A high rate of CLL phenotype lymphocytes in autoimmune haemolytic anaemia and immune thrombocytopenic purpura

Sajjan Mittal, Morgan G. Blaylock, Dominic J. Culligan, Robert N. Barker, Mark A. Vickers

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Minor CLL-like clones are found in ~3% of healthy individuals. AIHA and ITP are common in CLL and may be causally linked. We investigated the presence of CLL phenotype lymphocytes in 11 cases of primary AIHA, 18 of ITP and 2 of Evans’ Syndrome, compared with 26 age-matched healthy controls. A population of ‘CLL phenotype’ was seen in 6/31 patients compared to 1/26 healthy controls (2=3.9; p=0.05). Such clones may be important in the pathogenesis of autoimmune blood disorders.
Original languageEnglish
Pages (from-to)151-152
Number of pages2
JournalHaematologica
Volume93
Issue number1
DOIs
Publication statusPublished - Jan 2008

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Inosine Triphosphate
Autoimmune Hemolytic Anemia
Idiopathic Thrombocytopenic Purpura
Clone Cells
Lymphocytes
Phenotype
Population
Evans Syndrome

Keywords

  • autoimmune hemolytic anemia
  • immune thrombocytopenic purpura
  • clonal B-cells
  • CLL-phenotype lymphocytes

Cite this

A high rate of CLL phenotype lymphocytes in autoimmune haemolytic anaemia and immune thrombocytopenic purpura. / Mittal, Sajjan; Blaylock, Morgan G.; Culligan, Dominic J.; Barker, Robert N.; Vickers, Mark A.

In: Haematologica, Vol. 93, No. 1, 01.2008, p. 151-152.

Research output: Contribution to journalArticle

Mittal, Sajjan ; Blaylock, Morgan G. ; Culligan, Dominic J. ; Barker, Robert N. ; Vickers, Mark A. / A high rate of CLL phenotype lymphocytes in autoimmune haemolytic anaemia and immune thrombocytopenic purpura. In: Haematologica. 2008 ; Vol. 93, No. 1. pp. 151-152.
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