A cluster randomized trial of strategies to increase uptake amongst young women invited for their first cervical screen: The STRATEGIC trial

H. Kitchener*, M. Gittins, M. Cruickshank, C. Moseley, S. Fletcher, R. Albrow, A. Gray, L. Brabin, D. Torgerson, E. J. Crosbie, A. Sargent, C. Roberts

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)
11 Downloads (Pure)

Abstract

Objectives: To measure the feasibility and effectiveness of interventions to increase cervical screening uptake amongst young women.

Methods: A two-phase cluster randomized trial conducted in general practices in the NHS Cervical Screening Programme. In Phase 1, women in practices randomized to intervention due for their first invitation to cervical screening received a pre-invitation leaflet and, separately, access to online booking. In Phase 2, non-attenders at six months were randomized to one of: vaginal self-sample kits sent unrequested or offered; timed appointments; nurse navigator; or the choice between nurse navigator or self-sample kits. Primary outcome was uplift in intervention vs. control practices, at 3 and 12 months post invitation.

Results: Phase 1 randomized 20,879 women. Neither pre-invitation leaflet nor online booking increased screening uptake by three months (18.8% pre-invitation leaflet vs. 19.2% control and 17.8% online booking vs. 17.2% control). Uptake was higher amongst human papillomavirus vaccinees at three months (OR 2.07, 95% CI 1.69-2.53, p

Conclusions: Amongst non-attenders, self-sample kits sent and timed appointments achieved an uplift in screening over the short term; longer term impact is less certain. Prior human papillomavirus vaccination was associated with increased screening uptake.

Original languageEnglish
Pages (from-to)88-98
Number of pages11
JournalJournal of Medical Screening
Volume25
Issue number2
Early online date22 May 2018
DOIs
Publication statusPublished - 1 Jun 2018

Keywords

  • Cervical screening
  • young women
  • uptake
  • HUMAN-PAPILLOMAVIRUS
  • HEALTH-CARE
  • CANCER
  • METAANALYSIS
  • PROGRAM
  • IMPROVE
  • MODEL

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