A cohort study of reproductive risk factors, weight and weight change and the development of diabetes mellitus

S. I. Dawson, W. C. S. Smith (Corresponding Author), M. S. Watson, B. J. Wilson, G. J. Prescott, D. Campbell, P. Hannaford

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

AIMS: Reproductive factors (parity, miscarriages, terminations), oral contraceptive use, hormone replacement therapy, body weight at first pregnancy and weight gain following pregnancy may be associated with a long-term risk of diabetes. The aim of this study is to investigate the independent risks of reproductive factors and body weight for diabetes in later life. METHODS: This is a retrospective cohort study of 1257 parous women who had a first pregnancy between 1951 and 1970. Reproductive history, weight and height were measured at the time of first pregnancy, then assessed by questionnaire in 1997 for all women. A clinical examination and an analysis of blood samples were undertaken for 992 women. The main outcome was incidence of diabetes based on medical history, medication and random glucose measurement. RESULTS: Sixty of the 1257 (4.8%) women developed diabetes. Body mass index at index pregnancy and after 28-48 years follow-up were both significantly associated with risk of diabetes, this increased with greater weight gain. There was a non-significant increased risk of diabetes associated with stillbirths and miscarriages after age and BMI adjustment. CONCLUSIONS: In parous women, higher BMI at index pregnancy, weight gain during follow-up and BMI in later life strongly predict diabetes risk.
Original languageEnglish
Pages (from-to)244-250
Number of pages7
JournalDiabetes, Obesity & Metabolism
Volume5
Issue number4
Early online date6 Jun 2003
DOIs
Publication statusPublished - Jul 2003

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Diabetes Mellitus
Cohort Studies
Weights and Measures
Pregnancy
Weight Gain
Spontaneous Abortion
Body Weight
Reproductive History
Stillbirth
Hormone Replacement Therapy
Oral Contraceptives
Parity
Body Mass Index
Retrospective Studies
Glucose
Incidence

Keywords

  • reproduction
  • diabetes
  • body weight
  • weight gain
  • follow-up

Cite this

@article{787494edbc12431d9140621e5558976d,
title = "A cohort study of reproductive risk factors, weight and weight change and the development of diabetes mellitus",
abstract = "AIMS: Reproductive factors (parity, miscarriages, terminations), oral contraceptive use, hormone replacement therapy, body weight at first pregnancy and weight gain following pregnancy may be associated with a long-term risk of diabetes. The aim of this study is to investigate the independent risks of reproductive factors and body weight for diabetes in later life. METHODS: This is a retrospective cohort study of 1257 parous women who had a first pregnancy between 1951 and 1970. Reproductive history, weight and height were measured at the time of first pregnancy, then assessed by questionnaire in 1997 for all women. A clinical examination and an analysis of blood samples were undertaken for 992 women. The main outcome was incidence of diabetes based on medical history, medication and random glucose measurement. RESULTS: Sixty of the 1257 (4.8{\%}) women developed diabetes. Body mass index at index pregnancy and after 28-48 years follow-up were both significantly associated with risk of diabetes, this increased with greater weight gain. There was a non-significant increased risk of diabetes associated with stillbirths and miscarriages after age and BMI adjustment. CONCLUSIONS: In parous women, higher BMI at index pregnancy, weight gain during follow-up and BMI in later life strongly predict diabetes risk.",
keywords = "reproduction, diabetes, body weight, weight gain, follow-up",
author = "Dawson, {S. I.} and Smith, {W. C. S.} and Watson, {M. S.} and Wilson, {B. J.} and Prescott, {G. J.} and D. Campbell and P. Hannaford",
note = "This work was supported by a grant from the British Heart Foundation, and by a PhD studentship (SID)from the University of Aberdeen.We would like to acknowledge the contribution of the following people: Sarah Sunderland for conducting the clinical examinations, Dean Phillips for tracing and data management, Amanda Cardy for review of the original case notes, Nicola Torrance for assistance with the data collection and the operation of clinics, Linda Harrigan and Wendy Aiken for entering the data, Tracy Mapp for assistance with the study design, Isobel Ford and Ian Ross at Department of Medicine, Aberdeen for assistance with the laboratory analysis, and Val Angus of Practitioner Services at Grampian Health Board for the tracing of subjects.",
year = "2003",
month = "7",
doi = "10.1046/j.1463-1326.2003.00269.x",
language = "English",
volume = "5",
pages = "244--250",
journal = "Diabetes, Obesity & Metabolism",
issn = "1462-8902",
publisher = "Wiley-Blackwell",
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TY - JOUR

T1 - A cohort study of reproductive risk factors, weight and weight change and the development of diabetes mellitus

AU - Dawson, S. I.

AU - Smith, W. C. S.

AU - Watson, M. S.

AU - Wilson, B. J.

AU - Prescott, G. J.

AU - Campbell, D.

AU - Hannaford, P.

N1 - This work was supported by a grant from the British Heart Foundation, and by a PhD studentship (SID)from the University of Aberdeen.We would like to acknowledge the contribution of the following people: Sarah Sunderland for conducting the clinical examinations, Dean Phillips for tracing and data management, Amanda Cardy for review of the original case notes, Nicola Torrance for assistance with the data collection and the operation of clinics, Linda Harrigan and Wendy Aiken for entering the data, Tracy Mapp for assistance with the study design, Isobel Ford and Ian Ross at Department of Medicine, Aberdeen for assistance with the laboratory analysis, and Val Angus of Practitioner Services at Grampian Health Board for the tracing of subjects.

PY - 2003/7

Y1 - 2003/7

N2 - AIMS: Reproductive factors (parity, miscarriages, terminations), oral contraceptive use, hormone replacement therapy, body weight at first pregnancy and weight gain following pregnancy may be associated with a long-term risk of diabetes. The aim of this study is to investigate the independent risks of reproductive factors and body weight for diabetes in later life. METHODS: This is a retrospective cohort study of 1257 parous women who had a first pregnancy between 1951 and 1970. Reproductive history, weight and height were measured at the time of first pregnancy, then assessed by questionnaire in 1997 for all women. A clinical examination and an analysis of blood samples were undertaken for 992 women. The main outcome was incidence of diabetes based on medical history, medication and random glucose measurement. RESULTS: Sixty of the 1257 (4.8%) women developed diabetes. Body mass index at index pregnancy and after 28-48 years follow-up were both significantly associated with risk of diabetes, this increased with greater weight gain. There was a non-significant increased risk of diabetes associated with stillbirths and miscarriages after age and BMI adjustment. CONCLUSIONS: In parous women, higher BMI at index pregnancy, weight gain during follow-up and BMI in later life strongly predict diabetes risk.

AB - AIMS: Reproductive factors (parity, miscarriages, terminations), oral contraceptive use, hormone replacement therapy, body weight at first pregnancy and weight gain following pregnancy may be associated with a long-term risk of diabetes. The aim of this study is to investigate the independent risks of reproductive factors and body weight for diabetes in later life. METHODS: This is a retrospective cohort study of 1257 parous women who had a first pregnancy between 1951 and 1970. Reproductive history, weight and height were measured at the time of first pregnancy, then assessed by questionnaire in 1997 for all women. A clinical examination and an analysis of blood samples were undertaken for 992 women. The main outcome was incidence of diabetes based on medical history, medication and random glucose measurement. RESULTS: Sixty of the 1257 (4.8%) women developed diabetes. Body mass index at index pregnancy and after 28-48 years follow-up were both significantly associated with risk of diabetes, this increased with greater weight gain. There was a non-significant increased risk of diabetes associated with stillbirths and miscarriages after age and BMI adjustment. CONCLUSIONS: In parous women, higher BMI at index pregnancy, weight gain during follow-up and BMI in later life strongly predict diabetes risk.

KW - reproduction

KW - diabetes

KW - body weight

KW - weight gain

KW - follow-up

U2 - 10.1046/j.1463-1326.2003.00269.x

DO - 10.1046/j.1463-1326.2003.00269.x

M3 - Article

VL - 5

SP - 244

EP - 250

JO - Diabetes, Obesity & Metabolism

JF - Diabetes, Obesity & Metabolism

SN - 1462-8902

IS - 4

ER -