@article{57a66d1208b44fa1b296aebb6c8b56c2,
title = "A comparison of measurement methods of hippocampal atrophy rate for predicting Alzheimer's dementia in the Aberdeen Birth Cohort of 1936",
abstract = "INTRODUCTION: Various methods are available to measure hippocampal atrophy rate. We compared methods to predict Alzheimer's dementia.METHODS: Participants with brain imaging at ages 69 and 73 years were identified from a previous study. Simple manual measures and computationally automated volumetry were performed. Receiver operating characteristics assessed the predictive ability of each method at baseline and on logit regression analysis of two serial scans.RESULTS: Ten of 149 participants developed Alzheimer's dementia and had lower baseline volumes (3647 vs. 4194 mm(3)P = .002), rates of volume loss (-126 vs. -36 mm(3)/y; P = .001), and rates of loss in hippocampal fraction (-8.55 vs. -2.35 x 10(-5)/y; P = .001). Baseline volume with a rate of change gave the highest area under the curve value of 0.96.DISCUSSION: Automated volumetry measuring hippocampal size at age 69 years and subsequent rate of change predicts Alzheimer's dementia development.",
keywords = "hippocampal volume, Hippocampal atrophy rate, Alzheimer's disease, Automated volumetry, Scheltens' score, Rounding ratio",
author = "Rana, {Arnab K.} and Anca-Larisa Sandu and Robertson, {Kenna Louise} and McNeil, {Christopher J} and Whalley, {Lawrence J} and Staff, {Roger T} and Murray, {Alison D}",
note = "Acknowledgments The authors would like to thank all radiographers and doctors involved in gathering the data. A special thanks is given to the participants from the Aberdeen 1936 Birth Cohort studies for their voluntary contribution to these projects. R.T.S. receives funding from TauRx. A.D.M. provides brain imaging advice to TauRx but receives no remuneration for this. She has previously received honoraria from GE Healthcare for educational lectures on brain imaging in dementia and parkinsonian disorders. The other authors report no disclosures. Data collection was funded by grants from the Alzheimer's Research Trust (now Alzheimer's Research UK, grant reference ART/SPG2003B), Alzheimer's Research UK (grant reference ARUK-SB2012B-2), and the University of Aberdeen Development Trust.DG002 RGB3109. L.J.W., R.T.S., and A.D.M. acquired funding for the study and are steering committee members and guarantors of the imaging data. L.J.W. recruited participants. A.D.M. supervised all imaging acquisitions. Conflicts of interest: None declared Statistical analyses completed by Dr Arnab Rana, Aberdeen Biomedical Imaging Center Industry sponsorship: None.",
year = "2017",
doi = "10.1016/j.dadm.2016.11.007",
language = "English",
volume = "6",
pages = "31--39",
journal = "Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring",
issn = "2352-8729",
publisher = "Elsevier",
}