A Histogram-Based Similarity Measure for Quantitative Magnetic Resonance Imaging: Application in Acute Mild Traumatic Brain Injury

Benjamin S Aribisala, Christopher J A Cowie, Jiabao He, Joshua Wood, David A Mendelow, Patrick Mitchell, Andrew M Blamire

Research output: Contribution to journalArticle

Abstract

OBJECTIVES: The most commonly used summary metric in neuroimaging is the mean value, but this pays little attention to the shape of the data distribution and can therefore be insensitive to subtle changes that alter the data distribution.

METHODS: We propose a distributional-based metric called the normalized histogram similarity measure (HSM) for characterization of quantitative images. We applied HSM to quantitative magnetic resonance imaging T1 relaxation data of 44 patients with mild traumatic brain injury and compared with data of 43 age-matched controls.

RESULTS: Significant differences were found between the patients and the controls in 8 gray matter regions using the HSM whereas in only 1 gray matter region based on the mean values.

CONCLUSIONS: Our results show that HSM is more sensitive than the standard mean values in detecting brain tissue changes. Future studies on brain tissue properties using quantitative magnetic resonance imaging should consider the use of HSM to properly capture any tissue changes.

Original languageEnglish
Pages (from-to)915-923
Number of pages9
JournalJournal of Computer Assisted Tomography
Volume38
Issue number6
DOIs
Publication statusPublished - Nov 2014

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Brain Concussion
Magnetic Resonance Imaging
Brain
Neuroimaging
Gray Matter

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A Histogram-Based Similarity Measure for Quantitative Magnetic Resonance Imaging : Application in Acute Mild Traumatic Brain Injury. / Aribisala, Benjamin S; Cowie, Christopher J A; He, Jiabao; Wood, Joshua; Mendelow, David A; Mitchell, Patrick; Blamire, Andrew M.

In: Journal of Computer Assisted Tomography, Vol. 38, No. 6, 11.2014, p. 915-923.

Research output: Contribution to journalArticle

Aribisala, Benjamin S ; Cowie, Christopher J A ; He, Jiabao ; Wood, Joshua ; Mendelow, David A ; Mitchell, Patrick ; Blamire, Andrew M. / A Histogram-Based Similarity Measure for Quantitative Magnetic Resonance Imaging : Application in Acute Mild Traumatic Brain Injury. In: Journal of Computer Assisted Tomography. 2014 ; Vol. 38, No. 6. pp. 915-923.
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