A bioactive secosterol with an unusual A- and B-ring oxygenation pattern isolated from an Indonesian soft coral Lobophytum sp.

L. A. Morris; E. M. Christie; M. Jaspars; L. P. Van Ofwegen

doi:10.1021/np9705118

A bioactive secosterol with an unusual A- and B-ring oxygenation pattern isolated from an Indonesian soft coral Lobophytum sp.

L. A. Morris, E. M. Christie, M. Jaspars^*, L. P. Van Ofwegen

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

48 Citations (Scopus)

Abstract

A secosterol with a gorgosterol side chain and an unusual oxygenation pattern on the A and B rings was isolated from an Indonesian soft coral Lobophytum sp. The A and B rings of the reported compound 1 have hydroxyl groups at C-3 and C-7 and an epoxide ring at C-5-C-6. The structure of 1 was solved by 2D NMR methods and by chemical shift analogy to the known secogorgosterol 2. Compound 1 was found to have activity against human ovarian tumor and human leukemia cell lines.

Original language	English
Pages (from-to)	538-541
Number of pages	4
Journal	Journal of Natural Products
Volume	61
Issue number	4
DOIs	https://doi.org/10.1021/np9705118
Publication status	Published - 25 May 1998

Access to Document

10.1021/np9705118

Cite this

@article{ca35c980f069454e9d235e2f584ea34f,

title = "A bioactive secosterol with an unusual A- and B-ring oxygenation pattern isolated from an Indonesian soft coral Lobophytum sp.",

abstract = "A secosterol with a gorgosterol side chain and an unusual oxygenation pattern on the A and B rings was isolated from an Indonesian soft coral Lobophytum sp. The A and B rings of the reported compound 1 have hydroxyl groups at C-3 and C-7 and an epoxide ring at C-5-C-6. The structure of 1 was solved by 2D NMR methods and by chemical shift analogy to the known secogorgosterol 2. Compound 1 was found to have activity against human ovarian tumor and human leukemia cell lines.",

author = "Morris, {L. A.} and Christie, {E. M.} and M. Jaspars and {Van Ofwegen}, {L. P.}",

year = "1998",

month = may,

day = "25",

doi = "10.1021/np9705118",

language = "English",

volume = "61",

pages = "538--541",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

number = "4",

}

TY - JOUR

T1 - A bioactive secosterol with an unusual A- and B-ring oxygenation pattern isolated from an Indonesian soft coral Lobophytum sp.

AU - Morris, L. A.

AU - Christie, E. M.

AU - Jaspars, M.

AU - Van Ofwegen, L. P.

PY - 1998/5/25

Y1 - 1998/5/25

N2 - A secosterol with a gorgosterol side chain and an unusual oxygenation pattern on the A and B rings was isolated from an Indonesian soft coral Lobophytum sp. The A and B rings of the reported compound 1 have hydroxyl groups at C-3 and C-7 and an epoxide ring at C-5-C-6. The structure of 1 was solved by 2D NMR methods and by chemical shift analogy to the known secogorgosterol 2. Compound 1 was found to have activity against human ovarian tumor and human leukemia cell lines.

AB - A secosterol with a gorgosterol side chain and an unusual oxygenation pattern on the A and B rings was isolated from an Indonesian soft coral Lobophytum sp. The A and B rings of the reported compound 1 have hydroxyl groups at C-3 and C-7 and an epoxide ring at C-5-C-6. The structure of 1 was solved by 2D NMR methods and by chemical shift analogy to the known secogorgosterol 2. Compound 1 was found to have activity against human ovarian tumor and human leukemia cell lines.

UR - http://www.scopus.com/inward/record.url?scp=0031977402&partnerID=8YFLogxK

U2 - 10.1021/np9705118

DO - 10.1021/np9705118

M3 - Article

C2 - 9584407

AN - SCOPUS:0031977402

SN - 0163-3864

VL - 61

SP - 538

EP - 541

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 4

ER -

A bioactive secosterol with an unusual A- and B-ring oxygenation pattern isolated from an Indonesian soft coral Lobophytum sp.

Abstract

Access to Document

Other files and links

Fingerprint

Cite this