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  • Tiehui Wang

Analysis of adipose tissue immune gene expression after vaccination of rainbow trout with adjuvanted bacterins reveals an association with side effects

Veenstra, K. A., Wang, T., Alnabulsi, A., Douglas, A., Russell, K. S., Tubbs, L., Arous, J. B. & Secombes, C. J., Aug 2017, In : Molecular Immunology. 88, p. 89-98 10 p.

Research output: Contribution to journalArticle

Open Access
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10 Citations (Scopus)
38 Downloads (Pure)

An insight into piscidins: The discovery, modulation and bioactivity of greater amberjack, Seriola dumerili, piscidin

Milne, D. J., Fernández-Montero, Á., Gundappa, M. K., Wang, T., Acosta, F., Torrecillas, S., Montero, D., Zou, J., Sweetman, J. & Secombes, C. J., Oct 2019, In : Molecular Immunology. 114, p. 378-388 11 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

B cell receptor accessory molecule CD79α: characterisation and expression analysis in a cartilaginous fish, the spiny dogfish (Squalus acanthias)

Li, R., Wang, T., Bird, S., Zou, J., Dooley, H. & Secombes, C. J., Jun 2013, In : Fish & Shellfish Immunology. 34, 6, p. 1404-1415 12 p.

Research output: Contribution to journalArticle

Open Access
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9 Citations (Scopus)
4 Downloads (Pure)

Bioactivity studies of rainbow trout (Oncorhynchus mykiss) interleukin-6: effects on macrophage growth and antimicrobial peptide gene expression

Costa, M. M., Maehr, T., Diaz-Rosales, P., Secombes, C. J. & Wang, T., Sep 2011, In : Molecular Immunology. 48, 15-16, p. 1903-1916 14 p.

Research output: Contribution to journalArticle

90 Citations (Scopus)
Open Access
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14 Citations (Scopus)
4 Downloads (Pure)
24 Citations (Scopus)

Characterisation of arginase paralogues in salmonids and their modulation by immune stimulation/ infection

Benedicenti, O., Wang, T., Wangkahart, E., Milne, D. J., Holland, J. W., Collins, C. & Secombes, C. J., Feb 2017, In : Fish & Shellfish Immunology. 61, p. 138-151 14 p.

Research output: Contribution to journalArticle

Open Access
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9 Citations (Scopus)
8 Downloads (Pure)

Characterisation of rainbow trout peripheral blood leucocytes prepared by hypotonic lysis of erythrocytes, and analysis of their phagocytic activity, proliferation and response to PAMPs and proinflammatory cytokines

Hu, Y., Maisey, K., Subramani, P. A., Liu, F., Flores-Kossack, C., Imarai, M., Secombes, C. J. & Wang, T., Nov 2018, In : Developmental and Comparative Immunology. 88, p. 104-113 10 p.

Research output: Contribution to journalArticle

Open Access
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9 Citations (Scopus)
2 Downloads (Pure)

Characterisation of the TNF superfamily members CD40L and BAFF in the small-spotted catshark (Scyliorhinus canicula)

Li, R., Redmond, A. K., Wang, T., Bird, S., Dooley, H. & Secombes, C. J., 1 Nov 2015, In : Fish & Shellfish Immunology. 47, 1, p. 381-389 9 p.

Research output: Contribution to journalArticle

Open Access
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9 Citations (Scopus)
42 Downloads (Pure)

Characterisation of transcription factors in rainbow trout potentially involved in dendritic cell maturation and activation

Wang, J., Wang, T., Benedicenti, O., Collins, C., McCarthy, U., Wang, K., Secombes, C. J. & Zou, J., Jun 2016, In : Fish & Shellfish Immunology. 53, p. 74 1 p.

Research output: Contribution to journalAbstract

Characterisation of ZBTB46 and DC-SCRIPT/ZNF366 in rainbow trout, transcription factors potentially involved in dendritic cell maturation and activation in fish

Wang, J., Wang, T., Benedicenti, O., Collins, C., Wang, K., Secombes, C. J. & Zou, J., Mar 2018, In : Developmental and Comparative Immunology. 80, p. 2-14 13 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Characterization and expression analysis of chemokine-like receptor 3 gene in rainbow trout Oncorhynchus mykiss

Qi, Z., Zhang, Q., Holland, J. W., Gao, Q., Tafalla, C., Wang, X. & Wang, T., 1 Jul 2016, In : Reviews in Fisheries Science. 82, 4, p. 613-622 10 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Characterization and gene expression analysis of the two main Th17 cytokines (IL-17A/F and IL-22) in turbot, Scophthalmus maximus

Costa, M. M., Pereiro, P., Wang, T., Secombes, C. J., Figueras, A., Novoa, B. & Wang, T., Dec 2012, In : Developmental and Comparative Immunology. 38, 4, p. 505-516 12 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)
32 Citations (Scopus)

CK9, an ancient rainbow trout chemokine that attracts and regulates B lymphocytes, and macrophages

Aquilino, C., Granja, A. G., Castro, R., Wang, T., Abos, B., Parra, D., Secombes, C. J. & Tafalla, C., Jun 2016, In : Fish & Shellfish Immunology. 53, p. 82 1 p.

Research output: Contribution to journalAbstract

Cloning, expression analysis and bioactivity studies of rainbow trout (Onchorhynchus mykiss) interleukin-22

Monte, M. M., Zou, J., Wang, T., Carrington, A. & Secombes, C. J., Jul 2011, In : Cytokine. 55, 1, p. 62-73 12 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Cloning and expression analysis of the transforming growth factor-beta receptors type 1 and 2 in the rainbow trout Oncorhynchus mykiss

Maehr, T., Wang, T., González Vecino, J. L., Wadsworth, S. & Secombes, C. J., May 2012, In : Developmental and Comparative Immunology. 37, 1, p. 115-126 12 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Cloning and expression analysis of two ROR-γ homologues (ROR-γa1 and ROR-γa2) in rainbow trout Oncorhynchus mykiss

Monte, M. M., Wang, T., Costa, M. M., Harun, N. O. & Secombes, C. J., Aug 2012, In : Fish & Shellfish Immunology. 33, 2, p. 365-374 10 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Cloning of the IL-1β3 gene and IL-1β4 pseudogene in salmonids uncovers a second type of IL-1β gene in teleost fish

Husain, M., Bird, S., van Zwieten, R., Secombes, C. J. & Wang, T., Nov 2012, In : Developmental and Comparative Immunology. 38, 3, p. 431-446 16 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

Cloning of two rainbow trout nucleotide-binding oligomerization domain containing 2 (NOD2) splice variants and functional characterization of the NOD2 effector domains

Chang, M., Wang, T., Nie, P., Zou, J. & Secombes, C. J., Jan 2011, In : Fish & Shellfish Immunology. 30, 1, p. 118-127 10 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)

Cross Talk Between Growth and Immunity: Coupling of the IGF Axis to Conserved Cytokine Pathways in Rainbow Trout

Alzaid, A., Castro, R., Wang, T., Secombes, C. J., Boudinot, P., Macqueen, D. J. & Martin, S. A. M., 1 Apr 2016, In : Endocrinology. 157, 5, p. 1942–1955 13 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Detection of interleukin (IL)-22 protein expression in rainbow trout (Oncorhynchus mykiss)

Hu, Y., Wang, T., Carpio, Y., Scott, C., Wang, T., Liu, F., Monte, M., Alnabulsi, A. & Secombes, C. J., Aug 2019, In : Fish & Shellfish Immunology. 91, p. 445 1 p.

Research output: Contribution to journalAbstract

5 Citations (Scopus)

Differential effects of interleukin 6 and lipopolysaccharide on teleost B lymphocytes

Abos, B., Wang, T., Castro, R., Leal, E., Luque, A., Havixbeck, J., Barreda, D., Secombes, C. J. & Tafalla, C., Jun 2016, In : Fish & Shellfish Immunology. 53, SI, p. 72 1 p.

Research output: Contribution to journalAbstract

47 Citations (Scopus)
Open Access
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4 Citations (Scopus)
1 Downloads (Pure)
Open Access
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9 Citations (Scopus)
6 Downloads (Pure)

Distinct Differentiation Programs Triggered by IL-6 And LPS in Teleost IgM+ B Cells in the Absence of Germinal Centers

Abós, B., Wang, T., Castro, R., Granja, A. G., Leal, E., Havixbeck, J., Luque, A., Barreda, D. R., Secombes, C. J. & Tafalla, C., 2016, In : Scientific Reports. 6, p. 1-16 16 p., 30004.

Research output: Contribution to journalArticle

Open Access
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27 Citations (Scopus)
6 Downloads (Pure)
Open Access
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1 Downloads (Pure)
Open Access
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2 Citations (Scopus)

DNA vaccination against a fish rhabdovirus promotes an early chemokine-related recruitment of B cells to the muscle

Castro, R., Martínez-Alonso, S., Fischer, U., Haro, N. Á. D., Soto-Lampe, V., Wang, T., Secombes, C. J., Lorenzen, N., Lorenzen, E. & Tafalla, C., 26 Feb 2014, In : Vaccine. 32, 10, p. 1160-1168 9 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Effects of repeated anaesthesia on gill and general health of Atlantic salmon, Salmo salar

Chance, R. J., Cameron, G. A., Fordyce, M., Noguera, P., Wang, T., Collins, C., Secombes, C. J. & Collet, B., Dec 2018, In : Journal of Fish Biology. 93, 6, p. 1069-1081 13 p.

Research output: Contribution to journalArticle

Open Access
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4 Citations (Scopus)
9 Downloads (Pure)

Erratum to Role of pathogen-derived cell wall carbohydrates and prostaglandin E2 in immune response and suppression of fish immunity by the oomycete Saprolegnia parasitica

Belmonte, R., Wang, T., Duncan, G. J., Skaar, I., Mélida, H., Bulone, V., van West, P., Secombes, C. J. & Appleton, J. A. (ed.), Jan 2015, In : Infection and Immunity. 83, 1, p. 454 1 p.

Research output: Contribution to journalArticle

Evolution of IFN subgroups in bony fish - 2. analysis of subgroup appearance and expansion in teleost fish with a focus on salmonids

Liu, F., Wang, T., Petit, J., Forlenza, M., Chen, X., Chen, L., Zou, J. & Secombes, C. J., Mar 2020, In : Fish & Shellfish Immunology. 98, p. 564-573 10 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Evolution of Th2 responses: Characterization of IL-4/13 in sea bass (Dicentrarchus labrax L.) and studies of expression and biological activity

Stocchi, V., Wang, T., Randelli, E., Mazzini, M., Gerdol, M., Pallavicini, A., Secombes, C. J., Scapigliati, G. & Buonocore, F., 22 May 2017, In : Scientific Reports. 7, p. 1-15 15 p., 2240.

Research output: Contribution to journalArticle

Open Access
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10 Citations (Scopus)
7 Downloads (Pure)
1 Citation (Scopus)

First in-depth analysis of the novel Th2-type cytokines in salmonid fish reveals distinct patterns of expression and modulation but overlapping bioactivities

Wang, T., Johansson, P., Abós, B., Holt, A., Tafalla, C., Jiang, Y., Wang, A., Xu, Q., Zhitao, Q., Huang, W., Costa, M. M., Diaz-Rosales, P., Holland, J. W. & Secombes, C. J., 9 Feb 2016, In : Oncotarget. 7, 10, p. 10917-10946 30 p., 7295.

Research output: Contribution to journalArticle

Open Access
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58 Citations (Scopus)
8 Downloads (Pure)

Fish Suppressors of Cytokine Signaling (SOCS): Gene Discovery, Modulation of Expression and Function

Wang, T., Gorgoglione, B., Maehr, T., Holland, J. W., Vecino, J. L. G., Wadsworth, S. & Secombes, C. J., 2011, In : Journal of signal transduction. 2011, 20 p., 905813.

Research output: Contribution to journalArticle

Open Access
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6 Downloads (Pure)

Five subfamilies of β-defensin genes are present in salmonids: evolutionary insights and expression analysis in Atlantic salmon Salmo salar

Harte, A., Tian, G., Xu, Q., Secombes, C. J. & Wang, T., Mar 2020, In : Developmental and Comparative Immunology. 104, 103560.

Research output: Contribution to journalArticle

Four CISH paralogues are present in rainbow trout Oncorhynchus mykiss: differential expression and modulation during immune responses and development

Maehr, T., Vecino, J. L. G., Wadsworth, S., Wang, T. & Secombes, C. J., Nov 2014, In : Molecular Immunology. 62, 1, p. 186-198 13 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Four selenoprotein P genes exist in salmonids: Analysis of their origin and expression following Se supplementation and bacterial infection

Pohl, M. A. N., Wang, T., Pohl, T., Sweetman, J., Martin, S. A. M. & Secombes, C. J., 20 Dec 2018, In : PloS ONE. 13, 12, e0209381.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
6 Downloads (Pure)

Functional characterization of a nonmammalian IL-21: Rainbow trout Oncorhynchus mykiss IL-21 upregulates the expression of the Th cell signature cytokines IFN-γ, IL-10, and IL-22

Wang, T., Diaz-Rosales, P., Costa, M. M., Martin, S. A. M., Campbell, S., Snow, M., Collet, B. & Secombes, C. J., 15 Jan 2011, In : The Journal of Immunology. 186, 2, p. 708-721 14 p.

Research output: Contribution to journalArticle

108 Citations (Scopus)

Gene expression analysis of isolated salmonid GALT leucocytes in response to PAMPs and recombinant cytokines

Attaya, A., Wang, T., Zou, J., Herath, T., Adams, A., Secombes, C. J. & Yoon, S., 1 Sep 2018, In : Fish & Shellfish Immunology. 80, p. 426-436 11 p.

Research output: Contribution to journalArticle

Open Access
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5 Citations (Scopus)
3 Downloads (Pure)
77 Citations (Scopus)

Growth and immunity cross-talk in rainbow trout: Suppression of the insulin-like growth factor system during infection

Alzaid, A., Castro, R., Wang, T., Secombes, C. J., Boudinot, P., Macqueen, D. J. & Martin, S. A. M., Jun 2016, In : Fish & Shellfish Immunology. 53, p. 111 1 p.

Research output: Contribution to journalAbstract

Identification, molecular characterization and functional analysis of interleukin (IL)-2 and IL-2like (IL-2L) cytokines in sea bass (Dicentrarchus labrax L.)

Buonocore, F., Gerdol, M., Pallavicini, A., Stocchi, V., Randelli, E., Belardinelli, M. C., Miccoli, A., Saraceni, P. R., Secombes, C. J., Scapigliati, G. & Wang, T., Feb 2020, In : Cytokine. 126, 154898.

Research output: Contribution to journalArticle

2 Citations (Scopus)
16 Citations (Scopus)

Identification and characterization of three CXC chemokines in Asian swamp eel (Monopterus albus) uncover a third CXCL11_like group in fish

Yuan, H., Li, Y., Han, P., Tian, G., Zhang, W., Guo, H., Xu, Q. & Wang, T., Dec 2019, In : Developmental and Comparative Immunology. 101, 9 p., 103454.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Identification and expression analysis of an atypical chemokine receptor-2 (ACKR2)/CC chemokine binding protein-2 (CCBP2) in rainbow trout (Oncorhynchus mykiss)

Qi, Z., Jiang, Y., Holland, J. W., Nie, P., Secombes, C. J. & Wang, T., Jun 2015, In : Fish & Shellfish Immunology. 44, 2, p. 389-398 10 p.

Research output: Contribution to journalArticle