A core outcome set for future endometriosis research: an international consensus development study

J. M.N. Duffy*, M. Hirsch, M. Vercoe, J. Abbott, C. Barker, B. Collura, R. Drake, J. L.H. Evers, M. Hickey, A. W. Horne, M. L. Hull, S. Kolekar, S. Lensen, N. P. Johnson, V. Mahajan, B. W. Mol, A. S. Otter, L. Puscasiu, M. B. Rodriguez, L. RombautsA. Vail, R. Wang, C. M. Farquhar, Jane P. Daniels, Arianne C. Lim, Katie Edmonds, Claire E. MacLean, Amy C. Appleton, Sarah Skelton, Dominic L. Byrne, Rebecca K. White, Margarida Sardo, Rebecca C. Fowles, Baris Ata, Sarah A. Richatd, Casandra C. Puig Ybanez, Matthew C. Peterson, Jasmin L. Elms, Ann Parks, Bianca L.F. De Bie Rocks, Jodie C. Roe, Ruby Doran, Marcello Ceccaroni, Ceu A. Ferreira, Sofia Dias, Tracey Pinnington, Paula Laupa-Santiago, Marie C. Turner, Anneke M.F. Schreurs, Eleanor Baggot, Razvan V. Socolov, Menem Yossry, Tania M. Hodges, Marina W.P. Barbossa, Târgu Mures, Tracy L. Lytwyn, Sophia E.L. Egan-Reid, Susanna C.L. Devlin, Kira S. Crees, Bethany C. Baldwin, James R. Scott, Amy K. Gravolin, Errin F. Chapman, Stephanie N. Bartley, Alicia J. Hamilton, Kirstie J. Thorpe, Denise M. Carmody, Joanna Eyeson, Madeleine D. Davis, Jo Henry, Mike Armour, Presley Y.F.V. Cummings, Lisa A. Cook

*Corresponding author for this work

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective: To develop a core outcome set for endometriosis. Design: Consensus development study. Setting: International. Population: One hundred and sixteen healthcare professionals, 31 researchers and 206 patient representatives. Methods: Modified Delphi method and modified nominal group technique. Results: The final core outcome set includes three core outcomes for trials evaluating potential treatments for pain and other symptoms associated with endometriosis: overall pain; improvement in the most troublesome symptom; and quality of life. In addition, eight core outcomes for trials evaluating potential treatments for infertility associated with endometriosis were identified: viable intrauterine pregnancy confirmed by ultrasound; pregnancy loss, including ectopic pregnancy, miscarriage, stillbirth and termination of pregnancy; live birth; time to pregnancy leading to live birth; gestational age at delivery; birthweight; neonatal mortality; and major congenital abnormalities. Two core outcomes applicable to all trials were also identified: adverse events and patient satisfaction with treatment. Conclusions: Using robust consensus science methods, healthcare professionals, researchers and women with endometriosis have developed a core outcome set to standardise outcome selection, collection and reporting across future randomised controlled trials and systematic reviews evaluating potential treatments for endometriosis. Tweetable abstract: @coreoutcomes for future #endometriosis research have been developed @jamesmnduffy.

Original languageEnglish
Pages (from-to)967-974
Number of pages8
JournalBJOG: An International Journal of Obstetrics and Gynaecology
Volume127
Issue number8
Early online date30 Mar 2020
DOIs
Publication statusPublished - Jul 2020

Keywords

  • Consensus development study
  • core outcome set
  • endometriosis
  • modified Delphi method
  • modified nominal group technique
  • Prospective Studies
  • Humans
  • Endometriosis
  • Consensus
  • Delphi Technique
  • Research Personnel
  • Health Personnel
  • Endpoint Determination
  • Biomedical Research
  • Female
  • Research Design

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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  • Cite this

    Duffy, J. M. N., Hirsch, M., Vercoe, M., Abbott, J., Barker, C., Collura, B., Drake, R., Evers, J. L. H., Hickey, M., Horne, A. W., Hull, M. L., Kolekar, S., Lensen, S., Johnson, N. P., Mahajan, V., Mol, B. W., Otter, A. S., Puscasiu, L., Rodriguez, M. B., ... Cook, L. A. (2020). A core outcome set for future endometriosis research: an international consensus development study. BJOG: An International Journal of Obstetrics and Gynaecology, 127(8), 967-974. https://doi.org/10.1111/1471-0528.16157