A developmental program for Candida commensalism

Neil A R Gow

doi:10.1038/ng.2737

A developmental program for Candida commensalism

Neil A R Gow^*

^*Corresponding author for this work

Medical Sciences

Research output: Contribution to journal › Letter › peer-review

17 Citations (Scopus)

Abstract

Candida albicans is a frequent pathogen of immunologically compromised individuals, but it is an even more common commensal of healthy humans, where it resides in the gut in a benign state. A new study shows that a specific commensal form of the fungus is induced in the gut through a developmental program that downregulates virulence factors and induces metabolic functions, enabling it to thrive on the nutrients that are available in the large intestine without damaging its host.

Original language	English
Pages (from-to)	967-968
Number of pages	2
Journal	Nature Genetics
Volume	45
Issue number	9
Early online date	23 Aug 2013
DOIs	https://doi.org/10.1038/ng.2737
Publication status	Published - Sept 2013

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AB - Candida albicans is a frequent pathogen of immunologically compromised individuals, but it is an even more common commensal of healthy humans, where it resides in the gut in a benign state. A new study shows that a specific commensal form of the fungus is induced in the gut through a developmental program that downregulates virulence factors and induces metabolic functions, enabling it to thrive on the nutrients that are available in the large intestine without damaging its host.

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A developmental program for Candida commensalism

Abstract

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