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• Analysis of the relationship between the KRAS G12V oncogene and the Hippo effector YAP1 in embryonal rhabdomyosarcoma

  Mohamed, A. D., Shah, N., Hettmer, S., Vargesson, N. & Wackerhage, H., 23 Oct 2018, In: Scientific Reports. 8, 10 p., 15674.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Embryonal Rhabdomyosarcoma
  • Myoblasts
  • Oncogenes
  • Rhabdomyosarcoma
  • Gene Expression
  4 Citations (Scopus)

  7 Downloads (Pure)

• A new mammalian model system for thalidomide teratogenesis: Monodelphis domestica

  Sorensen, D., Sackett, A., Urban, D. J., Maier, J., Vargesson, N. & Sears, K. E., Jun 2017, In: Reproductive Toxicology. 70, p. 126-132 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Monodelphis
  • Teratogenesis
  • Thalidomide
  • Opossums
  • Defects
  5 Citations (Scopus)

  6 Downloads (Pure)

• Antiangiogenic Activity and in Silico Cereblon Binding Analysis of Novel Thalidomide Analogs

  Peach, M. L., Beedie, S-L., Chau, C. H., Collins, M. K., Markolovic, S., Luo, W., Tweedie, D., Steinebach, C., Greig, N. H., Gütschow, M., Vargesson, N., Nicklaus, M. C. & Figg, W. D., 2 Dec 2020, In: Molecules. 25, 23, 18 p., 5683.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Thalidomide
  • Computer Simulation
  • analogs
  • aorta
  • rats
  1 Citation (Scopus)

  1 Downloads (Pure)

• Arterial dysgenesis and limb defects: Clinical and experimental examples

  Vargesson, N. & Hootnick, D. R., 1 Jun 2017, In: Reproductive Toxicology. 70, p. 21-29 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Teratogens
  • Extremities
  • Defects
  • Aberrations
  • Thalidomide
  15 Citations (Scopus)

  6 Downloads (Pure)

• Common and Distinctive Functions of the Hippo Effectors Taz and Yap in Skeletal Muscle Stem Cell Function

  Sun, C., De Mello, V., Mohamed, A., Quiroga, H. P. O., Garcia-Munoz, A., Al Bloshi, A., Tremblay, A. M., von Kriegsheim, A., Collie-Duguid, E., Vargesson, N., Matallanas, D., Wackerhage, H. & Zammit, P. S., 1 Aug 2017, In: Stem Cells. 35, 8, p. 1958-1972 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Muscle Cells
  • Skeletal Muscle
  • Stem Cells
  • Regeneration
  • Myoblasts
  48 Citations (Scopus)

  11 Downloads (Pure)

• Congenital Embryonic Arterial and Skeletal Dysgeneses

  Hootnick, D. R., DeSesso, J. & Vargesson, N., Jul 2016, In: RadioGraphics. 36, 4, p. 1257-1257 1 p.

  Research output: Contribution to journal › Letter › peer-review
  1 Citation (Scopus)

• CPS49-induced neurotoxicity does not cause limb patterning anomalies in developing chicken embryos

  Mahony, C., McMenemy, S., Rafipay, A. J., Beedie, S-L., Rosa Fraga, L., Gutschow, M., Figg, W. D., Erskine, L. & Vargesson, N., 1 Mar 2018, In: Journal of Anatomy. 232, 4, p. 568-574 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • neurotoxicity
  • embryo
  • limbs (animal)
  • Chickens
  • chick embryos
  5 Citations (Scopus)

  6 Downloads (Pure)

• Design, synthesis and biological assessment of N-adamantyl, substituted adamantyl and noradamantyl phthalimidines for nitrite, TNF-α and angiogenesis inhibitory activities

  Luo, W., Tweedie, D., Beedie, S-L., Vargesson, N., Figg, W. D., Greig, N. H. & Scerba, M. T., 1 May 2018, In: Bioorganic & Medicinal Chemistry. 26, 8, p. 1547-1559 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • phthalimidine
  • Nitrites
  • Nitration
  • Thioamides
  • Libraries
  10 Citations (Scopus)

  8 Downloads (Pure)

• Developmental Angiogenesis

  Vargesson, N., Jun 2017, In: Reproductive Toxicology. 70, p. 1-2 2 p.

  Research output: Contribution to journal › Editorial › peer-review

  • Blood vessels
  • Molecules
  • Tissue
  • Endothelial cells
  • Teratogens

• Embryos, teratogens and birth defects

  Vargesson, N., Sep 2017, In: Journal of Anatomy. 231, 3, p. 449 1 p.

  Research output: Contribution to journal › Abstract › peer-review

• Expression analysis of limb element markers during mouse embryonic development

  Rafipay, A., Berg, A. L. R., Erskine, L. & Vargesson, N., 20 Nov 2018, In: Developmental Dynamics. 247, 11, p. 1217-1226 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Embryonic Development
  • Extremities
  • Intermediate Filaments
  • Ligaments
  • Tendons
  4 Citations (Scopus)

  7 Downloads (Pure)

• Genetic association and characterization of FSTL5 in isolated clubfoot

  Khanshour, A. M., Kidane, Y., Kozlitina, J., Cornelia, R., Rafipay, A., De Mello, V., Weston, M., Paria, N., Khalid, A., Hecht, J. T., Dobbs, M. B., Richards, B. S., Vargesson, N., Kent Hamra, F., Wilson, M., Wise, C., Gurnett, C. A. & Rios, J. J., 15 Nov 2020, In: Human Molecular Genetics. 29, 22, p. 3717-3728 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Clubfoot
  • Hindlimb
  • Follistatin
  • Growth Plate
  • Genome-Wide Association Study

• In Vivo screening and discovery of novel candidate thalidomide analogs in the zebrafish embryo and chicken embryo model systems

  Beedie, S. L., Rore, H. M., Barnett, S., Chau, C. H., Luo, W., Greig, N. H., Figg, W. D. & Vargesson, N., 22 Apr 2016, In: Oncotarget. 7, 22, p. 33237-33245 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Thalidomide
  • Zebrafish
  • Chickens
  • Embryonic Structures
  • Leprosy
  29 Citations (Scopus)

  5 Downloads (Pure)

• Knockdown of Slit signalling during limb development leads to a reduction in humerus length

  Rafipay, A., Dun, X-P., Parkinson, D. B., Erskine, L. & Vargesson, N., 21 Dec 2020, (E-pub ahead of print) In: Developmental Dynamics. 38 p.

  Research output: Contribution to journal › Article › peer-review

  • Humerus
  • Extremities
  • Chickens
  • Limb Buds
  • Human Mammary Glands

• Lens-regulated retinoic acid signalling controls expansion of the developing eye

  Smith, J. N., Walker, H. M., Thompson, H., Collinson, J. M., Vargesson, N. & Erskine, L., 10 Oct 2018, In: Development. 145, 19, 13 p., dev167171.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Tretinoin
  • Lenses
  • Crystalline Lens
  • Eye
  • Retina
  6 Citations (Scopus)

  1 Downloads (Pure)

• Limbal epithelial stem cell activity and corneal epithelial cell cycle parameters in adult and aging mice

  Sagga, N., Kuffova, L., Vargesson, N., Erskine, L. & Collinson, J. M., 31 Dec 2018, In: Stem Cell Research. 33, p. 185-198 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cell Cycle
  • Stem Cells
  • Epithelial Cells
  • Deoxyuridine
  • Eye
  8 Citations (Scopus)

  6 Downloads (Pure)

• Molecular analysis of regulative events in the developing chick limb

  Mahony, C. & Vargesson, N., 1 Jul 2013, In: Journal of Anatomy. 223, 1, p. 1-13 13 p.

  Research output: Contribution to journal › Article › peer-review

  • molecular analysis
  • limbs (animal)
  • limb
  • chicks
  • Extremities
  6 Citations (Scopus)

• Pomalidomide is nonteratogenic in chicken and zebrafish embryos and nonneurotoxic in vitro

  Mahony, C., Erskine, L., Niven, J., Greig, N. H., Figg, W. D. & Vargesson, N., 30 Jul 2013, In: PNAS. 110, 31, p. 12703-12708 6 p.

  Research output: Contribution to journal › Article › peer-review

  • pomalidomide
  • Lenalidomide
  • Thalidomide
  • Zebrafish
  • Chickens
  38 Citations (Scopus)

• Positional Information – a concept underpinning our understanding of developmental biology

  Vargesson, N., 1 Mar 2020, In: Developmental Dynamics. 249, 3, p. 298-312 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Developmental Biology
  • Embryonic Development
  • Regeneration
  • Extremities
  3 Citations (Scopus)

  1 Downloads (Pure)

• Quantitative assessment of intrinsic noise for visually guided behaviour in zebrafish

  Spilioti, M., Vargesson, N. & Neri, P., Oct 2016, In: Vision Research. 127, p. 104-114 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Zebrafish
  • Noise
  • Animals
  • Vertebrates
  • Equipment and Supplies
  1 Citation (Scopus)

  5 Downloads (Pure)

• Regarding a limb with PFFD, fibular dimelia and mirror foot deformity

  Hootnick, D. R., Vargesson, N. & Birch, J., 1 Nov 2017, In: Journal of Pediatric Orthopaedics B. 26, 6, p. 589-589 1 p.

  Research output: Contribution to journal › Letter › peer-review

• Reply to D’Amato et al. and Zeldis et al. Screening of thalidomide derivatives in chicken and zebrafish embryos

  Vargesson, N., Mahony, C., Erskine, L., Niven, J., Greig, N. H. & Figg, W. D., 10 Dec 2013, In: PNAS. 110, 50, E4820.

  Research output: Contribution to journal › Article › peer-review
  4 Citations (Scopus)

• Role of cereblon in angiogenesis and in mediating the antiangiogenic activity of immunomodulatory drugs

  Beedie, S. L., Huang, P. A., Harris, E. M., Strope, J. D., Mahony, C., Chau, C. H., Vargesson, N. & Figg, W. D., Sep 2020, In: The FASEB Journal. 34, 9, p. 11395-11404 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Endothelial cells
  • Endothelial Cells
  • Cell proliferation
  • Cullin Proteins
  • Pharmaceutical Preparations
  3 Citations (Scopus)

• Shared mechanism of teratogenicity of anti-angiogenic drugs identified in the chicken embryo model

  Beedie, S. L., Mahony, C., Walker, H. M., Chau, C. H., Figg, W. D. & Vargesson, N., 22 Jul 2016, In: Scientific Reports. 6, p. 1-10 10 p., 30038.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Angiogenesis Inhibitors
  • Chickens
  • Embryonic Structures
  • O-(Chloroacetylcarbamoyl)fumagillol
  • Axitinib
  27 Citations (Scopus)

  6 Downloads (Pure)

• Teratogenesis

  Vargesson, N. & Fraga, L., 15 Dec 2017, In: eLS. p. 1-7 7 p., a0026056.

  Research output: Contribution to journal › Article › peer-review

  • Teratogenesis
  • Teratogens
  • Teratology
  • Rubella virus
  • Zika Virus

• Thalidomide

  Vargesson, N., 21 Apr 2017, Reproductive and Developmental Toxicology . Gupta, R. C. (ed.). 2nd ed. Academic Press, p. 467-479 13 p. Chapter 26

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Thalidomide
  • Leprosy
  • Disasters
  • Multiple Myeloma
  • Crohn Disease

• Thalidomide and birth defects

  Fraga, L., Diamond, A. & Vargesson, N., 2016, In: eLS. January 2016, p. 1-11 11 p., a0026052.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Thalidomide
  • Ectromelia
  • Teratogenesis
  • Antiemetics
  • Inner Ear
  7 Downloads (Pure)

• Thalidomide embryopathy: an enigmatic challenge

  Vargesson, N., 2013, In: ISRN Developmental Biology. 2013, 18 p., 241016.

  Research output: Contribution to journal › Literature review › peer-review

  Open Access

  File

  • Fetal Diseases
  • Thalidomide
  • Leprosy
  • Pharmaceutical Preparations
  • Ectromelia
  9 Downloads (Pure)

• The chick limb: embryology, genetics and teratology

  Davey, M. G., Towers, M., Vargesson, N. & Tickle, C., 19 Mar 2018, In: International Journal of Developmental Biology. 62, p. 85-95 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Teratology
  • Embryology
  • Extremities
  • Chick Embryo
  • Vertebrates
  9 Citations (Scopus)

  6 Downloads (Pure)

• The developmental and genetic basis of ‘clubfoot’ in the peroneal muscular atrophy mutant mouse

  Collinson, J. M., Lindstrom, N. O., Neves, C., Wallace, K., Meharg, C., Charles, R., Fraser, A., Mbogo, I., Oras, K., Nakamoto, M., Barker, S., Duce, S., Miedzybrodzka, Z. & Vargesson, N., 8 Feb 2018, In: Development. 145, 3, 15 p., dev160093.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Clubfoot
  • Charcot-Marie-Tooth Disease
  • Lim Kinases
  • Motor Neurons
  • Sciatic Nerve
  7 Citations (Scopus)

  14 Downloads (Pure)

• 'The Legacy of Thalidomide' - a multidisciplinary Meeting held at the University of York, UK on September 30, 2016

  Newbronner, E., Vargesson, N. & Atkin, K., 1 Mar 2017, In: Birth Defects Research. 109, 4, p. 296–299 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Thalidomide
  • Survivors
  • Morning Sickness
  • Pharmaceutical Preparations
  • Fetal Diseases
  1 Citation (Scopus)

  5 Downloads (Pure)

• The Primodos components Noretheristerone acetate and Ethinyl estradiol induce developmental abnormalities in zebrafish embryos

  Brown, S., Rosa Fraga, L., Cameron, G., Erskine, L. & Vargesson, N., 13 Feb 2018, In: Scientific Reports. 8, 14 p., 2917.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Norethindrone Acetate
  • Ethinyl Estradiol
  • Zebrafish
  • Acetates
  • Embryonic Structures
  5 Citations (Scopus)

  9 Downloads (Pure)

• The syndrome of proximal femur, fibula, and midline metatarsal long bone deficiencies

  Hootnick, D. R. & Vargesson, N., 1 Sep 2018, In: Birth Defects Research. 110, 15, p. 1188-1193 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Fibula
  • Metatarsal Bones
  • Bone
  • Femur
  • Extremities
  6 Citations (Scopus)

  2 Downloads (Pure)

• The teratogenic effects of thalidomide on limbs

  Vargesson, N., 1 Jan 2019, In: Journal of hand surgery-European volume. 44, 1, p. 88-95 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Thalidomide
  • Extremities
  • Morning Sickness
  • Ectromelia
  • Erythema Nodosum
  16 Citations (Scopus)

  11 Downloads (Pure)

• Vascular anomalies of the upper limb

  Mende, K., Vargesson, N. & Sivakumar, B., 1 Mar 2019, In: Journal of hand surgery-European volume. 44, 3, p. 233-241 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Upper Extremity
  • Blood Vessels
  • Terminology
  • Hand
  • Pathology
  3 Citations (Scopus)

  2 Downloads (Pure)

• VEGF-A and neuropilin 1 (NRP1) shape axon projections in the developing CNS via dual roles in neurons and blood vessels

  Erskine, L., Francois, U., Denti, L., Joyce, A., Tillo, M., Bruce, F., Vargesson, N. & Ruhrberg, C., 4 Jul 2017, In: Development. 144, 13, p. 2504-2516 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Neuropilin-1
  • Axons
  • Vascular Endothelial Growth Factor A
  • Neurons
  • Blood Vessels
  19 Citations (Scopus)

  8 Downloads (Pure)

• Vertebrate embryos as tools for anti-angiogenic drug screening and function

  Beedie, S., Diamond, A. J., Rosa Fraga, L., Figg, W. D. & Vargesson, N., 1 Jun 2017, In: Reproductive Toxicology. 70, p. 49-59 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Angiogenesis Inhibitors
  • Preclinical Drug Evaluations
  • Assays
  • Screening
  • Vertebrates
  7 Citations (Scopus)

  14 Downloads (Pure)

• Vgll3 interacts with Yap/Taz-Tead1-4-dependent gene expression in skeletal muscle

  Figeac, N., Mohamed, A. A. D., Sun, C., Schonfelder, M., Gomez, D., Garcia-Munoz, A., Missiaglia, E., Collie-Duguid, E., De Mello, V., Pobbati, A. V., Jaka, O., Harridge, S. D. R., Hong, W., Shipley, J., Vargesson, N., Zammit, P. S. & Wackerhage, H., Mar 2019, In: European Journal of Translational Myology. 29, 1, p. 53-53 1 p.

  Research output: Contribution to journal › Abstract › peer-review

  Open Access

  File
  21 Downloads (Pure)

• VGLL3 operates via TEAD1, TEAD3 and TEAD4 to influence myogenesis in skeletal muscle

  Figeac, N., Mohamed, A. D., Sun, C., Schönfelder, M., Matallanas, D., Garcia-Munoz, A., Missiaglia, E., Collie-Duguid, E., De Mello, V., Pobbati, A. V., Pruller, J., Jaka, O., Harridge, S. D. R., Hong, W., Shipley, J., Vargesson, N., Zammit, P. S. & Wackerhage, H., 5 Jul 2019, In: Journal of Cell Science. 132, jcs225946 .

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Skeletal Muscle
  • Muscles
  • Myoblasts
  • Alveolar Rhabdomyosarcoma
  • Insulin-Like Growth Factor Binding Proteins
  15 Citations (Scopus)

  6 Downloads (Pure)