A European multicenter comparison of quantitative ultrasound measurement variables: The OPUS study

M. A. Paggiosi*, R. Barkmann, C. C. Glüer, C. Roux, D. M. Reid, D. Felsenberg, M. Bradburn, R. Eastell

*Corresponding author for this work

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Summary: Quantitative ultrasound (QUS) measurement variables vary between European countries in a different way to hip bone mineral density. Standardization of data can be achieved through statistical approaches to reduce any between-center differences in QUS measurement variables. However, further validation of this method is required before it can be widely applied. Introduction: European between-center differences in hip bone mineral density (BMD) have been shown to exist; however, little is known about the geographical heterogeneity of QUS measurement variables. We aimed to examine the differences in QUS variables between three different European countries. Methods: Five calcaneal and phalangeal QUS devices in Sheffield, Aberdeen (UK), Kiel and Berlin (Germany), and three devices in Paris (France) were used to measure QUS variables in younger (n0463, 20-39 years old) and older (n02,399, 55-79 years old) women participating in the European multicenter Osteoporosis and Ultrasound (OPUS) study. Broadband ultrasound attenuation, speed of sound, stiffness index, amplitude-dependent speed of sound, bone transmission time, and ultrasonic bone profiler index data were collected. Between-center differences were examined using ANOVA followed by post hoc Fisher's least significant difference tests, and ANCOVA with linear contrasts. p<0.05 indicated statistical significance. Results: Between-center differences in nonstandardized QUS measurement variables existed for younger (p0 0.0023 to p<0.0001) and older women (p<0.001). Anthropometric characteristics exerted a significant influence on nonstandardized data (p00.045 to p<0.001). However, following statistical standardization, based on height and weight or based on measurements made in young people, geographical heterogeneity in QUS measurement variables was no longer apparent. Conclusions: QUS measurement variables vary between European countries in a different way to those for hip BMD. Standardization of data can be achieved through statistical approaches to reduce any between-center differences in QUS measurement variables. However, further validation of this method is required before it can be widely applied.

Original languageEnglish
Pages (from-to)2815-2828
Number of pages14
JournalOsteoporosis International
Volume23
Issue number12
Early online date14 Feb 2012
DOIs
Publication statusPublished - 1 Dec 2012

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Keywords

  • European comparison
  • Geographical heterogeneity
  • OPUS study
  • Quantitative ultrasound
  • Reference intervals

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Paggiosi, M. A., Barkmann, R., Glüer, C. C., Roux, C., Reid, D. M., Felsenberg, D., ... Eastell, R. (2012). A European multicenter comparison of quantitative ultrasound measurement variables: The OPUS study. Osteoporosis International, 23(12), 2815-2828. https://doi.org/10.1007/s00198-012-1912-2