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  • 2020
  • 2019
  • 2017
  • 2016

Author

  • Laurent Trembleau
2020

A Novel Allosteric Modulator of the Cannabinoid CB1 Receptor Ameliorates Hyperdopaminergia Endophenotypes in Rodent Models

Mielnik, C. A., Sugamori, K. S., Finlay, D. B., Thorpe, H. H. A., Schapira, M., Sivananthan, N., Li, C. K., lam, V. M., Harrington, S., Abdelrahman, M. H., Trembleau, L. A., Burnham, W. M., Khokhar, J. Y., Salahpour, A., Ramsey, A. J., Glass, M., Greig, I. & Ross, R. A., 10 Aug 2020, (Accepted/In press) In : Neuropsychopharmacology.

Research output: Contribution to journalArticle

A Weakened Immune Response to Synthetic Exo-Peptides Predicts a Potential Biosecurity Risk in the Retrieval of Exo-Microorganisms

Schaefer, K., Dambuza, I. M., Dall'angelo, S., Trembleau, L., Zanda, M., Brown, G. D., Netea, M. G. & Gow, N. A. R., 17 Jul 2020, In : Microorganisms. 8, 7, 14 p., 1066.

Research output: Contribution to journalArticle

Open Access
File
2 Downloads (Pure)

Characterization of the promiscuous N-acyl CoA transferase, LgoC, in legonoxamine biosynthesis

Maglangit, F., Alrashdi, S., Renault, J., Trembleau, L., Victoria, C., Tong, M. H., Wang, S., Kyeremeh, K. & Deng, H., 28 Mar 2020, In : Organic & Biomolecular Chemistry. 18, 12, p. 2219-2222 4 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Productive Syntheses of Privileged Scaffolds Inspired by the Recognition of a Diels–Alder Pattern Common to Three Classes of Natural Products

Badarau, E., Reddy, K. H. V., Loudet, A., Simon, C., Trembleau, L., Claerhout, S., Pair, E., Massip, S., Breton, P., Lesur, B., Goldstein, S., Fourquez, J. M., Henlin, J. M. & Ghosez, L., 17 Sep 2020, In : Chemistry - A European Journal. 26, 6 p.

Research output: Contribution to journalArticle

Structure‐based design, synthesis and bioactivity of a new anti‐TNFα cyclopeptide

Idress, M., Milne, B. F., Thompson, G. S., Trembleau, L., Jaspars, M. & Houssen, W. E., 19 Feb 2020, In : Molecules. 25, 4, 11 p., 922.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
3 Downloads (Pure)
2019

Enzymatic Reconstitution and Biosynthetic Investigation of the Bacterial Carbazole Neocarazostatin A

Liu, Y., Su, L., Fang, Q., Tabudravu, J., Yang, X., Rickaby, K., Trembleau, L., Kyeremeh, K., Deng, Z., Deng, H. & Yu, Y., 20 Dec 2019, In : Journal of Organic Chemistry. 84, 24, p. 16323-16328 6 p.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
1 Downloads (Pure)
2017

A Blind Test of Computational Technique for Predicting the Likelihood of Peptide Sequences to Cyclize

Booth, J., Alexandru-Crivac, C-N., Rickaby, K. A., Nneoyiegbe, A. F., Umeobika, U., McEwan, A. R., Trembleau, L., Jaspars, M., Houssen, W. E. & Shalashilin, D. V., 18 May 2017, In : The Journal of Physical Chemistry Letters. 8, 10, p. 2310-2315 6 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
13 Downloads (Pure)

Cyclic peptide production using a macrocyclase with enhanced substrate promiscuity and relaxed recognition determinants

Alexandru-Crivac, C. N., Umeobika, C., Leikoski, N., Jokela, J., Rickaby, K., Grilo, A. M., Sjo, P., Plowright, A. T., Idress, M., Siebs, E., Nneoyi-Egbe, A., Wahlsten, M., Sivonen, K., Jaspars, M., Trembleau, L., Fewer, D. P. & Houssen Ibrahim, W. E., 4 Oct 2017, In : Chemical Communications. 53, 77, p. 10656-10659 4 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
12 Downloads (Pure)

Cyclic Peptides – A Look to the Future

Idress, M., Alexandru-Crivac, C. N., Jaspars, M., Trembleau, L. A. C., Houssen Ibrahim, W. E-S. M., Rickaby, K. A. & Dalponte, L., 15 Dec 2017, Cyclic Peptides: From Bioorganic Synthesis to Applications . Koehnke, J., Naismith, J. & van der Donk, W. A. (eds.). UK: Royal Society of Chemistry (Great Britain) , p. 340-373 34 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2016

A Unique Tryptophan C-Prenyltransferase from the Kawaguchipeptin Biosynthetic Pathway

Parajuli, A., Kwak, D. H., Dalponte, L., Leikoski, N., Galica, T., Umeobika, U., Trembleau, L., Bent, A., Sivonen, K., Wahlsten, M., Wang, H., Rizzi, E., De Bellis, G., Naismith, J., Jaspars, M., Liu, X., Houssen, W. & Fewer, D. P., 7 Mar 2016, In : Angewandte Chemie. 128, 11, p. 3660-3663 4 p.

Research output: Contribution to journalArticle

Open Access
File
17 Citations (Scopus)
10 Downloads (Pure)
3 Citations (Scopus)
11 Downloads (Pure)

Development of indole sulfonamides as cannabinoid receptor negative allosteric modulators

Greig, I. R., Baillie, G. L., Abdelrahman, M., Trembleau, L. & Ross, R. A., 15 Sep 2016, In : Bioorganic & Medicinal Chemistry Letters. 26, 18, p. 4403-4407 5 p.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
8 Downloads (Pure)

Different N—H···π interactions in two indole derivatives

Kerr, J. R., Trembleau, L., Storey, J. M. D., Wardell, J. L. & Harrison, W. T. A., May 2016, In : Acta Crystallographica Section E: Crystallographic Communications. 72, 5, p. 699-703 5 p.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
6 Downloads (Pure)
Open Access
File
1 Citation (Scopus)
7 Downloads (Pure)