A comparative evaluation of digital imaging, retinal photography and optometrist examination in screening for diabetic retinopathy

Jim Olson, F. M. Strachan, J. H. Hipwell, Keith A Goatman, K. C. McHardy, John Vincent Forrester, Peter Frederick Sharp

Research output: Contribution to journalArticle

121 Citations (Scopus)

Abstract

Aims To compare the respective performances of digital retinal imaging, fundus photography and slit-lamp biomicroscopy performed by trained optometrists, in screening for diabetic retinopathy. To assess the potential contribution of automated digital image analysis to a screening programme.

Methods A group of 586 patients recruited from a diabetic clinic underwent three or four mydriatic screening methods for retinal examination. The respective performances of digital imaging (n = 586; graded manually), colour slides (n = 586; graded manually), and slit-lamp examination by specially trained optometrists (n = 485), were evaluated against a reference standard of slit-lamp biomicroscopy by ophthalmologists with a special interest in medical retina. The performance of automated grading of the digital images by computer was also assessed.

Results Slit-lamp examination by optometrists for referable diabetic retinopathy achieved a sensitivity of 73% (52-88) and a specificity of 90% (87-93). Using two-field imaging, manual grading of red-free digital images achieved a sensitivity of 93% (82-98) and a specificity of 87% (84-90), and for colour slides, a sensitivity of 96% (87-100) and a specificity of 89% (86-91). Almost identical results were achieved for both methods with single macular field imaging. Digital imaging had a lower technical failure rate (4.4% of patients) than colour slide photography (11.9%). Applying an automated grading protocol to the digital images detected any retinopathy, with a sensitivity of 83% (77-89) and a specificity of 71% (66-75) and diabetic macular oedema with a sensitivity of 76% (53-92) and a specificity of 85% (82-88).

Conclusions Both manual grading methods produced similar results whether using a one- or two-field protocol. Technical failures rates, and hence need for recall, were lower with digital imaging. One-field grading of fundus photographs appeared to be as effective as two-field. The optometrists achieved the lowest sensitivities but reported no technical failures. Automated grading of retinal images can improve efficiency of resource utilization in diabetic retinopathy screening.

Original languageEnglish
Pages (from-to)528-534
Number of pages6
JournalDiabetic Medicine
Volume20
Issue number7
DOIs
Publication statusPublished - 2003

Keywords

  • diabetic retinopathy
  • screening
  • digital
  • colour slide
  • optometrist
  • automated
  • AUTOMATED DETECTION
  • EYE DISEASE
  • FLUORESCEIN ANGIOGRAMS
  • BLINDNESS
  • MICROANEURYSMS
  • QUANTIFICATION
  • POPULATION
  • FUNDUS
  • SYSTEM
  • TOOL

Cite this