A high tender point count is associated with the presence of multiple idiopathic pain disorders

Results from a population study

Vishal R. Aggarwal*, G. J. MacFarlane, J. McBeth

*Corresponding author for this work

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background/aims: To test whether mechanical hyperalgesia is associated with multiple idiopathic pain disorders (IPDs) and whether this relationship is independent of the confounding effects of psychosocial factors. Methods: One hundred eighteen subjects with chronic orofacial pain (COFP) were identified from their questionnaire responses to a population study in North West England. All subjects had a tender point examination according to the American College of Rheumatology classification. Validated tools on the questionnaire were used to identify presence of other IPDs (irritable bowel syndrome and chronic widespread pain) and psychosocial factors (anxiety, depression, health anxiety, sleep disturbance and reporting of somatic symptoms and adverse life events). Results: Of the 118 subjects, 47.6% (n = 56) had COFP, 34.7% (n = 41) had COFP plus one IPD and 17.8% (n = 21) had all three IPDs. Univariate analysis revealed a dose-response relationship between number of tender points (TPs) and number of IPDs [2-6 TPs (OR 2.6, 95% CI 1.0-7.3), ≥7 TPs (OR 10.5, 95% CI 3.8-29.3)] and number of IPDs and psychological distress [anxiety (OR 2.8, 95% CI 1.2-6.4), depression (OR 4.3, 95% CI 1.7-10.6), sleep disturbance (OR 4.8, 95% CI 1.6-14.6)]. The relationship between IPDs and TPs persisted after adjusting for psychosocial factors in multivariate analyses [2-6 TPs (OR 2.5, 95% CI 0.8-7.8) ≥7 TPs (OR 10.7, 95% CI 3.4-33.7)]. Conclusion: The dose-response relationship between TPs and IPDs needs further investigation to determine the temporal nature of these relationships and to disentangle the complex gene-environment relationships that may influence the occurrence of multiple IPDs.

Original languageEnglish
Pages (from-to)1195-1203
Number of pages9
JournalEuropean Journal of Pain (United Kingdom)
Volume16
Issue number8
Early online date6 Mar 2012
DOIs
Publication statusPublished - Sep 2012

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Somatoform Disorders
Population
Chronic Pain
Facial Pain
Psychology
Anxiety
Sleep
Depression
Irritable Bowel Syndrome
Hyperalgesia
England
Multivariate Analysis

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

A high tender point count is associated with the presence of multiple idiopathic pain disorders : Results from a population study. / Aggarwal, Vishal R.; MacFarlane, G. J.; McBeth, J.

In: European Journal of Pain (United Kingdom), Vol. 16, No. 8, 09.2012, p. 1195-1203.

Research output: Contribution to journalArticle

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abstract = "Background/aims: To test whether mechanical hyperalgesia is associated with multiple idiopathic pain disorders (IPDs) and whether this relationship is independent of the confounding effects of psychosocial factors. Methods: One hundred eighteen subjects with chronic orofacial pain (COFP) were identified from their questionnaire responses to a population study in North West England. All subjects had a tender point examination according to the American College of Rheumatology classification. Validated tools on the questionnaire were used to identify presence of other IPDs (irritable bowel syndrome and chronic widespread pain) and psychosocial factors (anxiety, depression, health anxiety, sleep disturbance and reporting of somatic symptoms and adverse life events). Results: Of the 118 subjects, 47.6{\%} (n = 56) had COFP, 34.7{\%} (n = 41) had COFP plus one IPD and 17.8{\%} (n = 21) had all three IPDs. Univariate analysis revealed a dose-response relationship between number of tender points (TPs) and number of IPDs [2-6 TPs (OR 2.6, 95{\%} CI 1.0-7.3), ≥7 TPs (OR 10.5, 95{\%} CI 3.8-29.3)] and number of IPDs and psychological distress [anxiety (OR 2.8, 95{\%} CI 1.2-6.4), depression (OR 4.3, 95{\%} CI 1.7-10.6), sleep disturbance (OR 4.8, 95{\%} CI 1.6-14.6)]. The relationship between IPDs and TPs persisted after adjusting for psychosocial factors in multivariate analyses [2-6 TPs (OR 2.5, 95{\%} CI 0.8-7.8) ≥7 TPs (OR 10.7, 95{\%} CI 3.4-33.7)]. Conclusion: The dose-response relationship between TPs and IPDs needs further investigation to determine the temporal nature of these relationships and to disentangle the complex gene-environment relationships that may influence the occurrence of multiple IPDs.",
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