A bioactive secosterol with an unusual A- and B-ring oxygenation pattern isolated from an Indonesian soft coral Lobophytum sp.

L. A. Morris, E. M. Christie, M. Jaspars*, L. P. Van Ofwegen

*Corresponding author for this work

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

A secosterol with a gorgosterol side chain and an unusual oxygenation pattern on the A and B rings was isolated from an Indonesian soft coral Lobophytum sp. The A and B rings of the reported compound 1 have hydroxyl groups at C-3 and C-7 and an epoxide ring at C-5-C-6. The structure of 1 was solved by 2D NMR methods and by chemical shift analogy to the known secogorgosterol 2. Compound 1 was found to have activity against human ovarian tumor and human leukemia cell lines.

Original languageEnglish
Pages (from-to)538-541
Number of pages4
JournalJournal of Natural Products
Volume61
Issue number4
DOIs
Publication statusPublished - 25 May 1998

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