M., Lobley, G. E., Parkhill, J. & Flint, H. J., Feb 2011, In : The ISME Journal. 5, 2, p. 220-230 11 p.

Research output: Contribution to journalArticle

801 Citations (Scopus)
1 Citation (Scopus)

Enhanced butyrate formation by cross-feeding between Faecalibacterium prausnitzii and Bifidobacterium adolescentis

Rios-Covian, D., Gueimonde, M., Duncan, S. H., Flint, H. J. & de Los Reyes-Gavilan, C. G., Nov 2015, In : FEMS Microbiology Letters. 362, 21, 7 p., fnv176.

Research output: Contribution to journalArticle

94 Citations (Scopus)

Enzymatic profiling of cellulosomal enzymes from the human gut bacterium, Ruminococcus champanellensis, reveals a fine-tuned system for cohesin-dockerin recognition

Morais, S., David, Y. B., Bensoussan, L., Duncan, S. H., Koropatkin, N. M., Martens, E. C., Flint, H. J. & Bayer, E. A., Feb 2016, In : Environmental Microbiology. 18, 2, p. 542-556 15 p.

Research output: Contribution to journalArticle

Open Access
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24 Citations (Scopus)
6 Downloads (Pure)

Evaluation of bacterial biomarkers to aid in challenging inflammatory bowel diseases diagnostics and subtype classification

Lopez-Siles, M., Aldeguer, X., Sabat-Mir, M., Serra-Pagès, M., Duncan, S. H., Flint, H. J., Garcia-Gil, L. J. & Martinez-Medina, M., 12 May 2020, In : World Journal of Gastrointestinal Pathophysiology. 11, 3, p. 64-77 14 p.

Research output: Contribution to journalArticle

Open Access
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7 Downloads (Pure)

Expert consensus document: The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic

Hill, C., Guarner, F., Reid, G., Gibson, G. R., Merenstein, D. J., Pot, B., Morelli, L., Canani, R. B., Flint, H. J., Salminen, S., Calder, P. C. & Sanders, M. E., Aug 2014, In : Nature Reviews Gastroenterology & Hepatology. 11, 8, p. 506-514 9 p.

Research output: Contribution to journalArticle

Open Access
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1832 Citations (Scopus)
7 Downloads (Pure)

Expression of Cellulosome Components and Type IV Pili within the Extracellular Proteome of Ruminococcus flavefaciens 007

Vodovnik, M., Duncan, S. H., Reid, M. D., Cantlay, L., Turner, K., Parkhill, J., Lamed, R., Yeoman, C. J., Miller, M. E. B., White, B. A., Bayer, E. A., Marinšek-Logar, R. & Flint, H. J., 4 Jun 2013, In : PloS ONE. 8, 6, p. 1-11 11 p., e65333.

Research output: Contribution to journalArticle

Open Access
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19 Citations (Scopus)
5 Downloads (Pure)

Faecalibacterium prausnitzii A2-165 has a high capacity to induce IL-10 in human and murine dendritic cells and modulates T cell responses

Rossi, O., van Berkel, L. A., Chain, F., Tanweer Khan, M., Taverne, N., Sokol, H., Duncan, S. H., Flint, H. J., Harmsen, H. J. M., Langella, P., Samsom, J. N. & Wells, J. M., Jan 2016, In : Scientific Reports. 6, p. 1-12 12 p., 18507.

Research output: Contribution to journalArticle

Open Access
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76 Citations (Scopus)
6 Downloads (Pure)

Faecalibacterium prausnitzii Strain HTF-F and Its Extracellular Polymeric Matrix Attenuate Clinical Parameters in DSS-Induced Colitis

Rossi, O., Khan, M. T., Schwarzer, M., Hudcovic, T., Srutkova, D., Duncan, S. H., Stolte, E. H., Kozakova, H., Flint, H. J., Samsom, J. N., Harmsen, H. J. M. & Wells, J. M., 24 Apr 2015, In : PloS ONE. 10, 4, 17 p., e0123013.

Research output: Contribution to journalArticle

Open Access
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46 Citations (Scopus)
6 Downloads (Pure)

Faecal microbiota profiling in human volunteers on low and high fruit and vegetable intakes

Farquharson, F. M., Ze, X., Scobbie, L., Milne, L., Duncan, S. H., Holtrop, G., Flint, H. J., Rungapamestry, V., Duthie, G. G., Bestwick, C. S., Duthie, S. J. & Louis, P. G., 2014, ROWETT-INRA 2014 Gut Microbiology: From Sequence to Function. Rowett Institute of Nutrition and Health, p. 116 1 p. P131

Research output: Chapter in Book/Report/Conference proceedingOther contribution

Fermentation of oats (Avena sativa) by the faecal microbiota using an in vitro colonic fermentor system

Chappell, A. J., Thies, F., Martin, P., Flint, H. J. & Scott, K. P., 2015, In : Proceedings of the Nutrition Society. 74, OCE5, p. E302-E302 1 p.

Research output: Contribution to journalAbstract

Open Access
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1 Citation (Scopus)
9 Downloads (Pure)

Formation of propionate and butyrate by the human colonic microbiota

Louis, P. & Flint, H. J., Jan 2017, In : Environmental Microbiology. 19, 1, p. 29-41 13 p.

Research output: Contribution to journalLiterature review

Open Access
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281 Citations (Scopus)
10 Downloads (Pure)

Functional dysbiosis within the intestinal microbiota of patients with irritable bowel syndrome

Chassard, C., Dapoingny, M., Scott, K. P., Crouzet, L., Del'homme, C., Marquet, P., Martin, J. C., Pikering, G., Ardid, D., Eschalier, A., Dubray, C., Flint, H. J. & Bernalier-Donadille, A., 2012, In : Alimentary Pharmacology & Therapeutics. 35, 7, p. 828-838 11 p.

Research output: Contribution to journalArticle

193 Citations (Scopus)

Functional genomics reveals that Clostridium difficile Spo0A coordinates sporulation, virulence and metabolism

Pettit, L. J., Browne, H. P., Yu, L., Smits, W. K., Fagan, R. P., Barquist, L., Martin, M. J., Goulding, D., Duncan, S. H., Flint, H. J., Dougan, G., Choudhary, J. S. & Lawley, T. D., 25 Feb 2014, In : BMC Genomics. 15, 15 p., 160.

Research output: Contribution to journalArticle

Open Access
File
50 Citations (Scopus)
6 Downloads (Pure)

Functional phylotyping approach for assessing intraspecific diversity of Ruminococcus albus within the rumen microbiome

Grinberg, I. R., Yin, G., Borovok, I., Miller, M. E. B., Yeoman, C. J., Dassa, B., Yu, Z., Mizrahi, I., Flint, H. J., Bayer, E. A., White, B. A. & Lamed, R., Feb 2015, In : FEMS Microbiology Letters. 362, 3, p. 1-10 10 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Gut environmental factors may shape the persistence of Faecalibacterium prausnitzii in the healthy and diseased large intestine

Lopez-Siles, M., Khan, T. M., Duncan, S. H., Mante, X. A., Harmsen, H. J. M., Garcia-Gil, L. J. & Flint, H. J., May 2011, In : Gastroenterology. 140, 5, p. S665 1 p., Mo1856.

Research output: Contribution to journalAbstract

Gut microbial metabolites in health and disease

Flint, H. J., 2016, In : Gut Microbes. 7, 3, p. 187-188 2 p.

Research output: Contribution to journalEditorial

6 Citations (Scopus)

Gut microbiome and obesity

Flint, H. J., Duncan, S. H. & Louis, P. G. H., 2014, Treatment of the obese patient. Kushner, R. F. & Bessesen, D. H. (eds.). 2nd ed. London: Springer Science+Business Media, p. 73-82 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)

Gut microbiota signatures predict host and microbiota responses to dietary interventions in obese individuals

Korpela, K., Flint, H. J., Johnstone, A. M., Lappi, J., Poutanen, K., Dewulf, E., Delzenne, N., de Vos, W. M. & Salonen, A., 6 Mar 2014, In : PloS ONE. 9, 3, 10 p., e90702.

Research output: Contribution to journalArticle

Open Access
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92 Citations (Scopus)
4 Downloads (Pure)

Heterologous gene expression in the human gut bacteria Eubacterium rectale and Roseburia inulinivorans by means of conjugative plasmids

Sheridan, P. O., Martin, J. C., Minton, N. P., Flint, H. J., O'Toole, P. W. & Scott, K. P., 1 Oct 2019, In : Anaerobe. 59, p. 131-140 10 p.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
1 Downloads (Pure)
328 Citations (Scopus)

How our gut microbes influence our behaviour

Louis, P. & Flint, HJ., May 2013, In : Journal of Neuroendocrinology. 25, 5, p. 517-518 2 p.

Research output: Contribution to journalLetter

2 Citations (Scopus)

How to Manipulate the Microbiota: Prebiotics

Louis, P., Flint, H. J. & Michel, C., 2016, Microbiota of the Human Body: Implications in Health and Disease. Schwiertz, A. (ed.). Switzerland: Springer , p. 119-142 24 p. ( Advances in Experimental Medicine and Biology; vol. 902).

Research output: Chapter in Book/Report/Conference proceedingChapter

26 Citations (Scopus)

Impact of carbohydrate substrate complexity on the diversity of the human colonic microbiota

Chung, W. S. F., Walker, A. W., Vermeiren, J., Sheridan, P. O., Bosscher, D., Garcia-Campayo, V., Parkhill, J., Flint, H. J. & Duncan, S. H., 1 Jan 2019, In : FEMS Microbiology Ecology. 95, 1, fiy201.

Research output: Contribution to journalArticle

Open Access
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8 Citations (Scopus)
3 Downloads (Pure)

Impact of diet and individual variation on intestinal microbiota composition and fermentation products in obese men

Salonen, A., Lahti, L., Salojärvi, J., Holtrop, G., Korpela, K., Duncan, S. H., Date, P., Farquharson, F., Johnstone, A. M., Lobley, G. E., Louis, P., Flint, H. J. & de Vos, W. M., Nov 2014, In : The ISME Journal. 8, 11, p. 2218-2230 13 p.

Research output: Contribution to journalArticle

220 Citations (Scopus)

Impact of Intestinal Microbial Communities upon Health

Flint, H. J., Duncan, S. H. & Louis, P., 2011, Beneficial microorganisms in multicellular life forms. Rosenberg, E. & Gophna, U. (eds.). Springer-Verlag, p. 243-252 252 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Intestinal microbiota in functional bowel disorders: a Rome foundation report

Simren, M., Barbara, G., Flint, H. J., Spiegel, B. M. R., Spiller, R. C., Vanner, S., Verdu, E. F., Whorwell, P. J. & Zoetendal, E. G., Jan 2013, In : Gut. 62, 1, p. 159-176 18 p.

Research output: Contribution to journalArticle

Open Access
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495 Citations (Scopus)
5 Downloads (Pure)

Kinetic modelling of lactate utilization and butyrate production by key human colonic bacterial species

Munoz-Tamayo, R., Laroche, B., Walter, E., Dore, J., Duncan, S. H., Flint, H. J. & Leclerc, M., Jun 2011, In : FEMS Microbiology Letters. 76, 3, p. 615-624 10 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)

Links between diet, gut microbiota composition and gut metabolism

Flint, H. J., Duncan, S. H., Scott, K. P. & Louis, P., Feb 2015, In : Proceedings of the Nutrition Society. 74, 1, p. 13-22 10 p.

Research output: Contribution to journalLiterature review

284 Citations (Scopus)