A Case-Control Study of Parkinson's Disease and Tobacco Use

Gene-Tobacco Interactions

Giuseppe De Palma*, Finlay D. Dick, Stefano Calzetti, Neil W. Scott, Gordon J. Prescott, Aileen Osborne, Neva Haites, Paola Mozzoni, Anna Negrotti, Augusto Scaglioni, Antonio Mutti, Geoparkinson Study Group

*Corresponding author for this work

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

A case-control study of genetic, environmental, and occupational risk factors for Parkinson's disease (PD) was carried out in five European countries (Italy, Malta, Romania, Scotland, and Sweden) to explore the possible contribution of interactions among host and environmental factors in sporadic PD. Whereas smoking habits confirmed its negative association with PD, a possible modulatory role of genetic polymorphisms was investigated to obtain further mechanistic insights. We recruited 767 cases of PD and 1989 age-matched and gender-matched controls. Participants completed an interviewer-administered questionnaire including the history of smoking habits. The polymorphisms of genes involved either in metabolism of compounds contained in tobacco smoke (CYP2D6, CYP1B1, GSTM1, GSTT1, GSTM3, GSTP1, NQO1, SOD2, EPHX and NAT2) or in dopaminergic neurotransmission (MAOA, MAOB, DAT1 and DRD2) were characterized by PCR based methods on genomic DNA. We found evidence of statistically significant gene-tobacco interaction for GSTM1. NAT2 and GSTP1, the negative association between tobacco smoking and PD being significantly enhanced in subjects expressing GSTM1-1 activity, in NAT2 fast acetylators, and in those with the GSTP1*B*C haplotype. Owing to the retrospective design of the study, these results require confirmation. (C) 2010 Movement Disorder Society

Original languageEnglish
Pages (from-to)912-919
Number of pages8
JournalMovement Disorders
Volume25
Issue number7
Early online date29 Mar 2010
DOIs
Publication statusPublished - 15 May 2010

Keywords

  • Aged
  • Case-Control Studies
  • Female
  • Gene Expression
  • Genotype
  • Humans
  • Male
  • Occupational Exposure
  • Parkinson Disease
  • Polymerase Chain Reaction
  • Polymorphism, Genetic
  • Tobacco Use Disorder
  • Tobacco smoking
  • Genetic polymorphism
  • Gene-environment interactions

Cite this

A Case-Control Study of Parkinson's Disease and Tobacco Use : Gene-Tobacco Interactions. / De Palma, Giuseppe; Dick, Finlay D.; Calzetti, Stefano; Scott, Neil W.; Prescott, Gordon J.; Osborne, Aileen; Haites, Neva; Mozzoni, Paola; Negrotti, Anna; Scaglioni, Augusto; Mutti, Antonio; Geoparkinson Study Group.

In: Movement Disorders, Vol. 25, No. 7, 15.05.2010, p. 912-919.

Research output: Contribution to journalArticle

De Palma, G, Dick, FD, Calzetti, S, Scott, NW, Prescott, GJ, Osborne, A, Haites, N, Mozzoni, P, Negrotti, A, Scaglioni, A, Mutti, A & Geoparkinson Study Group 2010, 'A Case-Control Study of Parkinson's Disease and Tobacco Use: Gene-Tobacco Interactions', Movement Disorders, vol. 25, no. 7, pp. 912-919. https://doi.org/10.1002/mds.22980
De Palma, Giuseppe ; Dick, Finlay D. ; Calzetti, Stefano ; Scott, Neil W. ; Prescott, Gordon J. ; Osborne, Aileen ; Haites, Neva ; Mozzoni, Paola ; Negrotti, Anna ; Scaglioni, Augusto ; Mutti, Antonio ; Geoparkinson Study Group. / A Case-Control Study of Parkinson's Disease and Tobacco Use : Gene-Tobacco Interactions. In: Movement Disorders. 2010 ; Vol. 25, No. 7. pp. 912-919.
@article{a3fe6734041e4928b4e7086e78de3bc8,
title = "A Case-Control Study of Parkinson's Disease and Tobacco Use: Gene-Tobacco Interactions",
abstract = "A case-control study of genetic, environmental, and occupational risk factors for Parkinson's disease (PD) was carried out in five European countries (Italy, Malta, Romania, Scotland, and Sweden) to explore the possible contribution of interactions among host and environmental factors in sporadic PD. Whereas smoking habits confirmed its negative association with PD, a possible modulatory role of genetic polymorphisms was investigated to obtain further mechanistic insights. We recruited 767 cases of PD and 1989 age-matched and gender-matched controls. Participants completed an interviewer-administered questionnaire including the history of smoking habits. The polymorphisms of genes involved either in metabolism of compounds contained in tobacco smoke (CYP2D6, CYP1B1, GSTM1, GSTT1, GSTM3, GSTP1, NQO1, SOD2, EPHX and NAT2) or in dopaminergic neurotransmission (MAOA, MAOB, DAT1 and DRD2) were characterized by PCR based methods on genomic DNA. We found evidence of statistically significant gene-tobacco interaction for GSTM1. NAT2 and GSTP1, the negative association between tobacco smoking and PD being significantly enhanced in subjects expressing GSTM1-1 activity, in NAT2 fast acetylators, and in those with the GSTP1*B*C haplotype. Owing to the retrospective design of the study, these results require confirmation. (C) 2010 Movement Disorder Society",
keywords = "Aged, Case-Control Studies, Female, Gene Expression, Genotype, Humans, Male, Occupational Exposure, Parkinson Disease, Polymerase Chain Reaction, Polymorphism, Genetic, Tobacco Use Disorder, Tobacco smoking, Genetic polymorphism, Gene-environment interactions",
author = "{De Palma}, Giuseppe and Dick, {Finlay D.} and Stefano Calzetti and Scott, {Neil W.} and Prescott, {Gordon J.} and Aileen Osborne and Neva Haites and Paola Mozzoni and Anna Negrotti and Augusto Scaglioni and Antonio Mutti and {Geoparkinson Study Group}",
note = "(c) 2010 Movement Disorder Society.",
year = "2010",
month = "5",
day = "15",
doi = "10.1002/mds.22980",
language = "English",
volume = "25",
pages = "912--919",
journal = "Movement Disorders",
issn = "0885-3185",
publisher = "John Wiley and Sons Inc.",
number = "7",

}

TY - JOUR

T1 - A Case-Control Study of Parkinson's Disease and Tobacco Use

T2 - Gene-Tobacco Interactions

AU - De Palma, Giuseppe

AU - Dick, Finlay D.

AU - Calzetti, Stefano

AU - Scott, Neil W.

AU - Prescott, Gordon J.

AU - Osborne, Aileen

AU - Haites, Neva

AU - Mozzoni, Paola

AU - Negrotti, Anna

AU - Scaglioni, Augusto

AU - Mutti, Antonio

AU - Geoparkinson Study Group

N1 - (c) 2010 Movement Disorder Society.

PY - 2010/5/15

Y1 - 2010/5/15

N2 - A case-control study of genetic, environmental, and occupational risk factors for Parkinson's disease (PD) was carried out in five European countries (Italy, Malta, Romania, Scotland, and Sweden) to explore the possible contribution of interactions among host and environmental factors in sporadic PD. Whereas smoking habits confirmed its negative association with PD, a possible modulatory role of genetic polymorphisms was investigated to obtain further mechanistic insights. We recruited 767 cases of PD and 1989 age-matched and gender-matched controls. Participants completed an interviewer-administered questionnaire including the history of smoking habits. The polymorphisms of genes involved either in metabolism of compounds contained in tobacco smoke (CYP2D6, CYP1B1, GSTM1, GSTT1, GSTM3, GSTP1, NQO1, SOD2, EPHX and NAT2) or in dopaminergic neurotransmission (MAOA, MAOB, DAT1 and DRD2) were characterized by PCR based methods on genomic DNA. We found evidence of statistically significant gene-tobacco interaction for GSTM1. NAT2 and GSTP1, the negative association between tobacco smoking and PD being significantly enhanced in subjects expressing GSTM1-1 activity, in NAT2 fast acetylators, and in those with the GSTP1*B*C haplotype. Owing to the retrospective design of the study, these results require confirmation. (C) 2010 Movement Disorder Society

AB - A case-control study of genetic, environmental, and occupational risk factors for Parkinson's disease (PD) was carried out in five European countries (Italy, Malta, Romania, Scotland, and Sweden) to explore the possible contribution of interactions among host and environmental factors in sporadic PD. Whereas smoking habits confirmed its negative association with PD, a possible modulatory role of genetic polymorphisms was investigated to obtain further mechanistic insights. We recruited 767 cases of PD and 1989 age-matched and gender-matched controls. Participants completed an interviewer-administered questionnaire including the history of smoking habits. The polymorphisms of genes involved either in metabolism of compounds contained in tobacco smoke (CYP2D6, CYP1B1, GSTM1, GSTT1, GSTM3, GSTP1, NQO1, SOD2, EPHX and NAT2) or in dopaminergic neurotransmission (MAOA, MAOB, DAT1 and DRD2) were characterized by PCR based methods on genomic DNA. We found evidence of statistically significant gene-tobacco interaction for GSTM1. NAT2 and GSTP1, the negative association between tobacco smoking and PD being significantly enhanced in subjects expressing GSTM1-1 activity, in NAT2 fast acetylators, and in those with the GSTP1*B*C haplotype. Owing to the retrospective design of the study, these results require confirmation. (C) 2010 Movement Disorder Society

KW - Aged

KW - Case-Control Studies

KW - Female

KW - Gene Expression

KW - Genotype

KW - Humans

KW - Male

KW - Occupational Exposure

KW - Parkinson Disease

KW - Polymerase Chain Reaction

KW - Polymorphism, Genetic

KW - Tobacco Use Disorder

KW - Tobacco smoking

KW - Genetic polymorphism

KW - Gene-environment interactions

U2 - 10.1002/mds.22980

DO - 10.1002/mds.22980

M3 - Article

VL - 25

SP - 912

EP - 919

JO - Movement Disorders

JF - Movement Disorders

SN - 0885-3185

IS - 7

ER -