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Publication Year

  • 2020
  • 2019
  • 2017
  • 2016

Author

  • Iain Greig
2020

A Novel Allosteric Modulator of the Cannabinoid CB1 Receptor Ameliorates Hyperdopaminergia Endophenotypes in Rodent Models

Mielnik, C. A., Sugamori, K. S., Finlay, D. B., Thorpe, H. H. A., Schapira, M., Sivananthan, N., Li, C. K., lam, V. M., Harrington, S., Abdelrahman, M. H., Trembleau, L. A., Burnham, W. M., Khokhar, J. Y., Salahpour, A., Ramsey, A. J., Glass, M., Greig, I. & Ross, R. A., 10 Aug 2020, (Accepted/In press) In : Neuropsychopharmacology.

Research output: Contribution to journalArticle

Evidence that cannabinoid CB1 receptors regulate intraocular pressure via two opposing mechanisms

Miller, S., Daily, L., Ploss, M., Greig, I., Ross, R., Rayana, N. P., Dai, J., Sugali, C. K., Mao, W. & Straiker, A., 14 Sep 2020, In : Experimental Eye Research. 200, 6 p., 108241.

Research output: Contribution to journalArticle

2019

Genomic and non-genomic pathways are both crucial for peak induction of neurite outgrowth by retinoids

Khatib, T., Marini, P., Nunna, S., Chisholm, D. R., Whiting, A., Redfern, C., Greig, I. R. & McCaffery, P., 2 May 2019, In : Cell Communication and Signaling. 17, 16 p., 40.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
8 Downloads (Pure)

Synthetic Retinoids for Use in RAR Mediated Conditions

Whiting, A., Chisholm, D., Valentine, R., Greig, I. R., McCaffery, P. J. A. & Alkhatib, T., 18 Apr 2019, IPC No. C07C 63/66, A61K 31/192, A61K 31/203, A61P 25/28, C07D 209/82, C07D 215/06, European Patent Office, Patent No. WO2017174999, Priority date 6 Apr 2017, Priority No. 2017050977

Research output: Patent

The Trifluoromethyl Group as a Bioisosteric Replacement of the Aliphatic Nitro Group in CB1 Receptor Positive Allosteric Modulators (PAMs)

Tseng, C-C., Baillie, G., Donvito, G., Mustafa, M. A., Juola, S. E., Zanato, C., Massarenti, C., Dall'angelo, S., Harrison, W. T. A., Lichtman, A. H., Ross, R. A., Zanda, M. & Greig, I. R., 2019, In : Journal of Medicinal Chemistry. 62, 10, p. 5049-5062 14 p.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
3 Downloads (Pure)
2017

Development of Fluorinated Analogues of Perhexiline with Improved Pharmacokinetic Properties and Retained Efficacy

Tseng, C-C., Noordali, H., Sani, M., Madhani, M., Grant, D. M., Frenneaux, M., Zanda, M. & Greig, I. R., 13 Apr 2017, In : Journal of Medicinal Chemistry. 60, 7, p. 2780-2789 10 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
6 Downloads (Pure)

Synthetic retinoids for use in RAR mediated conditions

Greig, I. R., McCaffery, P. J. A., Whiting, A., Valentine, R., Chisholm, D. & Khatib, T., 12 Oct 2017, Patent No. WO2017174999

Research output: Patent

2016

Asymmetric Synthesis and Absolute Configuration of (+)- and (–)-Perhexiline

Tseng, C-C., Greig, I. R., Harrison, W. T. A. & Zanda, M., Jan 2016, In : Synthesis. 48, 01, p. 73-78 6 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
7 Downloads (Pure)

Development of indole sulfonamides as cannabinoid receptor negative allosteric modulators

Greig, I. R., Baillie, G. L., Abdelrahman, M., Trembleau, L. & Ross, R. A., 15 Sep 2016, In : Bioorganic & Medicinal Chemistry Letters. 26, 18, p. 4403-4407 5 p.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
8 Downloads (Pure)