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• Literature review

  Thalidomide embryopathy: an enigmatic challenge

  Vargesson, N., 2013, In: ISRN Developmental Biology. 2013, 18 p., 241016.

  Research output: Contribution to journal › Literature review › peer-review

  Open Access

  File

  • Fetal Diseases
  • Thalidomide
  • Leprosy
  • Pharmaceutical Preparations
  • Ectromelia
  11 Downloads (Pure)
• Letter

  Congenital Embryonic Arterial and Skeletal Dysgeneses

  Hootnick, D. R., DeSesso, J. & Vargesson, N., Jul 2016, In: RadioGraphics. 36, 4, p. 1257-1257 1 p.

  Research output: Contribution to journal › Letter › peer-review
  1 Citation (Scopus)

• Regarding a limb with PFFD, fibular dimelia and mirror foot deformity

  Hootnick, D. R., Vargesson, N. & Birch, J., 1 Nov 2017, In: Journal of Pediatric Orthopaedics B. 26, 6, p. 589-589 1 p.

  Research output: Contribution to journal › Letter › peer-review
• Editorial

  Developmental Angiogenesis

  Vargesson, N., Jun 2017, In: Reproductive Toxicology. 70, p. 1-2 2 p.

  Research output: Contribution to journal › Editorial › peer-review

  • Blood vessels
  • Molecules
  • Tissue
  • Endothelial cells
  • Teratogens
• Chapter

  Thalidomide

  Vargesson, N., 21 Apr 2017, Reproductive and Developmental Toxicology . Gupta, R. C. (ed.). 2nd ed. Academic Press, p. 467-479 13 p. Chapter 26

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Thalidomide
  • Leprosy
  • Disasters
  • Multiple Myeloma
  • Crohn Disease
• Article

  A new mammalian model system for thalidomide teratogenesis: Monodelphis domestica

  Sorensen, D., Sackett, A., Urban, D. J., Maier, J., Vargesson, N. & Sears, K. E., Jun 2017, In: Reproductive Toxicology. 70, p. 126-132 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Monodelphis
  • Teratogenesis
  • Thalidomide
  • Opossums
  • Defects
  5 Citations (Scopus)

  6 Downloads (Pure)

• Antiangiogenic Activity and in Silico Cereblon Binding Analysis of Novel Thalidomide Analogs

  Peach, M. L., Beedie, S-L., Chau, C. H., Collins, M. K., Markolovic, S., Luo, W., Tweedie, D., Steinebach, C., Greig, N. H., Gütschow, M., Vargesson, N., Nicklaus, M. C. & Figg, W. D., 2 Dec 2020, In: Molecules. 25, 23, 18 p., 5683.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Thalidomide
  • Computer Simulation
  • analogs
  • aorta
  • rats
  1 Downloads (Pure)

• Anticancer Properties of a Novel Class of Tetrafluorinated Thalidomide Analogues

  Beedie, S. L., Peer, C. J., Pisle, S., Gardner, E. R., Mahony, C., Barnett, S., Ambrozak, A., Gütschow, M., Chau, C. H., Vargesson, N. & Figg, W. D., Oct 2015, In: Molecular Cancer Therapeutics. 14, 10, p. 2228-2237 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Thalidomide
  • Embryonic Structures
  • Zebrafish
  • carboxyamido-triazole
  • PC-3 Cells
  21 Citations (Scopus)

  6 Downloads (Pure)

• Arterial dysgenesis and limb defects: Clinical and experimental examples

  Vargesson, N. & Hootnick, D. R., 1 Jun 2017, In: Reproductive Toxicology. 70, p. 21-29 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Teratogens
  • Extremities
  • Defects
  • Aberrations
  • Thalidomide
  15 Citations (Scopus)

  10 Downloads (Pure)

• Common and Distinctive Functions of the Hippo Effectors Taz and Yap in Skeletal Muscle Stem Cell Function

  Sun, C., De Mello, V., Mohamed, A., Quiroga, H. P. O., Garcia-Munoz, A., Al Bloshi, A., Tremblay, A. M., von Kriegsheim, A., Collie-Duguid, E., Vargesson, N., Matallanas, D., Wackerhage, H. & Zammit, P. S., 1 Aug 2017, In: Stem Cells. 35, 8, p. 1958-1972 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Muscle Cells
  • Skeletal Muscle
  • Stem Cells
  • Regeneration
  • Myoblasts
  45 Citations (Scopus)

  11 Downloads (Pure)

• Genetic association and characterization of FSTL5 in isolated clubfoot

  Khanshour, A. M., Kidane, Y., Kozlitina, J., Cornelia, R., Rafipay, A., De Mello, V., Weston, M., Paria, N., Khalid, A., Hecht, J. T., Dobbs, M. B., Richards, B. S., Vargesson, N., Kent Hamra, F., Wilson, M., Wise, C., Gurnett, C. A. & Rios, J. J., 15 Nov 2020, In: Human Molecular Genetics. 29, 22, p. 3717-3728 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Clubfoot
  • Hindlimb
  • Follistatin
  • Growth Plate
  • Genome-Wide Association Study

• In Vivo screening and discovery of novel candidate thalidomide analogs in the zebrafish embryo and chicken embryo model systems

  Beedie, S. L., Rore, H. M., Barnett, S., Chau, C. H., Luo, W., Greig, N. H., Figg, W. D. & Vargesson, N., 22 Apr 2016, In: Oncotarget. 7, 22, p. 33237-33245 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Thalidomide
  • Zebrafish
  • Chickens
  • Embryonic Structures
  • Leprosy
  28 Citations (Scopus)

  5 Downloads (Pure)

• Knockdown of Slit signalling during limb development leads to a reduction in humerus length

  Rafipay, A., Dun, X-P., Parkinson, D. B., Erskine, L. & Vargesson, N., 21 Dec 2020, In: Developmental Dynamics. 38 p.

  Research output: Contribution to journal › Article › peer-review

  • Humerus
  • Extremities
  • Chickens
  • Limb Buds
  • Human Mammary Glands

• Molecular analysis of regulative events in the developing chick limb

  Mahony, C. & Vargesson, N., 1 Jul 2013, In: Journal of Anatomy. 223, 1, p. 1-13 13 p.

  Research output: Contribution to journal › Article › peer-review

  • molecular analysis
  • limbs (animal)
  • limb
  • chicks
  • Extremities
  6 Citations (Scopus)

• Pomalidomide is nonteratogenic in chicken and zebrafish embryos and nonneurotoxic in vitro

  Mahony, C., Erskine, L., Niven, J., Greig, N. H., Figg, W. D. & Vargesson, N., 30 Jul 2013, In: PNAS. 110, 31, p. 12703-12708 6 p.

  Research output: Contribution to journal › Article › peer-review

  • pomalidomide
  • Lenalidomide
  • Thalidomide
  • Zebrafish
  • Chickens
  37 Citations (Scopus)

• Positional Information – a concept underpinning our understanding of developmental biology

  Vargesson, N., 1 Mar 2020, In: Developmental Dynamics. 249, 3, p. 298-312 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Developmental Biology
  • Embryonic Development
  • Regeneration
  • Extremities
  2 Citations (Scopus)

  1 Downloads (Pure)

• Quantitative assessment of intrinsic noise for visually guided behaviour in zebrafish

  Spilioti, M., Vargesson, N. & Neri, P., Oct 2016, In: Vision Research. 127, p. 104-114 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Zebrafish
  • Noise
  • Animals
  • Vertebrates
  • Equipment and Supplies
  1 Citation (Scopus)

  5 Downloads (Pure)

• Reply to D’Amato et al. and Zeldis et al. Screening of thalidomide derivatives in chicken and zebrafish embryos

  Vargesson, N., Mahony, C., Erskine, L., Niven, J., Greig, N. H. & Figg, W. D., 10 Dec 2013, In: PNAS. 110, 50, E4820.

  Research output: Contribution to journal › Article › peer-review
  4 Citations (Scopus)

• Role of cereblon in angiogenesis and in mediating the antiangiogenic activity of immunomodulatory drugs

  Beedie, S. L., Huang, P. A., Harris, E. M., Strope, J. D., Mahony, C., Chau, C. H., Vargesson, N. & Figg, W. D., Sep 2020, In: The FASEB Journal. 34, 9, p. 11395-11404 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Endothelial cells
  • Endothelial Cells
  • Cell proliferation
  • Cullin Proteins
  • Pharmaceutical Preparations
  1 Citation (Scopus)

• Shared mechanism of teratogenicity of anti-angiogenic drugs identified in the chicken embryo model

  Beedie, S. L., Mahony, C., Walker, H. M., Chau, C. H., Figg, W. D. & Vargesson, N., 22 Jul 2016, In: Scientific Reports. 6, p. 1-10 10 p., 30038.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Angiogenesis Inhibitors
  • Chickens
  • Embryonic Structures
  • O-(Chloroacetylcarbamoyl)fumagillol
  • Axitinib
  27 Citations (Scopus)

  6 Downloads (Pure)

• Teratogenesis

  Vargesson, N. & Fraga, L., 15 Dec 2017, In: eLS. p. 1-7 7 p., a0026056.

  Research output: Contribution to journal › Article › peer-review

  • Teratogenesis
  • Teratogens
  • Teratology
  • Rubella virus
  • Zika Virus

• Thalidomide and birth defects

  Fraga, L., Diamond, A. & Vargesson, N., 2016, In: eLS. January 2016, p. 1-11 11 p., a0026052.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Thalidomide
  • Ectromelia
  • Teratogenesis
  • Antiemetics
  • Inner Ear
  7 Downloads (Pure)

• Thalidomide-induced Teratogenesis: History and Mechanisms

  Vargesson, N., Jun 2015, In: Birth Defects Research. Part C, Embryo Today: Reviews. 105, 2, p. 140-156 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Teratogenesis
  • Thalidomide
  • History
  • Pharmaceutical Preparations
  • Morning Sickness
  283 Citations (Scopus)

  15 Downloads (Pure)

• 'The Legacy of Thalidomide' - a multidisciplinary Meeting held at the University of York, UK on September 30, 2016

  Newbronner, E., Vargesson, N. & Atkin, K., 1 Mar 2017, In: Birth Defects Research. 109, 4, p. 296–299 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Thalidomide
  • Survivors
  • Morning Sickness
  • Pharmaceutical Preparations
  • Fetal Diseases
  1 Citation (Scopus)

  5 Downloads (Pure)

• VEGF-A and neuropilin 1 (NRP1) shape axon projections in the developing CNS via dual roles in neurons and blood vessels

  Erskine, L., Francois, U., Denti, L., Joyce, A., Tillo, M., Bruce, F., Vargesson, N. & Ruhrberg, C., 4 Jul 2017, In: Development. 144, 13, p. 2504-2516 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Neuropilin-1
  • Axons
  • Vascular Endothelial Growth Factor A
  • Neurons
  • Blood Vessels
  17 Citations (Scopus)

  8 Downloads (Pure)

• Vertebrate embryos as tools for anti-angiogenic drug screening and function

  Beedie, S., Diamond, A. J., Rosa Fraga, L., Figg, W. D. & Vargesson, N., 1 Jun 2017, In: Reproductive Toxicology. 70, p. 49-59 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Angiogenesis Inhibitors
  • Preclinical Drug Evaluations
  • Assays
  • Screening
  • Vertebrates
  7 Citations (Scopus)

  31 Downloads (Pure)
• Abstract

  Embryos, teratogens and birth defects

  Vargesson, N., Sep 2017, In: Journal of Anatomy. 231, 3, p. 449 1 p.

  Research output: Contribution to journal › Abstract › peer-review

• Roles of Roundabout and Slits in developing limb joint formation

  Diamond, A., Erskine, L. & Vargesson, N., Apr 2015, In: International journal of experimental pathology. 96, 2, p. A8-A8 1 p.

  Research output: Contribution to journal › Abstract › peer-review

• Thalidomide-Induced Teratogenesis: Lessons and Insights into Abnormal Development

  Vargesson, N., May 2015, In: Birth Defects Research Part A: Clinical and Molecular Teratology. 103, 5, p. 355-355 1 p., S8.

  Research output: Contribution to journal › Abstract › peer-review