A high rate of CLL phenotype lymphocytes in autoimmune haemolytic anaemia and immune thrombocytopenic purpura

Sajjan Mittal; Morgan G. Blaylock; Dominic J. Culligan; Robert N. Barker; Mark A. Vickers

doi:10.3324/haematol.11822

A high rate of CLL phenotype lymphocytes in autoimmune haemolytic anaemia and immune thrombocytopenic purpura

Sajjan Mittal, Morgan G. Blaylock, Dominic J. Culligan, Robert N. Barker, Mark A. Vickers

Research output: Contribution to journal › Article › peer-review

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Abstract

Minor CLL-like clones are found in ~3% of healthy individuals. AIHA and ITP are common in CLL and may be causally linked. We investigated the presence of CLL phenotype lymphocytes in 11 cases of primary AIHA, 18 of ITP and 2 of Evans’ Syndrome, compared with 26 age-matched healthy controls. A population of ‘CLL phenotype’ was seen in 6/31 patients compared to 1/26 healthy controls (2=3.9; p=0.05). Such clones may be important in the pathogenesis of autoimmune blood disorders.

Original language	English
Pages (from-to)	151-152
Number of pages	2
Journal	Haematologica
Volume	93
Issue number	1
DOIs	https://doi.org/10.3324/haematol.11822
Publication status	Published - Jan 2008

Keywords

autoimmune hemolytic anemia
immune thrombocytopenic purpura
clonal B-cells
CLL-phenotype lymphocytes

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10.3324/haematol.11822

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title = "A high rate of CLL phenotype lymphocytes in autoimmune haemolytic anaemia and immune thrombocytopenic purpura",

abstract = "Minor CLL-like clones are found in ~3% of healthy individuals. AIHA and ITP are common in CLL and may be causally linked. We investigated the presence of CLL phenotype lymphocytes in 11 cases of primary AIHA, 18 of ITP and 2 of Evans{\textquoteright} Syndrome, compared with 26 age-matched healthy controls. A population of {\textquoteleft}CLL phenotype{\textquoteright} was seen in 6/31 patients compared to 1/26 healthy controls (2=3.9; p=0.05). Such clones may be important in the pathogenesis of autoimmune blood disorders.",

keywords = "autoimmune hemolytic anemia, immune thrombocytopenic purpura, clonal B-cells, CLL-phenotype lymphocytes",

author = "Sajjan Mittal and Blaylock, {Morgan G.} and Culligan, {Dominic J.} and Barker, {Robert N.} and Vickers, {Mark A.}",

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T1 - A high rate of CLL phenotype lymphocytes in autoimmune haemolytic anaemia and immune thrombocytopenic purpura

AU - Mittal, Sajjan

AU - Blaylock, Morgan G.

AU - Culligan, Dominic J.

AU - Barker, Robert N.

AU - Vickers, Mark A.

PY - 2008/1

Y1 - 2008/1

N2 - Minor CLL-like clones are found in ~3% of healthy individuals. AIHA and ITP are common in CLL and may be causally linked. We investigated the presence of CLL phenotype lymphocytes in 11 cases of primary AIHA, 18 of ITP and 2 of Evans’ Syndrome, compared with 26 age-matched healthy controls. A population of ‘CLL phenotype’ was seen in 6/31 patients compared to 1/26 healthy controls (2=3.9; p=0.05). Such clones may be important in the pathogenesis of autoimmune blood disorders.

AB - Minor CLL-like clones are found in ~3% of healthy individuals. AIHA and ITP are common in CLL and may be causally linked. We investigated the presence of CLL phenotype lymphocytes in 11 cases of primary AIHA, 18 of ITP and 2 of Evans’ Syndrome, compared with 26 age-matched healthy controls. A population of ‘CLL phenotype’ was seen in 6/31 patients compared to 1/26 healthy controls (2=3.9; p=0.05). Such clones may be important in the pathogenesis of autoimmune blood disorders.

KW - autoimmune hemolytic anemia

KW - immune thrombocytopenic purpura

KW - clonal B-cells

KW - CLL-phenotype lymphocytes

U2 - 10.3324/haematol.11822

DO - 10.3324/haematol.11822

M3 - Article

SN - 1592-8721

VL - 93

SP - 151

EP - 152

JO - Haematologica

JF - Haematologica

IS - 1

ER -

A high rate of CLL phenotype lymphocytes in autoimmune haemolytic anaemia and immune thrombocytopenic purpura

Abstract

Keywords

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