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• A Blind Test of Computational Technique for Predicting the Likelihood of Peptide Sequences to Cyclize

  Booth, J., Alexandru-Crivac, C-N., Rickaby, K. A., Nneoyiegbe, A. F., Umeobika, U., McEwan, A. R., Trembleau, L., Jaspars, M., Houssen, W. E. & Shalashilin, D. V., 18 May 2017, In: The Journal of Physical Chemistry Letters. 8, 10, p. 2310-2315 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cyclization
  • Peptides
  • peptides
  • cyanobactins
  • Conformations
  4 Citations (Scopus)

  13 Downloads (Pure)

• A novel allosteric modulator of the cannabinoid CB1 receptor ameliorates hyperdopaminergia endophenotypes in rodent models

  Mielnik, C. A., Sugamori, K. S., Finlay, D. B., Thorpe, H. H. A., Schapira, M., Sivananthan, N., Li, C. K., lam, V. M., Harrington, S., Abdelrahman, M. H., Trembleau, L. A., Burnham, W. M., Khokhar, J. Y., Salahpour, A., Ramsey, A. J., Glass, M., Greig, I. & Ross, R. A., 8 Oct 2020, In: Neuropsychopharmacology. 46, 2, p. 413-422 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Endophenotypes
  • Cannabinoid Receptor CB1
  • Rodentia
  • Endocannabinoids
  • Inhibition (Psychology)

• A Unique Tryptophan C-Prenyltransferase from the Kawaguchipeptin Biosynthetic Pathway

  Parajuli, A., Kwak, D. H., Dalponte, L., Leikoski, N., Galica, T., Umeobika, U., Trembleau, L., Bent, A., Sivonen, K., Wahlsten, M., Wang, H., Rizzi, E., De Bellis, G., Naismith, J., Jaspars, M., Liu, X., Houssen, W. & Fewer, D. P., 7 Mar 2016, In: Angewandte Chemie. 128, 11, p. 3660-3663 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Biosynthetic Pathways
  • Cyclic Peptides
  • Genes
  • Cyanobacteria
  • Escherichia coli
  20 Citations (Scopus)

  10 Downloads (Pure)

• A Weakened Immune Response to Synthetic Exo-Peptides Predicts a Potential Biosecurity Risk in the Retrieval of Exo-Microorganisms

  Schaefer, K., Dambuza, I. M., Dall'angelo, S., Trembleau, L., Zanda, M., Brown, G. D., Netea, M. G. & Gow, N. A. R., 17 Jul 2020, In: Microorganisms. 8, 7, 14 p., 1066.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • biosecurity
  • immune response
  • peptides
  • microorganisms
  • amino acids
  2 Downloads (Pure)

• Characterization of the promiscuous N-acyl CoA transferase, LgoC, in legonoxamine biosynthesis

  Maglangit, F., Alrashdi, S., Renault, J., Trembleau, L., Victoria, C., Tong, M. H., Wang, S., Kyeremeh, K. & Deng, H., 28 Mar 2020, In: Organic & Biomolecular Chemistry. 18, 12, p. 2219-2222 4 p.

  Research output: Contribution to journal › Article › peer-review

  • acyl-CoA transferase
  • Biosynthesis
  • biosynthesis
  • Siderophores
  • microorganisms
  2 Citations (Scopus)

• Crystal structures of four indole derivatives with a phenyl substituent at the 2-position and a carbonyl group at the 3-position: the C(6) N-H⋯O chain remains the same, but the weak reinforcing inter-actions are different

  Kerr, J. R., Trembleau, L., Storey, J. M. D., Wardell, J. L. & Harrison, W. T. A., 1 Mar 2016, In: Acta Crystallographica Section E: Crystallographic Communications. 72, 3, p. 363-369 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Crystal symmetry
  • Dihedral angle
  • indoles
  • Hydrogen bonds
  • indole
  4 Citations (Scopus)

  11 Downloads (Pure)

• Cyclic peptide production using a macrocyclase with enhanced substrate promiscuity and relaxed recognition determinants

  Alexandru-Crivac, C. N., Umeobika, C., Leikoski, N., Jokela, J., Rickaby, K. A., Grilo, A. M., Sjö, P., Plowright, A. T., Idress, M., Siebs, E., Nneoyi-Egbe, A., Wahlsten, M., Sivonen, K., Jaspars, M., Trembleau, L., Fewer, D. P. & Houssen, W. E., 4 Oct 2017, In: Chemical Communications. 53, 77, p. 10656-10659 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • cyanobactins
  • Cyclic Peptides
  • Peptides
  • Proline
  • Substrates
  5 Citations (Scopus)

  12 Downloads (Pure)

• Cyclic Peptides – A Look to the Future

  Idress, M., Alexandru-Crivac, C. N., Jaspars, M., Trembleau, L. A. C., Houssen Ibrahim, W. E-S. M., Rickaby, K. A. & Dalponte, L., 15 Dec 2017, Cyclic Peptides: From Bioorganic Synthesis to Applications . Koehnke, J., Naismith, J. & van der Donk, W. A. (eds.). UK: Royal Society of Chemistry (Great Britain) , p. 340-373 34 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

• Development of indole sulfonamides as cannabinoid receptor negative allosteric modulators

  Greig, I. R., Baillie, G. L., Abdelrahman, M., Trembleau, L. & Ross, R. A., 15 Sep 2016, In: Bioorganic & Medicinal Chemistry Letters. 26, 18, p. 4403-4407 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • 5-chloro-3-ethyl-1H-indole-2-carboxylic acid (2-(4-piperidin-1-yl-phenyl)ethyl)amide
  • Pharmacokinetics
  • indole
  • Pulse amplitude modulation
  • Cannabinoid Receptors
  12 Citations (Scopus)

  8 Downloads (Pure)

• Different N—H···π interactions in two indole derivatives

  Kerr, J. R., Trembleau, L., Storey, J. M. D., Wardell, J. L. & Harrison, W. T. A., May 2016, In: Acta Crystallographica Section E: Crystallographic Communications. 72, 5, p. 699-703 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • indoles
  • Dimers
  • Hydrogen bonds
  • indole
  • Crystal structure
  2 Citations (Scopus)

  6 Downloads (Pure)

• Discovery and biosynthetic investigation of a new antibacterial dehydrated non‐ribosomal tripeptide

  Wang, S., Fang, Q., Lu, Z., Gao, Y., Trembleau, L., Ebel, R., Andersen, J. H., Philips, C., Law, S. & Deng, H., 11 Dec 2020, In: Angewandte Chemie International Edition.

  Research output: Contribution to journal › Article › peer-review

  • dehydrobutyrine
  • dehydroalanine
  • Peptides
  • Metabolites
  • Bioactivity

• Productive Syntheses of Privileged Scaffolds Inspired by the Recognition of a Diels–Alder Pattern Common to Three Classes of Natural Products

  Badarau, E., Reddy, K. H. V., Loudet, A., Simon, C., Trembleau, L., Claerhout, S., Pair, E., Massip, S., Breton, P., Lesur, B., Goldstein, S., Fourquez, J. M., Henlin, J. M. & Ghosez, L., 17 Sep 2020, In: Chemistry - A European Journal. 26, 67, p. 15477-15481 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Lactams
  • Scaffolds
  • diethyl fumarate
  • Cycloaddition
  • Biological Products

• Structure‐based design, synthesis and bioactivity of a new anti‐TNFα cyclopeptide

  Idress, M., Milne, B. F., Thompson, G. S., Trembleau, L., Jaspars, M. & Houssen, W. E., 19 Feb 2020, In: Molecules. 25, 4, 11 p., 922.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cyclic Peptides
  • Bioactivity
  • necrosis
  • synthesis
  • tumors
  2 Citations (Scopus)

  3 Downloads (Pure)

• Weak interactions in the crystal structures of two indole derivatives

  Kerr, J. R., Trembleau, L., Storey, J. M. D., Wardell, J. L. & Harrison, W. T. A., 1 Jul 2016, In: Acta Crystallographica Section E: Crystallographic Communications. 72, 7, p. 964-968 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • indole-2-carboxylate
  • indoles
  • Dimers
  • indole
  • Crystal structure
  1 Citation (Scopus)

  7 Downloads (Pure)