A genome-wide search for linkage to asthma phenotypes in the genetics of asthma international network families: evidence for a major susceptibility locus on chromosome 2p

S G Pillai, M N Chiano, Nicola J. White, M Speer, Kathleen C. Barnes, K Carlsen, J Gerritsen, Peter Joseph Benedict Helms, W Lenney, M Silverman, P Sly, J Sundy, J Tsanakas, Andrea von Berg, Moira Whyte, S Varsani, P Skelding, M Hauser, J Vance, M Pericak-Vance & 5 others D K Burns, Lefkos T. Middleton, S R Brewster, Wayne H. Anderson, John H. Riley

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Asthma is a complex disease and the intricate interplay between genetic and environmental factors underlies the overall phenotype of the disease. Families with at least two siblings with asthma were collected from Europe, Australia and the US. A genome scan using a set of 364 families with a panel of 396 microsatellite markers was conducted. Nonparametric linkage analyses were conducted for asthma and three asthma-related phenotypes: bronchial hyper-reactivity (BHR), strict definition of asthma and atopic asthma. Nine chromosomal regions with LOD scores greater than 1.5 were identified ( chromosomes 1q, 2p, 3q, 4p, 4q, 6q, 12q, 20p and 21). Linkage refinement analysis was performed for three BHR loci by genotyping single nucleotide polymorphisms at an average marker density of 1 cM. The LOD scores increased to 3.07 at chromosome 4p and 4.58 at chromosome 2p, while the chromosome 6p locus did not refine. The LOD score at the chromosome 2p locus is highly significant on a genome-wide basis. The refined locus covers a region with a physical size of 12.2 Mb. Taken together, these results provide evidence for a major asthma susceptibility locus on chromosome 2p.

Original languageEnglish
Pages (from-to)307-316
Number of pages10
JournalEJHG : European journal of human genetics : the official journal of the European Society of Human Genetics.
Volume14
Issue number3
Early online date4 Jan 2006
DOIs
Publication statusPublished - Mar 2006

Keywords

  • asthma
  • bronchial hyper-reactivity
  • SNP
  • STRP
  • linkage
  • founder population
  • positional cloning
  • atopic-dermatitis
  • allergic disease
  • screen
  • genes
  • tests
  • scan
  • association
  • markers
  • bronchial hyper-reactivity

Cite this

A genome-wide search for linkage to asthma phenotypes in the genetics of asthma international network families : evidence for a major susceptibility locus on chromosome 2p. / Pillai, S G ; Chiano, M N ; White, Nicola J.; Speer, M ; Barnes, Kathleen C.; Carlsen, K ; Gerritsen, J ; Helms, Peter Joseph Benedict; Lenney, W ; Silverman, M ; Sly, P ; Sundy, J ; Tsanakas, J ; Berg, Andrea von; Whyte, Moira; Varsani, S ; Skelding, P ; Hauser, M ; Vance, J ; Pericak-Vance, M ; Burns, D K ; Middleton, Lefkos T.; Brewster, S R ; Anderson, Wayne H.; Riley, John H. .

In: EJHG : European journal of human genetics : the official journal of the European Society of Human Genetics. , Vol. 14, No. 3, 03.2006, p. 307-316.

Research output: Contribution to journalArticle

Pillai, SG, Chiano, MN, White, NJ, Speer, M, Barnes, KC, Carlsen, K, Gerritsen, J, Helms, PJB, Lenney, W, Silverman, M, Sly, P, Sundy, J, Tsanakas, J, Berg, AV, Whyte, M, Varsani, S, Skelding, P, Hauser, M, Vance, J, Pericak-Vance, M, Burns, DK, Middleton, LT, Brewster, SR, Anderson, WH & Riley, JH 2006, 'A genome-wide search for linkage to asthma phenotypes in the genetics of asthma international network families: evidence for a major susceptibility locus on chromosome 2p' EJHG : European journal of human genetics : the official journal of the European Society of Human Genetics. , vol. 14, no. 3, pp. 307-316. https://doi.org/10.1038/sj.ejhg.5201532
Pillai, S G ; Chiano, M N ; White, Nicola J. ; Speer, M ; Barnes, Kathleen C. ; Carlsen, K ; Gerritsen, J ; Helms, Peter Joseph Benedict ; Lenney, W ; Silverman, M ; Sly, P ; Sundy, J ; Tsanakas, J ; Berg, Andrea von ; Whyte, Moira ; Varsani, S ; Skelding, P ; Hauser, M ; Vance, J ; Pericak-Vance, M ; Burns, D K ; Middleton, Lefkos T. ; Brewster, S R ; Anderson, Wayne H. ; Riley, John H. . / A genome-wide search for linkage to asthma phenotypes in the genetics of asthma international network families : evidence for a major susceptibility locus on chromosome 2p. In: EJHG : European journal of human genetics : the official journal of the European Society of Human Genetics. . 2006 ; Vol. 14, No. 3. pp. 307-316.
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AU - Barnes, Kathleen C.

AU - Carlsen, K

AU - Gerritsen, J

AU - Helms, Peter Joseph Benedict

AU - Lenney, W

AU - Silverman, M

AU - Sly, P

AU - Sundy, J

AU - Tsanakas, J

AU - Berg, Andrea von

AU - Whyte, Moira

AU - Varsani, S

AU - Skelding, P

AU - Hauser, M

AU - Vance, J

AU - Pericak-Vance, M

AU - Burns, D K

AU - Middleton, Lefkos T.

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N2 - Asthma is a complex disease and the intricate interplay between genetic and environmental factors underlies the overall phenotype of the disease. Families with at least two siblings with asthma were collected from Europe, Australia and the US. A genome scan using a set of 364 families with a panel of 396 microsatellite markers was conducted. Nonparametric linkage analyses were conducted for asthma and three asthma-related phenotypes: bronchial hyper-reactivity (BHR), strict definition of asthma and atopic asthma. Nine chromosomal regions with LOD scores greater than 1.5 were identified ( chromosomes 1q, 2p, 3q, 4p, 4q, 6q, 12q, 20p and 21). Linkage refinement analysis was performed for three BHR loci by genotyping single nucleotide polymorphisms at an average marker density of 1 cM. The LOD scores increased to 3.07 at chromosome 4p and 4.58 at chromosome 2p, while the chromosome 6p locus did not refine. The LOD score at the chromosome 2p locus is highly significant on a genome-wide basis. The refined locus covers a region with a physical size of 12.2 Mb. Taken together, these results provide evidence for a major asthma susceptibility locus on chromosome 2p.

AB - Asthma is a complex disease and the intricate interplay between genetic and environmental factors underlies the overall phenotype of the disease. Families with at least two siblings with asthma were collected from Europe, Australia and the US. A genome scan using a set of 364 families with a panel of 396 microsatellite markers was conducted. Nonparametric linkage analyses were conducted for asthma and three asthma-related phenotypes: bronchial hyper-reactivity (BHR), strict definition of asthma and atopic asthma. Nine chromosomal regions with LOD scores greater than 1.5 were identified ( chromosomes 1q, 2p, 3q, 4p, 4q, 6q, 12q, 20p and 21). Linkage refinement analysis was performed for three BHR loci by genotyping single nucleotide polymorphisms at an average marker density of 1 cM. The LOD scores increased to 3.07 at chromosome 4p and 4.58 at chromosome 2p, while the chromosome 6p locus did not refine. The LOD score at the chromosome 2p locus is highly significant on a genome-wide basis. The refined locus covers a region with a physical size of 12.2 Mb. Taken together, these results provide evidence for a major asthma susceptibility locus on chromosome 2p.

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KW - founder population

KW - positional cloning

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KW - allergic disease

KW - screen

KW - genes

KW - tests

KW - scan

KW - association

KW - markers

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