A core outcome set for future endometriosis research: an international consensus development study

J. M.N. Duffy; M. Hirsch; M. Vercoe; J. Abbott; C. Barker; B. Collura; R. Drake; J. L.H. Evers; M. Hickey; A. W. Horne; M. L. Hull; S. Kolekar; S. Lensen; N. P. Johnson; V. Mahajan; B. W. Mol; A. S. Otter; L. Puscasiu; M. B. Rodriguez; L. Rombauts; A. Vail; R. Wang; C. M. Farquhar; Jane P. Daniels; Arianne C. Lim; Katie Edmonds; Claire E. MacLean; Amy C. Appleton; Sarah Skelton; Dominic L. Byrne; Rebecca K. White; Margarida Sardo; Rebecca C. Fowles; Baris Ata; Sarah A. Richatd; Casandra C. Puig Ybanez; Matthew C. Peterson; Jasmin L. Elms; Ann Parks; Bianca L.F. De Bie Rocks; Jodie C. Roe; Ruby Doran; Marcello Ceccaroni; Ceu A. Ferreira; Sofia Dias; Tracey Pinnington; Paula Laupa-Santiago; Marie C. Turner; Anneke M.F. Schreurs; Eleanor Baggot; Razvan V. Socolov; Menem Yossry; Tania M. Hodges; Marina W.P. Barbossa; Târgu Mures; Tracy L. Lytwyn; Sophia E.L. Egan-Reid; Susanna C.L. Devlin; Kira S. Crees; Bethany C. Baldwin; James R. Scott; Amy K. Gravolin; Errin F. Chapman; Stephanie N. Bartley; Alicia J. Hamilton; Kirstie J. Thorpe; Denise M. Carmody; Joanna Eyeson; Madeleine D. Davis; Jo Henry; Mike Armour; Presley Y.F.V. Cummings; Lisa A. Cook

doi:10.1111/1471-0528.16157

A core outcome set for future endometriosis research: an international consensus development study

J. M.N. Duffy^*, M. Hirsch, M. Vercoe, J. Abbott, C. Barker, B. Collura, R. Drake, J. L.H. Evers, M. Hickey, A. W. Horne, M. L. Hull, S. Kolekar, S. Lensen, N. P. Johnson, V. Mahajan, B. W. Mol, A. S. Otter, L. Puscasiu, M. B. Rodriguez, L. RombautsA. Vail, R. Wang, C. M. Farquhar, Jane P. Daniels, Arianne C. Lim, Katie Edmonds, Claire E. MacLean, Amy C. Appleton, Sarah Skelton, Dominic L. Byrne, Rebecca K. White, Margarida Sardo, Rebecca C. Fowles, Baris Ata, Sarah A. Richatd, Casandra C. Puig Ybanez, Matthew C. Peterson, Jasmin L. Elms, Ann Parks, Bianca L.F. De Bie Rocks, Jodie C. Roe, Ruby Doran, Marcello Ceccaroni, Ceu A. Ferreira, Sofia Dias, Tracey Pinnington, Paula Laupa-Santiago, Marie C. Turner, Anneke M.F. Schreurs, Eleanor Baggot, Razvan V. Socolov, Menem Yossry, Tania M. Hodges, Marina W.P. Barbossa, Târgu Mures, Tracy L. Lytwyn, Sophia E.L. Egan-Reid, Susanna C.L. Devlin, Kira S. Crees, Bethany C. Baldwin, James R. Scott, Amy K. Gravolin, Errin F. Chapman, Stephanie N. Bartley, Alicia J. Hamilton, Kirstie J. Thorpe, Denise M. Carmody, Joanna Eyeson, Madeleine D. Davis, Jo Henry, Mike Armour, Presley Y.F.V. Cummings, Lisa A. Cook

^*Corresponding author for this work

Applied Health Sciences

Research output: Contribution to journal › Article › peer-review

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Abstract

Objective: To develop a core outcome set for endometriosis. Design: Consensus development study. Setting: International. Population: One hundred and sixteen healthcare professionals, 31 researchers and 206 patient representatives. Methods: Modified Delphi method and modified nominal group technique. Results: The final core outcome set includes three core outcomes for trials evaluating potential treatments for pain and other symptoms associated with endometriosis: overall pain; improvement in the most troublesome symptom; and quality of life. In addition, eight core outcomes for trials evaluating potential treatments for infertility associated with endometriosis were identified: viable intrauterine pregnancy confirmed by ultrasound; pregnancy loss, including ectopic pregnancy, miscarriage, stillbirth and termination of pregnancy; live birth; time to pregnancy leading to live birth; gestational age at delivery; birthweight; neonatal mortality; and major congenital abnormalities. Two core outcomes applicable to all trials were also identified: adverse events and patient satisfaction with treatment. Conclusions: Using robust consensus science methods, healthcare professionals, researchers and women with endometriosis have developed a core outcome set to standardise outcome selection, collection and reporting across future randomised controlled trials and systematic reviews evaluating potential treatments for endometriosis. Tweetable abstract: @coreoutcomes for future #endometriosis research have been developed @jamesmnduffy.

Original language	English
Pages (from-to)	967-974
Number of pages	8
Journal	BJOG: An International Journal of Obstetrics and Gynaecology
Volume	127
Issue number	8
Early online date	30 Mar 2020
DOIs	https://doi.org/10.1111/1471-0528.16157
Publication status	Published - Jul 2020

Keywords

Consensus development study
core outcome set
endometriosis
modified Delphi method
modified nominal group technique
Prospective Studies
Humans
Endometriosis
Consensus
Delphi Technique
Research Personnel
Health Personnel
Endpoint Determination
Biomedical Research
Female
Research Design

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Duffy, J. M. N., Hirsch, M., Vercoe, M., Abbott, J., Barker, C., Collura, B., Drake, R., Evers, J. L. H., Hickey, M., Horne, A. W., Hull, M. L., Kolekar, S., Lensen, S., Johnson, N. P., Mahajan, V., Mol, B. W., Otter, A. S., Puscasiu, L., Rodriguez, M. B., ... Cook, L. A. (2020). A core outcome set for future endometriosis research: an international consensus development study. BJOG: An International Journal of Obstetrics and Gynaecology, 127(8), 967-974. https://doi.org/10.1111/1471-0528.16157

Duffy, JMN, Hirsch, M, Vercoe, M, Abbott, J, Barker, C, Collura, B, Drake, R, Evers, JLH, Hickey, M, Horne, AW, Hull, ML, Kolekar, S, Lensen, S, Johnson, NP, Mahajan, V, Mol, BW, Otter, AS, Puscasiu, L, Rodriguez, MB, Rombauts, L, Vail, A, Wang, R, Farquhar, CM, Daniels, JP, Lim, AC, Edmonds, K, MacLean, CE, Appleton, AC, Skelton, S, Byrne, DL, White, RK, Sardo, M, Fowles, RC, Ata, B, Richatd, SA, Puig Ybanez, CC, Peterson, MC, Elms, JL, Parks, A, De Bie Rocks, BLF, Roe, JC, Doran, R, Ceccaroni, M, Ferreira, CA, Dias, S, Pinnington, T, Laupa-Santiago, P, Turner, MC, Schreurs, AMF, Baggot, E, Socolov, RV, Yossry, M, Hodges, TM, Barbossa, MWP, Mures, T, Lytwyn, TL, Egan-Reid, SEL, Devlin, SCL, Crees, KS, Baldwin, BC, Scott, JR, Gravolin, AK, Chapman, EF, Bartley, SN, Hamilton, AJ, Thorpe, KJ, Carmody, DM, Eyeson, J, Davis, MD, Henry, J, Armour, M, Cummings, PYFV & Cook, LA 2020, 'A core outcome set for future endometriosis research: an international consensus development study', BJOG: An International Journal of Obstetrics and Gynaecology, vol. 127, no. 8, pp. 967-974. https://doi.org/10.1111/1471-0528.16157

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title = "A core outcome set for future endometriosis research: an international consensus development study",

abstract = "Objective: To develop a core outcome set for endometriosis. Design: Consensus development study. Setting: International. Population: One hundred and sixteen healthcare professionals, 31 researchers and 206 patient representatives. Methods: Modified Delphi method and modified nominal group technique. Results: The final core outcome set includes three core outcomes for trials evaluating potential treatments for pain and other symptoms associated with endometriosis: overall pain; improvement in the most troublesome symptom; and quality of life. In addition, eight core outcomes for trials evaluating potential treatments for infertility associated with endometriosis were identified: viable intrauterine pregnancy confirmed by ultrasound; pregnancy loss, including ectopic pregnancy, miscarriage, stillbirth and termination of pregnancy; live birth; time to pregnancy leading to live birth; gestational age at delivery; birthweight; neonatal mortality; and major congenital abnormalities. Two core outcomes applicable to all trials were also identified: adverse events and patient satisfaction with treatment. Conclusions: Using robust consensus science methods, healthcare professionals, researchers and women with endometriosis have developed a core outcome set to standardise outcome selection, collection and reporting across future randomised controlled trials and systematic reviews evaluating potential treatments for endometriosis. Tweetable abstract: @coreoutcomes for future #endometriosis research have been developed @jamesmnduffy.",

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author = "Duffy, {J. M.N.} and M. Hirsch and M. Vercoe and J. Abbott and C. Barker and B. Collura and R. Drake and Evers, {J. L.H.} and M. Hickey and Horne, {A. W.} and Hull, {M. L.} and S. Kolekar and S. Lensen and Johnson, {N. P.} and V. Mahajan and Mol, {B. W.} and Otter, {A. S.} and L. Puscasiu and Rodriguez, {M. B.} and L. Rombauts and A. Vail and R. Wang and Farquhar, {C. M.} and Daniels, {Jane P.} and Lim, {Arianne C.} and Katie Edmonds and MacLean, {Claire E.} and Appleton, {Amy C.} and Sarah Skelton and Byrne, {Dominic L.} and White, {Rebecca K.} and Margarida Sardo and Fowles, {Rebecca C.} and Baris Ata and Richatd, {Sarah A.} and {Puig Ybanez}, {Casandra C.} and Peterson, {Matthew C.} and Elms, {Jasmin L.} and Ann Parks and {De Bie Rocks}, {Bianca L.F.} and Roe, {Jodie C.} and Ruby Doran and Marcello Ceccaroni and Ferreira, {Ceu A.} and Sofia Dias and Tracey Pinnington and Paula Laupa-Santiago and Turner, {Marie C.} and Schreurs, {Anneke M.F.} and Eleanor Baggot and Socolov, {Razvan V.} and Menem Yossry and Hodges, {Tania M.} and Barbossa, {Marina W.P.} and T{\^a}rgu Mures and Lytwyn, {Tracy L.} and Egan-Reid, {Sophia E.L.} and Devlin, {Susanna C.L.} and Crees, {Kira S.} and Baldwin, {Bethany C.} and Scott, {James R.} and Gravolin, {Amy K.} and Chapman, {Errin F.} and Bartley, {Stephanie N.} and Hamilton, {Alicia J.} and Thorpe, {Kirstie J.} and Carmody, {Denise M.} and Joanna Eyeson and Davis, {Madeleine D.} and Jo Henry and Mike Armour and Cummings, {Presley Y.F.V.} and Cook, {Lisa A.}",

note = "Funding Information Catalyst Fund Endometriosis Millennium Fund",

year = "2020",

month = jul,

doi = "10.1111/1471-0528.16157",

language = "English",

volume = "127",

pages = "967--974",

journal = "BJOG-An International Journal of Obstetrics and Gynaecology",

issn = "1470-0328",

publisher = "John Wiley & Sons, Ltd (10.1111)",

number = "8",

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TY - JOUR

T1 - A core outcome set for future endometriosis research

T2 - an international consensus development study

AU - Duffy, J. M.N.

AU - Hirsch, M.

AU - Vercoe, M.

AU - Abbott, J.

AU - Barker, C.

AU - Collura, B.

AU - Drake, R.

AU - Evers, J. L.H.

AU - Hickey, M.

AU - Horne, A. W.

AU - Hull, M. L.

AU - Kolekar, S.

AU - Lensen, S.

AU - Johnson, N. P.

AU - Mahajan, V.

AU - Mol, B. W.

AU - Otter, A. S.

AU - Puscasiu, L.

AU - Rodriguez, M. B.

AU - Rombauts, L.

AU - Vail, A.

AU - Wang, R.

AU - Farquhar, C. M.

AU - Daniels, Jane P.

AU - Lim, Arianne C.

AU - Edmonds, Katie

AU - MacLean, Claire E.

AU - Appleton, Amy C.

AU - Skelton, Sarah

AU - Byrne, Dominic L.

AU - White, Rebecca K.

AU - Sardo, Margarida

AU - Fowles, Rebecca C.

AU - Ata, Baris

AU - Richatd, Sarah A.

AU - Puig Ybanez, Casandra C.

AU - Peterson, Matthew C.

AU - Elms, Jasmin L.

AU - Parks, Ann

AU - De Bie Rocks, Bianca L.F.

AU - Roe, Jodie C.

AU - Doran, Ruby

AU - Ceccaroni, Marcello

AU - Ferreira, Ceu A.

AU - Dias, Sofia

AU - Pinnington, Tracey

AU - Laupa-Santiago, Paula

AU - Turner, Marie C.

AU - Schreurs, Anneke M.F.

AU - Baggot, Eleanor

AU - Socolov, Razvan V.

AU - Yossry, Menem

AU - Hodges, Tania M.

AU - Barbossa, Marina W.P.

AU - Mures, Târgu

AU - Lytwyn, Tracy L.

AU - Egan-Reid, Sophia E.L.

AU - Devlin, Susanna C.L.

AU - Crees, Kira S.

AU - Baldwin, Bethany C.

AU - Scott, James R.

AU - Gravolin, Amy K.

AU - Chapman, Errin F.

AU - Bartley, Stephanie N.

AU - Hamilton, Alicia J.

AU - Thorpe, Kirstie J.

AU - Carmody, Denise M.

AU - Eyeson, Joanna

AU - Davis, Madeleine D.

AU - Henry, Jo

AU - Armour, Mike

AU - Cummings, Presley Y.F.V.

AU - Cook, Lisa A.

N1 - Funding Information Catalyst Fund Endometriosis Millennium Fund

PY - 2020/7

Y1 - 2020/7

N2 - Objective: To develop a core outcome set for endometriosis. Design: Consensus development study. Setting: International. Population: One hundred and sixteen healthcare professionals, 31 researchers and 206 patient representatives. Methods: Modified Delphi method and modified nominal group technique. Results: The final core outcome set includes three core outcomes for trials evaluating potential treatments for pain and other symptoms associated with endometriosis: overall pain; improvement in the most troublesome symptom; and quality of life. In addition, eight core outcomes for trials evaluating potential treatments for infertility associated with endometriosis were identified: viable intrauterine pregnancy confirmed by ultrasound; pregnancy loss, including ectopic pregnancy, miscarriage, stillbirth and termination of pregnancy; live birth; time to pregnancy leading to live birth; gestational age at delivery; birthweight; neonatal mortality; and major congenital abnormalities. Two core outcomes applicable to all trials were also identified: adverse events and patient satisfaction with treatment. Conclusions: Using robust consensus science methods, healthcare professionals, researchers and women with endometriosis have developed a core outcome set to standardise outcome selection, collection and reporting across future randomised controlled trials and systematic reviews evaluating potential treatments for endometriosis. Tweetable abstract: @coreoutcomes for future #endometriosis research have been developed @jamesmnduffy.

AB - Objective: To develop a core outcome set for endometriosis. Design: Consensus development study. Setting: International. Population: One hundred and sixteen healthcare professionals, 31 researchers and 206 patient representatives. Methods: Modified Delphi method and modified nominal group technique. Results: The final core outcome set includes three core outcomes for trials evaluating potential treatments for pain and other symptoms associated with endometriosis: overall pain; improvement in the most troublesome symptom; and quality of life. In addition, eight core outcomes for trials evaluating potential treatments for infertility associated with endometriosis were identified: viable intrauterine pregnancy confirmed by ultrasound; pregnancy loss, including ectopic pregnancy, miscarriage, stillbirth and termination of pregnancy; live birth; time to pregnancy leading to live birth; gestational age at delivery; birthweight; neonatal mortality; and major congenital abnormalities. Two core outcomes applicable to all trials were also identified: adverse events and patient satisfaction with treatment. Conclusions: Using robust consensus science methods, healthcare professionals, researchers and women with endometriosis have developed a core outcome set to standardise outcome selection, collection and reporting across future randomised controlled trials and systematic reviews evaluating potential treatments for endometriosis. Tweetable abstract: @coreoutcomes for future #endometriosis research have been developed @jamesmnduffy.

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KW - core outcome set

KW - endometriosis

KW - modified Delphi method

KW - modified nominal group technique

KW - Prospective Studies

KW - Humans

KW - Endometriosis

KW - Consensus

KW - Delphi Technique

KW - Research Personnel

KW - Health Personnel

KW - Endpoint Determination

KW - Biomedical Research

KW - Female

KW - Research Design

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U2 - 10.1111/1471-0528.16157

DO - 10.1111/1471-0528.16157

M3 - Article

C2 - 32227676

AN - SCOPUS:85082518520

VL - 127

SP - 967

EP - 974

JO - BJOG-An International Journal of Obstetrics and Gynaecology

JF - BJOG-An International Journal of Obstetrics and Gynaecology

SN - 1470-0328

IS - 8

ER -

A core outcome set for future endometriosis research: an international consensus development study

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Keywords

UN SDGs

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