A large replication study and meta-analysis in European samples provides further support for association of AHI1 markers with schizophrenia

GROUP Investigators

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Abstract

The Abelson helper integration site 1 (AHI1) gene locus on chromosome 6q23 is among a group of candidate loci for schizophrenia susceptibility that were initially identified by linkage followed by linkage disequilibrium (LD) mapping, and subsequent replication of the association in an independent sample. Here, we present results of a replication study of AHI1 locus markers, previously implicated in schizophrenia, in a large European sample (in total 3,907 affected and 7,429 controls). Furthermore, we perform a meta-analysis of the implicated markers in 4,496 affected and 18,920 controls. Both the replication study of new samples and the meta-analysis show evidence for significant overrepresentation of all tested alleles in patients compared with controls (meta-analysis; P=8.2×10-5–1.7×10-3, common OR=1.09-1.11). The region contains two genes, AHI1and C6orf217, and both genes – as well as the neighbouring phosphodiesterase 7B (PDE7B) - may be considered candidates for involvement in the genetic aetiology of schizophrenia.
Original languageEnglish
Pages (from-to)1379-1386
Number of pages8
JournalHuman Molecular Genetics
Volume19
Issue number7
Early online date12 Jan 2010
DOIs
Publication statusPublished - 1 Apr 2010

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Meta-Analysis
Schizophrenia
Genes
Chromosome Mapping
Linkage Disequilibrium
Phosphoric Diester Hydrolases
Chromosomes
Alleles

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A large replication study and meta-analysis in European samples provides further support for association of AHI1 markers with schizophrenia. / GROUP Investigators.

In: Human Molecular Genetics, Vol. 19, No. 7, 01.04.2010, p. 1379-1386.

Research output: Contribution to journalArticle

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abstract = "The Abelson helper integration site 1 (AHI1) gene locus on chromosome 6q23 is among a group of candidate loci for schizophrenia susceptibility that were initially identified by linkage followed by linkage disequilibrium (LD) mapping, and subsequent replication of the association in an independent sample. Here, we present results of a replication study of AHI1 locus markers, previously implicated in schizophrenia, in a large European sample (in total 3,907 affected and 7,429 controls). Furthermore, we perform a meta-analysis of the implicated markers in 4,496 affected and 18,920 controls. Both the replication study of new samples and the meta-analysis show evidence for significant overrepresentation of all tested alleles in patients compared with controls (meta-analysis; P=8.2×10-5–1.7×10-3, common OR=1.09-1.11). The region contains two genes, AHI1and C6orf217, and both genes – as well as the neighbouring phosphodiesterase 7B (PDE7B) - may be considered candidates for involvement in the genetic aetiology of schizophrenia.",
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AU - Ingason, Andrés

AU - Giegling, Ina

AU - Cichon, Sven

AU - Hanson, Thomas

AU - Rasmussen, Henrik B.

AU - Nielsen, Jimmi

AU - Jürgens, Gesche

AU - Muglia, Pierandrea

AU - Hartmann, Annette M.

AU - Strengman, Eric

AU - Vasilescu, Catalina

AU - Mühleisen, Thomas W.

AU - Djurovic, Srdjan

AU - Melle, Ingrid

AU - Lerer, Bernard

AU - Möller, Hans-Jürgen

AU - Francks, Clyde

AU - Pietiläinen, Olli P. H.

AU - Lonnqvist, Jouko

AU - Suvisaari, Jaana

AU - Tuulio-Henriksson, Annamari

AU - Walshe, Muriel

AU - Vassos, Evangelos

AU - Forti, Marta Di

AU - Murray, Robin

AU - Bonetto, Chiara

AU - Tosato, Sarah

AU - GROUP Investigators

AU - Cantor, Rita M.

AU - Rietschel, Marcella

AU - Craddock, Nick

AU - Owen, Michael J.

AU - Peltonen, Leena

AU - Andreassen, Ole A.

AU - Nöthen, Markus M.

AU - St Clair, David M.

AU - Ophoff, Roel A.

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AU - Collier, David

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AU - Rujescu, Dan

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N2 - The Abelson helper integration site 1 (AHI1) gene locus on chromosome 6q23 is among a group of candidate loci for schizophrenia susceptibility that were initially identified by linkage followed by linkage disequilibrium (LD) mapping, and subsequent replication of the association in an independent sample. Here, we present results of a replication study of AHI1 locus markers, previously implicated in schizophrenia, in a large European sample (in total 3,907 affected and 7,429 controls). Furthermore, we perform a meta-analysis of the implicated markers in 4,496 affected and 18,920 controls. Both the replication study of new samples and the meta-analysis show evidence for significant overrepresentation of all tested alleles in patients compared with controls (meta-analysis; P=8.2×10-5–1.7×10-3, common OR=1.09-1.11). The region contains two genes, AHI1and C6orf217, and both genes – as well as the neighbouring phosphodiesterase 7B (PDE7B) - may be considered candidates for involvement in the genetic aetiology of schizophrenia.

AB - The Abelson helper integration site 1 (AHI1) gene locus on chromosome 6q23 is among a group of candidate loci for schizophrenia susceptibility that were initially identified by linkage followed by linkage disequilibrium (LD) mapping, and subsequent replication of the association in an independent sample. Here, we present results of a replication study of AHI1 locus markers, previously implicated in schizophrenia, in a large European sample (in total 3,907 affected and 7,429 controls). Furthermore, we perform a meta-analysis of the implicated markers in 4,496 affected and 18,920 controls. Both the replication study of new samples and the meta-analysis show evidence for significant overrepresentation of all tested alleles in patients compared with controls (meta-analysis; P=8.2×10-5–1.7×10-3, common OR=1.09-1.11). The region contains two genes, AHI1and C6orf217, and both genes – as well as the neighbouring phosphodiesterase 7B (PDE7B) - may be considered candidates for involvement in the genetic aetiology of schizophrenia.

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DO - 10.1093/hmg/ddq009

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SP - 1379

EP - 1386

JO - Human Molecular Genetics

JF - Human Molecular Genetics

SN - 0964-6906

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