A dermal model for spray painters. Part II: estimating the deposition and uptake of solvents

Sean Semple, D. H. Brouwer, Finlay David Dick, John Cherrie

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The contribution of dermal exposure to the total body burden of a given chemical is difficult to assess. However, it is possible that as regulatory pressures lead to reductions in inhalation exposure, the proportion of uptake via the dermal route will increase. This study brings together recent work in the field of dermal exposure to provide a model to estimate both exposure and uptake of solvents through the skin. Using spray painters as an example, the process of modelling exposure is described from identifying the determinants of exposure through to calculating the flux of solvent through the stratum corneum and thus the total dermal uptake. Results from a range of exposure scenarios are presented and areas requiring further research and validation are highlighted. The model should allow the estimation of combined dermal and inhalation exposure to solvents in both current work situations and retrospective epidemiological studies. Furthermore, it is envisaged that the model may provide the basis for generic assessment of dermal exposure and uptake. (C) 2001 British Occupational Hygiene Society. Published by Elsevier Science Ltd. ALI rights reserved.

Original languageEnglish
Pages (from-to)25-33
Number of pages9
JournalAnnals of Occupational Hygiene
Volume45
Issue number1
Early online date21 Dec 2000
DOIs
Publication statusPublished - Jan 2001

Keywords

  • dermal
  • exposure factors
  • modelling
  • painters
  • solvents
  • exposure
  • evaporation
  • skin

Cite this

A dermal model for spray painters. Part II: estimating the deposition and uptake of solvents. / Semple, Sean; Brouwer, D. H.; Dick, Finlay David; Cherrie, John.

In: Annals of Occupational Hygiene, Vol. 45, No. 1, 01.2001, p. 25-33.

Research output: Contribution to journalArticle

Semple, Sean ; Brouwer, D. H. ; Dick, Finlay David ; Cherrie, John. / A dermal model for spray painters. Part II: estimating the deposition and uptake of solvents. In: Annals of Occupational Hygiene. 2001 ; Vol. 45, No. 1. pp. 25-33.
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