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• Literature review

  Thalidomide embryopathy: an enigmatic challenge

  Vargesson, N., 2013, In: ISRN Developmental Biology. 2013, 18 p., 241016.

  Research output: Contribution to journal › Literature review › peer-review

  Open Access

  File

  • Fetal Diseases
  • Thalidomide
  • Leprosy
  • Pharmaceutical Preparations
  • Ectromelia
  11 Downloads (Pure)
• Letter

  Congenital Embryonic Arterial and Skeletal Dysgeneses

  Hootnick, D. R., DeSesso, J. & Vargesson, N., Jul 2016, In: RadioGraphics. 36, 4, p. 1257-1257 1 p.

  Research output: Contribution to journal › Letter › peer-review
  1 Citation (Scopus)
• Article

  Analysis of the relationship between the KRAS G12V oncogene and the Hippo effector YAP1 in embryonal rhabdomyosarcoma

  Mohamed, A. D., Shah, N., Hettmer, S., Vargesson, N. & Wackerhage, H., 23 Oct 2018, In: Scientific Reports. 8, 10 p., 15674.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Embryonal Rhabdomyosarcoma
  • Myoblasts
  • Oncogenes
  • Rhabdomyosarcoma
  • Gene Expression
  4 Citations (Scopus)

  9 Downloads (Pure)

• Antiangiogenic Activity and in Silico Cereblon Binding Analysis of Novel Thalidomide Analogs

  Peach, M. L., Beedie, S-L., Chau, C. H., Collins, M. K., Markolovic, S., Luo, W., Tweedie, D., Steinebach, C., Greig, N. H., Gütschow, M., Vargesson, N., Nicklaus, M. C. & Figg, W. D., 2 Dec 2020, In: Molecules. 25, 23, 18 p., 5683.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Thalidomide
  • Computer Simulation
  • analogs
  • aorta
  • rats
  1 Downloads (Pure)

• Anticancer Properties of a Novel Class of Tetrafluorinated Thalidomide Analogues

  Beedie, S. L., Peer, C. J., Pisle, S., Gardner, E. R., Mahony, C., Barnett, S., Ambrozak, A., Gütschow, M., Chau, C. H., Vargesson, N. & Figg, W. D., Oct 2015, In: Molecular Cancer Therapeutics. 14, 10, p. 2228-2237 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Thalidomide
  • Embryonic Structures
  • Zebrafish
  • carboxyamido-triazole
  • PC-3 Cells
  21 Citations (Scopus)

  6 Downloads (Pure)

• CPS49-induced neurotoxicity does not cause limb patterning anomalies in developing chicken embryos

  Mahony, C., McMenemy, S., Rafipay, A. J., Beedie, S-L., Rosa Fraga, L., Gutschow, M., Figg, W. D., Erskine, L. & Vargesson, N., 1 Mar 2018, In: Journal of Anatomy. 232, 4, p. 568-574 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • neurotoxicity
  • embryo
  • limbs (animal)
  • Chickens
  • chick embryos
  5 Citations (Scopus)

  6 Downloads (Pure)

• Design, synthesis and biological assessment of N-adamantyl, substituted adamantyl and noradamantyl phthalimidines for nitrite, TNF-α and angiogenesis inhibitory activities

  Luo, W., Tweedie, D., Beedie, S-L., Vargesson, N., Figg, W. D., Greig, N. H. & Scerba, M. T., 1 May 2018, In: Bioorganic & Medicinal Chemistry. 26, 8, p. 1547-1559 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • phthalimidine
  • Nitrites
  • Nitration
  • Thioamides
  • Libraries
  7 Citations (Scopus)

  8 Downloads (Pure)

• Expression analysis of limb element markers during mouse embryonic development

  Rafipay, A., Berg, A. L. R., Erskine, L. & Vargesson, N., 20 Nov 2018, In: Developmental Dynamics. 247, 11, p. 1217-1226 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Embryonic Development
  • Extremities
  • Intermediate Filaments
  • Ligaments
  • Tendons
  4 Citations (Scopus)

  7 Downloads (Pure)

• Genetic association and characterization of FSTL5 in isolated clubfoot

  Khanshour, A. M., Kidane, Y., Kozlitina, J., Cornelia, R., Rafipay, A., De Mello, V., Weston, M., Paria, N., Khalid, A., Hecht, J. T., Dobbs, M. B., Richards, B. S., Vargesson, N., Kent Hamra, F., Wilson, M., Wise, C., Gurnett, C. A. & Rios, J. J., 15 Nov 2020, In: Human Molecular Genetics. 29, 22, p. 3717-3728 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Clubfoot
  • Hindlimb
  • Follistatin
  • Growth Plate
  • Genome-Wide Association Study

• In Vivo screening and discovery of novel candidate thalidomide analogs in the zebrafish embryo and chicken embryo model systems

  Beedie, S. L., Rore, H. M., Barnett, S., Chau, C. H., Luo, W., Greig, N. H., Figg, W. D. & Vargesson, N., 22 Apr 2016, In: Oncotarget. 7, 22, p. 33237-33245 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Thalidomide
  • Zebrafish
  • Chickens
  • Embryonic Structures
  • Leprosy
  28 Citations (Scopus)

  5 Downloads (Pure)

• Knockdown of Slit signalling during limb development leads to a reduction in humerus length

  Rafipay, A., Dun, X-P., Parkinson, D. B., Erskine, L. & Vargesson, N., 21 Dec 2020, In: Developmental Dynamics. 38 p.

  Research output: Contribution to journal › Article › peer-review

  • Humerus
  • Extremities
  • Chickens
  • Limb Buds
  • Human Mammary Glands

• Lens-regulated retinoic acid signalling controls expansion of the developing eye

  Smith, J. N., Walker, H. M., Thompson, H., Collinson, J. M., Vargesson, N. & Erskine, L., 10 Oct 2018, In: Development. 145, 19, 13 p., dev167171.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Tretinoin
  • Lenses
  • Crystalline Lens
  • Eye
  • Retina
  6 Citations (Scopus)

  3 Downloads (Pure)

• Limbal epithelial stem cell activity and corneal epithelial cell cycle parameters in adult and aging mice

  Sagga, N., Kuffova, L., Vargesson, N., Erskine, L. & Collinson, J. M., 31 Dec 2018, In: Stem Cell Research. 33, p. 185-198 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cell Cycle
  • Stem Cells
  • Epithelial Cells
  • Deoxyuridine
  • Eye
  8 Citations (Scopus)

  6 Downloads (Pure)

• Molecular analysis of regulative events in the developing chick limb

  Mahony, C. & Vargesson, N., 1 Jul 2013, In: Journal of Anatomy. 223, 1, p. 1-13 13 p.

  Research output: Contribution to journal › Article › peer-review

  • molecular analysis
  • limbs (animal)
  • limb
  • chicks
  • Extremities
  6 Citations (Scopus)

• Pomalidomide is nonteratogenic in chicken and zebrafish embryos and nonneurotoxic in vitro

  Mahony, C., Erskine, L., Niven, J., Greig, N. H., Figg, W. D. & Vargesson, N., 30 Jul 2013, In: PNAS. 110, 31, p. 12703-12708 6 p.

  Research output: Contribution to journal › Article › peer-review

  • pomalidomide
  • Lenalidomide
  • Thalidomide
  • Zebrafish
  • Chickens
  37 Citations (Scopus)

• Positional Information – a concept underpinning our understanding of developmental biology

  Vargesson, N., 1 Mar 2020, In: Developmental Dynamics. 249, 3, p. 298-312 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Developmental Biology
  • Embryonic Development
  • Regeneration
  • Extremities
  2 Citations (Scopus)

  1 Downloads (Pure)

• Quantitative assessment of intrinsic noise for visually guided behaviour in zebrafish

  Spilioti, M., Vargesson, N. & Neri, P., Oct 2016, In: Vision Research. 127, p. 104-114 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Zebrafish
  • Noise
  • Animals
  • Vertebrates
  • Equipment and Supplies
  1 Citation (Scopus)

  5 Downloads (Pure)

• Reply to D’Amato et al. and Zeldis et al. Screening of thalidomide derivatives in chicken and zebrafish embryos

  Vargesson, N., Mahony, C., Erskine, L., Niven, J., Greig, N. H. & Figg, W. D., 10 Dec 2013, In: PNAS. 110, 50, E4820.

  Research output: Contribution to journal › Article › peer-review
  4 Citations (Scopus)

• Role of cereblon in angiogenesis and in mediating the antiangiogenic activity of immunomodulatory drugs

  Beedie, S. L., Huang, P. A., Harris, E. M., Strope, J. D., Mahony, C., Chau, C. H., Vargesson, N. & Figg, W. D., Sep 2020, In: The FASEB Journal. 34, 9, p. 11395-11404 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Endothelial cells
  • Endothelial Cells
  • Cell proliferation
  • Cullin Proteins
  • Pharmaceutical Preparations
  1 Citation (Scopus)

• Shared mechanism of teratogenicity of anti-angiogenic drugs identified in the chicken embryo model

  Beedie, S. L., Mahony, C., Walker, H. M., Chau, C. H., Figg, W. D. & Vargesson, N., 22 Jul 2016, In: Scientific Reports. 6, p. 1-10 10 p., 30038.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Angiogenesis Inhibitors
  • Chickens
  • Embryonic Structures
  • O-(Chloroacetylcarbamoyl)fumagillol
  • Axitinib
  27 Citations (Scopus)

  6 Downloads (Pure)

• Thalidomide and birth defects

  Fraga, L., Diamond, A. & Vargesson, N., 2016, In: eLS. January 2016, p. 1-11 11 p., a0026052.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Thalidomide
  • Ectromelia
  • Teratogenesis
  • Antiemetics
  • Inner Ear
  7 Downloads (Pure)

• Thalidomide-induced Teratogenesis: History and Mechanisms

  Vargesson, N., Jun 2015, In: Birth Defects Research. Part C, Embryo Today: Reviews. 105, 2, p. 140-156 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Teratogenesis
  • Thalidomide
  • History
  • Pharmaceutical Preparations
  • Morning Sickness
  283 Citations (Scopus)

  15 Downloads (Pure)

• The chick limb: embryology, genetics and teratology

  Davey, M. G., Towers, M., Vargesson, N. & Tickle, C., 19 Mar 2018, In: International Journal of Developmental Biology. 62, p. 85-95 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Teratology
  • Embryology
  • Extremities
  • Chick Embryo
  • Vertebrates
  8 Citations (Scopus)

  6 Downloads (Pure)

• The developmental and genetic basis of ‘clubfoot’ in the peroneal muscular atrophy mutant mouse

  Collinson, J. M., Lindstrom, N. O., Neves, C., Wallace, K., Meharg, C., Charles, R., Fraser, A., Mbogo, I., Oras, K., Nakamoto, M., Barker, S., Duce, S., Miedzybrodzka, Z. & Vargesson, N., 8 Feb 2018, In: Development. 145, 3, 15 p., dev160093.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Clubfoot
  • Charcot-Marie-Tooth Disease
  • Lim Kinases
  • Motor Neurons
  • Sciatic Nerve
  6 Citations (Scopus)

  18 Downloads (Pure)

• The Primodos components Noretheristerone acetate and Ethinyl estradiol induce developmental abnormalities in zebrafish embryos

  Brown, S., Rosa Fraga, L., Cameron, G., Erskine, L. & Vargesson, N., 13 Feb 2018, In: Scientific Reports. 8, 14 p., 2917.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Norethindrone Acetate
  • Ethinyl Estradiol
  • Zebrafish
  • Acetates
  • Embryonic Structures
  5 Citations (Scopus)

  9 Downloads (Pure)

• The syndrome of proximal femur, fibula, and midline metatarsal long bone deficiencies

  Hootnick, D. R. & Vargesson, N., 1 Sep 2018, In: Birth Defects Research. 110, 15, p. 1188-1193 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Fibula
  • Metatarsal Bones
  • Bone
  • Femur
  • Extremities
  6 Citations (Scopus)

  2 Downloads (Pure)
• Abstract

  Roles of Roundabout and Slits in developing limb joint formation

  Diamond, A., Erskine, L. & Vargesson, N., Apr 2015, In: International journal of experimental pathology. 96, 2, p. A8-A8 1 p.

  Research output: Contribution to journal › Abstract › peer-review

• Thalidomide-Induced Teratogenesis: Lessons and Insights into Abnormal Development

  Vargesson, N., May 2015, In: Birth Defects Research Part A: Clinical and Molecular Teratology. 103, 5, p. 355-355 1 p., S8.

  Research output: Contribution to journal › Abstract › peer-review