A high rate of CLL phenotype lymphocytes in autoimmune haemolytic anaemia and immune thrombocytopenic purpura

Sajjan Mittal, Morgan G. Blaylock, Dominic J. Culligan, Robert N. Barker, Mark A. Vickers

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)

Abstract

Minor CLL-like clones are found in ~3% of healthy individuals. AIHA and ITP are common in CLL and may be causally linked. We investigated the presence of CLL phenotype lymphocytes in 11 cases of primary AIHA, 18 of ITP and 2 of Evans’ Syndrome, compared with 26 age-matched healthy controls. A population of ‘CLL phenotype’ was seen in 6/31 patients compared to 1/26 healthy controls (2=3.9; p=0.05). Such clones may be important in the pathogenesis of autoimmune blood disorders.
Original languageEnglish
Pages (from-to)151-152
Number of pages2
JournalHaematologica
Volume93
Issue number1
DOIs
Publication statusPublished - Jan 2008

Keywords

  • autoimmune hemolytic anemia
  • immune thrombocytopenic purpura
  • clonal B-cells
  • CLL-phenotype lymphocytes

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