A generic biotic ligand model quantifying the development in time of Ni toxicity to Enchytraeus crypticus

Erkai He, Hao Qiu, Katya Dimitrova, Cornelis A.M. Van Gestel

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Biotic ligand models (BLMs) predicting metal toxicity for a fixed exposure time are available, but it is uncertain how to extrapolate predictions to a dynamic environment with time-variable exposure. Three BLM-based models were developed to describe change of Ni toxicity to Enchytraeus crypticus in time. These models assumed that: (a) biotic ligand binding constants of Ni and competing cations (KNiBL and KCBL) and the fraction of biotic ligands occupied by Ni to produce 50% mortality (f50) are fixed with time, (b) KNiBL and KCBL remain constant while f50 varies with time, and (c) KNiBL, KCBL, and f50 are all time-dependent. Model (a) successfully described the 7-d toxicity of Ni but failed in explaining Ni toxicity at longer exposure times. Both models (b) and (c) well described Ni toxicity, within a factor of 2, at varying solution chemistries and different exposure times. This shows that the acute BLM cannot directly be applied for predicting chronic metal toxicity and that some BLM parameters may vary with time. Our findings provide plausible explanations for differences in mechanisms of acute and chronic toxicity, offering a framework for incorporating toxicokinetic and toxicodynamic processes in describing Ni toxicity in time.
Original languageEnglish
Pages (from-to)170-176
Number of pages7
JournalChemosphere
Volume124
Early online date2 Jan 2015
DOIs
Publication statusPublished - Apr 2015

Fingerprint

ligand
Toxicity
Ligands
toxicity
Metals
metal
Cations
Positive ions
cation
mortality
Mortality
exposure
prediction

Keywords

  • Enchytraeus crypticus
  • Ni
  • toxicodynamic
  • biotic ligand model

Cite this

A generic biotic ligand model quantifying the development in time of Ni toxicity to Enchytraeus crypticus. / He, Erkai; Qiu, Hao; Dimitrova, Katya; Van Gestel, Cornelis A.M. .

In: Chemosphere, Vol. 124, 04.2015, p. 170-176.

Research output: Contribution to journalArticle

He, Erkai ; Qiu, Hao ; Dimitrova, Katya ; Van Gestel, Cornelis A.M. . / A generic biotic ligand model quantifying the development in time of Ni toxicity to Enchytraeus crypticus. In: Chemosphere. 2015 ; Vol. 124. pp. 170-176.
@article{b6e8536661fc4d4389f62323de55c39f,
title = "A generic biotic ligand model quantifying the development in time of Ni toxicity to Enchytraeus crypticus",
abstract = "Biotic ligand models (BLMs) predicting metal toxicity for a fixed exposure time are available, but it is uncertain how to extrapolate predictions to a dynamic environment with time-variable exposure. Three BLM-based models were developed to describe change of Ni toxicity to Enchytraeus crypticus in time. These models assumed that: (a) biotic ligand binding constants of Ni and competing cations (KNiBL and KCBL) and the fraction of biotic ligands occupied by Ni to produce 50{\%} mortality (f50) are fixed with time, (b) KNiBL and KCBL remain constant while f50 varies with time, and (c) KNiBL, KCBL, and f50 are all time-dependent. Model (a) successfully described the 7-d toxicity of Ni but failed in explaining Ni toxicity at longer exposure times. Both models (b) and (c) well described Ni toxicity, within a factor of 2, at varying solution chemistries and different exposure times. This shows that the acute BLM cannot directly be applied for predicting chronic metal toxicity and that some BLM parameters may vary with time. Our findings provide plausible explanations for differences in mechanisms of acute and chronic toxicity, offering a framework for incorporating toxicokinetic and toxicodynamic processes in describing Ni toxicity in time.",
keywords = "Enchytraeus crypticus, Ni, toxicodynamic, biotic ligand model",
author = "Erkai He and Hao Qiu and Katya Dimitrova and {Van Gestel}, {Cornelis A.M.}",
note = "Erkai He received a PhD Grant (2011638012) from the China Scholarship Council. The authors are grateful to Rudo Verweij and Nico M. Van Straalen, for supporting the data analysis, experimental work and manuscript preparation.",
year = "2015",
month = "4",
doi = "10.1016/j.chemosphere.2014.12.034",
language = "English",
volume = "124",
pages = "170--176",
journal = "Chemosphere",
issn = "0045-6535",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - A generic biotic ligand model quantifying the development in time of Ni toxicity to Enchytraeus crypticus

AU - He, Erkai

AU - Qiu, Hao

AU - Dimitrova, Katya

AU - Van Gestel, Cornelis A.M.

N1 - Erkai He received a PhD Grant (2011638012) from the China Scholarship Council. The authors are grateful to Rudo Verweij and Nico M. Van Straalen, for supporting the data analysis, experimental work and manuscript preparation.

PY - 2015/4

Y1 - 2015/4

N2 - Biotic ligand models (BLMs) predicting metal toxicity for a fixed exposure time are available, but it is uncertain how to extrapolate predictions to a dynamic environment with time-variable exposure. Three BLM-based models were developed to describe change of Ni toxicity to Enchytraeus crypticus in time. These models assumed that: (a) biotic ligand binding constants of Ni and competing cations (KNiBL and KCBL) and the fraction of biotic ligands occupied by Ni to produce 50% mortality (f50) are fixed with time, (b) KNiBL and KCBL remain constant while f50 varies with time, and (c) KNiBL, KCBL, and f50 are all time-dependent. Model (a) successfully described the 7-d toxicity of Ni but failed in explaining Ni toxicity at longer exposure times. Both models (b) and (c) well described Ni toxicity, within a factor of 2, at varying solution chemistries and different exposure times. This shows that the acute BLM cannot directly be applied for predicting chronic metal toxicity and that some BLM parameters may vary with time. Our findings provide plausible explanations for differences in mechanisms of acute and chronic toxicity, offering a framework for incorporating toxicokinetic and toxicodynamic processes in describing Ni toxicity in time.

AB - Biotic ligand models (BLMs) predicting metal toxicity for a fixed exposure time are available, but it is uncertain how to extrapolate predictions to a dynamic environment with time-variable exposure. Three BLM-based models were developed to describe change of Ni toxicity to Enchytraeus crypticus in time. These models assumed that: (a) biotic ligand binding constants of Ni and competing cations (KNiBL and KCBL) and the fraction of biotic ligands occupied by Ni to produce 50% mortality (f50) are fixed with time, (b) KNiBL and KCBL remain constant while f50 varies with time, and (c) KNiBL, KCBL, and f50 are all time-dependent. Model (a) successfully described the 7-d toxicity of Ni but failed in explaining Ni toxicity at longer exposure times. Both models (b) and (c) well described Ni toxicity, within a factor of 2, at varying solution chemistries and different exposure times. This shows that the acute BLM cannot directly be applied for predicting chronic metal toxicity and that some BLM parameters may vary with time. Our findings provide plausible explanations for differences in mechanisms of acute and chronic toxicity, offering a framework for incorporating toxicokinetic and toxicodynamic processes in describing Ni toxicity in time.

KW - Enchytraeus crypticus

KW - Ni

KW - toxicodynamic

KW - biotic ligand model

U2 - 10.1016/j.chemosphere.2014.12.034

DO - 10.1016/j.chemosphere.2014.12.034

M3 - Article

VL - 124

SP - 170

EP - 176

JO - Chemosphere

JF - Chemosphere

SN - 0045-6535

ER -