Abstract
The obesity paradox is often attributed to fat acting as a buffer to protect individuals in fragile metabolic states. If this was the case, one would predict that the reverse epidemiology would be apparent across all causes of mortality including that of the particular disease state. We performed a dose-response meta-analysis to assess the impact of body mass index (BMI) on all-cause and stroke-specific mortality among stroke patients. Data from relevant studies were identified by systematically searching PubMed, OVID and Scopus databases and were analysed using a random-effects dose-response model. Eight cohort studies on all-cause mortality (with 20,807 deaths of 95,651 stroke patients) and nine studies of mortality exclusively because of stroke (with 8,087 deaths of 28,6270 patients) were evaluated in the meta-analysis. Non-linear associations of BMI with all-cause mortality (P
| Original language | English |
|---|---|
| Pages (from-to) | 416-423 |
| Number of pages | 8 |
| Journal | Obesity Reviews |
| Volume | 16 |
| Issue number | 5 |
| Early online date | 5 Mar 2015 |
| DOIs | |
| Publication status | Published - May 2015 |
Bibliographical note
AcknowledgementsWe thank Dr. Nicola Orsini for helping us with the statistical analysis. This study was supported by Tehran University of Medical Sciences.
Keywords
- Body mass index
- dose-response meta-analysis
- obesity
- paradox
- stroke
- obesity paradox
- follow-up
- cardiovascular-disease
- dialysis patients
- trend estimation
- risk-factors
- women
- men
- population
- overweight
