A long-range restriction map across 3 Mb of the chromosome 11 breakpoint region of a translocation linked to schizophrenia: Localization of the breakpoint and the search for neighbouring genes

J. K. Millar*, J. Brown, J. C. Maule, Y. Shibasaki, S. Christie, D. Lawson, S. Anderson, J. C. Wilson-Annan, R. S. Devon, D. M. St Clair, D. H.R. Blackwood, W. J. Muir, D. J. Porteous

*Corresponding author for this work

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

A balanced t(1;11)(q42.1;q14.3) translocation segregates with schizophrenia and related mental illness in a single large Scottish pedigree. We have constructed a long-range restriction map covering at least 3 Mb of the chromosome 11 breakpoint region and conducted searches for genes whose expression could be altered by the translocation, resulting in schizophrenia. Novel transcribed sequences of unknown function clustered around putative CpG islands, located approximately 500 kb and 700 kb above the breakpoint, represent the only evidence to date for expressed genes within the mapped region.

Original languageEnglish
Pages (from-to)175-181
Number of pages7
JournalPsychiatric Genetics
Volume8
Issue number3
Publication statusPublished - 2 Nov 1998

Keywords

  • Gene identification
  • Long-range restriction map
  • Schizophrenia
  • Translocation

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)
  • Psychiatry and Mental health
  • Biological Psychiatry

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    Millar, J. K., Brown, J., Maule, J. C., Shibasaki, Y., Christie, S., Lawson, D., Anderson, S., Wilson-Annan, J. C., Devon, R. S., St Clair, D. M., Blackwood, D. H. R., Muir, W. J., & Porteous, D. J. (1998). A long-range restriction map across 3 Mb of the chromosome 11 breakpoint region of a translocation linked to schizophrenia: Localization of the breakpoint and the search for neighbouring genes. Psychiatric Genetics, 8(3), 175-181.